Article
Biochemistry & Molecular Biology
S. Charisis, E. Ntanasi, M. Yannakoulia, C. A. Anastasiou, M. H. Kosmidis, E. Dardiotis, G. Hadjigeorgiou, P. Sakka, A. S. Veskoukis, D. Kouretas, N. Scarmeas
Summary: The study found that higher baseline plasma GSH levels were associated with a decreased risk of developing AD and with a better preservation of executive functioning longitudinally in non-demented older adults living in the community.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Review
Neurosciences
Sneha R. Sharma, Yu Chen
Summary: The association between rheumatoid arthritis and dementia or cognitive impairment is still uncertain, as studies have produced mixed results. Further research is needed to clarify the possible shared biological underpinnings of these two conditions.
JOURNAL OF ALZHEIMERS DISEASE
(2023)
Review
Geriatrics & Gerontology
Xiaowei Han, Muhammad Ashraf, Srinivas M. Tipparaju, Wanling Xuan
Summary: Sarcopenia is the age-related loss of skeletal muscle mass and strength, and Alzheimer's disease is the most common cause of dementia in elderly adults. The association between sarcopenia and Alzheimer's disease is still unclear, but understanding the mechanism of muscle-brain crosstalk during cognitive impairment may provide new insights and therapeutic approaches for combating cognitive decline and Alzheimer's disease.
FRONTIERS IN AGING NEUROSCIENCE
(2023)
Article
Clinical Neurology
Jennifer Weuve, Jennifer D'Souza, Todd Beck, Denis A. Evans, Joel D. Kaufman, Kumar B. Rajan, Carlos F. Mendes de Leon, Sara D. Adar
Summary: The study found that an increase in noise level was associated with higher odds of prevalent MCI and AD, as well as worse global cognitive performance, mainly in perceptual speed. However, the association with cognitive decline was not consistent.
ALZHEIMERS & DEMENTIA
(2021)
Article
Neurosciences
Marcia C. de Oliveira Otto, Jason H. Y. Wu, Evan L. Thacker, Heidi Tsz Mung Lai, Rozenn N. Lemaitre, Nikhil Padhye, Xiaoling Song, Irena B. King, Oscar Lopez, David S. Siscovick, Dariush Mozaffarian
Summary: The study found that circulating arachidonic acid (AA) and docosapentaenoic acid (DPA) are associated with a slower rate of cognitive decline and a lower risk of cognitive impairment, while other PUFA show no significant associations.
JOURNAL OF ALZHEIMERS DISEASE
(2023)
Article
Neurosciences
Jenna Rajczyk, Amy Ferketich, Jeffrey J. Wing
Summary: This study examined the association between smoking status and subjective cognitive decline (SCD) in middle age and older adults, and whether this association is modified by sex. The results showed a graded association between smoking and SCD, with current smokers having the highest prevalence followed by recent former smokers and remote former smokers, compared to never smokers. There was no evidence of effect modification by sex.
JOURNAL OF ALZHEIMERS DISEASE
(2023)
Article
Clinical Neurology
Tatiana Karpouzian-Rogers, Emily Ho, Miriam Novack, Miriam Chinkers, Katy Bedjeti, Cindy Nowinski, Bruno Giordani, Richard Gershon, Sandra Weintraub
Summary: This article reports on the characteristics of participants in the ARMADA study, which aims to validate the NIH Toolbox across the cognitive aging spectrum. The study sample includes individuals with normal cognition, mild cognitive impairment, and dementia of the Alzheimer's type. The results indicate that the groups had well-matched demographic characteristics, while their clinical characteristics differed as expected.
ALZHEIMERS & DEMENTIA
(2023)
Article
Geriatrics & Gerontology
Aron S. Buchman, Ana W. Capuano, Veronique VanderHorst, Robert S. Wilson, Shahram Oveisgharan, Julie A. Schneider, David A. Bennett
Summary: This study examined the relationship between changes in body mass index (BMI) and cognitive decline in older adults. The results showed that BMI changes were associated with cognitive decline, and this association was mediated by certain brain pathologies, such as beta-amyloid accumulation. Understanding the molecular mechanisms underlying these associations may lead to the development of interventions for maintaining brain health and metabolic homeostasis in old age.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2023)
Review
Genetics & Heredity
Desyrre Tedeschi, Anderson F. da Cunha, Marcia R. Cominetti, Renata Valle Pedroso
Summary: Research indicates that gene therapy has a positive impact on improving cognition in AD, but clinical studies have shown inconclusive results, with viral vector delivery methods being a key factor. Interpretation of the potential of gene therapy in treating AD should be approached with caution.
CURRENT GENE THERAPY
(2021)
Article
Clinical Neurology
Terry E. Goldberg, Seonjoo Lee, Davangere P. Devanand, Lon S. Schneider
Summary: Using per cent slowing of decline as a metric of outcome in Alzheimer's disease clinical trials may be misleading, while Cohen's d is a more valid and informative measure of efficacy. Standardised effect size determines group overlap, influences NNT computations, and provides information on the likelihood of minimum clinically important differences.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2023)
Article
Clinical Neurology
Jochum J. Van 't Hooft, Wiesje Pelkmans, Jori Tomassen, Cas Smits, Nienke Legdeur, Anouk Den Braber, Frederik Barkhof, Bart Van Berckel, Maqsood Yaqub, Philip Scheltens, Yolande A. L. Pijnenburg, Pieter Jelle Visser, Betty M. Tijms
Summary: Hearing loss in older adults is associated with increased dementia risk, and the underlying mechanisms connecting the two remain unclear. This study found an association between hearing loss and biomarkers for dementia risk, and the association varied between different age groups. In older adults, hearing loss was associated with a decline in memory, global cognition, and language.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2023)
Article
Clinical Neurology
Sarah-Naomi James, Yu-Jie Chiou, Nasri Fatih, Louisa P. Needham, Jonathan M. Schott, Marcus Richards
Summary: This study found that being physically active at any time and to any extent in adulthood is associated with higher cognitive function in later life. Long-term maintenance of physical activity is particularly beneficial for cognitive state in old age. These associations are partly explained by childhood cognition and education, but are independent of cardiovascular and mental health and APOE-E4.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2023)
Review
Geriatrics & Gerontology
Samantha J. Waite, Stuart Maitland, Alan Thomas, Alison J. Yarnall
Summary: Population aging has led to an increase in age-related conditions, including sarcopenia and frailty, which are common causes of functional decline in older individuals. This review found that there is a higher prevalence of frailty and sarcopenia in dementia patients, but there is still limited research on how they interrelate with dementia.
ARCHIVES OF GERONTOLOGY AND GERIATRICS
(2021)
Article
Geriatrics & Gerontology
Leatha A. Clark, Todd M. Manini, Nathan P. Wages, Janet E. Simon, David W. Russ, Brian C. Clark
Summary: The study revealed that the presence of meaningful leg extensor weakness in older adults can lead to changes in neural excitability, with neural excitability variables and thigh lean mass explaining part of the variability in muscle strength.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Lauren Jun, Megan Robinson, Thangiah Geetha, Tom L. L. Broderick, Jeganathan Ramesh Babu
Summary: Skeletal muscle atrophy is a prevalent issue in numerous pathological conditions and has significant implications for the health of society, particularly older adults. The detrimental effects of muscle atrophy include functional disability, increased fracture risk, decreased metabolic rate, and reduced bone density. This review article focuses on the prevalence and mechanisms of skeletal muscle atrophy, with particular emphasis on high-fat, high-sugar diets, obesity, and diabetes, as well as other conditions such as sarcopenia, Alzheimer's disease, cancer cachexia, and heart failure.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Rehabilitation
Ryan Bailey
DISABILITY AND REHABILITATION
(2020)
Article
Health Care Sciences & Services
Ryan R. Bailey, Monica C. Serra, Ryan P. McGrath
DISABILITY AND HEALTH JOURNAL
(2020)
Article
Neurosciences
Simon Driver, Evan McShan, Chad Swank, Katherine Grobe, Stephanie Calhoun, Ryan Bailey, Kaye Kramer
Article
Rehabilitation
Ryan R. Bailey, Molly Conroy
Summary: This study investigated the impact of obesity and diabetes on disability risk in stroke survivors. The results indicated that stroke survivors with obesity or diabetes had significantly higher risks of disability in terms of mobility and basic activities of daily living.
TOPICS IN STROKE REHABILITATION
(2022)
Article
Health Care Sciences & Services
Ryan R. Bailey, Miranda Ipsen
Summary: This study examined the facilitators and barriers to performing dietary behaviors in stroke survivors through qualitative analysis. The findings indicate that stroke-related impairments, such as changes in body functions and structures, limit the execution of dietary behaviors. However, environmental supports and activity modification can be employed to overcome these limitations and promote dietary behaviors. Negative affect and activity limitations also negatively impact dietary behaviors and social participation.
DISABILITY AND HEALTH JOURNAL
(2022)
Article
Clinical Neurology
Ryan R. Bailey, Natalie Miner
Summary: This study examined the differences in health characteristics and health behaviors between rural and non-rural stroke survivors in the USA. The results showed higher prevalences of disability, poor health, weekly aerobic exercise, and smoking among rural stroke survivors compared to non-rural stroke survivors. However, these differences were attenuated after controlling for sociodemographic and health characteristics.
Review
Public, Environmental & Occupational Health
Ryan R. Bailey, Alfonso L. Neri, Monica C. Serra
Summary: This article conducts a scoping review to identify and summarize studies on dietary behavior interventions and dietary outcomes in community-dwelling adult stroke survivors. The review supports the efficacy of dietary behavior interventions in improving dietary outcomes; however, the variability in intervention formats and assessment measures hinders the ability to conduct meta-analyses.
AMERICAN JOURNAL OF LIFESTYLE MEDICINE
(2022)
Article
Rehabilitation
Ryan R. Bailey, Sarah Waddoups
Summary: This mixed-methods study aimed to understand the post-stroke dietary behaviors among chronic, community-dwelling stroke survivors. The findings showed that post-stroke performance in most dietary behaviors decreased, but there was an increased desire to eat healthily to prevent recurrent stroke. The use of adaptive equipment and compensatory strategies varied, and there was limited healthcare-based dietary behavior education and training.
OCCUPATIONAL THERAPY IN HEALTH CARE
(2022)
Article
Public, Environmental & Occupational Health
Ryan R. Bailey, Jennifer L. Stevenson, Simon Driver, Evan McShan
Summary: The study found that stroke survivors face an increased risk of recurrent stroke and therefore need specific adaptations for the Diabetes Prevention Program-Group Lifestyle Balance (DPP-GLB) program. Adaptations for stroke survivors include modifying content and format, adjusting physical activity and dietary recommendations, and involving care-partners.
AMERICAN JOURNAL OF LIFESTYLE MEDICINE
(2022)
Article
Primary Health Care
Ryan R. Bailey, John Robinson Singleton, Jennifer J. Majersik
Summary: This study compared the prevalence of low fruit and vegetable consumption and low physical activity among stroke survivors, finding high rates of unhealthy behaviors across different obesity-diabetes categories.
Article
Public, Environmental & Occupational Health
Ryan R. Bailey
AMERICAN JOURNAL OF LIFESTYLE MEDICINE
(2019)
Meeting Abstract
Psychology, Multidisciplinary
Ryan Bailey
ANNALS OF BEHAVIORAL MEDICINE
(2019)
Article
Rehabilitation
Ryan R. Bailey
OCCUPATIONAL THERAPY IN HEALTH CARE
(2019)
Article
Health Care Sciences & Services
Ryan R. Bailey, Miranda Ipsen
Summary: This study found that stroke survivors face various obstacles in performing dietary behaviors, such as changes in body functions, environmental supports, and negative emotions, but these barriers can be overcome by environmental support and activity modification.
DISABILITY AND HEALTH JOURNAL
(2022)
