Article
Urology & Nephrology
Alberto Martini, Luca Afferi, Stefania Zamboni, Julianne G. Schultz, Chiara Lonati, Agostino Mattei, R. Jeffrey Karnes, Matteo Soligo, Armando Stabile, Ettore Di Trapani, Ottavio De Cobelli, Giuseppe Simone, Claudio Simeone, Mario Alvarez-Maestro, Giorgio Gandaglia, Andrea Gallina, Renzo Colombo, Alberto Briganti, Francesco Montorsi, Evanguelos Xylinas, Shahrokh F. Shariat, Marco Moschini
Summary: The study found that patients with variant histology bladder cancer have a higher risk of recurrence, requiring extended surveillance time, and different histological types have different risks of recurrence and metastasis.
JOURNAL OF UROLOGY
(2021)
Article
Urology & Nephrology
Ekaterina Laukhtina, Axelle Boehm, Benoit Peyronnet, Carlo Andrea Bravi, Jose Batista Da Costa, Francesco Soria, David D'Andrea, Pawel Rajwa, Fahad Quhal, Takafumi Yanagisawa, Frederik Koenig, Hadi Mostafaei, Dmitry Enikeev, Alexandre Ingels, Gregory Verhoest, Frederiek D'Hondt, Alexandre Mottrie, Steven Joniau, Hendrik Van Poppel, Alexandre de la Taille, Karim Bensalah, Franck Bruyere, Shahrokh F. Shariat, Benjamin Pradere
Summary: Through evaluating the impact of urethrectomy on patients undergoing radical cystectomy for non-metastatic urothelial carcinoma, we found that this procedure seems to benefit only high-risk patients for urethral recurrence.
WORLD JOURNAL OF UROLOGY
(2022)
Review
Oncology
Junhao Long, Li Wang, Ni Dong, Xiaoli Bai, Siyu Chen, Shujun Sun, Huageng Liang, Yun Lin
Summary: The meta-analysis shows that robotic-assisted radical cystectomy (RARC) is as safe and effective as laparoscopic radical cystectomy (LRC) in the treatment of bladder cancer. Patients who undergo RARC experience less blood loss and fewer long-term complications related to surgery compared to LRC. RARC should be considered as a viable alternative to LRC. However, further high-quality, larger sample, multi-centric, long-term follow-up randomized controlled trials (RCTs) are still needed to confirm these findings.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Stefano Tappero, Andrea Panunzio, Lukas Hohenhorst, Cristina Cano Garcia, Francesco Barletta, Mattia Piccinelli, Zhe Tian, Stefano Parodi, Alessandro Antonelli, Markus Graefen, Felix K. H. Chun, Alberto Briganti, Ottavio De Cobelli, Fred Saad, Shahrokh F. Shariat, Nazareno Suardi, Marco Borghesi, Carlo Terrone, Pierre I. Karakiewicz
Summary: The effect of radical cystectomy (RC) on cancer-specific mortality (CSM) is uncertain in non-metastatic sarcomatoid bladder cancer (SBC) patients. This study aimed to evaluate the benefit of RC in SBC patients and compare it with urothelial bladder cancer (UCB).
Article
Oncology
Angelo Porreca, Katie Palmer, Walter Artibani, Alessandro Antonelli, Lorenzo Bianchi, Eugenio Brunocilla, Aldo Massimo Bocciardi, Maurizio Brausi, Gian Maria Busetto, Marco Carini, Giuseppe Carrieri, Antonio Celia, Luca Cindolo, Giovanni Cochetti, Renzo Colombo, Ettore De Berardinis, Ottavio De Cobelli, Fabrizio Di Maida, Amelio Ercolino, Franco Gaboardi, Antonio Galfano, Andrea Gallina, Michele Gallucci, Carlo Introini, Ettore Mearini, Andrea Minervini, Francesco Montorsi, Gennaro Musi, Giovannalberto Pini, Riccardo Schiavina, Silvia Secco, Sergio Serni, Claudio Simeone, Giovanni Tasso, Daniele DAgostino
Summary: Bladder cancer is the ninth most common type of cancer worldwide, and radical cystectomy has been a traditional treatment. The project aims to compare three surgical techniques for radical cystectomy in bladder cancer patients and analyze short- and long-term outcomes. The trial will provide data on factors influencing choice of surgical technique and their impact on patient outcomes.
Article
Urology & Nephrology
Carl J. Wijburg, Charlotte T. J. Michels, Gerjon Hannink, Janneke P. C. Grutters, Maroeska M. Rovers, J. Alfred Witjes
Summary: This study did not find significant differences in complications and health-related quality of life between robot-assisted radical cystectomy and open radical cystectomy. However, there were some differences in secondary outcomes, with the main limitation being residual confounding.
Article
Oncology
Duo Zheng, Junyao Liu, Gongjin Wu, Shujun Yang, Chuang Luo, Tianci Du, Yao Luo, Junsheng Bao, Junqiang Tian, Zhiping Wang, Panfeng Shang, Zhongjin Yue
Summary: The study compared perioperative and oncologic outcomes of OMUUD and IMUUD after LRC, finding that IMUUD has faster postoperative recovery with similar perioperative and oncologic results compared to OMUUD.
WORLD JOURNAL OF SURGICAL ONCOLOGY
(2021)
Article
Urology & Nephrology
Francesco Soria, Peter C. Black, Adrian S. Fairey, Michael S. Cookson, Evan Y. Yu, Wassim Kassouf, Marc A. Dall'Era, Srikala S. Sridhar, John S. McGrath, Jonathan L. Wright, Andrew C. Thorpe, Todd M. Morgan, Siamak Daneshmand, Jeff M. Holzbeierlein, Trinity J. Bivalacqua, Scott North, Daniel A. Barocas, Yair Lotan, Petros Grivas, Andrew J. Stephenson, Jay B. Shah, Bas W. van Rhijn, Philippe E. Spiess, Shahrokh F. Shariat, Paolo Gontero
Summary: In patients with cT2N0 bladder cancer and no preoperative hydronephrosis, neoadjuvant chemotherapy (NAC) increased the rate of pathological complete response and downstaging, showing a positive impact on overall survival.
Article
Environmental Sciences
Janusz Lisinski, Jakub Kienitz, Piotr Tousty, Krystian Kaczmarek, Artur Leminski, Marcin Slojewski
Summary: The study compared laparoscopic and open radical cystectomy in the treatment of muscle-invasive bladder cancer. The results showed comparable overall survival rates, but laparoscopic cystectomy had less blood loss and faster recovery.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Nanoscience & Nanotechnology
Hongyang Qian, Yiqiu Wang, Zehua Ma, Lei Qian, Xiaoguang Shao, Di Jin, Ming Cao, Shupeng Liu, Haige Chen, Jiahua Pan, Wei Xue
Summary: Surface-enhanced Raman spectroscopy analysis of pretreated plasma samples can accurately predict disease recurrence in bladder cancer patients after neoadjuvant chemotherapy and radical cystectomy. SERS analysis showed higher levels of circulating free nucleic acid components and lower levels of tryptophan in recurrent patients, which are independent predictors of recurrence. Combining SERS analysis with clinicopathological parameters significantly improves the predictive model, and the diagnostic model based on SERS spectra has a high accuracy in predicting disease recurrence.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2022)
Article
Urology & Nephrology
Igor Duquesne, Daniel Benamran, Alexandra Masson-Lecomte, Alexandre De la Taille, Michael Peyromaure, Morgan Roupret, Nicolas Barry Delongchamps
Summary: Despite advancements in surgical and anesthetic techniques, radical cystectomy for bladder cancer remains a highly risky procedure. This study aimed to describe intraoperative complications and evaluate the impact of surgical approach on complication rates.
WORLD JOURNAL OF UROLOGY
(2023)
Article
Oncology
Francois-Xavier Nouhaud, Marouene Chakroun, Claire Lenormand, Idir Ouzaid, Benoit Peyronnet, Alexandre Gryn, Thomas Prudhomme, Vivien Grafeille, Michel Soulie, Mathieu Roumiguie, Gregory Verhoest, Evanguelos Xylinas, Abderrazak Bouzouita, Mohamed Chebil, Christian Pfister
Summary: The study aimed to assess the prognosis differences between primary and progressive muscle invasive bladder cancer (MIBC) after radical cystectomy. Results showed that patients with progressive MIBC had worse overall survival, cancer specific survival, and recurrence-free survival. Pathological stage, positive surgical margins, and positive lymph nodes status were also found to be predictors of prognosis.
UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS
(2021)
Article
Urology & Nephrology
P. Baron, Z. Khene, F. Lannes, G. Pignot, A. S. Bajeot, G. Ploussard, G. Verhoest, A. Gasmi, O. Perrot, M. Roumiguie, K. Mori, G. E. Cacciamani, M. Roupret, F. Bruyere, B. Pradere
Summary: The study confirmed that RC-pentafecta can be used to evaluate the surgical outcomes of RARC patients, with age being an independent predictor of pentafecta achievement and surgeon experience impacting the validation of the criteria.
WORLD JOURNAL OF UROLOGY
(2021)
Article
Oncology
Aleksander Slusarczyk, Piotr Zapala, Tomasz Piecha, Lukasz Zapala, Tomasz Borkowski, Piotr Radziszewski
Summary: The study found that patients who underwent radical nephroureterectomy for upper urinary tract urothelial cancer after radical cystectomy experienced poor overall survival and cancer-specific survival, with most surgeries being performed for locally advanced tumors. Independent risk factors for worse survival included UTUC T stage, presence of metastasis, and male gender.
ANNALS OF SURGICAL ONCOLOGY
(2023)
Review
Urology & Nephrology
George E. Koch, Amy N. Luckenbaugh, Sam S. Chang
Summary: The heterogeneous nature of high-risk nonmuscle invasive bladder cancer encompasses a wide range of tumor biologies with varying risks of recurrence and progression. Radical cystectomy may provide excellent oncologic outcomes but is often underused. Timeliness is critical for these patients.