Article
Dentistry, Oral Surgery & Medicine
Loyse Martorano-Fernandes, Antonio Pedro Ricomini-Filho, Altair Antoninha Del Bel Cury
Summary: The influence of Streptococcus oralis supernatant on the proliferation and virulence of Candida albicans was evaluated. Results showed that the addition of S. oralis supernatant increased the metabolic activity of C. albicans biofilms, but did not affect their total biomass and cell counts. However, it enhanced hyphae formation in C. albicans biofilms. This suggests that the secreted metabolites in S. oralis supernatant may contribute to the metabolism and virulence of C. albicans.
ARCHIVES OF ORAL BIOLOGY
(2023)
Review
Microbiology
Hao Li, Ming-xing Miao, Cheng-lin Jia, Yong-bing Cao, Tian-hua Yan, Yuan-ying Jiang, Feng Yang
Summary: This review focuses on the interactions between Candida albicans and the host microbiota in the mouth, gut, blood, and vagina, and highlights important future research directions. Evaluating these interactions will contribute to a better understanding of the etiology of fungal infections and provide new insights for therapeutic approaches.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Dentistry, Oral Surgery & Medicine
S. X. Wan, J. Tian, Y. Liu, A. Dhall, H. Koo, G. Hwang
Summary: The study revealed differences in binding forces between S. gordonii and S. mutans with Candida albicans, with the latter exhibiting significantly enhanced binding forces when the fungal surface is coated with extracellular glucans. This enhanced binding affinity led to the formation of larger structures during early biofilm initiation and ultimately resulted in the dominance of S. mutans in the 3-species biofilm model under cariogenic conditions.
JOURNAL OF DENTAL RESEARCH
(2021)
Article
Microbiology
Nikola Atanasov, Yana Evstatieva, Dilyana Nikolova
Summary: Oral probiotic lactic acid bacteria exhibit antagonistic activities against oral pathogens, including Streptococcus mutans and Candida albicans. Twelve previously isolated oral strains were evaluated for their antagonistic effects, and four strains (Limosilactobacillus fermentum N 2, TC 3-11, NA 2-2, and Weissella confusa NN 1) showed significant inhibition against Streptococcus mutans. All tested strains also exhibited antagonistic activity against Candida albicans. The strains demonstrated specific self-biofilm formation and strong antibiofilm properties.
Review
Microbiology
Nicole O. Ponde, Lea Lortal, Gordon Ramage, Julian R. Naglik, Jonathan P. Richardson
Summary: Candida albicans is a common fungus in the human microbiota that can form biofilms, which are difficult to eradicate and can lead to infections. Biofilm-associated infections present a major clinical challenge.
CRITICAL REVIEWS IN MICROBIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Hong Chen, Sihong Xie, Jing Gao, Liwen He, Wenping Luo, Yunhao Tang, Michael D. Weir, Thomas W. Oates, Hockin H. K. Xu, Deqin Yang
Summary: This study investigated the effects of using flavonoids to inhibit Streptococcus mutans, Candida albicans, and dual-species biofilms, and to protect enamel hardness in a biofilm-based caries model for the first time. Baicalein showed promising results in reducing biofilm formation and protecting enamel hardness in the model.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Yan Zeng, Ahmed Fadaak, Nora Alomeir, Yan Wu, Tong Tong Wu, Shuang Qing, Jin Xiao
Summary: This study found that a probiotic strain, Lactobacillus plantarum 14917, has a remarkable inhibitory effect on the pathogenic microorganisms Streptococcus mutans and Candida albicans. It can reduce their growth, alter biofilm structure, and decrease their virulence. This discovery could lead to a new approach for preventing dental caries.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biotechnology & Applied Microbiology
Zhiyan Zhou, Biao Ren, Jiyao Li, Xuedong Zhou, Xin Xu, Yuan Zhou
Summary: This study revealed the glycoside hydrolase-related cross-kingdom communications between Streptococcus gordonii and Candida albicans under the low-fermentable-carbohydrate condition. We demonstrated that Candida albicans can promote the growth and metabolic activities of Streptococcus gordonii by elevating the activities of cell-wall-anchored glycoside hydrolases of Streptococcus gordonii. The Candida albicans gene TEC1 is critical for this cross-kingdom metabolic communication.
APPLIED AND ENVIRONMENTAL MICROBIOLOGY
(2022)
Article
Microbiology
So-Young Ham, Han-Shin Kim, Eunji Cha, Taehyeung Lim, Youngjoo Byun, Hee-Deung Park
Summary: Raffinose, a natural oligosaccharide, strongly inhibits biofilm formation and GTF-related gene expression in Streptococcus mutans, making it a potential antibiofilm agent for oral supplies and dental materials to prevent dental caries.
MICROBIOLOGY SPECTRUM
(2022)
Article
Microbiology
Eunsoo Do, Max Cravener, Manning Y. Huang, Gemma May, C. Joel McManus, Aaron P. Mitchell
Summary: In this study, natural variation in the fungal pathogen Candida albicans was investigated to understand the gene regulatory control of biofilm formation, an important aspect of its virulence. Collaboration between the transcription factors Efg1 and Wor1 was found to drive natural variation in biofilm formation and gene expression. These findings highlight the importance of studying natural isolates to uncover unexpected features of gene function.
Review
Immunology
Yijun Li, Shan Huang, Jingyun Du, Minjing Wu, Xiaojing Huang
Summary: Candida albicans (C. albicans) is commonly found in oral cross-kingdom infections. The coexistence of Streptococcus mutans (S. mutans) and C. albicans has been observed in carious lesions, particularly in children with early childhood caries (ECC), suggesting a close interaction between them. Both S. mutans and C. albicans have developed complex regulatory mechanisms to enhance cariogenic virulence and adapt to stress changes in the environment. This intricate relationship poses challenges for therapy, highlighting the need for novel antimicrobial strategies that target multiple aspects or utilize combination therapies.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Article
Microbiology
Sabi Pokhrel, Nawarat Boonmee, Orawan Tulyaprawat, Sujiraphong Pharkjaksu, Iyarit Thaipisutikul, Phoom Chairatana, Popchai Ngamskulrungroj, Chalermchai Mitrpant
Summary: Biofilm formation is an important virulence factor for the pathogenesis of Candida albicans. This study used the zebrafish model to evaluate the in vivo virulence of strains with different biofilm formation strengths. The results showed that stronger biofilm formation was associated with shorter survival time in zebrafish and higher up-regulation of biofilm-associated genes.
Article
Microbiology
Tenzin Kunchok Lueyar, Lamprini Karygianni, Thomas Attin, Thomas Thurnheer
Summary: This study investigates the interactions between streptococcal species and the yeast Candida albicans in the development of oral biofilms. The results show that different species of streptococci have varying effects on the colony formation of C. albicans in the presence of Streptococcus mutans.
Article
Immunology
Sanjib Das, Achintya Mohan Goswami, Tanima Saha
Summary: Candida albicans, a common member of the human microbiome, causes infections through the regulation of kinases, which control morphological features and virulence factors.
MICROBIAL PATHOGENESIS
(2022)
Review
Microbiology
Dallas L. Mould, Deborah A. Hogan
Summary: Microbial interactions play a crucial role in microbial physiology, with quorum sensing and metabolite exchange being key elements. Loss-of-function mutations in quorum-sensing components are common across different species, and quorum sensing is modulated by small molecules and environmental conditions. Recent evidence suggests that strain heterogeneity can impact microbial interactions and act as selective pressures on the emergence of common mutations in quorum sensing genes.
CURRENT OPINION IN MICROBIOLOGY
(2021)
Article
Dentistry, Oral Surgery & Medicine
Caroline Dini, Marta Maria Alves Pereira, Joao Gabriel Silva Souza, Jamil A. Shibli, Erica Dorigatti Avila, Valentim Adelino R. Barao
Summary: Industry support does not appear to have a significant association with positive outcomes in implant dentistry RCTs. However, industry trends do show a correlation with geographic origins, number of institutions, and specific research topics.
CLINICAL IMPLANT DENTISTRY AND RELATED RESEARCH
(2022)
Review
Dentistry, Oral Surgery & Medicine
Guilherme Almeida Borges, Denise Juncom Codello, Leticia Del Rio Silva, Caroline Dini, Valentim Adelino Ricardo Barao, Marcelo Ferraz Mesquita
Summary: Mini-implants may serve as an alternative choice due to fewer prosthetic complications and maintenance events compared to standard implants, while showing comparable clinical outcomes.
JOURNAL OF PROSTHETIC DENTISTRY
(2023)
Review
Dentistry, Oral Surgery & Medicine
Melissa Barral Maia, Joao G. S. Souza, Martinna Bertolini, Raphael C. Costa, Gustavo S. Costa, Silverio de A. S. Torres, Efigenia F. Ferreira, Andrea M. E. B. L. Martins
Summary: This systematic review evaluates the level of knowledge of the bidirectional relationship between diabetes mellitus and periodontal disease among patients. The results show that less than half of people with diabetes have knowledge about their increased risk for periodontal disease, and often the dentist is not the main source of information to motivate them.
INTERNATIONAL JOURNAL OF DENTAL HYGIENE
(2023)
Review
Microbiology
Raphael C. Costa, Martinna Bertolini, Barbara E. Costa Oliveira, Bruna E. Nagay, Caroline Dini, Bruna Benso, Marlise I. Klein, Valentim A. R. Barao, Joao Gabriel S. Souza
Summary: This paper discusses the role of the EPS matrix in biofilm growth, virulence, and implant-related infections on dental implant surfaces. EPS-enriched biofilms promote microbial accumulation, microbiological shift, cross-kingdom interaction, antimicrobial resistance, and biofilm virulence, leading to peri-implant tissue damage. However, the importance of EPS in implant-related infections and the development of matrix-targeted therapeutic strategies have been neglected. Therefore, further analysis of polymicrobial interactions within the EPS matrix and the development of EPS-targeting technologies are needed to disrupt the complex biofilm microenvironment for better translation to implant applications in the future.
CRITICAL REVIEWS IN MICROBIOLOGY
(2023)
Article
Dentistry, Oral Surgery & Medicine
Raquel Conceicao Ferreira, Joao Gabriel Silva Souza, Anna Rachel dos Santos Soares, Renato Vitor Vieira, Ichiro Kawachi
Summary: Objective tooth loss is more prevalent among adults and older adults with lower education and income levels. The utilization of dental services can reduce the impact of education-based inequality in edentulism.
COMMUNITY DENTISTRY AND ORAL EPIDEMIOLOGY
(2023)
Article
Dentistry, Oral Surgery & Medicine
Marcelo Faveri, Belen Retamal-Valdes, Maria Josefa Mestnik, Luciene Cristina de Figueiredo, Valentim Adelino Ricardo Barao, Joao Gabriel Silva Souza, Poliana Mendes Duarte, Magda Feres
Summary: This study evaluated the microbiological effects of adjunctive MTZ+AMX in the treatment of young patients with periodontitis. The results showed that SRP+MTZ+AMX was more effective than SRP alone in reducing levels/proportions of pathogens and improving clinical symptoms.
JOURNAL OF PERIODONTOLOGY
(2023)
Article
Chemistry, Physical
Raphael C. Costa, Bruna E. Nagay, Caroline Dini, Maria H. R. Borges, Luis F. B. Miranda, Jairo M. Cordeiro, Joao G. S. Souza, Cortino Sukotjo, Nilson C. Cruz, Valentim A. R. Bara
Summary: Plasma electrolytic oxidation (PEO) is a low-cost and environmentally friendly surface modification method for producing antimicrobial implant surfaces. This review comprehensively discusses the microbiological and biological properties of antimicrobial PEO-treated surfaces, emphasizing the importance of using clinically relevant infection models and long-term assessments for rational design.
ADVANCES IN COLLOID AND INTERFACE SCIENCE
(2023)
Article
Biochemical Research Methods
Luis Fernando B. Miranda, Carolina V. Lima, Rafaela Pagin, Raphael C. Costa, Marta Maria A. Pereira, Erica D. de Avila, Martinna Bertolini, Belen Retamal-Valdes, Jamil A. Shibli, Magda Feres, Valentim A. R. Barao, Joao Gabriel S. Souza
Summary: This study investigated the effect of different processing methods on the proteomic profile of saliva. The results showed that the processing methods had an impact on the protein composition of saliva, with differences in the types and quantities of proteins in the processed saliva. However, the different processing methods had minimal effect on microbial adhesion and cell viability.
JOURNAL OF PROTEOME RESEARCH
(2023)
Review
Dentistry, Oral Surgery & Medicine
Magda Feres, Rodrigo Martins, Joao Gabriel S. Souza, Martinna Bertolini, Valentim A. R. Barao, Jamil A. Shibli
Summary: This review aimed to evaluate the efficacy of antibiotics in treating peri-implantitis. The results showed that the use of systemic metronidazole combined with ultrasonic debridement can effectively improve the outcomes of nonsurgical treatment. However, further research is needed to assess the clinical and microbiological effects of different antibiotic protocols.
CLINICAL IMPLANT DENTISTRY AND RELATED RESEARCH
(2023)
Article
Nanoscience & Nanotechnology
Mostafa Alhamad, Valentim Adelino Ricardo Barao, Cortino Sukotjo, Aleksey Yerokhin, Mathew Thoppil Mathew
Summary: This study aimed to evaluate the synergistic effect of hydrogen peroxide, lactic acid, and titanium ions on titanium corrosion. The results showed that the corrosion kinetics significantly increased when titanium ions, lactic acid, and hydrogen peroxide were present simultaneously in the vicinity of the titanium surface, which may increase the risk of peri-implantitis.
ACS APPLIED BIO MATERIALS
(2023)
Article
Engineering, Biomedical
Soumya Saha, Raphael Cavalcante Costa, Mirela Caroline Silva, Joao Matheus Fonseca-Santos, Lin Chen, Abhijit H. Phakatkar, Harshdeep Bhatia, Leonardo P. Faverani, Valentim A. R. Barao, Tolou Shokuhfar, Cortino Sukotjo, Christos Takoudis
Summary: A novel method using room-temperature atomic layer deposition (ALD) to coat collagen membranes with MgO is reported in this study. The MgO-coated collagen membranes show excellent chemical nature, surface topography, and biological properties, making them promising candidates for guided bone regeneration.
BIOACTIVE MATERIALS
(2023)
Article
Dentistry, Oral Surgery & Medicine
Michele Oliveira Lima, Marcela Alvarez Ferretti, Ricardo Armini Caldas, Valentim Adelino Ricardo Barao, Fabiana Mantovani Gomes Franca, Debora Alves Nunes Leite Lima, Luis Roberto Martins, Flavio Henrique Baggio Aguiar
Summary: The feasibility of using a milled PEEK post and core in endodontically treated teeth with or without a ferrule was evaluated. The results showed that the ferrule groups had higher fracture resistance and more catastrophic failure modes.
BRAZILIAN ORAL RESEARCH
(2023)
Article
Nanoscience & Nanotechnology
Guilherme Almeida Borges, Raphael Cavalcante Costa, Bruna Egumi Nagay, Catharina Marques Sacramento, Karina Gonzales Silverio Ruiz, Larissa Solano de Almeida, Luciana Sgarbi Rossino, Carlos Alberto Fortulan, Elidiane Cipriano Rangel, Valentim A. R. Barao, Marcelo Ferraz Mesquita
Summary: This study presents a new method for coating titanium abutments with a protective diamond-like carbon (DLC) film. The results show that the DLC film deposited using a silicon interlayer and pulsed-direct current plasma-enhanced chemical vapor deposition (DC-PECVD) method demonstrates improved mechanical, tribological, and corrosion resistance properties compared to bare titanium. The DLC film is found to be equally effective as titanium in preventing bacterial growth while exhibiting good cytocompatibility with human gingival fibroblast cells.
ACS APPLIED BIO MATERIALS
(2023)