Contributions of Myosin Light Chain Kinase to Regulation of Epithelial Paracellular Permeability and Mucosal Homeostasis

Graft-versus-host disease propagation depends on increased intestinal epithelial tight junction permeability

(2019) Sam C. Nalle et al.   JOURNAL OF CLINICAL INVESTIGATION

Leaky gut: mechanisms, measurement and clinical implications in humans

(2019) Michael Camilleri   GUT

Intracellular MLCK1 diversion reverses barrier loss to restore mucosal homeostasis

(2019) W. Vallen Graham et al.   NATURE MEDICINE

Role of Tricellular Tight Junction Protein Lipolysis-Stimulated Lipoprotein Receptor (LSR) in Cancer Cells

(2019) Takayuki Kohno et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Innate immune cell–epithelial crosstalk during wound repair

(2019) Jennifer C. Brazil et al.   JOURNAL OF CLINICAL INVESTIGATION

Inflammation-induced Occludin Downregulation Limits Epithelial Apoptosis by Suppressing Caspase 3 Expression

(2019) Wei-Ting Kuo et al.   GASTROENTEROLOGY

Claudins and JAM-A coordinately regulate tight junction formation and epithelial polarity

(2019) Tetsuhisa Otani et al.   JOURNAL OF CELL BIOLOGY

Phase Separation of Zonula Occludens Proteins Drives Formation of Tight Junctions

(2019) Oliver Beutel et al.   CELL

Mechanosensation of Tight Junctions Depends on ZO-1 Phase Separation and Flow

(2019) Cornelia Schwayer et al.   CELL

Mechanical Force-Driven Adherens Junction Remodeling and Epithelial Dynamics

(2018) Diana Pinheiro et al.   DEVELOPMENTAL CELL

Tricellulin is regulated via interleukin-13-receptor α2, affects macromolecule uptake, and is decreased in ulcerative colitis

(2017) S M Krug et al.   Mucosal Immunology

Paracellular epithelial sodium transport maximizes energy efficiency in the kidney

(2016) Lei Pei et al.   JOURNAL OF CLINICAL INVESTIGATION

Polarized Protein Transport and Lumen Formation During Epithelial Tissue Morphogenesis

(2015) Alex J. Blasky et al.   Annual Review of Cell and Developmental Biology

Claudin-2-dependent paracellular channels are dynamically gated

(2015) Christopher R Weber et al.   eLife

Comprehensive Cysteine-scanning Mutagenesis Reveals Claudin-2 Pore-lining Residues with Different Intrapore Locations

(2014) Jiahua Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

MarvelD3 couples tight junctions to the MEKK1–JNK pathway to regulate cell behavior and survival

(2014) Emily Steed et al.   JOURNAL OF CELL BIOLOGY

Shaping the intestinal brush border

(2014) Scott W. Crawley et al.   JOURNAL OF CELL BIOLOGY

TNF-α Modulation of Intestinal Epithelial Tight Junction Barrier Is Regulated by ERK1/2 Activation of Elk-1

(2013) Rana Al-Sadi et al.   AMERICAN JOURNAL OF PATHOLOGY

TNFR2 Activates MLCK-Dependent Tight Junction Dysregulation to Cause Apoptosis-Mediated Barrier Loss and Experimental Colitis

(2013) Liping Su et al.   GASTROENTEROLOGY

Mechanism of IL-1  Modulation of Intestinal Epithelial Barrier Involves p38 Kinase and Activating Transcription Factor-2 Activation

(2013) R. Al-Sadi et al.   JOURNAL OF IMMUNOLOGY

Occludin OCEL-domain interactions are required for maintenance and regulation of the tight junction barrier to macromolecular flux

(2013) Mary M. Buschmann et al.   MOLECULAR BIOLOGY OF THE CELL

Loss of Claudins 2 and 15 From Mice Causes Defects in Paracellular Na+ Flow and Nutrient Transport in Gut and Leads to Death from Malnutrition

(2012) Masami Wada et al.   GASTROENTEROLOGY

In tight junctions, claudins regulate the interactions between occludin, tricellulin and marvelD3, which, inversely, modulate claudin oligomerization

(2012) J. Cording et al.   JOURNAL OF CELL SCIENCE

Crystallization and preliminary X-ray analysis of the human long myosin light-chain kinase 1-specific domain IgCAM3

(2011) W. Vallen Graham et al.   Acta Crystallographica Section F-Structural Biology and Crystallization Communications

MicroRNA Regulation of Intestinal Epithelial Tight Junction Permeability

(2011) Dongmei Ye et al.   GASTROENTEROLOGY

Cell-cell connectivity: desmosomes and disease

(2011) Matthew A Brooke et al.   JOURNAL OF PATHOLOGY

Role of claudin species–specific dynamics in reconstitution and remodeling of the zonula occludens

(2011) Yuji Yamazaki et al.   MOLECULAR BIOLOGY OF THE CELL

Ion transport in the small intestine

(2010) Jayashree Venkatasubramanian et al.   CURRENT OPINION IN GASTROENTEROLOGY

D-Glucose Acts via Sodium/Glucose Cotransporter 1 to Increase NHE3 in Mouse Jejunal Brush Border by a Na+/H+ Exchange Regulatory Factor 2–Dependent Process

(2010) Rong Lin et al.   GASTROENTEROLOGY

Loss of Claudin-15, but Not Claudin-2, Causes Na+ Deficiency and Glucose Malabsorption in Mouse Small Intestine

(2010) Atsushi Tamura et al.   GASTROENTEROLOGY

Caveolin-1–dependent occludin endocytosis is required for TNF-induced tight junction regulation in vivo

(2010) Amanda M. Marchiando et al.   JOURNAL OF CELL BIOLOGY

Occludin is required for cytokine-induced regulation of tight junction barriers

(2010) C. M. Van Itallie et al.   JOURNAL OF CELL SCIENCE

Tight Junction–associated MARVEL Proteins MarvelD3, Tricellulin, and Occludin Have Distinct but Overlapping Functions

(2010) David R. Raleigh et al.   MOLECULAR BIOLOGY OF THE CELL

Adherens junctions: from molecules to morphogenesis

(2010) Tony J. C. Harris et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

MLCK-dependent exchange and actin binding region-dependent anchoring of ZO-1 regulate tight junction barrier function

(2010) D. Yu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Epithelial NF-κB Enhances Transmucosal Fluid Movement by Altering Tight Junction Protein Composition after T Cell Activation

(2009) Yueming Tang et al.   AMERICAN JOURNAL OF PATHOLOGY

Identification of MarvelD3 as a tight junction-associated transmembrane protein of the occludin family

(2009) Emily Steed et al.   BMC CELL BIOLOGY

Tricellulin Forms a Barrier to Macromolecules in Tricellular Tight Junctions without Affecting Ion Permeability

(2009) Susanne M. Krug et al.   MOLECULAR BIOLOGY OF THE CELL

Physiology and Function of the Tight Junction

(2009) J. M. Anderson et al.   Cold Spring Harbor Perspectives in Biology

Myosin Light Chain Kinase Is Central to Smooth Muscle Contraction and Required for Gastrointestinal Motility in Mice

(2008) Wei–Qi He et al.   GASTROENTEROLOGY

Targeted Epithelial Tight Junction Dysfunction Causes Immune Activation and Contributes to Development of Experimental Colitis

(2008) Liping Su et al.   GASTROENTEROLOGY

The tight junction protein complex undergoes rapid and continuous molecular remodeling at steady state

(2008) Le Shen et al.   JOURNAL OF CELL BIOLOGY

Cellular and molecular mechanisms that mediate basal and tumour necrosis factor-α-induced regulation of myosin light chain kinase gene activity

(2008) Dongmei Ye et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Molecular Basis for Cation Selectivity in Claudin-2–based Paracellular Pores: Identification of an Electrostatic Interaction Site

(2008) Alan S.L. Yu et al.   JOURNAL OF GENERAL PHYSIOLOGY

Tight junction and polarity interaction in the transporting epithelial phenotype

(2007) Marcelino Cereijido et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES