Article
Chemistry, Inorganic & Nuclear
Hong Wang, Changli Zhang, Zhiyong Jiang, Li Xu, Zhipeng Liu
Summary: In this study, phenothiazine-fused boron complexes were identified as promising scaffolds for ratiometric fluorescent hypochlorite probes. The synthesized complexes demonstrated ultrafast and ratiometric absorption/fluorescence changes for hypochlorite. Additionally, an endoplasmic reticulum-targeting probe was developed and showed excellent real-time imaging ability for both endogenous and exogenous hypochlorite in living cells.
DALTON TRANSACTIONS
(2023)
Article
Biochemistry & Molecular Biology
Junshuai Tang, Pingzhu Zhang, Zimeng Li, Yuehua Zhang, Hua Chen, Xiaoliu Li, Chao Wei
Summary: A simple ratiometric two-photon fluorescent probe RTFP was designed and synthesized for effective monitoring of carbon monoxide (CO) in living systems. The probe showed excellent selectivity and sensitivity towards CO, and successfully imaged endogenous CO in living cells and zebrafish.
BIOORGANIC CHEMISTRY
(2023)
Article
Chemistry, Analytical
Zhoupeng Zheng, Shumin Feng, Shengyi Gong, Guoqiang Feng
Summary: Gol-CO is an effective fluorescence probe for imaging CO in Golgi apparatus, with high selectivity and sensitivity. It can target Golgi apparatus in living cells and zebrafish, and visualize the level increase of CO under oxidative stress.
SENSORS AND ACTUATORS B-CHEMICAL
(2021)
Article
Chemistry, Analytical
Peilian Liu, Bowen Li, Jian Zheng, Qiqi Liang, Cailing Wu, Liping Huang, Peisheng Zhang, Yongmei Jia, Sheng Wang
Summary: A novel ratiometric fluorescence probe AC-SA was designed to detect NO with high selectivity and sensitivity, which can be applied for imaging endogenous NO in cells and organisms.
SENSORS AND ACTUATORS B-CHEMICAL
(2021)
Article
Chemistry, Analytical
Dongmei Wang, Jiajia He, Junyong Sun
Summary: The thiolysis of NBD-A enables specific detection of H2S and real-time imaging in living organisms. The NBD@PFO probes, constructed with ratiometric mode and two-photon excitation, show high selectivity, fast response, and are successfully applied for monitoring H2S concentration in living cells and zebrafish. This work demonstrates the potential of polymer nanoparticles to enhance the imaging capability of an organic small molecular probe.
Article
Chemistry, Analytical
Yaru Sun, Ruifei Wang, Jingxian Wang, Hua Wei, Qingxian Chen, Yue Wang, Baoli Dong
Summary: A ratiometric two-photon fluorescent probe, NAB, was developed for the precise detection of peroxynitrite (ONOO-) in living cells and brain tissues. NAB showed highly sensitive response and excellent selectivity to ONOO-, and could selectively locate at the endoplasmic reticulum (ER). The probe NAB demonstrated the capability of detecting exogenous and endogenous ONOO- in living cells and brain tissues.
SENSORS AND ACTUATORS B-CHEMICAL
(2022)
Article
Engineering, Environmental
Zongyan Quan, Fei Xue, Haoyuan Li, Zhiping Chen, Lei Wang, Hongxiang Zhu, Chunlin Pang, Hui He
Summary: A ratiometric fluorescent probe based on CNC-stabilized gold nanoclusters was developed for the detection of hROS, showing good stability and high sensitivity, and demonstrated satisfactory fluorescence imaging of hROS in living cells and zebrafish.
CHEMICAL ENGINEERING JOURNAL
(2022)
Article
Chemistry, Organic
Nai-Jie Lin, Huan Wu, Jing Peng, Shu-Han Yang, Rui Tan, Yu Peng, Ya-Wen Wang
Summary: A novel ratiometric probe SWJT-10 based on isophorone derivatives was successfully designed and synthesized for the detection of formaldehyde (FA). This probe exhibited significant ratiometric fluorescence response to FA in aqueous solution, with a blue shift from NIR (680 nm) to yellow light region (600 nm). It showed excellent selectivity, high sensitivity, and rapid response to FA (less than 5 s) due to a new recognition mechanism. Furthermore, SWJT-10 has been successfully applied for monitoring FA in living cells and zebrafish.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2023)
Article
Chemistry, Analytical
Wenjuan Chen, Haihong Liu, Fuxiang Song, Liantao Xin, Qian Zhang, Peng Zhang, Caifeng Ding
Summary: Rheumatoid arthritis (RA) is an autoimmune disease that causes pain and complications in multiple organs. There is no cure for RA, but early diagnosis and treatment can provide relief. Therefore, finding an effective tool for assisting early diagnosis of RA is important. In this study, a near-infrared receptor, Lyso-Cy, was developed to specifically target lysosomes during the early stage of RA. This innovative dual-targeting design shows promise for assisting early-stage diagnosis of RA at the organism level.
ANALYTICAL CHEMISTRY
(2022)
Article
Chemistry, Analytical
Ya-Nan Wei, Bo Lin, Yang Shu, Jian-Hua Wang
Summary: A novel fluorescent probe ANET was designed to target mitochondria for detecting Cys, showing advantages of ratiometric fluorescence, high selectivity, and a large Stokes shift. Imaging of Cys was confirmed in HepG2 cells using this probe.
Article
Chemistry, Analytical
Wenlong Sheng, Xue Zhang, Miaohui Yu, Meng Jin, Ning Li, Chen Sun, Lizhen Wang, Qing Xia, Xiaobin Li, Yun Zhang, Baocun Zhu, Kechun Liu
Summary: A novel fluorescent probe Mem-FA was developed to sensitively detect and distinguish internal and external sources of formaldehyde on cell membrane, showing potential for specific tracing of formaldehyde-induced diseases.
Article
Chemistry, Analytical
Libin Tan, Haiyuan Ding, Supphachok Chanmungkalakul, Longpeng Peng, Gangqiang Yuan, Qiaomei Yang, Xiaogang Liu, Liyi Zhou
Summary: NPXH is a reversible fluorescence sensor based on TP-FRET technology, with fast response, ultra-low detection limit, and excellent detection capability in various samples.
SENSORS AND ACTUATORS B-CHEMICAL
(2021)
Article
Chemistry, Applied
Lin Wang, Kang Niu, Shijun Chen, Yuanyuan Wu, Yangyou Tang, Shicong Hou, Wenxue Wu
Summary: In this study, a highly selective and sensitive near-infrared ratiometric fluorescent probe was developed for real-time monitoring of alkaline phosphatase activity. The probe exhibited the shortest response time, large Stokes shift, low cytotoxicity, and strong anti-interference ability.
Article
Chemistry, Analytical
Shihan Ma, Yanyan Ma, Qinglong Liu, Weiying Lin
Summary: Superoxide anion plays a crucial role in maintaining organelle functions but excessive amounts can lead to diseases. The newly synthesized Lyso-MHC fluorescent probe has good selectivity and low toxicity, allowing for imaging of O-2(-) in lysosomes. This probe can track endogenous O-2(-) fluctuations in pneumonia tissues of living mice, showcasing its potential for future research.
SENSORS AND ACTUATORS B-CHEMICAL
(2021)
Article
Chemistry, Applied
Yan Zhang, Haiyan Yang, Mingxin Li, Shuai Gong, Jie Song, Zhonglong Wang, Shifa Wang
Summary: A novel ratiometric fluorescent probe BIDID was designed to track exogenously and endogenously generated HClO in vitro and vivo, demonstrating high responsiveness, low detection limit, rapid response, and applicability across a wide pH range. Confocal fluorescent images showed that BIDID can serve as a reliable tool for studying HClO-related physiological and pathological processes both in vitro and in vivo.
Article
Chemistry, Analytical
Longpeng Peng, Gangqiang Yuan, Haiyuan Ding, Libin Tan, Qiaomei Yang, Liyi Zhou
Summary: A novel supramolecular near-infrared (NIR) fluorescent nanosensor (NIRCD-Ca) has been developed for detecting and imaging analysis of Ca2+ both in vitro and in vivo. The nanosensor exhibits excellent water solubility, low background fluorescence, high fluorescence intensity enhancement in the presence of Ca2+, superb resolution for mice imaging by NIR-emission, and extremely low detection line. It is a promising tool for detecting and imaging analysis of Ca2+ in complex biological samples and in mouse models.
SENSORS AND ACTUATORS B-CHEMICAL
(2021)
Article
Spectroscopy
Pinghua Ou, Yali Wang, Cong Hao, Yongbo Peng, Li-yi Zhou
Summary: Hydrogen sulfide (H2S) is a crucial endogenously generated gaseous signaling molecule, but its physiological and pathological relationship in inflamed tissues is still unclear. A novel two-photon bioimaging probe NP-H2S was developed with improved sensitivity for direct monitoring of H2S in complex biological samples, showing potential for further biological applications.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2021)
Article
Agriculture, Multidisciplinary
Gangqiang Yuan, Liyi Zhou, Qiaomei Yang, Haiyuan Ding, Libin Tan, Longpeng Peng
Summary: A novel reaction-based ratiometric fluorescent probe KQ-SO2 was developed for highly selective detection of bisulfite (HSO3-), showing fast response time, high sensitivity, and low cytotoxicity. It has been successfully applied for detecting bisulfite in tap water, real food samples, onion tissues, and zebrafish, serving as a valuable tool for investigating the impact of bisulfite on human health.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2021)
Article
Spectroscopy
Mei Zhao, Di Shi, Wandi Hu, Tao Ma, Lei He, Danqing Lu, Yunchu Hu, Liyi Zhou
Summary: Selenocysteine (Sec), recognized as the 21st amino acid, is essential for selenoproteins and plays a significant role in physiological processes. A new two-photon fluorescent probe, BNT-Sec, was developed for Sec detection and imaging in living cells and zebrafish, showing great potential in biological applications.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2021)
Article
Engineering, Environmental
Longpeng Peng, Qiaomei Yang, Libin Tan, Liyi Zhou
Summary: DSF shows high sensitivity and low detection limits for Thiophenol and hydrosulphite; it can detect these pollutants in water, real-food samples, and biological systems; serving as a powerful new logical monitoring tool.
JOURNAL OF HAZARDOUS MATERIALS
(2022)
Article
Chemistry, Analytical
Weizhen Xu, Qiaomei Yang, Jiaqi Zeng, Libin Tan, Liyi Zhou, Longpeng Peng, Yizhuang Zhou, Can Xie, Kun Luo, Zhen Zhang
Summary: Understanding the relationship between reactive oxygen species (ROS) and arthritis, a new multi-color fluorescent probe (MULTI-ONOO) was developed for detecting and visualizing ONOO- levels in arthritis. The probe showed rapid response time and low detection limits, making it a robust tool for investigating the role of ONOO- in various inflammatory diseases.
SENSORS AND ACTUATORS B-CHEMICAL
(2022)
Article
Biophysics
Weizhen Xu, Libin Tan, Jiaqi Zeng, Qiaomei Yang, Yizhuang Zhou, Liyi Zhou
Summary: This study presents the construction of a fluorescent nanoprobe based on FRET that can be activated by ONOO- for multicolor fluorescence imaging, diagnosis, and treatment of arthritis. The nanoprobe shows a fast response time, excellent selectivity, and low detection limits. It has been successfully used for intracellular multichannel imaging and diagnosis and treatment in a mice model of arthritis.
BIOSENSORS & BIOELECTRONICS
(2022)
Article
Engineering, Environmental
Libin Tan, Qiaomei Yang, Longpeng Peng, Can Xie, Kun Luo, Liyi Zhou
Summary: This study reports a dual-response fluorescent sensor CGT for simultaneous detection of bisulphites and nitrites. The results show that CGT has good detection capability for HSO3- and NO2- in complex aqueous samples and biosystems.
JOURNAL OF HAZARDOUS MATERIALS
(2022)
Article
Chemistry, Analytical
Can Xie, Yizhuang Zhou, Kun Luo, Qiaomei Yang, Libin Tan, Liyi Zhou
Summary: In this study, a TP-NIR ratiometric fluorescent nanoprobe (NTC) was designed and synthesized for the visual diagnosis and assessment of liver injury. The NTC nanoprobe exhibited high selectivity and sensitivity towards peroxynitrite (ONOO-) and has the potential to enable early diagnosis of liver injury.
ANALYTICAL CHEMISTRY
(2022)
Article
Chemistry, Applied
Qiaomei Yang, Can Xie, Kun Luo, Libin Tan, Longpeng Peng, Liyi Zhou
Summary: In this work, a fluorescent sensor NIR-Sec was developed for the detection of selenium in Se-enriched foods. The sensor showed rapid response time, high selectivity and sensitivity, and was successfully used for detecting and imaging selenium in complex real-food samples.
Article
Chemistry, Analytical
Qiaomei Yang, Yizhuang Zhou, Libin Tan, Can Xie, Xiaowen Li, Miao Zeng, Liyi Zhou
Summary: For the early diagnosis and effective evaluation of treatment effects of inflammation, a de novo bioanalytical method is urgently needed to monitor the metabolite nitric oxide (NO) associated with inflammatory diseases. In this work, a de novo host-guest self-assembled nanosensor CTA was reported for the quantitative detection and visualization of NO levels in inflammatory models.
ANALYTICAL CHEMISTRY
(2023)
Article
Spectroscopy
Yizhuang Zhou, Jiaqi Zeng, Qiaomei Yang, Liyi Zhou
Summary: Modern medical research has identified hypochlorous acid (HClO) and peroxynitrite (ONOO-) as important biomarkers of oxidative stress. This study has successfully developed a fluorescent sensor that can detect the presence of HClO and ONOO- rapidly and accurately, making it a valuable tool for studying their role in inflammatory diseases.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2022)
Article
Chemistry, Applied
Libin Tan, Can Xie, Qiaomei Yang, Kun Luo, Liyi Zhou
Summary: A novel nanoprobe called MTB was developed for the detection of NO2-/FA, which exhibited different optical signals. MTB showed high water solubility and biocompatibility, and had a rapid response and high sensitivity towards NO2-/FA. The nanoprobe was successfully applied for the detection of NO2-/FA in real foods.
Article
Engineering, Environmental
Kun Luo, Liyi Zhou, Can Xie, Qiaomei Yang, Libin Tan, Qinlu Lin
Summary: Cadmium (Cd), a widespread and highly toxic environmental contaminant, has seriously impacted the growth of rice and the quality of its products. Selenium (Se) can chelate cadmium ion (Cd2+) in rice, and in this study, two probes, NN-Sec and SCP, were used to visualize the inhibition of Cd2+ uptake in rice by Se. The reduced fluorescence observed indicated the formation of Cd-Se complexes and the decrease in Cd2+ content in rice. This study provides a robust tool for developing organic fertilizers and reagents to reduce Cd2+ content in rice and the environment.
JOURNAL OF HAZARDOUS MATERIALS
(2023)
Article
Chemistry, Analytical
Can Xie, Yizhuang Zhou, Kun Luo, Qiaomei Yang, Libin Tan, Liyi Zhou
Summary: A reliable and robust two-photon near-infrared ratio fluorescent nanoprobe (NTC) was designed for rapid diagnosis and assessment of ONOO-. NTC showed short response time, high selectivity and sensitivity, excellent detection limit, and was successfully used for detection and imaging of ONOO- in living cells and tissues, providing a powerful tool for early diagnosis and assessment of liver injury.
ANALYTICAL CHEMISTRY
(2022)
