Article
Polymer Science
Azam Ghadami, Somayeh Taheri, Zeinab Alinejad, Mohammad Dinari
Summary: Two kinds of hydrogels based on AA and AAm were synthesized to form DN and TN IPN gels, respectively. FTIR confirmed the formation of IPN gels, and SEM images showed microporous morphology of the gels, with TN hydrogels being more compact than DN hydrogels.
POLYMERS FOR ADVANCED TECHNOLOGIES
(2022)
Review
Chemistry, Inorganic & Nuclear
Moslem Ahmadian, Mehdi Jaymand
Summary: The treatment of wastewater containing synthetic dyes is crucial due to their potential risks to the environment and public health. Adsorption process using interpenetrating polymer networks (IPNs) and semi-IPNs hydrogels as adsorbents have gained attention for their stability, high swelling capacity, non-toxicity, biocompatibility, and biodegradability. This review examines the removal of synthetic dyes from aqueous media using semi-IPNs and IPNs hydrogels, discussing their preparation, adsorption capacities, and future perspectives.
COORDINATION CHEMISTRY REVIEWS
(2023)
Article
Polymer Science
Trevor Gilbert, Matthew A. Campea, Nahieli Preciado Rivera, Michael Majcher, Richard Alsop, Mouhanad Babi, Thomas Kalab, Jose Moran-Mirabal, Maikel Rheinstadter, Todd Hoare
Summary: In this study, injectable PNIPAM/PVP interpenetrating polymer networks were fabricated and characterized. The results show that the internal structure of the injectable IPNs can be controlled by adjusting the PVP molecular weight and degree of thiolation. The PNIPAM gelation drives the formation of domains, with PNIPAM mainly located in the PVP-rich domains and PVP entrapped in the PNIPAM-rich domain. Additionally, the structural reconfiguration of the IPNs can be achieved by heating above the volume phase transition temperature of the PNIPAM phase, which is influenced by the molecular weight and thiolation degree of the PVP precursor polymers.
Article
Chemistry, Physical
Agnieszka Lipowczan, Andrzej W. Trochimczuk
Summary: By introducing organophosphorus polymers based on MEP, novel hydrogels with better swelling properties can be obtained. This method allows for the introduction of larger amounts of phosphorus into polymer structures without significant loss of water regain ability, which is crucial for agricultural applications.
Review
Chemistry, Multidisciplinary
Mithun Rajendra Dethe, A. Prabakaran, Hafiz Ahmed, Mukta Agrawal, Upal Roy, Amit Alexander
Summary: Stimuli-responsive hydrogels have been extensively studied in biomedical applications due to their biodegradability and biocompatibility. The emergence of in situ stimuli-responsive hydrogels is the result of advancements in synthetic chemistry and materials science. The copolymer PCL-PEG, recognized by the FDA, can form thermosensitive injectable hydrogels that exhibit rapid and reversible gelation behavior.
JOURNAL OF CONTROLLED RELEASE
(2022)
Article
Polymer Science
Yang Feng, Shao-Cong Dai, Khoon Lim, Yogambha Ramaswamy, Ahmad Jabbarzadeh
Summary: Polymeric PVA-based composite hydrogels were fabricated with gellan gum (GG) and their rheological and tribological properties were investigated. Increasing the concentration of GG enhanced the storage modulus of the hydrogels, making them suitable for cartilage regeneration applications. Furthermore, the addition of GG reduced the friction coefficient, increasing the chance of survival under mechanical shear stresses.
Article
Engineering, Biomedical
Jiezhang Tang, Huichen Li, Han Peng, Zhaoxiang Zhang, Chaohua Liu, Yi Cheng, Kai Wang, Zhou Yu, Zhuomin Lyu, Jie Zhang, Chenggang Yi
Summary: This study developed a thermosensitive injectable hydrogel based on decellularized adipose tissue and temperature-controlled platelet-rich plasma, and demonstrated its positive effects on wound healing.
MATERIALS TODAY BIO
(2022)
Article
Engineering, Biomedical
Qiaomei Tang, Bing Lu, Jian He, Xiao Chen, Qiuli Fu, Haijie Han, Chenqi Luo, Houfa Yin, Zhenwei Qin, Danni Lyu, Lifang Zhang, Min Zhou, Ke Yao
Summary: In this study, a novel approach based on exosomes and a thermosensitive hydrogel was developed for the treatment of corneal diseases. This method effectively reduces scar formation and accelerates the healing process by promoting the repair of damaged corneal epithelium and stromal layer.
Article
Polymer Science
Nima Alizadeh, David P. Thorne, Maria L. Auad, Asha-Dee N. Celestine
Summary: A carbon fiber/vinyl ester-polyurethane interpenetrating polymer network (IPN) laminate composite was successfully fabricated and characterized for the first time, showing improved damping response and lowered glass transition temperature with the addition of polyurethane. Although the IPN composite exhibited lower tensile properties compared to the vinyl ester composite, its flexural properties were comparable to the latter.
JOURNAL OF APPLIED POLYMER SCIENCE
(2021)
Article
Chemistry, Multidisciplinary
Seung Hun Park, Richard S. Kim, Wesley R. Stiles, Minjoo Jo, Lingxue Zeng, Sunghoon Rho, Yoonji Baek, Jonghan Kim, Moon Suk Kim, Homan Kang, Hak Soo Choi
Summary: Deferoxamine (DFO) is an FDA-approved iron-chelating agent with good therapeutic efficacy, but its short blood half-life poses challenges for patients who require frequent administrations. By integrating crosslinked hyaluronic acid and Pluronic F127 into an injectable hydrogel formulation, a prolonged release of DFO nanochelators is achieved, significantly extending the half-life and demonstrating potential for the treatment of iron overload disorders.
Article
Chemistry, Multidisciplinary
D. Massana Roquero, P. Bollella, O. Smutok, E. Katz, A. Melman
Summary: This biocompatible drug delivery system shows a highly sensitive stimuli-responsive behavior to hydrogen peroxide, effectively releasing encapsulated proteins through oxidative degradation of boronate esters. The release can be triggered by low concentrations of hydrogen peroxide and can also be induced by incorporating oxidase enzymes in the presence of their substrates, serving as biomarkers for physiological disorders.
MATERIALS TODAY CHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
Mengyuan Zhang, Yuxuan Yang, Meng Li, Qinghua Shang, Ruilin Xie, Jing Yu, Kaixiang Shen, Yanfeng Zhang, Yilong Cheng
Summary: The Hoffmeister effect of polyelectrolytes is found to significantly improve the mechanical performance of hydrogels, especially the double-network hydrogel. The mechanical properties of the hydrogels can be flexibly tuned by adjusting polyelectrolyte concentration, ionization degree, relative hydrophobicity, and polyelectrolyte type. Introducing urea bonds into the polyelectrolyte further enhances the mechanical properties and anti-swelling capability of the hydrogels. In a biomedical application, the advanced hydrogel effectively inhibits hernia formation and promotes tissue regeneration in an abdominal wall defect model.
ADVANCED MATERIALS
(2023)
Article
Engineering, Environmental
Jianbin Zhang, Xingwei Wang, Chaoyang Zhang, Hai yan Feng, Bo Yu, Wufang Yang, Xiaowei Pei, Feng Zhou
Summary: A new antifouling technology using interpenetrating polymer networks (IPNs) with autocrine property has been developed for marine protection, showing both quasi-static and dynamic antifouling properties, excellent mechanical performance, over 95% fouling resistance efficiency, good fouling release ability, and weak interfacial adhesion to biomass.
CHEMICAL ENGINEERING JOURNAL
(2022)
Review
Engineering, Chemical
Cody O. Crosby, Brett Stern, Nikhith Kalkunte, Shahar Pedahzur, Shreya Ramesh, Janet Zoldan
Summary: This article proposes the development of interpenetrating polymer network (IPN) hydrogels as biomaterial scaffolds in tissue engineering, aiming to address the current challenges in clinical translation. The authors review recent advancements in improving the mechanical strength, substrate-scale stiffness, electrical conductivity, and degradation of IPN hydrogels and highlight their incorporation into state-of-the-art tissue engineering technologies. These materials have critical importance in engineering functional tissues for transplantation, disease modeling, and drug screening.
REVIEWS IN CHEMICAL ENGINEERING
(2022)
Review
Polymer Science
Ranran Fan, Yi Cheng, Rongrong Wang, Ting Zhang, Hui Zhang, Jianchun Li, Shenghan Song, Aiping Zheng
Summary: Thermosensitive hydrogels are highly promising and practical drug delivery systems with unique sol-gel transition properties. They can undergo phase transition near body temperature, aiding in local drug delivery and enhancing therapeutic efficacy. This paper provides an overview of thermosensitive hydrogel materials, including their structural characteristics, gelation mechanism, drug release mechanism, and applications in disease treatment.
Article
Endocrinology & Metabolism
Dimitrios Agas, Vladimir Gabai, Albert A. Sufianov, Alexander Shneider, Maria Giovanna Sabbieti
Summary: Bone marrow-derived mesenchymal/stromal stem cells (MSCs) have anti-inflammatory features and osteogenic commitment, which can prevent inflamm-aging and osteopenia. The p62 protein plays a critical role in MSC dynamics, and lack of p62 impairs osteogenic pathways and alters MSC differentiation. MSCs from p62-/- mice exhibit increased NFcB/Smad1/5/8 co-localization and NFcB activation, preventing Smads from binding to target promoters. Using p62 deficient MSCs for cell therapy may be a treatment for bone and bone marrow disorders.
GENERAL AND COMPARATIVE ENDOCRINOLOGY
(2022)
Review
Biology
Maria Giovanna Sabbieti, Andrea Marchegiani, Albert A. Sufianov, Vladimir L. Gabai, Alexander Shneider, Dimitrios Agas
Summary: Inflammation is a preceding condition for various diseases in humans and animals, and p62 protein has gained attention as a potential tool to counter inflammation and oxidative stress.
Article
Cell Biology
Dimitrios Agas, Andrea Marchegiani, Fulvio Laus, Vladimir Gabai, Albert A. Sufianov, Alexander Shneider, Maria Giovanna Sabbieti
Summary: Intramuscular administration of p62 plasmid can modulate bone marrow MSCs, partially reversing osteoporosis, reducing adipogenesis, and restoring the MSC subpopulation within the bone marrow. This study suggests that remote modulation of progenitor MSCs via administering a p62-encoding plasmid may constitute a mechanism for its previously reported effects and presents a feasible disease-preventing and/or therapeutic strategy.
JOURNAL OF CELLULAR PHYSIOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Saniya Salathia, Maria Rosa Gigliobianco, Cristina Casadidio, Piera Di Martino, Roberta Censi
Summary: The nervous and immune systems are closely related in causing inflammation and pain. Macrophages play a crucial role in modulating inflammation to induce neuropathic pain. Varying the molecular weight of hyaluronic acid can resolve inflammation and relieve pain and inflammation by using HA-based drug delivery nanosystems.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Pharmacology & Pharmacy
Cristina Casadidio, Laura Mayol, Marco Biondi, Stefania Scuri, Manuela Cortese, Wim E. Hennink, Tina Vermonden, Giuseppe De Rosa, Piera Di Martino, Roberta Censi
Summary: This study investigated the use of anionic polysaccharides to increase the chemical stability and sustained release of antimicrobial peptides. Results showed that electrostatic interactions between the drugs and polysaccharides can slow down the degradation of the peptides, enhancing their stability.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Biochemistry & Molecular Biology
Lucrezia Di Nicolantonio, Marta Ferrati, Maria Cristino, Dolores Vargas Peregrina, Marco Zannotti, Luca Agostino Vitali, Sonia Ilaria Ciancia, Rita Giovannetti, Stefano Ferraro, Susi Zara, Valentina Di Valerio, Amelia Cataldi, Maria Rosa Gigliobianco, Roberta Censi, Piera Di Martino
Summary: The purpose of this study was to fully characterize wine lees from Verdicchio's wine and exploit them as beneficial ingredients in cosmetic products. The microbial composition of the wine lees was analyzed, and the parameters for sonication extraction were optimized. The physicochemical properties of the extract were analyzed, and the efficiency of the extraction process was assessed through microscopy and protein assays. The extracted supernatant was tested for phenol content, antioxidant capacity, and presence of beneficial elements and was found to be safe for skin cells. Sonicated lees were found to be more interesting due to the release of active ingredients, and they were included in new cosmetic products and tested for various parameters.
Article
Chemistry, Medicinal
Pegi Pavletic, Ana Semeano, Hideaki Yano, Alessandro Bonifazi, Gianfabio Giorgioni, Alessandro Piergentili, Wilma Quaglia, Maria Giovanna Sabbieti, Dimitrios Agas, Giorgio Santoni, Roberto Pallini, Lucia Ricci-Vitiani, Emanuela Sabato, Giulio Vistoli, Fabio Del Bello
Summary: In this paper, new ligands with high affinity and selectivity for D4R were discovered to better understand its role in GBM. The D4R antagonist 24 and biased ligand 29 showed the most potential and induced a decreased viability of GBM cells. Interestingly, these compounds had a greater effect in reducing cell viability compared to temozolomide, the first-choice chemotherapeutic drug in GBM.
JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Review
Cell & Tissue Engineering
Andrea Amaroli, Claudio Pasquale, Angelina Zekiy, Stefano Benedicenti, Andrea Marchegiani, Maria Giovanna Sabbieti, Dimitrios Agas
Summary: Bone marrow-derived multipotent mesenchymal cells (MSCs) have diverse applications in clinical settings. Photobiomodulation therapy (PBM-t) can enhance the anti-inflammatory and osteogenic properties of MSCs.
JOURNAL OF TISSUE ENGINEERING
(2022)
Article
Cell Biology
Andrea Amaroli, Maria Giovanna Sabbieti, Luigi Marchetti, Angelina O. Zekiy, Anatoliy S. Utyuzh, Andrea Marchegiani, Fulvio Laus, Vincenzo Cuteri, Stefano Benedicenti, Dimitrios Agas
Summary: Cell organelles can be tailored to change cell behavior for enhanced viability, differentiation, or anti-inflammatory effects. Photobiomodulation (PBM) is recognized as an effective cell manipulation technique with potential therapeutic benefits. Using 808-nm laser light at specific settings can regulate differentiation of bone marrow stromal cells towards osteogenesis. The findings suggest that PBM therapy could stimulate biochemical pathways to modulate actin polymerization and cytoskeletal characteristics of cells, showing promise for novel therapeutic protocols.
CELL AND TISSUE RESEARCH
(2021)