GBT440 increases haemoglobin oxygen affinity, reduces sickling and prolongs RBC half-life in a murine model of sickle cell disease

Randomized phase 2 study of GMI-1070 in SCD: reduction in time to resolution of vaso-occlusive events and decreased opioid use

(2015) M. J. Telen et al.   BLOOD

Therapeutic Strategies to Alter the Oxygen Affinity of Sickle Hemoglobin

(2014) Martin K. Safo et al.   HEMATOLOGY-ONCOLOGY CLINICS OF NORTH AMERICA

Vaso-occlusion in sickle cell disease: pathophysiology and novel targeted therapies

(2013) D. Manwani et al.   BLOOD

Crystallographic analysis of human hemoglobin elucidates the structural basis of the potent and dual antisickling activity of pyridyl derivatives of vanillin

(2011) Osheiza Abdulmalik et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Fetal hemoglobin in sickle cell anemia

(2011) I. Akinsheye et al.   BLOOD

Improvements in haemolysis and indicators of erythrocyte survival do not correlate with acute vaso-occlusive crises in patients with sickle cell disease: a phase III randomized, placebo-controlled, double-blind study of the gardos channel blocker senicapo

(2011) Kenneth I. Ataga et al.   BRITISH JOURNAL OF HAEMATOLOGY

myo-Inositol Trispyrophosphate: A Novel Allosteric Effector of Hemoglobin with High Permeation Selectivity across the Red Blood Cell Plasma Membrane

(2010) Carolina D. Duarte  et al.   CHEMBIOCHEM

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(2010) David C Rees et al.   LANCET

Hydroxyurea use in sickle cell disease: the battle with low prescription rates, poor patient compliance and fears of toxicities

(2010) Amanda M Brandow et al.   Expert Review of Hematology

Current issues in blood transfusion for sickle cell disease

(2009) Shannon Wahl et al.   CURRENT OPINION IN PEDIATRICS

Haemoglobinopathies with high oxygen affinity. Experience of Erythropathology Cooperative Spanish Group

(2008) F. A. González Fernández et al.   ANNALS OF HEMATOLOGY