Article
Pediatrics
Leah Bruno, Jerica Lenberg, Dzung Le, David Dimmock, Courtney D. Thornburg, Benjamin Briggs
Summary: This study aimed to characterize the bleeding phenotype in patients with Noonan syndrome (NS), evaluate the utility of following national guidelines in detecting this phenotype, assess thromboelastography (TEG) as a diagnostic tool, and determine genotype-phenotype correlations. Results showed that 5 out of 20 participants had a bleeding phenotype, with 4 of them having platelet aggregation defects and at least one additional coagulation defect. Based on available data, incorporating TEG into clinical practice for NS patients is not recommended. A new algorithm is proposed.
JOURNAL OF PEDIATRICS
(2023)
Article
Hematology
Christine J. Guelcher, Jaime Chase, Debra Pollard
Summary: Over the last few decades, there has been an increasing focus on women with inherited bleeding disorders (WBD), leading to more patients being treated at Haemophilia Treatment Centres (HTC) worldwide. These women face unique challenges, including a significant risk of heavy menstrual bleeding (HMB). Nurses, who play a central role in patient and family education within the HTC, are well positioned to provide clinical care and education specifically for WBD. However, there is a lack of literature highlighting the role of HTC nurses and their potential impact on this growing but understudied patient population.
Article
Hematology
Zi Wang, Ye Zou, Limin Xia, Xiaoye Li, Yao Yao, Yanrong Ye, Qianzhou Lv
Summary: Platelet function assessment is useful for predicting postoperative bleeding in patients treated with clopidogrel or ticagrelor undergoing off-pump coronary artery bypass grafting (OPCABG), but it is not effective in predicting major bleeding complications.
THROMBOSIS RESEARCH
(2022)
Article
Hematology
Annie E. I. Collins, Nicola Curry, Sayma Raza-Burton, Patricia Bignell, Claire Davies, Michael Joffe, Susan Shapiro, Michael J. R. Desborough
Summary: This retrospective cohort study found no significant differences in factor VIII levels during pregnancy for carriers of mild, moderate, or severe haemophilia A. However, carriers of severe haemophilia A had higher post-partum hemorrhage rates.
BRITISH JOURNAL OF HAEMATOLOGY
(2021)
Article
Medicine, General & Internal
Richard A. Wilkins, David Stephensen, Heidi Siddle, Martin J. Scott, Hua Xiang, Elizabeth Horn, Ben Palmer, Graham J. Chapman, Michael Richards, Rebecca Walwyn, Anthony Redmond
Summary: This study reports the prevalence of joint bleeds in children and adults with severe haemophilia A and B, as well as the concurrent joint disease status using the haemophilia joint health score. The results show that even in a UK cohort selected for high compliance with prophylaxis, only two-thirds of children and one-third of adults were bleed-free. Joint health was relatively unaffected during childhood, but bleed rates were highest in ankles and substantially affected joint health scores in adults.
Review
Medicine, General & Internal
Giulia Cannata, Elena Mariotti Zani, Alberto Argentiero, Caterina Caminiti, Serafina Perrone, Susanna Esposito
Summary: This study discusses the developmental characteristics of the coagulation system in neonates and the role of viscoelastic tests in neonatal care. Viscoelastic tests are considered to be a useful supplementary technique that can assist in targeted therapy quickly.
Review
Radiology, Nuclear Medicine & Medical Imaging
Joseph Willis, Caleb Carroll, Virginia Planz, Samuel J. Galgano
Summary: Thromboelastography (TEG) and rotational thromboelastometry are emerging technologies that are being increasingly accepted in the medical field for evaluating the coagulation status of patients. TEG has been proven to reduce blood product use and improve patient outcomes. However, there are currently no guidelines or recommendations for the utilization of TEG in interventional or diagnostic radiology.
ABDOMINAL RADIOLOGY
(2022)
Article
Statistics & Probability
Andrew C. Titman, Martin J. Wolfsegger, Thomas F. Jaki
Summary: The study developed a PK-PD approach for modelling recurrent bleeding events in severe haemophilia patients and found that the new method outperforms existing methods in terms of bias and mean squared error by investigating the relationship between factor VIII and risk of a bleed using all bleeding times.
JOURNAL OF THE ROYAL STATISTICAL SOCIETY SERIES C-APPLIED STATISTICS
(2021)
Review
Emergency Medicine
Patrick D. Tyler, Lauren M. Yang, Samuel B. Snider, Adam B. Lerner, William C. Aird, Nathan Shapiro
Summary: Viscoelastic monitoring (VEM) is a real-time coagulation test that measures the timing and strength of blood clot development, and is used to investigate coagulation disturbance. VEM is widely used and studied in cardiac surgery, liver transplant surgery, anesthesia, and trauma.
ANNALS OF EMERGENCY MEDICINE
(2021)
Article
Pediatrics
Abhishek Chakraborty, Gary Beasley, Hugo Martinez, Rohith Jesudas, Pilar Anton-Martin, Georgios Christakopoulos, Jennifer Kramer
Summary: This is a case report about a teenage patient with Noonan syndrome who underwent mechanical mitral valve replacement and experienced recurrent severe bleeding. After unsuccessful treatment attempts, the use of selumetinib as a gene-targeted therapy successfully controlled the bleeding.
Article
Biochemical Research Methods
Donghao Li, Xinyu Liu, Yujuan Chai, Jieying Shan, Yihan Xie, Yong Liang, Susu Huang, Weidong Zheng, Zida Li
Summary: In this study, a novel blood coagulation assay was developed using digital microfluidics and printed circuit board technology to simultaneously assess clotting tendency and clot stiffness. The assay was validated through experiments on blood samples with different coagulation abilities, and the results showed a high correlation with standard coagulation assays. This method has the potential to serve as a powerful point-of-care coagulation testing method.
Review
Medicine, General & Internal
Omotola O. Olasupo, Megan S. Lowe, Ashma Krishan, Peter Collins, Alfonso Iorio, Davide Matino
Summary: The evidence from randomized controlled trials suggests that prophylaxis, compared to on-demand treatment, can reduce bleeding frequency and improve joint function, pain, and quality of life in previously-treated people with hemophilia. However, prophylactic regimens did not show significant differences in protection from bleeding, and dose optimization could potentially enhance efficacy. Well-designed RCTs and controlled studies are needed to establish optimal and cost-effective treatment regimens.
COCHRANE DATABASE OF SYSTEMATIC REVIEWS
(2021)
Article
Hematology
Connor M. Bunch, Margaret Berquist, Aida Ansari, Max L. McCoy, Jack H. Langford, Toby J. Brenner, Michael Aboukhaled, Samuel J. Thomas, Ethan Peck, Shivani Patel, Emily Cancel, Mahmoud D. Al-Fadhl, Nuha Zackariya, Anthony Thomas, John G. Aversa, Ryan B. Greene, Christopher W. Seder, Jacob Speybroeck, Joseph B. Miller, Hau C. Kwaan, Mark M. Walsh
Summary: There has been a growing interest in the use of viscoelastic tests (VETs) to determine the hemostatic competence of bleeding patients. Compared to common coagulation tests (CCTs), VETs have a wider range of applications and can be used for treatment guidance and hemostatic adjunctive therapy in various medical conditions.
SEMINARS IN THROMBOSIS AND HEMOSTASIS
(2022)
Article
Hematology
Marilyn J. Manco-Johnson, Beth Boulden Warren, Tyler W. Buckner, Sharon M. Funk, Michael Wang
Summary: New therapeutic approaches and improved prophylaxis regimens have reduced bleeding rates, making traditional factor assays less applicable for some treatments; global assays are being investigated for their usefulness.
Article
Gastroenterology & Hepatology
Abhishek Shenoy, Jeremy Louissaint, Carol Shannon, Elliot B. Tapper, Anna S. Lok
Summary: The study found that in patients with cirrhosis, utilizing TEG or ROTEM can significantly reduce the utilization of blood products prior to non-surgical procedures, without increasing post-procedural bleeding or mortality. This suggests that viscoelastic testing can improve transfusion stewardship and provide high-value care in this population.
DIGESTIVE DISEASES AND SCIENCES
(2022)