Article
Psychiatry
Amir Garakani, Frank D. Buono, Kaitlyn Larkin, Maxim Polonsky, Joseph F. Goldberg
Summary: This study adapted a standardized measure of obsessive-compulsive thinking to assess chronic suicidal ideation in patients with mood disorder, finding that the tool is internally consistent and reliable.
JOURNAL OF PSYCHIATRIC RESEARCH
(2022)
Article
Psychiatry
Jane E. Persons, Paul Lodder, William H. Coryell, John Nurnberger, Jess G. Fiedorowicz
Summary: This study found that manic and anxiety symptoms did not significantly contribute to suicidal ideation and behavior in individuals with bipolar disorder during a depressive state, with the main risk factor being severe depressive symptoms. The limitations of small sample size and measurement tools may have influenced these findings, suggesting future studies would benefit from larger samples and more rigorous assessments.
PSYCHIATRY RESEARCH
(2022)
Review
Psychology, Clinical
Samuel T. Wilkinson, Daniel Trujillo Diaz, Zachary W. Rupp, Anubhav Kidambi, Karina L. Ramirez, Jose M. Flores, Victor J. Avila-Quintero, T. Greg Rhee, Mark Olfson, Michael H. Bloch
Summary: This study found that lithium has a protective effect against suicide in bipolar disorder, as well as in mixed diagnostic samples. Clozapine was also shown to reduce the odds of suicide in psychotic disorders. However, other treatments such as electroconvulsive therapy and antipsychotics did not show significant associations with suicide risk.
DEPRESSION AND ANXIETY
(2022)
Article
Clinical Neurology
Danielle A. Goldman, Anjali Sankar, Alexandra Rich, Jihoon A. Kim, Brian Pittman, R. Todd Constable, Dustin Scheinost, Hilary P. Blumberg
Summary: This study aimed to identify functional connectivity differences between depressions of bipolar disorder (BD-Dep) and depressions of major depressive disorder (MDD-Dep). The results showed that there were significant differences in functional connectivity patterns between these two groups, suggesting the potential for early diagnosis and treatment strategies.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Review
Psychiatry
Yazen Alnefeesi, David Chen-Li, Ella Krane, Muhammad Youshay Jawad, Nelson B. Rodrigues, Felicia Ceban, Joshua D. Di Vincenzo, Shakila Meshkat, Roger C. M. Ho, Hartej Gill, Kayla M. Teopiz, Bing Cao, Yena Lee, Roger S. McIntyre, Joshua D. Rosenblat
Summary: Ketamine shows promising clinical effectiveness in the treatment of treatment-resistant depression (TRD), as demonstrated by a systematic review and meta-analysis. The study findings indicate a substantial mean antidepressant effect, with potential benefits for even the most treatment-resistant patients.
JOURNAL OF PSYCHIATRIC RESEARCH
(2022)
Article
Clinical Neurology
Yang Yang, Qian Cui, Fengmei Lu, Yajing Pang, Yuyan Chen, Qin Tang, Di Li, Ting Lei, Zongling He, Shan Hu, Jiaxin Deng, Huafu Chen
Summary: The study revealed abnormal functional connectivity patterns of DMN subsystems in patients with bipolar disorder during major depressive episodes, and these abnormalities were associated with high levels of pessimism, highlighting the importance of pathological mechanisms in this disorder.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Clinical Neurology
Raphael O. Cerqueira, Carolina Ziebold, Daniel Cavalcante, Giovany Oliveira, Javiera Vasquez, Juan Undurraga, Alfonso Gonzalez-Valderrama, Ruben Nachar, Carlos Lopez-Jaramillo, Cristiano Noto, Nicolas Crossley, Ary Gadelha
Summary: This study compares patients with affective and non-affective psychosis (A-FEP and NA-FEP) in a Latin American sample. The findings suggest that characteristics of FEP patients could be utilized to enhance diagnosis and inform treatment decisions.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Review
Psychiatry
Agnieszka Kulak-Bejda, Grzegorz Bejda, Napoleon Waszkiewicz
Summary: Suicide among the elderly is a serious public health problem, which is strongly associated with physical illnesses, neurologic disorders, and mental disorders such as dementia, depression, bipolar disorder, and anxiety. Dementia, depression, bipolar disorder, and anxiety increase the risk of suicide in older people, highlighting the importance of providing comprehensive psychiatric and psychological support to this population.
FRONTIERS IN PSYCHIATRY
(2021)
Article
Clinical Neurology
Shuming Zhong, Pan Chen, Shunkai Lai, Guanmao Chen, Yiliang Zhang, Sihui Lv, Jiali He, Guixian Tang, Youling Pan, Ying Wang, Yanbin Jia
Summary: This study found differences in dynamic functional connectivity of corticostriatal circuitry between bipolar II disorder patients with recent suicide attempts and those without, suggesting a potential neural marker for suicidal behavior. Additionally, there were cognitive differences between the two groups, providing clues for identifying suicidal bipolar II disorder patients.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Psychiatry
Huan Wang, Rongxin Zhu, Shui Tian, Siqi Zhang, Zhongpeng Dai, Junneng Shao, Li Xue, Zhijian Yao, Qing Lu
Summary: By studying the dynamic functional connectivity in patients with bipolar disorder, the dysfunction of anterior cingulate cortex (ACC) was found to be relevant to suicide attempts. Specifically, suicide attempt patients showed significantly reduced dwell time in the suicide-related functional state, accompanied by a significantly increased functional connectivity strength between the right ACC and the regions within the subcortical network. These altered indicators were significantly correlated with suicide risk.
JOURNAL OF PSYCHIATRIC RESEARCH
(2022)
Article
Multidisciplinary Sciences
Imtiyaz Ali Mir, Shang Kuan Ng, Muhammad Noh Zulfikri Mohd Jamali, Mohammed AbdulRazzaq Jabbar, Syeda Humayra
Summary: University students, particularly young adults, are more vulnerable to developing psychological distress, anxiety, and depression during the COVID-19 pandemic. This study aimed to investigate and compare the factors influencing and predicting mental health (anxiety and depression) during and after the COVID-19 lockdown among university students.
Article
Clinical Neurology
Jess G. Fiedorowicz, Jane E. Persons, Shervin Assari, Michael J. Ostacher, Fernando S. Goes, John Nurnberger, William H. Coryell
Summary: Depressive symptoms are strongly linked to suicidal ideation and behavior, serving as important risk factors for suicide. However, manic symptoms show no clear association with suicide risk, and mixed symptoms do not convey a greater risk of suicidal ideation or behavior than depressive symptoms alone.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Review
Psychiatry
Zainab Nabi, Jacki Stansfeld, Martin Ploderl, Lisa Wood, Joanna Moncrieff
Summary: This study is a systematic review and meta-analysis that includes all eligible data and evaluates the effect of lithium on suicide, non-fatal suicidal behavior, and suicide attempts. The results suggest that evidence from randomized trials is inconclusive and does not support the idea that lithium prevents suicide or suicidal behavior.
EPIDEMIOLOGY AND PSYCHIATRIC SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Ivana Jovcevska, Alja Videtic Paska
Summary: Understanding the complexities of psychiatric disorders involves exploring both genetic and epigenetic factors. The study of long noncoding RNAs (lncRNAs) presents a new field with potential for molecular testing advancements. However, further research and characterization of lncRNAs is needed before clinical implementation can be achieved.
NEUROCHEMISTRY INTERNATIONAL
(2021)
Article
Psychiatry
Ana Paula Anzolin, Jeferson Ferraz Goularte, Jairo Vinicius Pinto, Paulo Belmonte-de-Abreu, Luciane Nascimento Cruz, Victor Hugo Schaly Cordova, Lucas Sueti Magalhaes, Adriane R. Rosa, Keila Maria Cereser, Marcia Kauer-Sant'Anna
Summary: This study aims to assess the control effect of ketamine on suicidal ideation and behavior in patients with depressive episodes, as well as its impact on psychopathology and inflammatory biomarkers.
FRONTIERS IN PSYCHIATRY
(2023)
Review
Psychiatry
Kristina Mozuraityte, Agne Stanyte, Naomi A. Fineberg, Alessandro Serretti, Julija Gecaite-Stonciene, Julius Burkauskas
Summary: This study conducted a scoping review of published literature to examine the relationship between mental fatigue and various psychiatric disorders. The findings suggest that mental fatigue is studied in mood disorders, anxiety disorders, obsessive-compulsive disorder, and obsessive-compulsive personality disorder. Cognitive factors such as unhelpful beliefs about sleep and symptom-focussed rumination, as well as personality risk factors, were found to be relevant in predicting mental fatigue symptoms. Further investigation is needed to explore mental fatigue in adult psychiatric samples.
INTERNATIONAL JOURNAL OF PSYCHIATRY IN CLINICAL PRACTICE
(2023)
Article
Psychiatry
Fabio Panariello, Siegfried Kasper, Joseph Zohar, Daniel Souery, Stuart Montgomery, Panagiotis Ferentinos, Dan Rujescu, Julien Mendlewicz, Diana De Ronchi, Alessandro Serretti, Chiara Fabbri
Summary: This study aimed to identify factors associated with side effects of psychotropic drugs in a real-world setting enriched with treatment-resistant depression (TRD) patients. Results showed that the severity of depressive symptoms was associated with total, psychic, and neurological side effects, while autonomic side effects were higher in patients with somatic comorbidities and lower in patients receiving trazodone. Multivariate analyses revealed that depressive symptom severity was associated with psychic and total side effects, generalized anxiety disorder (GAD) with neurological side effects, and somatic comorbidities remained associated with autonomic side effects. Trazodone was associated with lower side effects and with augmentation treatments. Augmentation therapies showed opposite effects depending on response status, i.e. increased or decreased the risk of side effects in responders and non-responders/resistant patients, respectively.
WORLD JOURNAL OF BIOLOGICAL PSYCHIATRY
(2023)
Article
Psychiatry
Serena Borroni, Linda Franchini, Silvia Brioschi, Giulia Vassena, Elisabetta Masci, Chiara Franzoni, Giulia Ruotolo, Cristina Colombo, Andrea Fossati
Summary: This study examines the role of sociodemographic and clinical variables as well as personality pathological features in predicting high lethality suicide attempts. The results indicate that previous suicide attempts and current suicide ideation play a role in predicting serious suicide attempts. Specifically, the Detachment domain is associated with high lethality suicide attempts and remains a significant predictor even when considering the effects of previous attempts and ideation.
PERSONALITY AND MENTAL HEALTH
(2023)
Article
Clinical Neurology
Elena Mazza, Federico Calesella, Marco Paolini, Camilla di Pasquasio, Sara Poletti, Cristina Lorenzi, Andrea Falini, Raffaella Zanardi, Cristina Colombo, Francesco Benedetti
Summary: Our study investigated the effects of insulin and its derived measures on white matter microstructure and neural functional connectivity in patients with bipolar disorder (BD). The results showed that insulin was negatively associated with fractional anisotropy and positively influenced radial diffusivity and mean diffusivity. Additionally, insulin resistance had a significant effect on radial diffusivity, while insulin sensitivity was positively associated with fractional anisotropy and negatively associated with radial diffusivity and mean diffusivity. These findings suggest that insulin may play a role in the pathophysiology of BD by affecting white matter microstructure and functional connectivity.
Article
Pharmacology & Pharmacy
Laura Mandelli, Yuri Milaneschi, Sarah Hiles, Alessandro Serretti, Brenda W. Penninx
Summary: An unhealthy lifestyle plays a crucial role in the development and progression of chronic disorders, and it may also affect biological systems involved in stress response. Using data from the Netherlands Study of Depression and Anxiety, researchers calculated a global index of unhealthy lifestyle based on five self-reported habits. They found that the index was associated with hyperactivity of the hypothalamus-pituitary-adrenal axis and increased inflammation, indicating that unhealthy habits increase biological stress. The use of drugs also impacted the autonomic nervous system activity.
INTERNATIONAL CLINICAL PSYCHOPHARMACOLOGY
(2023)
Editorial Material
Pharmacology & Pharmacy
Alessandro Serretti
INTERNATIONAL CLINICAL PSYCHOPHARMACOLOGY
(2023)
Article
Clinical Neurology
Marco Paolini, Mariagrazia Palladini, Mario Gennaro Mazza, Federica Colombo, Benedetta Vai, Patrizia Rovere-Querini, Andrea Falini, Sara Poletti, Francesco Benedetti
Summary: Cognitive impairment is a common residual symptom in COVID-19 survivors and is associated with various brain changes. This study investigated the neural correlates of subjective cognitive decline using multimodal imaging in a sample of 58 COVID-19 survivors. The findings revealed widespread white matter disruption and abnormal functional connectivity in the brains of individuals with cognitive complaints. These results suggest a potential brain signature of cognitive decline in COVID-19 survivors and may aid in the identification of therapeutic targets for mitigating long-term cognitive dysfunction.
EUROPEAN NEUROPSYCHOPHARMACOLOGY
(2023)
Editorial Material
Pharmacology & Pharmacy
Paolo Olgiati, Alessandro Serretti
INTERNATIONAL CLINICAL PSYCHOPHARMACOLOGY
(2023)
Editorial Material
Pharmacology & Pharmacy
Alessandro Serretti
INTERNATIONAL CLINICAL PSYCHOPHARMACOLOGY
(2023)
Article
Psychiatry
Sigrid Breit, Elena Mazza, Sara Poletti, Francesco Benedetti
Summary: Major depressive disorder (MDD) is a complex and serious mental disorder that can result in chronic recurrent symptoms, treatment resistance, and suicidal behavior. Immune dysregulation and brain volume changes, particularly in white matter (WM), are associated with MDD. Neuroimaging markers and blood markers, such as inflammation-related cytokines, may serve as predictors of treatment response in MDD, but the relationship between peripheral inflammation, WM integrity, and antidepressant response is still not clearly understood. This review aims to explore the association between inflammation and WM integrity, and their impact on MDD pathophysiology and progression, as well as the potential role of novel biomarkers in improving MDD prevention and treatment strategies.
JOURNAL OF PSYCHIATRIC RESEARCH
(2023)
Article
Clinical Neurology
Benedetta Vai, Federico Calesella, Claudia Lenti, Lidia Fortaner-Uya, Elisa Caselani, Paola Fiore, Sigrid Breit, Sara Poletti, Cristina Colombo, Raffaella Zanardi, Francesco Benedetti
Summary: Suicide attempts in Bipolar Disorder are characterized by high levels of lethality and impulsivity. Reduced rates of amygdala and cortico-limbic habituation can identify a fMRI phenotype of suicidality in the disorder related to internal over-arousing states. This study found that bipolar suicide attempters have lower habituation levels in several cortico-limbic areas, suggesting that reduced habituation in the cortico-limbic system may serve as a biomarker for suicidality. Machine learning techniques achieved high accuracy in differentiating suicide attempters from non-attempters.
PSYCHIATRY RESEARCH-NEUROIMAGING
(2023)
Article
Medicine, General & Internal
Mariagrazia Palladini, Mario Gennaro Mazza, Andrea Scalabrini, Patrizia Rovere Querini, Sara Poletti, Francesco Benedetti
Summary: COVID-19 survivors experience intense depressive and post-traumatic symptoms in the sub-acute stages. Survivor guilt may contribute to the development of post-COVID psychiatric implications. This study aims to uncover the affective mechanism behind these implications by examining the association between survivor guilt, psychopathology, and maladaptive attributional style. The study evaluated symptoms of depression, post-traumatic distress, and sleep disturbances in 195 COVID-19 survivors one month after discharge.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Clinical Neurology
Marco Paolini, Yasmin Harrington, Laura Raffaelli, Sara Poletti, Raffaella Zanardi, Cristina Colombo, Francesco Benedetti
Summary: This study investigated the impact of Neutrophil-to-lymphocyte ratio (NLR) on treatment response in Major Depressive Disorder (MDD) patients, and the influence of sex and hippocampal volume on this relationship. The results showed that NLR had a different effect on treatment response in females compared to males. Additionally, NLR negatively affected hippocampal volume in females, and hippocampal volume partially mediated the effect of NLR on treatment response in females.
EUROPEAN NEUROPSYCHOPHARMACOLOGY
(2023)
Article
Chemistry, Analytical
Jaime Millan-Santiago, Rosalba Vitagliano, Fortunata Mondella, Roberto Mandrioli, Roccaldo Sardella, Rafael Lucena, Tomaz Vovk, Soledad Cardenas, Federico Boaron, Alessandro Serretti, Carmine Petio, Michele Protti, Laura Mercolini
Summary: In this study, a bioanalytical method using volumetric absorptive microsampling (VAMS) was developed and validated for therapeutic drug monitoring (TDM) of psychiatric patients under cariprazine treatment. The VAMS-UHPLC-MS methodology showed satisfactory results and was proven to be a useful alternative to cariprazine plasma analysis in clinical practice.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2023)
Article
Clinical Neurology
Marco Paolini, Yasmin Harrington, Federica Colombo, Valentina Bettonagli, Sara Poletti, Matteo Carminati, Cristina Colombo, Francesco Benedetti, Raffaella Zanardi
Summary: A study found that there is a correlation between MRI imaging and treatment response in patients with major depressive disorder (MDD). The study analyzed MRI scans of 100 patients and found that lower grey matter volumes, particularly in the hippocampus and temporal lobe-related areas, were associated with worse treatment outcomes. Functional connectivity patterns were also found to be related to treatment response.
JOURNAL OF PSYCHOPHARMACOLOGY
(2023)
Article
Clinical Neurology
Jai Carmichael, Jennie Ponsford, Kate Rachel Gould, Gershon Spitz
Summary: The traditional approaches to measuring depression after traumatic brain injury (TBI) have limitations. This study adopted a symptom-oriented approach and found that post-TBI depression is highly heterogeneous. Different depressive symptoms have distinct associations with personal, injury-related, treatment, and outcome factors.
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Letter
Clinical Neurology
Xiaoning Sun, Min Chen, Guanghai Wang, Fan Jiang
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Letter
Clinical Neurology
Aleksander Kwas
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Letter
Clinical Neurology
Josine E. Verhoeven, Laura K. M. Han, Brenda W. J. H. Penninx
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Review
Clinical Neurology
Erin Crowe, Petra K. Staiger, Steven J. Bowe, Imogen Rehm, Richard Moulding, Caitlyn Herrick, David J. Hallford
Summary: This study aimed to integrate the evidence regarding the relationship between emotion regulation difficulties and TTM symptoms, and found that individuals with higher levels of TTM severity appear to exhibit decreased overall emotion regulation abilities and strategies.
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Letter
Clinical Neurology
Fjolla Berisha, Marjolaine Rivest-Beauregard, Jai Shah, Michelle Lonergan, Alain Brunet
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Article
Clinical Neurology
Yi-Tseng Tsai, Tzu-Jung Chuang, Sriyani Padmalatha Konara Mudiyanselage, Han-Chang Ku, Yi-Lin Wu, Chung-Yi Li, Nai-Ying Ko
Summary: Sleep disturbances are associated with higher suicide rates, and this association is independent of depression. Paying attention to sleep disturbances among PLHIV is crucial when monitoring suicidal ideation.
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Article
Clinical Neurology
Junyou Chen, Ingrid D. Lui, Yu Cheng Hsu, Paul S. F. Yip
Summary: Despite rapid social changes in Hong Kong, marriage remains a strong protective factor against suicide for both men and women, particularly among younger individuals. Increasing suicide rates among divorced/separated, never-married, or widowed individuals suggest a need for more psychosocial support.
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Article
Clinical Neurology
A. Perry, K. Gordon-Smith, K. J. S. Lewis, A. Di Florio, N. Craddock, L. Jones, I. Jones
Summary: This study found that the experience of losing at least one night of sleep was associated with an increased risk of postpartum psychosis in women with bipolar disorder. Sleep quality in late pregnancy was not associated with postpartum psychosis, and perinatal sleep disruption was not associated with postpartum depression.
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Letter
Clinical Neurology
Dear J. Affect Disord, Mark J. Niciu, Robert C. Meisner, Brent R. Carr, Ali A. Farooqui, David Feifel, Adam Kaplin, Paul M. Kim, Christopher D. Schneck, Jennifer L. Vande Voort, Sagar Parikh, E. Jeremy Kendrick
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Article
Clinical Neurology
Tao Wang, Li Yang, Lan Yang, Bao-Peng Liu, Cun-Xian Jia
Summary: This study systematically reviewed the association between psychological pain and suicidality in patients with major depressive disorder (MDD). The results showed that psychological pain was a risk factor for suicidality in MDD patients, especially for those of advancing age. Reducing psychological pain in MDD patients is important for preventing suicidality.
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Letter
Clinical Neurology
Juan Carlos Hugues, Abel Nogueira-Lopeza, Maeva Flayellea, Cora von Hammersteind, Joel Billieuxa
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Article
Clinical Neurology
Ogechi Cynthia Onyeka, Samuel D. Spencer, Alison Salloum, Katie Jiannetto, Eric A. Storch
Summary: This study examined the relationship among family accommodation (FA), posttraumatic stress symptoms (PTSS), and functional impairment. The results showed that FA was significantly associated with PTSS and functional impairment. Baseline FA partially mediated the relationship between baseline PTSS and functional impairment. Changes in FA from pre- to post-treatment were associated with relevant outcome variables at post-treatment and 12-month follow-up.
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Article
Clinical Neurology
Yumeng Shi, Chao Yu
Summary: This study found a negative correlation between the intake of active microbes in the diet and depression.
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Article
Clinical Neurology
Qiurui Nie, Yu Shen, Mengqin Luo, Zhiyong Sheng, Rui Zhou, Guangmin Li, Wei Huang, Shenjian Chen
Summary: The study assessed the sleep duration, sleep disorders, and trouble sleeping among adults in the United States from 2005 to 2018, revealing a high prevalence of abnormal sleep durations and increasing rates of sleep disorders and trouble sleeping.
JOURNAL OF AFFECTIVE DISORDERS
(2024)