Review
Geriatrics & Gerontology
Jiayu Li, Yanguo Xin, Jingye Li, Hui Chen, Hongwei Li
Summary: Phosphatidyl Ethanolamine Methyltransferase (PEMT), located on the endoplasmic reticulum and mitochondria associated membrane, regulates phospholipid metabolism. Dysregulation of PEMT is associated with the development of diseases such as fatty liver and cardiovascular diseases.
Article
Biochemistry & Molecular Biology
Siraphat Taesuwan, Melissa Q. McDougall, Olga V. Malysheva, Erica Bender, Julie E. H. Nevins, Srisatish Devapatla, Ramesh Vidavalur, Marie A. Caudill, Kevin C. Klatt
Summary: This study investigated the impact of prenatal choline supplementation on maternal and fetal biomarkers of choline metabolism. Results showed that higher doses of supplemental choline significantly affected plasma concentrations of free choline, betaine, dimethylglycine, phosphatidylcholine, and sphingomyelin. Greater plasma enrichments of specific metabolites were observed in the intervention group, indicating enhanced choline metabolism and lipid synthesis pathways during pregnancy.
Article
Nutrition & Dietetics
Chien-Hsien Wu, Ting-Yu Chang, Yen-Chu Chen, Rwei-Fen S. Huang
Summary: The PEMT rs7946 polymorphism has sex-specific effects on choline requirement and hepatic steatosis (HS) risk in humans. This study explored the interaction effect of the PEMT rs7946 polymorphism and sex on the impact of adequate choline intake on HS risk. The findings suggest that elevated levels of the PEMT rs7946 A allele are associated with decreased HS risk and body mass index in both men and women.
Article
Nutrition & Dietetics
Aura (alex) P. Loinard-Gonzalez, Olga Malysheva, Kevin C. Klatt, Marie A. Caudill
Summary: This study investigated the impact of genetic variants in one-carbon metabolism genes on DHA status, and found that genotype may influence maternal and fetal DHA levels, highlighting the importance of considering genetic variants in one-carbon metabolic genes during pregnancy.
Article
Genetics & Heredity
Jose Suazo, Carlos Salamanca, Patricio Gonzalez-Hormazabal, Gabriela Caceres-Rojas, Roberto Pantoja, Noemi Leiva, Rosa Pardo
Summary: This study assessed the association between PEMT variants and nonsyndromic cleft lip with or without cleft palate in Chile, as well as the effects of these variants on global DNA methylation. The study found that the variants rs7649 and rs4646409 increased the risk of nonsyndromic cleft lip with or without cleft palate in the Chilean population and led to a decrease in DNA methylation. This suggests that this gene may be involved in this birth defect.
Article
Biochemistry & Molecular Biology
Mosleh Abomughaid, Enoch S. E. Tay, Russell Pickford, Chandra Malladi, Scott A. Read, Jens R. Coorssen, Brian S. Gloss, Jacob George, Mark W. Douglas
Summary: HCV infection increases neutral lipid and phospholipids in cells and induces the expression of PEMT, a key enzyme promoting lipid accumulation and virus replication. The induction of PEMT may explain the genotype-specific differences in hepatic steatosis caused by the virus.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Nutrition & Dietetics
Monika A. Mlodzik-Czyzewska, Anna M. Malinowska, Artur Szwengiel, Agata Chmurzynska
Summary: The study examined the associations between plasma levels of trimethylamine N-oxide (TMAO), choline, and betaine with anthropometric measurements. Higher plasma choline was associated with higher BMI, body weight, body fat mass, and waist circumference, while higher choline intake was associated with lower body fat mass and waist circumference. Plasma betaine was found to be associated with lower BMI and body weight in men only. These associations appear to be sex-specific.
JOURNAL OF HUMAN NUTRITION AND DIETETICS
(2022)
Article
Endocrinology & Metabolism
Monika A. Mlodzik-Czyzewska, Artur Szwengiel, Anna M. Malinowska, Agata Chmurzynska
Summary: The study compared biomarkers of one-carbon metabolism, lipid metabolism, and fatty liver in individuals with normal and increased body weight. Results showed differences in associations between OCM markers, fatty liver indices, and blood lipids among subjects with normal and excessive body weight, with higher choline and L-carnitine levels observed in overweight/obese participants.
ANNALS OF NUTRITION AND METABOLISM
(2021)
Review
Nutrition & Dietetics
Krystyna Yeroshkina, Zoia Rossokha, Liliya Fishchuk, Nataliia Gorovenko
Summary: The most important pathway in the development of folate-related pathologies is the increase in homocysteine (HC) level. This article provides a theoretical analysis of the contribution of betaine metabolism and the genetic polymorphism of the BHMT gene to folate metabolism disturbances and the development of folate-related pathologies. The study emphasizes the potential clinical significance of using betaine and identifying BHMT gene variants in the remethylation reaction of HC.
Article
Nutrition & Dietetics
Heleen Van Puyvelde, Nikos Papadimitriou, Joanna Clasen, David Muller, Carine Biessy, Pietro Ferrari, Jytte Halkjaer, Kim Overvad, Anne Tjonneland, Renee T. Fortner, Verena Katzke, Matthias B. Schulze, Paolo Chiodini, Giovanna Masala, Valeria Pala, Carlotta Sacerdote, Rosario Tumino, Marije F. Bakker, Antonio Agudo, Eva Ardanaz, Maria Dolores Chirlaque Lopez, Maria-Jose Sanchez, Ulrika Ericson, Bjorn Gylling, Therese Karlsson, Jonas Manjer, Julie A. Schmidt, Genevieve Nicolas, Corinne Casagrande, Elisabete Weiderpass, Alicia K. Heath, Lode Godderis, Koen Van Herck, Dirk De Bacquer, Marc J. Gunter, Inge Huybrechts
Summary: The study did not find strong evidence for an association between methyl-group donors involved in one-carbon metabolism and breast cancer risk. However, there was a potential U-shaped trend suggested for dietary folate intake and breast cancer risk. Further research is needed to clarify this association.
Article
Nutrition & Dietetics
Tong Wu, Qiu-Ye Lan, Fang Tian, Xiao-Ying Xiong, Meng-Tao Yang, Si-Yu Huang, Xiao-Yan Chen, Matthew J. Kuchan, Xiang Li, Yan-Rong Zhao, Ying-Yi Mao, Hui-Lian Zhu
Summary: This study describes the concentration changes of individual choline and choline-containing compounds in Chinese human breast milk for the first time. Results show that water-soluble choline is the major component, with concentrations increasing from colostrum to transitional milk and then declining in mature milk, while lipid-soluble choline has the opposite trajectory. Delivery mode and parity history also influence choline composition.
CLINICAL NUTRITION
(2023)
Review
Nutrition & Dietetics
Wolfgang Bernhard
Summary: Cystic fibrosis (CF) patients often experience choline deficiency due to exocrine pancreatic insufficiency, impacting organ functions. Choline deficiency results in hepatic choline/phosphatidylcholine accretion from lung tissue, explaining the link between choline deficiency and lung function. Evaluation of choline supplementation in CF patients of all ages is necessary.
EUROPEAN JOURNAL OF NUTRITION
(2021)
Article
Endocrinology & Metabolism
Jie Zhu, Yu-Hong Liu, Xiang-Long He, Martin Kohlmeier, Li-Li Zhou, Li-Wei Shen, Xin-xuan Yi, Qing-Ya Tang, Wei Cai, Bei Wang
Summary: This case-control study suggests that high maternal choline intake during pregnancy is associated with reduced risk of preterm birth. The interaction between maternal choline intake and PEMT gene polymorphism rs7946 may affect the risk of preterm birth, with AA genotype carriers and low choline intake showing a higher risk. It was also found that cases with AA genotype and low choline intake had the highest levels of plasma Hcy.
ANNALS OF NUTRITION AND METABOLISM
(2021)
Article
Nutrition & Dietetics
Manjun Luo, Tingting Wang, Peng Huang, Senmao Zhang, Xinli Song, Mengting Sun, Yiping Liu, Jianhui Wei, Jing Shu, Taowei Zhong, Qian Chen, Ping Zhu, Jiabi Qin
Summary: This study explored the association between maternal BHMT gene polymorphisms, maternal dietary habits, and their interactions on the risk of ventricular septal defects (VSD) in offspring. The results showed that excessive intake of smoked, barbecued, fried, and pickled foods increased the risk of VSD, while regular intake of fresh fruits, fish and shrimp, fresh eggs, beans, and milk products decreased the risk. Maternal BHMT gene polymorphisms at rs1316753 and rs1915706 were also associated with an increased risk of VSD. Furthermore, an interaction between BHMT polymorphisms and maternal bean intake was identified.
Article
Biochemical Research Methods
Yojana Gadiya, Andrea Zaliani, Philip Gribbon, Martin Hofmann-Apitius
Summary: The study develops a patent enrichment tool called PEMT, which extracts relevant patent information linked to chemical structures and gene names. It supports drug discovery and research by establishing a patent landscape around genes of interest. The tool is open-source and its source code and software package are available through the provided link.
Article
Oncology
Jianguang Ji, Wuqing Huang, Jan Sundquist, Kristina Sundquist
JOURNAL OF CANCER SURVIVORSHIP
(2019)
Review
Oncology
Kari Hemminki, Wuqing Huang, Jan Sundquist, Kristina Sundquist, Jianguang Ji
SEMINARS IN CANCER BIOLOGY
(2020)
Article
Oncology
Wuqing Huang, Kristina Sundquist, Jan Sundquist, Casey Crump, Jianguang Ji
INTERNATIONAL JOURNAL OF CANCER
(2020)
Article
Oncology
Huang Wuqing, Kristina Sundquist, Jan Sundquist, Ji Jianguang
INTERNATIONAL JOURNAL OF CANCER
(2020)
Article
Multidisciplinary Sciences
Wuqing Huang, Jan Sundquist, Kristina Sundquist, Jianguang Ji
NATURE COMMUNICATIONS
(2020)
Article
Oncology
Wuqing Huang, Kristina Sundquist, Jan Sundquist, Jianguang Ji
FRONTIERS IN ONCOLOGY
(2020)
Article
Oncology
Wuqing Huang, Kristina Sundquist, Jan Sundquist, Jianguang Ji
Summary: Children of survivors with CNS tumor before the age of 20 did not show a significantly higher risk of overall somatic diseases compared to population controls. However, children with a paternal diagnosis of CNS tumor had a significantly increased risk of malignancies, infectious, and parasitic diseases.
INTERNATIONAL JOURNAL OF CANCER
(2021)
Letter
Hematology
Bengt Zoller, Peter J. Svensson, Wuqing Huang, Ji Jianguang
THROMBOSIS AND HAEMOSTASIS
(2021)
Article
Hematology
Wuqing Huang, Kristina Sundquist, Jan Sundquist, Jianguang Ji
Summary: The study found that compared with non-users, dipyridamole users have a significantly decreased risk of lymphoid neoplasms, especially for non-Hodgkin lymphomas, particularly B-cell lymphomas.
BRITISH JOURNAL OF HAEMATOLOGY
(2022)
Article
Biology
Wuqing Huang, Jun Xiao, Jianguang Ji, Liangwan Chen
Summary: The study suggested a potential causal relationship between lipid-lowering drugs, especially statins, and a reduced risk of COVID-19 hospitalization. This indicates that they should be prioritized in future clinical trials for the treatment of COVID-19.
Article
Biotechnology & Applied Microbiology
Li-Peng Hu, Wuqing Huang, Xu Wang, Chunjie Xu, Wei -Ting Qin, Dongxue Li, Guangang Tian, Qing Li, Yaoqi Zhou, Suyuan Chen, Hui-Zhen Nie, Yujun Hao, Jian Song, Xue-Li Zhang, Jan Sundquist, Kristina Sundquist, Jun Li, Shu-Heng Jiang, Zhi-Gang Zhang, Jianguang Ji
Summary: Research suggests that reversing gut fungal dysbiosis with terbinafine can inhibit the development of colorectal cancer (CRC). Terbinafine reduces fungal load, suppresses tumor cell proliferation, inhibits fungus-induced myeloid-derived suppressor cell expansion, and restores antitumor immune response.
Article
Cardiac & Cardiovascular Systems
Jun Xiao, Jianguang Ji, Naiqi Zhang, Xi Yang, Keyuan Chen, Liangwan Chen, Wuqing Huang
Summary: This study assessed the association between genetically predicted lipid traits, their modification through licensed or investigational targets, and heart failure. The results showed a significant relationship between genetically predicted LDL-C, TG, HDL-C, and ApoB levels and heart failure, mainly mediated by coronary heart disease. Drug target analysis identified PCSK9, CETP, and LPL as potential targets for heart failure prevention.
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2023)
Article
Oncology
Shan Huang, Nai-Qi Zhang, Chun-Jie Xu, Wu-Qing Huang, Dong-Xue Li, Jun Li, Lin-Li Yao, Kristina Sundquist, Jan Sundquist, Shu-Heng Jiang, Xin Xing, Li-Peng Hu, Zhi-Gang Zhang, Jianguang Ji, Xue-Li Zhang
Summary: Combined administration of dipyridamole and aspirin enhances the anti-cancer effect of aspirin against colorectal cancer by inducing endoplasmic reticulum stress and apoptosis.
Article
Public, Environmental & Occupational Health
Wuqing Huang, Ruimei Feng, Xin Xu, Mingyang Ma, Jun Chen, Junzhuo Wang, Zhijian Hu, Shanshan Du, Weimin Ye
Summary: This study aimed to quantify the complex relationships between anthropometric indices and lipid profile. The results showed that the relationship between body mass index (BMI) and low-density lipoprotein cholesterol (LDLc) was more likely to be lost in obese adults compared to other lipids. Additionally, the presence of other metabolic disorders contributed to the loss of anthropometry-lipids relationships.
CLINICAL EPIDEMIOLOGY
(2023)
Article
Oncology
Wuqing Huang, Kristina Sundquist, Jan Sundquist, Jianguang Ji
Summary: Children of survivors with childhood or adolescent central nervous system (CNS) tumors did not have a significantly increased risk of overall psychiatric disorders, except for an elevated risk of mental retardation, particularly mild mental retardation. Boys of survivors had a higher risk of psychiatric disorders.