GIP as a Potential Therapeutic Target for Atherosclerotic Cardiovascular Disease–A Systematic Review
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Title
GIP as a Potential Therapeutic Target for Atherosclerotic Cardiovascular Disease–A Systematic Review
Authors
Keywords
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Journal
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Volume 21, Issue 4, Pages 1509
Publisher
MDPI AG
Online
2020-02-24
DOI
10.3390/ijms21041509
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Note: Only part of the references are listed.- Sex differences in the risk of vascular disease associated with diabetes
- (2020) Rianneke de Ritter et al. Biology of Sex Differences
- Heart Failure in Type 2 Diabetes Mellitus
- (2019) Helena C. Kenny et al. CIRCULATION RESEARCH
- Twincretin as a potential therapeutic for the management of type 2 diabetes with obesity
- (2019) Ryota Usui et al. Journal of Diabetes Investigation
- Hypoglycaemia, cardiovascular disease, and mortality in diabetes: epidemiology, pathogenesis, and management
- (2019) Stephanie A Amiel et al. Lancet Diabetes & Endocrinology
- Separate and Combined Effects of GIP and GLP-1 Infusions on Bone Metabolism in Overweight Men without Diabetes
- (2019) Natasha Chidekel Bergmann et al. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
- Anti-atherogenic effects of liraglutide in hyperglycemic apolipoprotein E-null mice via AMP-activated protein kinase independent mechanisms
- (2019) Masakazu Koshibu et al. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
- Dulaglutide and cardiovascular outcomes in type 2 diabetes (REWIND): a double-blind, randomised placebo-controlled trial
- (2019) Hertzel C Gerstein et al. LANCET
- Oral Semaglutide and Cardiovascular Outcomes in Patients with Type 2 Diabetes
- (2019) Mansoor Husain et al. NEW ENGLAND JOURNAL OF MEDICINE
- GLP-2 and GIP exert separate effects on bone turnover: A randomized, placebo-controlled, crossover study in healthy young men
- (2019) Kirsa Skov-Jeppesen et al. BONE
- Glucose-Dependent Insulinotropic Polypeptide Receptor-Expressing Cells in the Hypothalamus Regulate Food Intake
- (2019) Alice E. Adriaenssens et al. Cell Metabolism
- Effect of Linagliptin vs Glimepiride on Major Adverse Cardiovascular Outcomes in Patients With Type 2 Diabetes
- (2019) Julio Rosenstock et al. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
- GIP analogues augment bone strength by modulating bone composition in diet-induced obesity in mice
- (2019) Sagar S. Vyavahare et al. PEPTIDES
- No evidence of tachyphylaxis for insulinotropic actions of glucose-dependent insulinotropic polypeptide (GIP) in subjects with type 2 diabetes, their first-degree relatives, or in healthy subjects
- (2019) M.A. Nauck et al. PEPTIDES
- Inactivation of the Glucose-Dependent Insulinotropic Polypeptide Receptor Improves Outcomes following Experimental Myocardial Infarction
- (2018) John R. Ussher et al. Cell Metabolism
- Diabetic Cardiomyopathy
- (2018) Guanghong Jia et al. CIRCULATION RESEARCH
- Risk of Incident Heart Failure in Patients With Diabetes and Asymptomatic Left Ventricular Systolic Dysfunction
- (2018) Rasmus Rørth et al. DIABETES CARE
- Nitric oxide signalling in cardiovascular health and disease
- (2018) Charlotte Farah et al. Nature Reviews Cardiology
- A potential strategy for treating atherosclerosis: improving endothelial function via AMP-activated protein kinase
- (2018) Feng Gao et al. Science China-Life Sciences
- Stimulation of the endogenous incretin glucose-dependent insulinotropic peptide by enteral dextrose improves glucose homeostasis and inflammation in murine endotoxemia
- (2018) Faraaz Ali Shah et al. Translational Research
- Sex-specific relevance of diabetes to occlusive vascular and other mortality: a collaborative meta-analysis of individual data from 980 793 adults from 68 prospective studies
- (2018) L Gnatiuc et al. Lancet Diabetes & Endocrinology
- The incretin hormone GIP is upregulated in patients with atherosclerosis and stabilizes plaques in ApoE −/− mice by blocking monocyte/macrophage activation
- (2018) Florian Kahles et al. Molecular Metabolism
- OUP accepted manuscript
- (2018) EUROPEAN HEART JOURNAL
- D-Ala2GIP Facilitated Synaptic Plasticity and Reduces Plaque Load in Aged Wild Type Mice and in an Alzheimer's Disease Mouse Model
- (2018) Emilie Faivre et al. JOURNAL OF ALZHEIMERS DISEASE
- Effect of Linagliptin vs Placebo on Major Cardiovascular Events in Adults With Type 2 Diabetes and High Cardiovascular and Renal Risk
- (2018) Julio Rosenstock et al. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
- Efficacy and safety of LY3298176, a novel dual GIP and GLP-1 receptor agonist, in patients with type 2 diabetes: a randomised, placebo-controlled and active comparator-controlled phase 2 trial
- (2018) Juan Pablo Frias et al. LANCET
- Albiglutide and cardiovascular outcomes in patients with type 2 diabetes and cardiovascular disease (Harmony Outcomes): a double-blind, randomised placebo-controlled trial
- (2018) Adrian F Hernandez et al. LANCET
- Glucose-dependent insulinotropic polypeptide deficiency reduced fat accumulation and insulin resistance, but deteriorated bone loss in ovariectomized mice
- (2018) Satoko Shimazu-Kuwahara et al. Journal of Diabetes Investigation
- Optimized GIP analogs promote body weight lowering in mice through GIPR agonism not antagonism
- (2018) Piotr A. Mroz et al. Molecular Metabolism
- Targeting white, brown and perivascular adipose tissue in atherosclerosis development
- (2017) Andrea D. van Dam et al. EUROPEAN JOURNAL OF PHARMACOLOGY
- Glucose-Dependent Insulinotropic Polypeptide (GIP) Inhibits Bone Resorption Independently of Insulin and Glycemia
- (2017) Mikkel B Christensen et al. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
- Difference in protective effects of GIP and GLP-1 on endothelial cells according to cyclic adenosine monophosphate response
- (2017) Dong-Mee Lim et al. Experimental and Therapeutic Medicine
- Sitagliptin decreases ventricular arrhythmias by attenuated glucose-dependent insulinotropic polypeptide (GIP)-dependent resistin signalling in infarcted rats
- (2016) T.-M. Lee et al. BIOSCIENCE REPORTS
- Clinical Update: Cardiovascular Disease in Diabetes Mellitus
- (2016) Cecilia C. Low Wang et al. CIRCULATION
- Suppressive Effects of Glucose-Dependent Insulinotropic Polypeptide on Cardiac Hypertrophy and Fibrosis in Angiotensin II-Infused Mouse Models
- (2016) Munenori Hiromura et al. CIRCULATION JOURNAL
- Anagliptin, A Dipeptidyl Peptidase-4 Inhibitor Ameliorates Arterial Stiffness in Association with Reduction of Remnant-Like Particle Cholesterol and Alanine Transaminase Levels in Type 2 Diabetic Patients
- (2016) Nobuhiro Tahara et al. Current Vascular Pharmacology
- Cardiovascular Mortality in Patients With Type 2 Diabetes and Recent Acute Coronary Syndromes From the EXAMINE Trial
- (2016) William B. White et al. DIABETES CARE
- Sitagliptin Attenuates the Progression of Carotid Intima-Media Thickening in Insulin-Treated Patients With Type 2 Diabetes: The Sitagliptin Preventive Study of Intima-Media Thickness Evaluation (SPIKE)
- (2016) Tomoya Mita et al. DIABETES CARE
- Semaglutide and Cardiovascular Outcomes in Patients with Type 2 Diabetes
- (2016) Steven P. Marso et al. NEW ENGLAND JOURNAL OF MEDICINE
- Liraglutide and Cardiovascular Outcomes in Type 2 Diabetes
- (2016) Steven P. Marso et al. NEW ENGLAND JOURNAL OF MEDICINE
- Anti-inflammatory role of glucose-dependent insulinotropic polypeptide in periodontitis
- (2016) Yuki Suzuki et al. Journal of Diabetes Investigation
- Understanding and managing in-stent restenosis: a review of clinical data, from pathogenesis to treatment
- (2016) Dario Buccheri et al. Journal of Thoracic Disease
- Direct effect of incretin hormones on glucose and glycerol metabolism and hemodynamics
- (2015) Kristian Karstoft et al. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
- Increased GIP signaling induces adipose inflammation via a HIF-1α-dependent pathway and impairs insulin sensitivity in mice
- (2015) Shu Chen et al. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
- Influence of insulin resistance on in-stent restenosis in patients undergoing coronary drug-eluting stent implantation after long-term angiographic follow-up
- (2015) Liang-Ping Zhao et al. CORONARY ARTERY DISEASE
- Glucose-Dependent Insulinotropic Polypeptide (GIP) Stimulates Osteopontin Expression in the Vasculature via Endothelin-1 and CREB
- (2015) Lisa M. Berglund et al. DIABETES
- Alogliptin, a Dipeptidyl Peptidase 4 Inhibitor, Prevents the Progression of Carotid Atherosclerosis in Patients With Type 2 Diabetes: The Study of Preventive Effects of Alogliptin on Diabetic Atherosclerosis (SPEAD-A)
- (2015) Tomoya Mita et al. DIABETES CARE
- GIP increases adipose tissue expression and blood levels of MCP-1 in humans and links high energy diets to inflammation: a randomised trial
- (2015) Özlem Gögebakan et al. DIABETOLOGIA
- Macrophage-mediated cholesterol handling in atherosclerosis
- (2015) Dimitry A. Chistiakov et al. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
- Stable Incretin Mimetics Counter Rapid Deterioration of Bone Quality in Type 1 Diabetes Mellitus
- (2015) Sity Aishah Mansur et al. JOURNAL OF CELLULAR PHYSIOLOGY
- Internalization and desensitization of the human glucose-dependent-insulinotropic receptor is affected by N-terminal acetylation of the agonist
- (2015) Sadek Ismail et al. MOLECULAR AND CELLULAR ENDOCRINOLOGY
- Effect of Sitagliptin on Cardiovascular Outcomes in Type 2 Diabetes
- (2015) Jennifer B. Green et al. NEW ENGLAND JOURNAL OF MEDICINE
- Effects of glucose-dependent insulinotropic polypeptide receptor knockout and a high-fat diet on cognitive function and hippocampal gene expression in mice
- (2015) RACHAEL R. LENNOX et al. Molecular Medicine Reports
- Osteopontin – A multi-modal marker and mediator in atherosclerotic vascular disease
- (2014) Talya Wolak ATHEROSCLEROSIS
- Molecular Imaging of Vascular Inflammation
- (2014) Nobuhiro Tahara et al. CURRENT PHARMACEUTICAL DESIGN
- Chronic Reduction of GIP Secretion Alleviates Obesity and Insulin Resistance Under High-Fat Diet Conditions
- (2014) D. Nasteska et al. DIABETES
- Functional Consequences of Glucagon-like Peptide-1 Receptor Cross-talk and Trafficking
- (2014) Sarah Noerklit Roed et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Glucose-Dependent Insulinotropic Polypeptide Inhibits Bone Resorption in Humans
- (2014) Anne Nissen et al. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
- Long-Acting Glucose-Dependent Insulinotropic Polypeptide Ameliorates Obesity-Induced Adipose Tissue Inflammation
- (2014) Chen Varol et al. JOURNAL OF IMMUNOLOGY
- A Naturally Occurring GIP Receptor Variant Undergoes Enhanced Agonist-Induced Desensitization, Which Impairs GIP Control of Adipose Insulin Sensitivity
- (2014) S. Mohammad et al. MOLECULAR AND CELLULAR BIOLOGY
- Macrophage subsets in atherosclerosis
- (2014) Giulia Chinetti-Gbaguidi et al. Nature Reviews Cardiology
- A glucagon-like peptide-1 analog liraglutide suppresses macrophage foam cell formation and atherosclerosis
- (2014) Yuko Tashiro et al. PEPTIDES
- Advanced glycation end products evoke endothelial cell damage by stimulating soluble dipeptidyl peptidase-4 production and its interaction with mannose 6-phosphate/insulin-like growth factor II receptor
- (2013) Yuji Ishibashi et al. Cardiovascular Diabetology
- Biological responses in stented arteries
- (2013) Chiraz Chaabane et al. CARDIOVASCULAR RESEARCH
- Pharmacology, Physiology, and Mechanisms of Incretin Hormone Action
- (2013) Jonathan E. Campbell et al. Cell Metabolism
- Link Between GIP and Osteopontin in Adipose Tissue and Insulin Resistance
- (2013) E. Ahlqvist et al. DIABETES
- Saxagliptin and Cardiovascular Outcomes in Patients with Type 2 Diabetes Mellitus
- (2013) Benjamin M. Scirica et al. NEW ENGLAND JOURNAL OF MEDICINE
- Role of glucose-dependent insulinotropic polypeptide in adipose tissue inflammation of dipeptidylpeptidase 4-deficient rats
- (2013) Shani Ben-Shlomo et al. Obesity
- Preventive Effect of Dipeptidyl Peptidase-4 Inhibitor on Atherosclerosis Is Mainly Attributable to Incretin's Actions in Nondiabetic and Diabetic Apolipoprotein E-Null Mice
- (2013) Michishige Terasaki et al. PLoS One
- Glucose-dependent insulinotropic polypeptide and glucagon-like peptide-1: Incretin actions beyond the pancreas
- (2013) Yutaka Seino et al. Journal of Diabetes Investigation
- Neuroprotective effects of D-Ala2GIP on Alzheimer's disease biomarkers in an APP/PS1 mouse model
- (2013) Emilie Faivre et al. Alzheimers Research & Therapy
- Severe hypoglycaemia and cardiovascular disease: systematic review and meta-analysis with bias analysis
- (2013) A. Goto et al. BMJ-British Medical Journal
- Glucose-dependent insulinotropic polypeptide induces cytokine expression, lipolysis, and insulin resistance in human adipocytes
- (2012) Katharina Timper et al. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
- Animal Models of Atherosclerosis
- (2012) Godfrey S. Getz et al. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
- Regulation of the pro-inflammatory cytokine osteopontin by GIP in adipocytes – A role for the transcription factor NFAT and phosphodiesterase 3B
- (2012) Bilal Omar et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Xenin-25 Amplifies GIP-Mediated Insulin Secretion in Humans With Normal and Impaired Glucose Tolerance but Not Type 2 Diabetes
- (2012) B. M. Wice et al. DIABETES
- Positive Association Between Serum Level of Glyceraldehyde-Derived Advanced Glycation End Products and Vascular Inflammation Evaluated by [18F]Fluorodeoxyglucose Positron Emission Tomography
- (2012) N. Tahara et al. DIABETES CARE
- Glucose-dependent insulinotropic peptide impairs insulin signaling via inducing adipocyte inflammation in glucose-dependent insulinotropic peptide receptor-overexpressing adipocytes
- (2012) Yaohui Nie et al. FASEB JOURNAL
- Glucose-dependent Insulinotropic Polypeptide (GIP) Inhibits Signaling Pathways of Advanced Glycation End Products (AGEs) in Endothelial Cells via its Antioxidative Properties
- (2012) A. Ojima et al. HORMONE AND METABOLIC RESEARCH
- Effects of PKF275-055, a dipeptidyl peptidase–4 inhibitor, on the development of atherosclerotic lesions in apolipoprotein E–null mice
- (2012) Michishige Terasaki et al. METABOLISM-CLINICAL AND EXPERIMENTAL
- The incretin analogue D-Ala2GIP reduces plaque load, astrogliosis and oxidative stress in an APP/PS1 mouse model of Alzheimer’s disease
- (2012) A.M. Duffy et al. NEUROSCIENCE
- Regulation of GIP and GLP1 Receptor Cell Surface Expression by N-Glycosylation and Receptor Heteromerization
- (2012) Gina M. Whitaker et al. PLoS One
- Glucose-Dependent Insulinotropic Polypeptide Prevents the Progression of Macrophage-Driven Atherosclerosis in Diabetic Apolipoprotein E-Null Mice
- (2012) Yukinori Nogi et al. PLoS One
- GIP-Overexpressing Mice Demonstrate Reduced Diet-Induced Obesity and Steatosis, and Improved Glucose Homeostasis
- (2012) Su-Jin Kim et al. PLoS One
- Glucagon-like peptide-1 receptor dimerization differentially regulates agonist signaling but does not affect small molecule allostery
- (2012) K. G. Harikumar et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- EXamination of CArdiovascular OutcoMes with AlogliptIN versus Standard of CarE in Patients with Type 2 Diabetes Mellitus and Acute Coronary Syndrome (EXAMINE)
- (2011) William B. White et al. AMERICAN HEART JOURNAL
- Role of Advanced Glycation End Products (AGEs) in Osteoporosis in Diabetes
- (2011) Sho-ichi Yamagishi CURRENT DRUG TARGETS
- Estimated morbidity and mortality in adolescents and young adults diagnosed with Type 2 diabetes mellitus
- (2011) E. T. Rhodes et al. DIABETIC MEDICINE
- Native incretins prevent the development of atherosclerotic lesions in apolipoprotein E knockout mice
- (2011) M. Nagashima et al. DIABETOLOGIA
- Long-term in vivo resistin overexpression induces myocardial dysfunction and remodeling in rats
- (2011) Elie R. Chemaly et al. JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
- Glucose-dependent insulinotropic polypeptide receptor knockout mice are impaired in learning, synaptic plasticity, and neurogenesis
- (2011) Emilie Faivre et al. JOURNAL OF NEUROPHYSIOLOGY
- Diabetes Mellitus, Fasting Glucose, and Risk of Cause-Specific Death
- (2011) NEW ENGLAND JOURNAL OF MEDICINE
- Sub-chronic administration of stable GIP analog in mice decreases serum LPL activity and body weight
- (2011) Ewa Szalowska et al. PEPTIDES
- Vildagliptin blocks vascular injury in thoracic aorta of diabetic rats by suppressing advanced glycation end product–receptor axis
- (2011) Takanori Matsui et al. PHARMACOLOGICAL RESEARCH
- Intact Glucagon-like Peptide-1 Levels are not Decreased in Japanese Patients with Type 2 Diabetes
- (2010) Soushou LEE et al. ENDOCRINE JOURNAL
- AMPK and vasculoprotection
- (2010) Marie-Ann Ewart et al. PHARMACOLOGY & THERAPEUTICS
- GIP and GLP-1, the two incretin hormones: Similarities and differences
- (2010) Yutaka Seino et al. Journal of Diabetes Investigation
- Cytokine Biomarkers, Endothelial Inflammation, and Atherosclerosis in the Metabolic Syndrome: Emerging Concepts
- (2009) Ali A. Rizvi AMERICAN JOURNAL OF THE MEDICAL SCIENCES
- Glucagon-like peptide-1 (GLP-1) inhibits advanced glycation end product (AGE)-induced up-regulation of VCAM-1 mRNA levels in endothelial cells by suppressing AGE receptor (RAGE) expression
- (2009) Yuji Ishibashi et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Inflammation in Atherosclerosis
- (2009) Peter Libby et al. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
- Incretin-based therapies for type 2 diabetes mellitus
- (2009) Julie A. Lovshin et al. Nature Reviews Endocrinology
- Inflammation at the Molecular Interface of Atherogenesis
- (2008) Brian D. Lamon et al. AMERICAN JOURNAL OF PATHOLOGY
- Role of Oxidative Stress in the Development of Vascular Injury and its Therapeutic Intervention by Nifedipine
- (2008) Sho-ichi Yamagishi et al. CURRENT MEDICINAL CHEMISTRY
- Possible Involvement of Advanced Glycation End-Products (AGEs) in the Pathogenesis of Alzheimers Disease
- (2008) Masayoshi Takeuchi et al. CURRENT PHARMACEUTICAL DESIGN
- Four weeks of near-normalisation of blood glucose improves the insulin response to glucagon-like peptide-1 and glucose-dependent insulinotropic polypeptide in patients with type 2 diabetes
- (2008) P. V. Højberg et al. DIABETOLOGIA
- Functional expression of glucose-dependent insulinotropic polypeptide receptors is coupled to differentiation in a human adipocyte model
- (2008) R E Weaver et al. INTERNATIONAL JOURNAL OF OBESITY
- The regulation of AMP-activated protein kinase by upstream kinases
- (2008) D Carling et al. INTERNATIONAL JOURNAL OF OBESITY
- Role of resistin in cardiac contractility and hypertrophy
- (2008) Maengjo Kim et al. JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
- Protease-Resistant Glucose-Dependent Insulinotropic Polypeptide Agonists Facilitate Hippocampal LTP and Reverse the Impairment of LTP Induced by Beta-Amyloid
- (2008) Victor A. Gault et al. JOURNAL OF NEUROPHYSIOLOGY
- Intensive Blood Glucose Control and Vascular Outcomes in Patients with Type 2 Diabetes
- (2008) NEW ENGLAND JOURNAL OF MEDICINE
- Effects of Intensive Glucose Lowering in Type 2 Diabetes
- (2008) NEW ENGLAND JOURNAL OF MEDICINE
- 10-Year Follow-up of Intensive Glucose Control in Type 2 Diabetes
- (2008) Rury R. Holman et al. NEW ENGLAND JOURNAL OF MEDICINE
- Glucose Control and Vascular Complications in Veterans with Type 2 Diabetes
- (2008) William Duckworth et al. NEW ENGLAND JOURNAL OF MEDICINE
- GPCR monomers and oligomers: it takes all kinds
- (2008) Vsevolod V. Gurevich et al. TRENDS IN NEUROSCIENCES
- A novel GIP receptor splice variant influences GIP sensitivity of pancreatic β-cells in obese mice
- (2007) Norio Harada et al. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
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