Article
Nutrition & Dietetics
Hengfang Tang, Zhiming Zheng, Han Wang, Li Wang, Genhai Zhao, Peng Wang
Summary: Vitamin K2 can alleviate neuronal cell death mediated by mitochondrial damage by regulating the mitochondrial quality-control loop and repairing mitochondrial dysfunction.
Article
Environmental Sciences
Yu Shang, Wanlei Xue, Jiexing Kong, Yingjun Chen, Xinghua Qiu, Xingqin An, Yi Li, Hongli Wang, Jing An
Summary: This study found that exposure to ambient ultrafine black carbon causes mitochondrial oxidative stress, leading to mitochondrial dysfunction and neurotoxicity. Regulation of mitophagy process can mitigate mitochondrial damage.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Article
Multidisciplinary Sciences
Erin Buchanan, Caitlyn Mahony, Sophia Bam, Mohamed Jaffer, Sarah Macleod, Asandile Mangali, Mignon van der Watt, Sholto de Wet, Rensu Theart, Caron Jacobs, Ben Loos, Colleen O'Ryan
Summary: This study used quantitative visualization techniques to examine the influence of PPA on mitochondrial ultrastructure, morphology, and dynamics in neuronal-like cells. The results showed that PPA caused a decrease in mitochondrial area and morphology, but increased fission and fusion events to maintain mitochondrial network integrity. Additionally, PPA significantly decreased the expression of genes related to mitochondrial morphology and biogenesis.
SCIENTIFIC REPORTS
(2023)
Article
Biochemistry & Molecular Biology
Shun Zhu, Nan Xu, Yanyan Han, Xiaofei Ye, Ling Yang, Ji Zuo, Wen Liu
Summary: This study reveals the important role of mitochondrial transcription termination factor 3 (MTERF3) in Parkinson's disease and explores its dual function in mitochondrial DNA transcription and translation. It shows that MTERF3 plays a protective role in MPP+-induced mitochondrial dysfunction. This study provides valuable insights for understanding the pathogenesis of Parkinson's disease and designing therapeutic approaches.
ACTA BIOCHIMICA ET BIOPHYSICA SINICA
(2022)
Article
Cell Biology
Andrea Evinova, Zuzana Hatokova, Zuzana Tatarkova, Maria Brodnanova, Katarina Dibdiakova, Peter Racay
Summary: In this study, we found that treating cells with either thapsigargin or tunicamycin resulted in a decrease in mitochondrial respiration and Delta psi m, and affected the activity of succinyl-CoA ligase and complex II. Despite the induction of ER-specific UPR, mitochondrial UPR was not induced. Inhibition of IRE1 alpha ribonuclease did not protect cells from ER stress-induced mitochondrial dysfunction. STF-083010 had a significant impact on mitochondrial function, leading to the uncoupling of the respiratory chain from ATP synthesis.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2022)
Article
Food Science & Technology
Nadia Perez-Fuentes, Rebeca Alvarin, Amparo Alfonso, Jesus Gonzalez-Jartin, Sandra Gegunde, Mercedes R. Vieytes, Luis M. Botana
Summary: The study revealed that individual mycotoxins had the most damaging effects on neuronal cells, while non-regulated mycotoxins induced apoptosis by affecting mitochondrial membrane potential. Antagonistic effects were observed in all cases when regulated and non-regulated mycotoxins were combined in binary mixtures.
FOOD AND CHEMICAL TOXICOLOGY
(2021)
Article
Geriatrics & Gerontology
Peizheng Li, Hongbo Lv, Bohan Zhang, Ruonan Duan, Xiufang Zhang, Pengfei Lin, Chengyuan Song, Yiming Liu
Summary: This study found that GDF15 can protect mitochondrial function and reduce apoptosis in PD cell models by upregulating PGC1 alpha. Additionally, GDF15 overexpression can improve cell protection by activating the PI3K/Akt/mTOR signaling pathway.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Biao Xiang, Daowen Li, Yiqiang Chen, Meng Li, Yuan Zhang, Tun Sun, Shusheng Tang
Summary: The study demonstrated that curcumin has neuroprotective properties against copper-induced neurotoxicity and apoptosis. The potential mechanisms may involve the reduction of oxidative stress and mitochondrial apoptosis.
NEUROCHEMICAL RESEARCH
(2021)
Article
Neurosciences
Xiaofan Ning, Xinyue Li, Kai Ma, Huan Pang, Tiantian Tian, Huifang Hao, Qiaohong Hou, Meng Li, Tianxiang Liu, Shanshan Hou, Haiying Du, Xiuling Song, Zhiwei Sun, Chao Zhao, Minghua Jin
Summary: Silica nanoparticles are widely used in industry, electronics, and pharmaceutical industries, as well as medicine, tumor treatment and diagnosis, and other biomedical and biotechnology fields. The increasing exposure to silica nanoparticles through iatrogenic, occupational, and environmental sources has raised concerns about their potential damage and effects on the nervous system.
MOLECULAR NEUROBIOLOGY
(2023)
Article
Nutrition & Dietetics
Chia-Ling Ho, Ning-Jo Kao, Ching- Lin, Tzu-Wen L. Cross, Shyh-Hsiang Lin
Summary: Alzheimer's disease is a common neurodegenerative disorder, with oxidative stress and mitochondrial biogenesis being implicated in its progression. Quercetin has been found to increase mitochondrial biogenesis and reduce oxidative stress-induced damage, showing promise in protecting neuronal cells.
Article
Biochemistry & Molecular Biology
Muhammet Ay
Summary: This study found that vanillic acid can stimulate mitochondrial biogenesis in neuronal cells and alter the expression of genes related to the pathogenesis of Parkinson's disease and neuronal differentiation.
MOLECULAR BIOLOGY REPORTS
(2022)
Article
Biochemistry & Molecular Biology
Christopher Simon, Tomoko Soga, Ishwar Parhar
Summary: This study found that the hypothalamic neurohormone kisspeptin-10 (KP-10) plays an important role in cholinergic neurodegenerative diseases. KP-10 interacts with α-synuclein (α-syn) through its cognate G-protein-coupled receptor GPR54 and protects cholinergic-like neurons from damage. These findings have important implications for the affinity mechanism and neuroprotective effects.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Stephanie Cristine Hepp Rehfeldt, Stefan Laufer, Marcia Ines Goettert
Summary: Current treatments for neurodegenerative diseases are limited in slowing down disease progression. This research evaluates the neuroprotective, anti-inflammatory, and antioxidant effects of a synthetic compound with JNK3 inhibitory activity in neuroblastoma cells, showing promising results in reducing cell damage and inflammation. This compound could be a potential candidate for treating neurodegenerative disorders.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Environmental Sciences
Xin Wang, Hongfei Ni, Wenping Xu, Bing Wu, Te Xie, Cheng Zhang, Jiagao Cheng, Zhong Li, Liming Tao, Yang Zhang
Summary: Difenoconazole exhibits neurotoxicity at the cellular level, causing cell apoptosis and DNA damage, and adversely affecting cell function.
Article
Pharmacology & Pharmacy
Zahra Madadi, Shiva Akbari-Birgani, Saeed Mohammadi, Mitra Khademy, Seyed Asadollah Mousavi
Summary: Neuroblastoma is a common malignant tumor in infants and young children, with differentiation-inducing potential. The activation of caspase-9 plays a crucial role in the differentiation process of human neuroblastoma cells, promoting a change in cell morphology and protein expression.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Review
Toxicology
Joshua Klingberg, Bethany Keen, Adam Cawley, Daniel Pasin, Shanlin Fu
Summary: This paper reviews the novel applications of HRMS techniques in the analysis of NPS, including the identification of usage trends in the community through wastewater analysis and the examination of the effects of drugs of abuse on endogenous compounds using metabolomic approaches.
ARCHIVES OF TOXICOLOGY
(2022)
Article
Toxicology
Shimpei Watanabe, Takahiro Iwai, Ritsuko Matsushita, Toshio Nakanishi, Unnikrishnan Kuzhiumparambil, Shanlin Fu, Yasuo Seto
Summary: This study compared the metabolism of synthetic cannabinoid JWH-424 using human liver microsomes (HLM) and the fungus Cunninghamella elegans as catalysts. The results showed that there were differences in the metabolic pathways and products between HLM and the fungus, highlighting the importance of verifying metabolites in authentic urine samples.
FORENSIC TOXICOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Alexander Leathem, Martin Simone, Joanne M. Dennis, Paul K. Witting
Summary: Research suggests that cyclic nitroxide TEMPOL can protect dopaminergic neurons by attenuating oxidative stress and mitochondrial dysfunction in Parkinson's disease (PD), but has no effect on the inflammatory mediators that contribute to cellular damage and neurodegeneration.
Review
Biochemical Research Methods
Bethany Keen, Adam Cawley, Brian Reedy, Shanlin Fu
Summary: Metabolomics is a multidisciplinary field that provides workflows for analyzing metabolically related compounds or novel pathways. This review explores the procedural stages of metabolomics, including experimental design, sample preparation, analytical determinations, data processing, compound identification, and validation strategies. The selected approach depends on the type of study, and proper assessment of experimental design and harmonization of data processing and statistical analysis are crucial. Metabolomics applications are discussed in various fields such as clinical toxicology, anti-doping, and veterinary residues.
DRUG TESTING AND ANALYSIS
(2022)
Article
Biochemical Research Methods
Kathy Tou, Adam Cawley, Christopher Bowen, Kireesan Sornalingam, Shanlin Fu
Summary: The aim of this research was to investigate the plasma concentrations of hydrocortisone (HC) and cortisone (C) in race day samples compared to the administration of Triamcinolone Acetonide (TACA). The results showed that the use of TACA resulted in a decrease in HC/C values for up to 96 hours post-administration, longer than the detection period of TACA itself.
DRUG TESTING AND ANALYSIS
(2022)
Review
Biochemistry & Molecular Biology
Alexander Leathem, Tamara Ortiz-Cerda, Joanne M. Dennis, Paul K. Witting
Summary: Parkinson's disease is a progressive neurodegenerative disorder caused by a complex interplay of age, genetic, and environmental factors. Current treatments do not stop or reverse neurodegeneration, so it's important to develop new approaches. Mitochondrial dysfunction, oxidative damage, and inflammation are implicated in the selective loss of dopaminergic neurons. However, the effectiveness of inhibiting these pathways is variable, thus further development and testing of novel therapies are needed.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Kathy Tou, Adam Cawley, Christopher Bowen, David P. Bishop, Shanlin Fu
Summary: The current approach to equine anti-doping focuses on targeted detection, but there is a need for complementary monitoring methods to ensure integrity in the racing industry. Lipidomics, a growing field, has potential in characterizing lipids and their effects in the equine system. Eicosanoids, a class of lipids, have been studied as potential inflammatory markers for monitoring in equine anti-doping.
Editorial Material
Biochemistry & Molecular Biology
Tamara Ortiz-Cerda, Kangzhe Xie, Albaraa Mojadadi, Paul K. K. Witting
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Yutang Wang, Dinh Tam Nguyen, Jack Anesi, Ahmed Alramahi, Paul K. Witting, Zhonglin Chai, Abdul Waheed Khan, Jason Kelly, Kate M. Denton, Jonathan Golledge
Summary: This study aimed to investigate the effect of the sympatholytic drug moxonidine on atherosclerosis. The results showed that moxonidine increased the uptake of oxidised LDL by vascular smooth muscle cells (VSMCs), as well as the expression of LDL receptors and the lipid efflux transporter ABCG1. Moxonidine also inhibited inflammatory gene expression and increased VSMC migration. In vivo experiments on ApoE(-/-) mice showed that moxonidine administration reduced atherosclerosis formation and increased plasma lipid hydroperoxide levels.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Alice Au, Albaraa Mojadadi, Jia-Ying Shao, Gulfam Ahmad, Paul K. Witting
Summary: Dietary selenium intake is crucial for maintaining biological functions, and different chemical forms of selenium have varying health impacts. Recent studies have focused on the use of selenium nanoparticles, which show lower toxicity and higher bioavailability compared to traditional forms. These nanoparticles have shown promising effects on growth, reproduction, oxidative stress, and inflammation, making them potential candidates for agriculture and therapeutic applications.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemical Research Methods
Lana Brockbals, Samara Garrett-Rickman, Shanlin Fu, Maiken Ueland, Dennis McNevin, Matthew P. Padula
Summary: The aim of this study was to investigate the human decomposition process up to 3 months after death and propose novel time-dependent biomarkers for the estimation of decomposition time. An untargeted liquid chromatography tandem mass spectrometry-based bottom-up proteomics workflow was utilized to analyze skeletal muscle, and multiple peptide ratios were successfully proposed as a first step towards generalized, objective biochemical estimation of decomposition time.
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2023)
Letter
Gastroenterology & Hepatology
Kangzhe Xie, Tamara Ortiz Cerda, Angie Schroder, Nicolette Shiung, Bruno Lemos Wimmer, Belal Chami, Paul K. Witting
INFLAMMATORY BOWEL DISEASES
(2023)
Article
Criminology & Penology
Morgan Alonzo, Rhiannon Alder, Laura Clancy, Shanlin Fu
Summary: Analysis of drug material in the field is a crucial task for law enforcement agencies, forensic drug laboratories, and drug checking services. Different groups utilize various portable testing techniques, ranging from basic screening tools to advanced portable analytical methods. Advancements in technology have led to the development of new portable testing techniques, including paper spray ionization-MS (PSI-MS) and optical/electrochemical portable (bio)sensors. These developments indicate the potential availability of new commercial sensors for drug detection in the future.
WILEY INTERDISCIPLINARY REVIEWS: FORENSIC SCIENCE
(2022)
Article
Medicine, Legal
Ahmad Yusri Mohd Yusop, Linda Xiao, Shanlin Fu
Summary: A comprehensive analytical strategy is needed to identify adulterants in adulterated health foods and beverages. This study identified and analyzed a PDE5 inhibitor in an instant coffee premix using liquid chromatography-quadrupole time-of-flight mass spectrometry and confirmed its identity through liquid chromatography-ultraviolet spectroscopy and nuclear magnetic resonance spectroscopy. The presence of 3,5-dimethylpiperazinyl-dithiodesmethylcarbodenafil in the instant coffee premix was reported for the first time.
FORENSIC SCIENCES RESEARCH
(2022)