Article
Oncology
Hidde Eijkelenkamp, Guus Grimbergen, Lois A. Daamen, Hanne D. Heerkens, Saskia van de Ven, Stella Mook, Gert J. Meijer, Izaak Q. Molenaar, Hjalmar C. van Santvoort, Eric Paulson, Beth Ann Erickson, Helena M. Verkooijen, William Adrian Hall, Martijn P. W. Intven
Summary: Clinical outcomes of online adaptive MRgRT for (peri)pancreatic tumors were evaluated in a large international cohort. The study found that the treatment was associated with limited toxicity and stable quality of life for patients.
FRONTIERS IN ONCOLOGY
(2023)
Article
Oncology
Stephanie M. Yoon, Elaine Luterstein, Fang- Chu, Minsong Cao, James Lamb, Nzhde Agazaryan, Daniel Low, Ann Raldow, Michael L. Steinberg, Percy Lee
Summary: The study reports favorable local control and progression-free survival outcomes with minimal morbidity for abdominal and pelvic tumors treated with SMART. Prospective clinical trials are needed to confirm these findings.
Article
Oncology
Karl Bordeau, Morgan Michalet, Aicha Keskes, Simon Valdenaire, Pierre Debuire, Marie Cantaloube, Morgane Cabaille, Fabienne Portales, Roxana Draghici, Marc Ychou, Eric Assenat, Thibault Mazard, Emmanuelle Samalin, Ludovic Gauthier, Pierre-Emmanuel Colombo, Sebastien Carrere, Francois-Regis Souche, Norbert Ailleres, Pascal Fenoglietto, David Azria, Olivier Riou
Summary: Stereotactic MR-guided Adaptive RadioTherapy (SMART) is a promising treatment for pancreatic tumors, providing effective and well-tolerated therapy. It has the potential to improve the management of pancreatic adenocarcinoma, but further studies are needed to confirm its exact role.
Article
Oncology
Laura Uder, Marcel Nachbar, Sarah Butzer, Jessica Boldt, Sabrina Baumeister, Michael Bitzer, Alfred Koenigsrainer, Thomas Seufferlein, Ruediger Hoffmann, Sergios Gatidis, Konstantin Nikolaou, Daniel Zips, Daniela Thorwarth, Cihan Gani, Simon Boeke
Summary: This study reported on the use of online magnetic resonance guided radiotherapy for liver metastases. The results showed high local control rates and improvements in patient reported outcome measures and quality of life. Further prospective trials are ongoing to define the patient population that will benefit most from this online adaptive workflow.
FRONTIERS IN ONCOLOGY
(2023)
Review
Oncology
John Michael Bryant, Joseph Weygand, Emily Keit, Ruben Cruz-Chamorro, Maria L. Sandoval, Ibrahim M. Oraiqat, Jacqueline Andreozzi, Gage Redler, Kujtim Latifi, Vladimir Feygelman, Stephen A. Rosenberg
Summary: Stereotactic body radiotherapy (SBRT) is an effective radiation therapy technique that shortens treatment courses by using daily image guidance. Magnetic resonance imaging (MRI) improves soft-tissue visualization for better tumor targeting. MR-guided SBRT (MRgSBRT) with a combined MRI and linear accelerator offers superior soft-tissue visualization, real-time assessment, and online adaptive replanning.
Article
Oncology
Teo Stanescu, Andrea Shessel, Cathy Carpino-Rocca, Edward Taylor, Oleksii Semeniuk, Winnie Li, Aisling Barry, Jelena Lukovic, Laura Dawson, Ali Hosni
Summary: This article describes a comprehensive workflow for MRI-guided online adaptive stereotactic body radiation therapy (SBRT) specific to upper gastrointestinal cancer patients with abdominal compression on a 1.5T MR-Linac system. The study shows that the workflow is feasible for these patients and significantly reduces treatment session time.
Article
Oncology
Francesco Cuccia, Michele Rigo, Vanessa Figlia, Niccolo Giaj-Levra, Rosario Mazzola, Luca Nicosia, Francesco Ricchetti, Giovanna Trapani, Antonio De Simone, Davide Gurrera, Stefania Naccarato, Gianluisa Sicignano, Ruggero Ruggieri, Filippo Alongi
Summary: This study reports the preliminary data of using 1.5T MR-Linacs for prostate or prostate bed re-irradiation. The study found that this treatment option has minimal toxicity and encouraging clinical outcomes.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Sebastian Regnery, Carolin Buchele, Fabian Weykamp, Moritz Pohl, Philipp Hoegen, Tanja Eichkorn, Thomas Held, Jonas Ristau, Carolin Rippke, Laila Koenig, Michael Thomas, Hauke Winter, Sebastian Adeberg, Juergen Debus, Sebastian Klueter, Juliane Hoerner-Rieber
Summary: This study explores the benefit of adaptive magnetic resonance-guided stereotactic body radiotherapy for lung tumors, particularly ultracentral lung tumors. The results show that plan adaptation can effectively improve the shortcomings of predicted plans and reduce the risk of exceeding maximum dose and violating organ-at-risk constraints.
FRONTIERS IN ONCOLOGY
(2022)
Review
Oncology
Brigid A. McDonald, Cornel Zachiu, John Christodouleas, Mohamed A. Naser, Mark Ruschin, Jan-Jakob Sonke, Daniela Thorwarth, Daniel Letourneau, Neelam Tyagi, Tony Tadic, Jinzhong Yang, X. Allen Li, Uffe Bernchou, Daniel E. Hyer, Jeffrey E. Snyder, Edyta Bubula-Rehm, Clifton D. Fuller, Kristy K. Brock
Summary: MRI-linear accelerator (MR-linac) devices have enabled MR-guided adaptive radiation therapy (MRgART). However, adaptive radiation therapy highlights challenges in calculating the total delivered dose due to anatomical changes and different treatment plans. Dose accumulation strategies can be employed for ART to estimate the delivered dose. In MRgART, plan adaptation on MRI requires additional considerations in the dose accumulation process.
FRONTIERS IN ONCOLOGY
(2023)
Article
Oncology
Yajun Song, Yun Zhang, Huadong Wang, Mengyu Zhao, Fada Guan, Zhenjiang Li, Jinbo Yue
Summary: The stomach is a highly deformable organ, making it challenging to treat gastric cancer with conventional image-guided radiotherapy. However, magnetic resonance imaging guided radiotherapy (MRgRT) using MR-LINAC offers a feasible solution for adaptive treatment of deformable organs such as the stomach, leading to promising results.
FRONTIERS IN ONCOLOGY
(2023)
Article
Oncology
Morgan Michalet, Karl Bordeau, Marie Cantaloube, Simon Valdenaire, Pierre Debuire, Sebastien Simeon, Fabienne Portales, Roxana Draghici, Marc Ychou, Eric Assenat, Marie Dupuy, Sophie Gourgou, Pierre-Emmanuel Colombo, Sebastien Carrere, Francois-Regis Souche, Norbert Ailleres, Pascal Fenoglietto, David Azria, Olivier Riou
Summary: This study investigated the dosimetric benefits and clinical outcomes of SMART treatment for pancreatic tumors. The results showed that daily adaptation of SMART improved tumor coverage and organ protection, with low toxicity and promising survival rates.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
M. P. W. Intven, S. R. de Mol van Otterloo, S. Mook, P. A. H. Doornaert, E. N. de Groot-van Breugel, G. G. Sikkes, M. E. Willemsen-Bosman, H. M. van Zijp, R. H. N. Tijssen
Summary: This study evaluates the feasibility and implementation of MR-guided radiotherapy for rectal cancer on a 1.5T MR-linac. Results show that daily online adaptation of the CTV can reduce margins effectively and achieve good treatment outcomes. The treatment process takes about 48 minutes per fraction.
RADIOTHERAPY AND ONCOLOGY
(2021)
Article
Oncology
Laura Buchanan, Saleh Hamdan, Ying Zhang, Xinfeng Chen, X. Allen Li
Summary: The feasibility of using deep learning to predict deliverable adaptive plans based on a target dose distribution for MRgOART/MRgRART was investigated. A conditional generative adversarial network (cGAN) was trained to predict the MLC leaf sequence corresponding to a target dose distribution based on reference plan created prior to MRgOART. The results showed that complete adaptive plans could be predicted in less than 20 seconds using a GTX 1660TI GPU.
FRONTIERS IN ONCOLOGY
(2023)
Article
Oncology
Stefanie Corradini, Rieke von Bestenbostel, Angela Romano, Adrian Curta, Dorit Di Gioia, Lorenzo Placidi, Maximilian Niyazi, Luca Boldrini
Summary: Primary cardiac tumors are rare with limited prognosis, often treated with surgery. Other options include chemotherapy and radiation therapy. The development of hybrid MR-guided radiation therapy offers better visualization and high doses in sensitive organs like the heart. In a retrospective study of patients with primary cardiac sarcomas, treatment with MR-guided RT showed feasibility and minimal side effects, but further studies are needed to assess long-term outcomes.
RADIATION ONCOLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Hassan Jassar, An Tai, Xinfeng Chen, Timothy D. D. Keiper, Eric Paulson, Fabienne Lathuiliere, Silvain Beriault, Francois Hebert, Laurence Savard, David T. T. Cooper, Sneha Cloake, X. Allen Li
Summary: This study develops and tests an improved real-time motion monitoring technique for accurate motion management during radiation therapy. The results show that the technique can achieve accurate motion monitoring on MR-Linac without using contrast agents or radio-opaque implants.
Article
Oncology
Matthew Van Oirschot, Alanah Bergman, Wilko F. A. R. Verbakel, Lucy Ward, Isabelle Gagne, Vicky Huang, Nick Chng, Peter Houston, Kerry Symes, Christopher G. Thomas, Parminder Basran, David Bowes, Stephen Harrow, Robert Olson, Suresh Senan, Andrew Warner, David A. Palma, Stewart Gaede
Summary: This study assessed the association between target coverage compromise and patient outcomes in SABR treatment for oligometastases. The results showed that for some lesions, a reduction in dose or target coverage was necessary to meet organ at risk constraints. However, target coverage was not significantly associated with survival outcomes or lesional control.
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2022)
Article
Oncology
David R. Spigel, Corinne Faivre-Finn, Jhanelle E. Gray, David Vicente, David Planchard, Luis Paz-Ares, Johan F. Vansteenkiste, Marina C. Garassino, Rina Hui, Xavier Quantin, Andreas Rimner, Yi-Long Wu, Mustafa Ozguroglu, Ki H. Lee, Terufumi Kato, Maike de Wit, Takayasu Kurata, Martin Reck, Byoung C. Cho, Suresh Senan, Jarushka Naidoo, Helen Mann, Michael Newton, Piruntha Thiyagarajah, Scott J. Antonia
Summary: The study examined the efficacy of consolidation durvalumab in patients with non-small-cell lung cancer, showing significant improvements in overall survival and progression-free survival, with manageable safety. The 5-year follow-up data continued to demonstrate the positive effects of durvalumab on survival and disease progression.
JOURNAL OF CLINICAL ONCOLOGY
(2022)
Article
Oncology
Florien W. Boele, Patricia W. M. den Otter, Jaap C. Reijneveld, Philip C. de Witt Hamer, Hinke F. van Thuijl, Linda M. C. Lorenz, Pieter Wesseling, Frank J. Lagerwaard, Martin J. B. Taphoorn, Mathilde C. M. Kouwenhoven, Tom J. Snijders, Linda Douw, Martin Klein
Summary: HRQOL and NCF do not appear greatly impacted during long-term survivorship in LGG, but depressive symptoms and fatigue are persistent.
Article
Radiology, Nuclear Medicine & Medical Imaging
Koen J. Nelissen, Eva Versteijne, Suresh Senan, Daan Hoffmans, Ben J. Slotman, Wilko F. A. R. Verbakel
Summary: A workflow involving preplanning on diagnostic CT imaging and online plan adaption using cone-beam CT scan was developed for single-visit radiotherapy. The study showed that this workflow can meet clinical goals and outperform initial treatment plans based on daily CT scan.
JOURNAL OF APPLIED CLINICAL MEDICAL PHYSICS
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Moritz Rabe, Miguel A. Palacios, John van Sornsen R. de Koste, Chukwuka Eze, Martin Hillbrand, Claus Belka, Guillaume Landry, Suresh Senan, Christopher Kurz
Summary: This study compared the accumulated doses of MRgRT, non-adaptive IMPT, and online adaptive IMPT for central lung tumors, with a focus on the bronchial tree dose. The results showed that non-adaptive and online adaptive proton therapy achieved significant dose sparing for organs in close proximity to central lung tumors compared to MRgRT. Online adaptive IMPT achieved significantly lower doses to the bronchial tree compared to MRgRT.
Article
Oncology
Koen J. Nelissen, Eva Versteijne, Suresh Senan, Barbara Rijksen, Marjan Admiraal, Jorrit Visser, Sarah Barink, Amy L. de la Fuente, Daan Hoffmans, Ben J. Slotman, Wilko F. A. R. Verbakel
Summary: We developed a rapid palliative radiotherapy workflow using diagnostic imaging for pre-planning and on-couch target and plan adaptation based on a synthetic CT obtained from CBCT. The adapted treatment plans showed significant improvements in target coverage compared to the original plans. Most patients were satisfied with the workflow. The average treatment time, including consultation and on-couch adaptive treatment, was 85 minutes.
RADIOTHERAPY AND ONCOLOGY
(2023)
Article
Oncology
Puneeth Iyengar, Sean All, Mark F. Berry, Thomas P. Boike, Lisa Brad fi Eld, Anne -Marie C. Dingemans, Jill Feldman, Daniel R. Gomez, Paul J. Hesketh, Salma K. Jabbour, Melenda Jeter, Mirjana Josipovic, Yolande Lievens, Fiona Mcdonald, Bradford A. Perez, Umberto Ricardi, Enrico Ruffini, Dirk De Ruysscher, Hina Saeed, Bryan J. Schneider, Suresh Senan, Joachim Widder, Matthias Guckenberger
Summary: This guideline aims to review the use of local therapy in the management of extracranial oligometastatic non-small cell lung cancer (NSCLC) and provide recommendations. Currently, data is limited, but with increasing evidence supporting the use of local therapy in NSCLC, this guideline attempts to provide recommendations based on the quality of available data.
PRACTICAL RADIATION ONCOLOGY
(2023)
Article
Oncology
Miguel A. Palacios, Georgi Gerganov, Paul Cobussen, Shyama U. Tetar, Tobias Finazzi, Berend J. Slotman, Suresh Senan, Cornelis J. A. Haasbeek, Iwan Kawrakow
Summary: This study evaluated the accuracy of automatic tumor segmentation in MR-guided radiotherapy (MRgRT) by comparing it to manual delineations performed by experienced observers. The results showed a high level of agreement between automatic segmentation and manual delineation.
PHYSICS & IMAGING IN RADIATION ONCOLOGY
(2023)
Article
Oncology
Hilal Tekatli, Miguel A. Palacios, Famke L. Schneiders, Cornelis J. A. Haasbeek, Ben J. Slotman, Frank J. Lagerwaard, Suresh Senan
Summary: This study investigated the long-term clinical outcomes of MR-guided SF-SABR on a 0.35 T linac for lung tumors. The results showed that SF-SABR, using automatic beam gating during breath-holds, achieved good tumor control and low toxicity.
RADIOTHERAPY AND ONCOLOGY
(2023)
Article
Oncology
Famke L. Schneiders, Claire van Vliet, Nicolas Giraud, Anna M. E. Bruynzeel, Ben J. Slotman, Miguel A. Palacios, Suresh Senan
Summary: This study retrospectively reviewed the outcomes of MR-guided adrenal SABR and found that this approach is well tolerated and achieves high local control rates. Further research using deformable dose accumulation is needed to better understand the dose-response relationship.
CLINICAL AND TRANSLATIONAL RADIATION ONCOLOGY
(2023)
Meeting Abstract
Oncology
Amir H. Safavi, Alexander V. Louie, R. Gabriel Boldt, Anna M. E. Bruynzeel, Frank J. Lagerwaard, Suresh Senan, Hanbo Chen
RADIOTHERAPY AND ONCOLOGY
(2022)
Article
Oncology
Miguel A. Palacios, Sonja Verheijen, Famke L. Schneiders, Omar Bohoudi, Berend J. Slotman, Frank J. Lagerwaard, Suresh Senan
Summary: The study investigated the clinical feasibility, patient satisfaction, and delivery accuracy of single-fraction MR-guided SABR in a single day. All 10 patients completed the one-stop-shop procedure in a single day and reported satisfaction with the process. The accuracy of SABR delivery was high with little impact of system-latency.
PHYSICS & IMAGING IN RADIATION ONCOLOGY
(2022)