Journal
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Volume 21, Issue 3, Pages -Publisher
MDPI
DOI: 10.3390/ijms21030811
Keywords
lysosome function; cardiovascular disease; autophagy; Danon disease
Funding
- University of Colorado Consortium for Fibrosis Research & Translation, Colorado Clinical & Translational Institute [TL1 TR001081]
- Boettcher Foundation
- American Heart Association
- Gates Frontiers Fund
- NIH [HL133230]
- American Heart Association [18PRE34030030]
- University of Colorado Department of Medicine Outstanding Early Career Scholar Program
Ask authors/readers for more resources
The lysosome, a key organelle for cellular clearance, is associated with a wide variety of pathological conditions in humans. Lysosome function and its related pathways are particularly important for maintaining the health of the cardiovascular system. In this review, we highlighted studies that have improved our understanding of the connection between lysosome function and cardiovascular diseases with an emphasis on a recent breakthrough that characterized a unique autophagosome-lysosome fusion mechanism employed by cardiomyocytes through a lysosomal membrane protein LAMP-2B. This finding may impact the development of future therapeutic applications.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available