Article
Biotechnology & Applied Microbiology
Jacqueline Schiessl, Konrad Kosciow, Laura S. Garschagen, Juliane J. Hoffmann, Julia Heymuth, Thomas Franke, Uwe Deppenmeier
Summary: The study suggests that the fructose derivative 5-KF could serve as a potential low-calorie sugar substitute, but is not degradable by most common and abundant intestinal bacteria in the human gut.
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
(2021)
Article
Nutrition & Dietetics
Govindarajan Raghavan, Arohi Bapna, Arti Mehta, Akash Shah, Tejas Vyas
Summary: Added sugars contribute to caloric intake and may lead to obesity. Replacing added sugar with a natural substitute like stevia can help reduce sugar and calorie intake.
Article
Chemistry, Applied
Zifan Wan, Sucheta Khubber, Madhuresh Dwivedi, N. N. Misra
Summary: The rising awareness of the adverse health effects of high sugar consumption has led to regulatory amendments for triggering sugar reduction in food products. Sugar reduction in yogurt is a challenging endeavor, requiring consideration of taste, cost, and consumer acceptability. The dairy industry is exploring various methods for reducing sugar content, with a focus on alternative sweeteners and novel solutions.
Article
Medicine, Research & Experimental
Chung-Hao Li, Chung-Teng Wang, Ying-Ju Lin, Hsin-Yu Kuo, Juei-Seng Wu, Tzu-Chun Hong, Chih-Jen Chang, Hung-Tsung Wu
Summary: Long-term consumption of sorbitol may alter gut microbiome composition and potentially induce glucose intolerance.
Article
Chemistry, Applied
Majid Nooshkam, Mehdi Varidi, Fatemeh Alkobeisi
Summary: This study examined the effects of whey protein isolate/sodium alginate/licorice root extract ternary foam as a fat and sugar replacer on the properties of ice creams. The results showed that increasing the substitution level led to changes in the physicochemical, rheological, and sensory properties of the ice creams. However, ice creams with 25% substitution of sugar and fat by the foam were similar to the control sample.
FOOD HYDROCOLLOIDS
(2023)
Article
Food Science & Technology
Yu-Jung Jang, Seo-Jin Chung, Seong-Bo Kim, Sunghee Park
Summary: The study found that including a larger number of combined sweeteners as well as a larger proportion of bulk sweeteners in the mixtures increased the likelihood of sweetness synergism and minimal off notes such as bitterness and astringency. Through evaluating sensory characteristics, some sweetener blends were identified to exhibit sweetness properties similar to those of sucrose.
FOOD QUALITY AND PREFERENCE
(2021)
Article
Microbiology
Zhongzhi Sun, Wenju Wang, Leyuan Li, Xu Zhang, Zhibin Ning, Janice Mayne, Krystal Walker, Alain Stintzi, Daniel Figeysa
Summary: The composition and function of the human gut microbiome are closely related to human health. Sugar substitute sweeteners, as commonly used food additives, have potential impacts on the functionality of the microbiome. This study systematically investigated the responses of the human gut microbiome to commonly used sugar substitute sweeteners and revealed the associations between sweetener properties and metaproteomic responses of individual microbiomes.
MICROBIOLOGY SPECTRUM
(2022)
Article
Biochemistry & Molecular Biology
Laura L. Koekkoek, Margo Slomp, Julien Castel, Michael Mutersbaugh, Ian Linville, Mireille J. Serlie, Serge H. Luquet, Susanne E. la Fleur
Summary: Research shows that glutamatergic neurons in the lateral hypothalamus can differentiate between low-calorie sweeteners and caloric sweeteners, and consuming a high fat diet disrupts their ability to detect calories.
Review
Nutrition & Dietetics
Han Youl Lee, Maia Jack, Theresa Poon, Daniel Noori, Carolina Venditti, Samer Hamamji, Kathy Musa-Veloso
Summary: The study found that in isocaloric comparisons, low-/no-calorie sweetener (LNCS)-sweetened preloads resulted in reduced energy intake at ad libitum meals compared to unsweetened preloads. In isosweet comparisons, while LNCS-sweetened preloads led to increased energy intake at ad libitum meals, there was a reversal in the pattern when total energy intake was considered. Unsweetened or LNCS-sweetened preloads have similar effects on intake compared to caloric sweetener (CS)-sweetened preloads.
ADVANCES IN NUTRITION
(2021)
Editorial Material
Cell Biology
Han Fang, Fernando F. Anhe, Jonathan D. Schertzer
Summary: This study demonstrates that dietary sugar can disrupt the balance of intestinal microbiota, lower protective immunity, and exacerbate metabolic diseases.
Article
Nutrition & Dietetics
Liam T. Graneri, John C. L. Mamo, Zachary D'Alonzo, Virginie Lam, Ryusuke Takechi
Summary: The study found that consuming both sugary and sugar-free energy drinks can lead to metabolic syndrome, particularly insulin resistance, affecting parameters such as body weight, blood glucose, and cholesterol levels in mice.
Article
Nutrition & Dietetics
Heidi Morahan, Kieron Rooney
Summary: Reducing consumption of sugar-sweetened beverages is important due to its link to obesity, but the consumption of non-nutritive sweetened beverages is increasing. Most animal studies do not accurately reflect human consumption of these beverages, limiting their translational capacity. This study aimed to develop an ecologically valid model of non-nutritive sweetened beverage consumption and assess metabolic recovery after switching from sucrose to non-nutritive sweeteners. The findings suggest limited metabolic recovery in both male and female rats.
Article
Nutrition & Dietetics
Elena Tragni, Luisella Vigna, Massimiliano Ruscica, Chiara Macchi, Manuela Casula, Alfonso Santelia, Alberico L. Catapano, Paolo Magni
Summary: The multi-center VLCKD program conducted in a real-world setting for overweight/obese women was shown to be safe and effective, resulting in significant improvements in cardiometabolic parameters, substantial reductions in body weight and waist circumference.
Article
Nutrition & Dietetics
Valentina Guarnotta, Roberta Amodei, Francesca Di Gaudio, Carla Giordano
Summary: This study confirms the efficacy of a ketogenic diet as an adjunctive therapy for patients with Cushing's disease, showing significant improvements in metabolic disorders. Furthermore, it suggests that a nutritional approach can be combined with conventional treatment for Cushing's disease to improve metabolic and cardiovascular comorbidities.
Article
Biochemistry & Molecular Biology
Sing -Young Chen, Martina Beretta, Ellen M. Olzomer, Stephanie J. Alexopoulos, Divya P. Shah, Frances L. Byrne, Joseph M. Salamoun, Christopher J. Garcia, Greg C. Smith, Mark Larance, Andrew Philp, Nigel Turner, Webster L. Santos, James Cantley, Kyle L. Hoehn
Summary: This study compared various treatment strategies for metabolic diseases and found that mitochondrial uncouplers showed the best efficacy in improving multiple facets of metabolic diseases.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2024)
Article
Cell Biology
Sungguan Hong, Seungwoo Hong, Sung Hoon Lee
Summary: Alzheimer's disease is the most common neurodegenerative disease characterized by the deposition of amyloid plaques in the brain. Epidemiological studies suggest a link between diabetes, impaired glucose metabolism, obesity, and the prevalence of AD. The liver plays a crucial role in the crosstalk between AD and metabolic syndrome and the clearance of A β in the periphery.
ANIMAL CELLS AND SYSTEMS
(2023)
Article
Multidisciplinary Sciences
Jun Hyung Park, Seungwoo Hong, Ok-Hyeon Kim, Chul-Hong Kim, Jinho Kim, Jung-Woong Kim, Sungguan Hong, Hyun Jung Lee
Summary: Microplastics, particularly fragment-type polypropylene microplastics (PPMPs), have detrimental effects on breast cancer metastasis and can alter the expression of related genes. Studies on fragment-type MPs are limited, but this research suggests that they play a significant role in exacerbating breast cancer metastasis.
SCIENTIFIC REPORTS
(2023)
