Article
Endocrinology & Metabolism
Wen-bin Zheng, Jing Hu, Di-Chen Zhao, Bing-Na Zhou, Ou Wang, Yan Jiang, Wei-Bo Xia, Xiao-ping Xing, Mei Li
Summary: Osteogenesis imperfecta (OI) patients commonly exhibit obesity, glucolipid metabolic abnormalities, and reduced grip strength. Circulating osteocalcin and undercarboxylated osteocalcin may play an important role in regulating glucose metabolism and muscle function in children with OI.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
Jyotirmaya Behera, Jessica Ison, Michael J. Voor, Neetu Tyagi
Summary: Recent evidence suggests that physical exercise has a positive impact on skeletal development and can protect against bone loss and deterioration. This study investigated the effects of exercise on bone mass and mechanical quality in mice with type 2 diabetes mellitus. The results showed that diabetes leads to a decrease in Irisin, which further contributes to bone loss through inflammation. Exercise, along with certain interventions, can restore Irisin levels and improve bone formation in diabetic mice. This study demonstrates that exercise-induced skeletal Irisin can ameliorate diabetes-associated glucose intolerance and bone loss.
Review
Endocrinology & Metabolism
Jialiang S. Wang, Courtney M. Mazur, Marc N. Wein
Summary: The skeleton serves as an endocrine organ controlling mineral metabolism and energy homeostasis. Different bone cell types secrete factors that affect multiple target organs, with osteocalcin and sclerostin playing key roles.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Medicine, General & Internal
Sylwia Czajkowska, Joanna Rupa-Matysek, Ewelina Wojtasinska, Kacper Nijakowski, Anna Surdacka, Lidia Gil
Summary: This study evaluated selected biomarkers of bone turnover, inflammation, and neutrophil traps in patients with hemophilia, and analyzed their relationship with clinical features, treatment, and complications. The results showed that concentrations of these markers were associated with the development of hemophilic arthropathy and bone metabolic abnormalities.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Pharmacology & Pharmacy
Sonia Gera, Sunitha Sampathi, Sravya Maddukuri, Sujatha Dodoala, Vijayabhaskarreddy Junnuthula, Sathish Dyawanapelly
Summary: Naringenin nanosuspension (NRG-NS) demonstrated anti-osteoporotic activity by upregulating osteocalcin levels in MG-63 cells and normalized bone density and biochemical parameters in an osteoporotic rat model. The results suggest that oral administration of NRG-NS could be a potential therapeutic formulation for osteoporosis treatment.
Article
Endocrinology & Metabolism
Yang Xu, Li Shen, Lianyong Liu, Zhenlin Zhang, Weiwei Hu
Summary: This study investigated the profile of serum undercarboxylated osteocalcin (ucOC) levels and their associations with bone mineral density (BMD), bone turnover markers (BTMs), and prevalence of osteopenia and osteoporosis in the Chinese population. The results showed that ucOC levels were higher in men than women and decreased with age until the age of 50, after which they increased. Higher ucOC levels were correlated with lower BMD values and higher levels of BTMs in both men and women. Furthermore, an increase in ucOC levels was associated with an increased risk of osteopenia and osteoporosis in both genders.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
Arnold Z. Olali, Qiuhu Shi, Donald R. Hoover, Mariana Bucovsky, Elizabeth Shane, Michael T. Yin, Ryan D. Ross
Summary: In individuals with HIV initiating cART, changes in bone density and fat content are related to changes in bone-derived and fat-derived hormones. This study found that alterations in certain hormones are associated with changes in fat and bone density.
Article
Endocrinology & Metabolism
Xiaoying Liu, Bu B. Yeap, Kaye E. Brock, Itamar Levinger, Jonathan Golledge, Leon Flicker, Tara C. Brennan-Speranza
Summary: The study found that lower levels of serum ucOC and cOC, as well as %cOC, were associated with less favorable metabolic parameters and a higher risk of MetS. Conversely, a lower proportion of ucOC was linked to better metabolic parameters and reduced risk of MetS. Further research is needed to determine if ucOC and cOC are suitable biomarkers for cardiometabolic risk in men.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Endocrinology & Metabolism
Xiaoying Liu, Bu B. Yeap, Kaye E. Brock, Itamar Levinger, Jonathan Golledge, Leon Flicker, Tara C. Brennan-Speranza
Summary: The study demonstrated that lower levels of serum ucOC or cOC were associated with less favorable metabolic parameters and a higher risk of MetS, while a lower proportion of ucOC was associated with better metabolic parameters and lower MetS risk.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Multidisciplinary Sciences
Hailong Wang, Jinqiao Li, Zihan Xu, Feng Wu, Hongyu Zhang, Chao Yang, Jian Chen, Bai Ding, Xiukun Sui, Zhifeng Guo, Yinghui Li, Zhongquan Dai
Summary: Our study demonstrated that ucOCN negatively affected the early differentiation and bone resorption of osteoclasts through the Gprc6a receptor. The inhibitory effects of ucOCN on osteoclasts were mainly observed at the early stage of osteoclastogenesis. Signaling analysis suggested that Gprc6a receptor played a crucial role in mediating the effects of ucOCN.
Article
Environmental Sciences
Tianyu Zhao, Iana Markevych, Marie Standl, Zhonglin Lyu, Tamara Schikowski, Dietrich Berdel, Sibylle Koletzko, Andrea von Berg, Joachim Heinrich
Summary: This study found that long-term exposure to ambient ozone was associated with decreased concentrations of bone turnover markers in German children. However, unless other studies confirm these results, the detrimental effects of ambient ozone on bone development in children should be interpreted cautiously.
ENVIRONMENTAL RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Gelavizh Gharati, Sadegh Shirian, Siavash Sharifi, Esmaeil Mirzaei, Behnam Bakhtirimoghadam, Iraj Karimi, Hassan Nazari
Summary: In this study, different combinations of materials and cells were used to treat full-thickness bone defects in rabbits, with the Co/BGSr2% + MSC group showing the best treatment outcomes. Through X-ray radiography, histology, and immunohistochemistry, it was found that the Co/BGSr2% nanocomposite scaffold seeded with MSCs can accelerate bone regeneration, with osteocalcin protein playing a key role in this process.
BIOLOGICAL TRACE ELEMENT RESEARCH
(2022)
Article
Nutrition & Dietetics
Jesica Tamara Jacoby, Bruna Bento dos Santos, Tatiele Nalin, Karina Colonetti, Lilia Farret Refosco, Carolina F. M. de Souza, Poli Mara Spritzer, Soraia Poloni, Roberta Hack-Mendes, Ida Vanessa Doederlein Schwartz
Summary: The association between bone mineral density (BMD) and hepatic glycogen storage diseases (GSDs) is still unclear. This study found that patients with hepatic GSDs may have low BMD, especially in the presence of muscular involvement and poor metabolic control. Systematic nutritional monitoring of these patients is essential.
Article
Biochemistry & Molecular Biology
Mariana Lima Mascarenhas Moreira, Iana Mizumukai de Araujo, Sandra Yasuyo Fukada, Lucas Gabriel R. Venturini, Natalia Rossin Guidorizzi, Carlos Ernesto Garrido, Clifford J. Rosen, Francisco Jose Albuquerque de Paula
Summary: This cross-sectional observational study aimed to assess adipose tissue in DS patients and define their bone phenotype. DS patients showed increased adiposity in the lumbar spine and muscle tissue, as well as impaired bone quality and lower bone mass in the 1/3 radius. The study also found associations between insulin resistance, lipids, bone turnover markers, and bone parameters in DS patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Geriatrics & Gerontology
Belle Yu-Hsuan Wang, Yi-Fan Chen, Allen Wei-Ting Hsiao, Wan-Jing Chen, Chien-Wei Lee, Oscar Kuang-Sheng Lee
Summary: Ginkgolide B (GB) improves muscle regeneration in aged mice by restoring the bone-to-muscle endocrine axis and promoting the expression of osteocalcin. It also enhances muscle function, exercise performance, and reduces fibrosis and inflammation.
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
(2023)
Review
Biochemistry & Molecular Biology
Giulia Battafarano, Michela Rossi, Viviana De Martino, Francesco Marampon, Luca Borro, Aurelio Secinaro, Andrea Del Fattore
Summary: Bone is a regenerative organ with self-renewal ability, but impaired bone healing may require medical intervention using natural or synthetic bone grafts for regeneration. Tissue engineering relies on the combination of cells, growth factors, and scaffold materials, with various materials and cell types being investigated for bone regeneration strategies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Endocrinology & Metabolism
A. Deodati, D. Fintini, E. Levtchenko, M. Rossi, G. Ubertini, H. Segers, G. Battafarano, M. Cappa, A. Del Fattore
Summary: The anti-RANK-L antibody Denosumab is effective in reducing bone erosion, but caution must be taken when therapy is interrupted to prevent hypercalcemia. Monitoring of osteoclast precursors through cytofluorimetric analysis of PBMC is recommended to prevent adverse effects.
JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION
(2022)
Review
Environmental Sciences
Eleonora Di Piazza, Elisabetta Pandolfi, Ilaria Cacciotti, Andrea Del Fattore, Alberto Eugenio Tozzi, Aurelio Secinaro, Luca Borro
Summary: Bioprinting is an emerging technology with great potential in tissue engineering, but it faces limitations and challenges due to insufficient complexity in design and the lack of clear regulations and guidelines. Despite years of research, bridging the gap between bench and bedside remains a significant hurdle.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2021)
Article
Environmental Sciences
Luca Borro, Massimiliano Raponi, Andrea Del Fattore, Franco Zanini, Francesca di Lillo, Adriano Contillo, Veronica Bordonaro, Eleonora Di Piazza, Alberto E. Tozzi, Aurelio Secinaro
Summary: The effects of heat and ultraviolet (UV) irradiation on the microstructure of P3 facial respirator filters were evaluated. The results showed that the dry heat and UV sterilization processes did not significantly alter the internal microstructure of the filters. This suggests that reusing P3 filters may be feasible and should be explored further.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Biochemistry & Molecular Biology
Ester De Leo, Anna Taranta, Roberto Raso, Elena Polishchuk, Valentina D'Oria, Marco Pezzullo, Bianca Maria Goffredo, Sara Cairoli, Francesco Bellomo, Giulia Battafarano, Francesca Diomedi Camassei, Andrea Del Fattore, Roman Polishchuk, Francesco Emma, Laura Rita Rega
Summary: Cysteamine is the only therapy for nephropathic cystinosis, but compliance to therapy is often weak. Genistein, found in soy, has been found to improve kidney injury caused by cystinosis and may represent a potential treatment.
HUMAN MOLECULAR GENETICS
(2023)
Article
Otorhinolaryngology
Miriam Torsello, Antonio Salvati, Luca Borro, Duino Meucci, Maria Luisa Tropiano, Fabrizio Cialente, Aurelio Secinaro, Andrea Del Fattore, Caristo Maria Emiliana, Paola Francalanci, Giulia Battafarano, Ilaria Cacciotti, Marilena Trozzi
Summary: The study evaluates the feasibility of using 3D printing technology to create scaffolds for surgeries treating congenital subglottic stenosis. The preliminary data suggests that the excessive stiffness of the material is a major limitation due to inherent constraints. Future research may require developing a new biocompatible, more flexible and elastic graft for better integration into surrounding tissues.
INTERNATIONAL JOURNAL OF PEDIATRIC OTORHINOLARYNGOLOGY
(2022)
Article
Endocrinology & Metabolism
Jessica Pepe, Michela Rossi, Giulia Battafarano, Pamela Vernocchi, Federica Conte, Valeria Marzano, Eda Mariani, Stefano Levi Mortera, Cristiana Cipriani, Ippolita Rana, Paola Sabrina Buonuomo, Andrea Bartuli, Viviana De Martino, Simone Pelle, Luisa Pascucci, Renato Maria Toniolo, Lorenza Putignani, Salvatore Minisola, Andrea Del Fattore
Summary: This study characterized plasma extracellular vesicles (EVs) in osteoporotic (OP) postmenopausal women and found that OP patients had significantly increased numbers of EVs and RANKL(+) EVs. In vitro studies revealed that OP EVs promoted osteoclastogenesis and inhibited osteoblast differentiation. miRNA analysis identified specific miRNAs associated with OP EVs and revealed their role in osteoclast differentiation and WNT pathway regulation. Proteomic comparison between OPN and control EVs revealed differences in protein composition. EVs may serve as potential biomarkers for bone loss diseases.
JOURNAL OF BONE AND MINERAL RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Michela Rossi, Viviana De Martino, Laura Di Giuseppe, Giulia Battafarano, Jacopo Di Gregorio, Sara Terreri, Francesco Marampon, Salvatore Minisola, Andrea Del Fattore
Summary: The effects of the histone deacetylase inhibitor PXD-101 on human osteosarcoma cells were investigated. The study found that PXD-101 inhibited cell proliferation, induced apoptosis, and inhibited cell migration. This study suggests that PXD-101 may be a potential new therapeutic approach for osteosarcoma patients.
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
(2023)
Editorial Material
Biochemistry & Molecular Biology
Michela Rossi, Andrea Del Fattore
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Oncology
Silvia Sideri, Francesco Petragnano, Roberto Maggio, Simonetta Petrungaro, Angela Catizone, Luisa Gesualdi, Viviana De Martino, Giulia Battafarano, Andrea Del Fattore, Domenico Liguoro, Paola De Cesaris, Antonio Filippini, Francesco Marampon, Anna Riccioli
Summary: The study found that highly metastatic prostate cancer cells show increased sensitivity to Docetaxel after radiotherapy failure and suggests immediate chemotherapy after radiotherapy failure may benefit certain patients. Furthermore, using a higher dose per fraction for radiotherapy in castration-resistant prostate cancer cells was not successful, but the results may vary between different cell lines.
Editorial Material
Cell Biology
Amelie Coudert, Giulia Battafarano, Andrea Del Fattore
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)