Review
Biochemical Research Methods
Juan Wang, Boxuan Li, Li Qiu, Xin Qiao, Hu Yang
Summary: This article provides an overview of the history and properties of dendrimers, as well as the latest developments in their applications as drug delivery systems. The review focuses on active drug release strategies, size-adaptive and charge reversal dendrimer delivery systems, and bulk and micro/nano dendrimer gel delivery systems.
JOURNAL OF BIOLOGICAL ENGINEERING
(2022)
Article
Chemistry, Physical
Made Budiarta, Wenjing Xu, Lukas Schubert, Maria Meledina, Alexander Meledin, Dominik Woell, Andrij Pich, Tobias Beck
Summary: The integration of ferritin containers into microgels can protect ferritin against degradation by protease and a stimuli-responsive microgel system can be designed by employing an acid-degradable crosslinker. Experimental results showed that around 80% of the ferritin containers were integrated into microgels with approximately 85% and 50% released in buffer pH 2.5 and 4.0, respectively.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2021)
Review
Polymer Science
Brielle Stawicki, Tyler Schacher, Hyunah Cho
Summary: Chemotherapy and radiation are mainstays in cancer treatment globally, but some therapies have limited specificity and cause harsh side effects in patients. Nanogels, as a unique drug delivery system, show promise in the treatment of brain cancer, despite complications such as handling and chemical stability. Ongoing development of nanogels offers a patient-centered approach for managing brain cancer.
Article
Pharmacology & Pharmacy
Wioletta Liwinska, Ewelina Waleka-Bagiel, Zbigniew Stojek, Marcin Karbarz, Ewelina Zabost
Summary: Enzyme-responsive polymeric-based nanostructures show potential as targeted drug delivery carriers, but their major risks are the fast disassembling of short-lived structures and limited accessibility of the enzyme to internal moieties. A modified environmentally responsive and enzymatically cleavable nanogel carrier was developed, which allowed independent shrinking of different parts of the network and targeted interaction with cellular receptors. Tunable nanogels efficiently stored and triggered the release of doxorubicin and mitoxantrone, with enhanced enzymatic degradation by introducing more hyaluronidase enzyme.
Article
Biochemistry & Molecular Biology
Yongchao Jiang, Yingying Guo, Haonan Wang, Xiaofeng Wang, Qian Li
Summary: A double-layered hydrogel coating with spatiotemporal drug release capacity was applied on a poly-caprolactone (PCL) fibrous scaffold to promote quick endothelialization on vascular grafts. The composite coating consisted of dopamine-modified hyaluronic acid (HA) hydrogel and gelatin hydrogel, with heparin and chondroitin sulfate introduced for drug release behavior. The coating improved the surface properties of the PCL scaffold and enhanced endothelial cell proliferation and angiogenesis behaviors. In vitro tests confirmed the long-term anticoagulation property of the modified scaffold. This research provides a universal strategy for promoting endothelialization and anticoagulation in vascular grafts.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Green & Sustainable Science & Technology
Ning Ma, Hanchen Lin, Like Ning, Xinyue Ji, Fei Wang, Cuie Shi, Peng Xu, Chaoqun You
Summary: The utilization of nanomaterials to develop an intelligent pesticide release system is of great importance in improving pesticide efficiency and reducing pollution. A novel biocompatible gel with excellent properties has been successfully developed and evaluated. The gel exhibited improved foliar wettability, rain erosion resistance, deposition rate, and controlled release performance, and showed higher inhibitory efficiency against bacteria.
JOURNAL OF CLEANER PRODUCTION
(2023)
Article
Biochemistry & Molecular Biology
Lei Liu, Shujuan Luan, Chunli Zhang, Rui Wang, Yanan Zhang, Mengying Zhang, Qianli Sheng, Guang Han, Tianshun Wang, Shiyong Song
Summary: By introducing dopamine groups onto the skeleton of nanogels, efficient loading and pH-controlled release of bortezomib were achieved, leading to enhanced bioavailability and therapeutic effect of the drug. The pH-sensitive borated bonds between bortezomib and catechol groups endowed the drug with pH-responsive release behavior. In vivo experiments demonstrated that loading bortezomib into nanogels significantly enhanced its anti-tumor effect.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Environmental Sciences
Afsana Sheikh, Sahim Aziz Hazari, Nagashekhara Molugulu, Saad Ali Alshehri, Shadma Wahab, Amirhossein Sahebkar, Prashant Kesharwani
Summary: This article investigates the potential of chitosan nanoparticles loaded with gallic acid (GA) for the treatment of psoriasis. The study found that coating the nanoparticles with hyaluronic acid (HA) slightly increased the particle size but enhanced their inhibitory effect on cells. In vivo experiments demonstrated the potential of HA-modified nanoparticles in restricting psoriasis. Further research should explore the application of HA-modified nanoparticles in the treatment of other skin-related conditions.
ENVIRONMENTAL RESEARCH
(2023)
Article
Polymer Science
Manuel Quesada-Perez, Luis Perez-Mas, David Carrizo-Tejero, Jose-Alberto Maroto-Centeno, Maria del Mar Ramos-Tejada, Alberto Martin-Molina
Summary: The release of drugs in flexible nanogels is influenced by the initial drug distribution, and surface phenomena driven by steric interactions can result in counterintuitive behaviors. These findings have implications for understanding drug release kinetics and interpreting release curves.
Article
Chemistry, Physical
Jiaqi Lu, Weiting Zhong, Jun Hou, Yanbao Zhao
Summary: Current research on silica-based drug delivery systems (DDS) focuses on improving uptake efficiency using asymmetric silica carriers, such as the designed and prepared asymmetric mesoporous silica (AMS) nanocarriers in this study. These carriers displayed higher cell uptake efficiency compared to spherical carriers, and they also demonstrated pH/enzyme-triggered drug release when loaded with doxorubicin (DOX) and blocked with hyaluronic acid (HA) molecules.
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
(2023)
Article
Polymer Science
Damla Ulker, Inci Barut, Erol Sener, Vural Butun
Summary: Micro/nano-sized particles play a crucial role in optimizing the therapeutic index of cancer drugs. This study successfully modified multi-responsive microgels for sustained drug delivery of 5-FU, with PEGylated PMEMA microgel system showing faster drug release than DPPC liposome-based microgel system. The DPPC liposome-based microgel system demonstrated effective release of 5-FU on MCF-7 breast cancer cell line, indicating promising potential for further in-vivo studies.
EUROPEAN POLYMER JOURNAL
(2021)
Article
Chemistry, Multidisciplinary
Rafael Itzhakov, Hagit Hak, Sudharsan Sadhasivam, Eduard Belausov, Elazar Fallik, Ziv Spiegelman, Edward Sionov, Elena Poverenov
Summary: This work successfully delivers bioactive molecules through designing biocompatible nanogel particles (NGPs) using modified nature-sourced building blocks. NGPs are able to deliver drugs and proteins to plant cells, and can co-deliver multiple biomolecules. Furthermore, NGPs successfully encapsulate amphotericin B and reduce its toxicity.
Article
Chemistry, Medicinal
Huiting Chen, Zhou Fang, Mengdi Song, Kehai Liu
Summary: The study presents a hierarchical drug delivery system, HA-GDT-Lip, which exhibits high cell uptake efficiency and mitochondrial targeting ability, inducing cell apoptosis and showing excellent antitumor activity and in vivo safety.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Article
Pharmacology & Pharmacy
Parbeen Singh, Yongli Chen, Deependra Tyagi, Li Wu, Xiaohong Ren, Jinglong Feng, Andrew Carrier, Tiangang Luan, Yongjun Tang, Jiwen Zhang, Xu Zhang
Summary: 13-Cyclodextrin was grafted onto hyaluronic acid in a single step to create a supramolecular biopolymer, HA-13-CD, which showed high loading capacity for drugs doxorubicin and Rhodamine B. The polymer also exhibited targeted drug delivery to cancerous cells with a high level of CD44 receptor expression, potentially making it a promising cancer-cell-targeting drug carrier.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Article
Pharmacology & Pharmacy
Shaojun Peng, Boshu Ouyang, Yongjie Xin, Wei Zhao, Shun Shen, Meixiao Zhan, Ligong Lu
Summary: Hypoxia-responsive nanogels have been developed for tumor drug delivery, showing superior drug release and tumor inhibition effects compared to other degradable nanogels. The synthesized (PMPC)-P-H nanogel exhibits ultra-long blood circulation, desirable immune compatibility, and high and long-lasting accumulation in tumor tissue, making it a promising nanocarrier for advanced tumor drug delivery.
ACTA PHARMACEUTICA SINICA B
(2021)
Article
Pharmacology & Pharmacy
Greta Camilla Magnano, Marika Quadri, Elisabetta Palazzo, Roberta Lotti, Francesca Loschi, Stefano Dall'Acqua, Michela Abrami, Francesca Larese Filon, Alessandra Marconi, Dritan Hasa
Summary: This study aimed to investigate the loading of sildenafil citrate in three commercial transdermal vehicles using 3D full-thickness skin equivalent and compare the results with permeability experiments using porcine skin. The results showed that the results obtained using the 3D skin equivalent were comparable to those obtained using porcine skin, suggesting that the 3D skin model can be a valid alternative for ex-vivo skin absorption experiments.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2024)
Article
Pharmacology & Pharmacy
James W. Mckeage, Andrew Z. H. Tan, Andrew J. Taberner
Summary: Needle-free jet injection is a promising alternative drug delivery technique that offers rapid, non-invasive, and large-volume injections. The study presents a prototype multi-orifice nozzle and a computational fluid dynamic model to demonstrate the feasibility and effectiveness of this technology.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2024)