Article
Oncology
Ting Guo, Yinxing Zhu, Miao Yue, Fujin Wang, Zhifeng Li, Mei Lin
Summary: In this study, a new integrated therapy for ovarian cancer was developed using PEG-MZF-NPs/DDP/CD44-shRNA magnetic nanoliposomes as a carrier. The therapy combining magnetic fluid hyperthermia, gene therapy, and chemotherapy showed satisfactory therapeutic effects on ovarian cancer in vitro and in vivo, better than any single treatment regimen, with no significant side effects.
FRONTIERS IN ONCOLOGY
(2022)
Article
Materials Science, Multidisciplinary
Hima Patel, Kinnari Parekh, Lionel Fernel Gamarra, Javier Bustamante Mamani, Arielly da Hora Alves, A. M. Figueiredo Neto
Summary: Magnetic fluid hyperthermia (MFH) is a potential alternative treatment therapy for cancer with low side effects. This study investigates the potential of nanoclusters based on MFH for the treatment of breast cancer cells. The results show that MFH can kill almost 87% of cells within 30 minutes, indicating the potential of nanoflowers for cancer treatment over other magnetic nanoparticles.
JOURNAL OF MAGNETISM AND MAGNETIC MATERIALS
(2023)
Article
Acoustics
Thanaa Shalaby, Ahmed Gawish, Hesham Hamad
Summary: This study evaluated the potential of combining MNPs with ultrasound treatment for cancer therapy, showing a significant increase in cytotoxicity on tumor cells both in vitro and in vivo.
ULTRASOUND IN MEDICINE AND BIOLOGY
(2021)
Article
Physics, Applied
Zs Iszaly, I Gresits, I. G. Marian, Gy Thuroczy, O. Sagi, B. G. Markus, F. Simon, I Nandori
Summary: Magnetic hyperthermia is an adjuvant therapy that uses magnetic nanoparticles to transfer energy and increase the local temperature of the human body. The combination of static and alternating magnetic fields can enhance this localization effect. Research shows a significant polarization effect in superlocalization for small frequencies and large field strengths, which is important for practical applications.
JOURNAL OF PHYSICS D-APPLIED PHYSICS
(2022)
Article
Biotechnology & Applied Microbiology
Aikaterini-Rafailia Tsiapla, Konstantinos Angelou, Mavroeidis Angelakeris
Summary: This study investigates the evolution of eddy currents in magnetically driven treatments like MRI and MPH, proposing mitigation strategies through careful control of field parameters. Findings show that by tuning frequency, amplitude, and applying a pulsed field mode, undesirable heating caused by eddy currents can be successfully attenuated while maintaining beneficial effects within the malignant region, ensuring reliable treatment with milder side effects.
Article
Engineering, Biomedical
Junrui Wang, Weixiang Song, Xingyue Wang, Zhuoyan Xie, Wenli Zhang, Weixi Jiang, Shuling Liu, Jingxin Hou, Yixin Zhong, Jie Xu, Haitao Ran, Dajing Guo
Summary: The use of magnetic nanodroplets (MNDs) as carriers for ferroptosis-based nanomedicine presents a novel strategy to address delivery and penetration challenges, enhancing the efficacy of antitumor therapy by allowing targeted and deep tissue penetration under multimodal imaging guidance.
Article
Thermodynamics
Muhammad Suleman, Samia Riaz, Rashid Jalil
Summary: Magnetic nanoparticles-induced hyperthermia can heat tumors to 41-43 degrees Celsius, destroying cancer cells while keeping normal cells unharmed. This review discusses the basic physical mechanisms, recent advances in mathematical modeling, integration with other therapies, challenges, and future directions of hyperthermia.
JOURNAL OF THERMAL ANALYSIS AND CALORIMETRY
(2021)
Review
Chemistry, Multidisciplinary
Carolyn Shasha, Kannan M. Krishnan
Summary: Magnetic nanoparticles are currently a focus of research in biomedical applications such as imaging, sensing, and therapeutics. Understanding nanoparticle magnetization dynamics is crucial for optimizing and further developing these applications. Both theoretical models and computational nonequilibrium models are utilized to study nanoparticle dynamics. The effect of field amplitude and nanoparticle size on magnetization response is explored, with a focus on applications in magnetic particle imaging and magnetic fluid hyperthermia in biomedicine.
ADVANCED MATERIALS
(2021)
Article
Materials Science, Multidisciplinary
Zs Iszaly, I. G. Marian, I. A. Szabo, A. Trombettoni, I Nandori
Summary: The main idea of magnetic hyperthermia is to locally increase body temperature by means of injected superparamagnetic nanoparticles, absorbing energy from an external magnetic field. The study demonstrates the influence of thermal effects on superlocalization and heating efficiency, showing similarities between deterministic and stochastic results in the presence of time-dependent steady state motions of the magnetization vector. It also highlights the importance of oscillating applied field in low frequency range for hyperthermia.
JOURNAL OF MAGNETISM AND MAGNETIC MATERIALS
(2022)
Article
Nanoscience & Nanotechnology
Yilian Fernandez-Afonso, Laura Asin, Lilianne Beola, Raluca M. Fratila, Lucia Gutierrez
Summary: This study investigates how the transformations of magnetic nanoparticles in vivo affect their heating properties in hyperthermia treatments. Iron oxide magnetic nanoparticles with two different coatings were subjected to accelerated degradation to simulate lysosome conditions. The degradation process was monitored for 24 days, revealing that DMSA-coated particles degraded faster than PMAO-coated ones. Changes in physicochemical properties were found to impact the heating capacity under an alternating magnetic field or near infrared light. Additionally, intratumoral administration of PMAO-coated particles showed no significant changes in size and size distribution over time. This research is particularly relevant for the design of in vivo hyperthermia treatments using magnetic nanoparticles.
ACS APPLIED NANO MATERIALS
(2022)
Article
Pharmacology & Pharmacy
Javier B. Mamani, Taylla K. F. Souza, Mariana P. Nucci, Fernando A. Oliveira, Leopoldo P. Nucci, Arielly H. Alves, Gabriel N. A. Rego, Luciana Marti, Lionel F. Gamarra
Summary: This in vitro study assessed the use of magnetic hyperthermia (MHT) and the best strategy for internalizing magnetic nanoparticles in glioblastoma tumor cells. The study identified optimal conditions for SPIONAmine internalization, resulting in a significant decrease in cell viability. This promising approach suggests the potential of using magnetic nanoparticles in anti-tumor treatments.
Article
Chemistry, Multidisciplinary
Fuyao Liu, Haoan Wu, Bin Peng, Shenqi Zhang, Junning Ma, Gang Deng, Pan Zou, Jun Liu, Ann T. Chen, Dongfang Li, Stefania Bellone, Alessandro Davide Santin, Jennifer Moliterno, Jiangbing Zhou
Summary: Although magnetic hyperthermia shows promise for brain cancer treatment, its clinical application is hindered by highly invasive intracranial injections. The development of gallic acid-coated magnetic nanoclovers (GA-MNCs) offers a noninvasive and targeted delivery system for magnetic hyperthermia and systemic chemotherapy, showing great potential for improved treatment outcomes in brain cancer.
Article
Engineering, Biomedical
Zachary R. Stephen, Miqin Zhang
Summary: Immunotherapy has shown success in certain cancers, and combinational approaches with hyperthermia therapy are being explored to enhance its effectiveness. Nanoparticle-based hyperthermia increases tumor immunogenicity and permeability, particularly effective in solid tumors.
ADVANCED HEALTHCARE MATERIALS
(2021)
Article
Engineering, Biomedical
Junrui Wang, Wenli Zhang, Zhuoyan Xie, Xingyue Wang, Ying Luo, Weixi Jiang, Yun Liu, Zhigang Wang, Haitao Ran, Weixiang Song, Dajing Guo
Summary: In this study, a biocompatible nanotheranostic agent was developed for targeted therapy of deep-seated cells in solid tumors. The nanoparticles exhibited excellent magnetothermal conversion and controllable magnetic hyperthermia, allowing for deep penetration in tumors. Furthermore, the study found that magnetic hyperthermia not only induced apoptotic damage in tumor cells but also improved the response rate to immunotherapy, suggesting its potential as a dual therapeutic strategy.
ADVANCED HEALTHCARE MATERIALS
(2022)
Article
Nanoscience & Nanotechnology
Arunima Rajan, Niroj Kumar Sahu
Summary: Magnetically induced hyperthermia using iron oxide nanoparticles presents an effective alternative to traditional cancer treatments, with monodisperse oleate-coated magnetite nanorods demonstrating promising performance in biological studies.
ACS APPLIED NANO MATERIALS
(2021)
