Article
Microbiology
Xin Ma, Yuchen Zhang, Tingting Xu, Mengqi Qian, Zhiren Yang, Xiuan Zhan, Xinyan Han
Summary: The study showed that early-life FMT can alleviate weaning stress in piglets by modifying the intestinal microbiota, leading to decreased diarrhea incidence, improved intestinal morphology, reduced intestinal inflammation, and modified bacterial composition and function in the intestine.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Immunology
Wenjie Tang, Jingliang Liu, Yanfei Ma, Yusen Wei, Jianxin Liu, Haifeng Wang
Summary: This study found that early weaning in piglets results in severe enteric inflammatory responses and microbiota dysbiosis, potentially due to dysregulations in autophagy and apoptosis pathways as well as adjustments in gut microbiota.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Agriculture, Dairy & Animal Science
Fernanda Rosa, Tainara Cristina Michelotti, Benoit St-Pierre, Erminio Trevisi, Johan S. Osorio
Summary: Early life fecal microbiota transplantation in neonatal dairy calves is a relatively safe method that can influence growth, development, and possibly alleviate the stress caused by weaning procedures. The transplantation has positive effects on mediating the inflammatory response and gut microbial maturation in the calves.
Article
Immunology
Yifan Zhong, Jiahong Cao, Yanfei Ma, Yu Zhang, Jianxin Liu, Haifeng Wang
Summary: Transforming the gut microbiota through fecal microbiota transplantation (FMT) has become an intriguing intervention for various gastrointestinal and non-gastrointestinal disorders. This study investigated the effects of different diets on the gut microbiota post-FMT from donors with different diets. The results showed that different dietary fiber contents paired with FMT from different donors led to distinct patterns of gut microbiota and metabolites, highlighting the importance of precise dietary interventions post-FMT.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Gastroenterology & Hepatology
Shaodong Wei, Martin Iain Bahl, Simon Mark Dahl Baunwall, Jens Frederik Dahlerup, Christian Lodberg Hvas, Tine Rask Licht
Summary: This study aimed to explore the relationship between early changes in the intestinal microbiota and clinical outcomes following fecal microbiota transplantation (FMT) for recurrent Clostridioides difficile infection (CDI). The results showed that patients with sustained resolution after FMT had different microbial diversity, abundance, and gut microbiota dysbiosis compared to non-responders. Additionally, a constructed index based on clinically feasible methods successfully predicted treatment failure. It was also found that FMT had a more pronounced impact on the gut microbiota compared to antibiotic monotherapy. Therefore, early identification of microbial community structures after FMT is clinically valuable for predicting treatment response.
Article
Veterinary Sciences
Xinwei Xiong, Yousheng Rao, Xutang Tu, Zhangfeng Wang, Jishang Gong, Yanbei Yang, Haobin Wu, Xianxian Liu
Summary: This study investigated the gut fungal and archaeal community composition in Large White piglets using shotgun metagenomic sequencing. The results showed specific successional alterations in the gut archaea, fungi, bacteria, and serum metabolites during piglet weaning transitions, providing a theoretical framework for understanding how gut bacterial colonization and succession are associated with archaea.
BMC VETERINARY RESEARCH
(2022)
Article
Nutrition & Dietetics
Yongbo Kang, Yue Cai, Yanqin Zhao, Ying Yang
Summary: This article explores the impact of gut microbiota on alopecia areata, early diagnostic biomarkers, and fecal microbial transplantation (FMT) as a treatment option.
FRONTIERS IN NUTRITION
(2022)
Article
Immunology
Yonggang Huang, Miaomiao Wu, Hao Xiao, Hongnan Liu, Guan Yang
Summary: This study suggests that MES treatment can alleviate DSS-induced ulcerative colitis in piglets by reducing symptoms, improving intestinal microbiota, and regulating immune cell function.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Jiuxi Liu, Jiapei Cai, Naisheng Zhang, Jiandong Tai, Peng Fan, Xue Dong, Yongguo Cao
Summary: Salidroside, a plant compound, can ameliorate high-fat diet-induced obesity by modulating gut microbiota. It reduces body weight and fat accumulation, decreases liver inflammation and metabolic endotoxemia, and repairs intestinal damage.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Review
Immunology
Yunxia Li, Siting Xia, Xiaohan Jiang, Can Feng, Saiming Gong, Jie Ma, Zhengfeng Fang, Jie Yin, Yulong Yin
Summary: Diarrhea is closely linked to gut microbiota, and reshaping gut microbiota through dietary probiotics or fecal bacteria transplantation can help prevent or treat diarrhea.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Review
Multidisciplinary Sciences
Quanhang Xiang, Xudong Yan, Wei Shi, Huiping Li, Kai Zhou
Summary: Preterm birth is a major cause of death in children under five, primarily due to incomplete development of the intestinal immune system. The gut microbiota plays a critical role in promoting the development and function of the intestinal immune system after birth, but premature infants are at high risk of dysbiosis, which negatively affects the early life immune system. Early intervention can modulate the colonization and development of gut microbiota and has long-term effects on the intestinal immune system. This review summarizes the characterization of gut microbiota and intestinal innate immunity in premature infants, discusses the status and prospects of different intervention strategies, and highlights the complexity of the underlying mechanism.
JOURNAL OF ADVANCED RESEARCH
(2023)
Review
Immunology
Hanghang Yuan, Ruirui Gui, Zhicheng Wang, Fang Fang, Hongguang Zhao
Summary: Colorectal cancer (CRC) is a common and deadly cancer that poses a major burden on human health. Gut microbiota regulate human immunity and metabolism through producing numerous metabolites, but the specific mechanisms by which gut microbiota interact with immunotherapy and radiotherapy remain incongruent. This review discusses recent advances and the potential of targeting gut microbiota to enhance the efficacy of radioimmunotherapy in CRC, providing references and fresh ideas for the clinical application of this novel strategy.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Microbiology
Sandrine Dufourny, Nadine Antoine, Elena Pitchugina, Veronique Delcenserie, Stephane Godbout, Caroline Douny, Marie-Louise Scippo, Eric Froidmont, Pierre Rondia, Jose Wavreille, Nadia Everaert
Summary: The study found that the addition of apple pomace feed has a beneficial effect on the growth performance, intestinal morphology, and microbiota of weaned piglets, with the 4% inclusion level showing the most promising results.
Article
Gastroenterology & Hepatology
Ruiqiao He, Pan Li, Jinfeng Wang, Bota Cui, Faming Zhang, Fangqing Zhao
Summary: Fecal microbiota transplantation is a promising treatment for microbiota dysbiosis associated diseases. This study investigated the effect of different types of donor-derived microbiota on FMT efficacy. The research found two dominant types of microbiota in CDI and IBD patients, and observed the interaction between recipient and donor-derived microbiota during FMT.
Article
Environmental Sciences
Jing Xu, Mingzhu Wang, Qiuping Liu, Xiaoying Lin, Kefeng Pu, Zhixing He
Summary: Nitrite has toxic effects on mice, and gut microbiota can mediate the toxicity of nitrite. High doses of nitrite can cause dysbiosis in the gut microbiota, affecting metabolism and stress response.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2022)
Review
Food Science & Technology
Ningning Huang, Miaomiao Wang, Jian Peng, Hongkui Wei
Summary: ARA plays a significant role in growth and development, while its release can lead to the production of eicosanoids, which have various physiological functions.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2021)
Article
Agriculture, Dairy & Animal Science
Chao Wang, Ze-Xue Liu, Ying-Hui Wu, Hong-Kui Wei, Jian Peng
Summary: This study aimed to establish a feasible model for analysing factors affecting piglet litter performance at birth. The results showed that MLM is superior to GLM and can replace MPM in analysing discrete data with hierarchical structure in pig production. Additionally, other potential influencing factors of litter performance at birth can be analysed using the established MLM in the future.
REPRODUCTION IN DOMESTIC ANIMALS
(2021)
Correction
Food Science & Technology
Zhao Deng, Huichao Yu, Zhipeng Yang, Lingling Hu, Yanan Wang, Qi Liu, Hong-Kui Wei, Jian Peng
FOOD RESEARCH INTERNATIONAL
(2022)
Article
Biochemistry & Molecular Biology
Yuanfei Zhou, Mao Xia, Chenbin Cui, Hongkui Wei, Siwen Jiang, Jian Peng
Summary: The study revealed that exosomes from obese sows, particularly enriched with miR-221, inhibit endothelial cell migration and angiogenesis by suppressing the expression of Angptl2. This suggests that miR-221 plays a key role in mediating angiogenesis through adipocyte-secreted exosomal vesicles. The findings indicate a novel mechanism where harmful exosomes secreted from obesity adipose tissues lead to placental dysplasia during gestation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Chenbin Cui, Qi Liu, Bingbing Duan, Xiangchen Liu, Hongkui Wei, Jian Peng
Summary: This study found that a bioactive triple peptide (BTP) can alleviate intestinal injuries and inflammation caused by Salmonella typhimurium, inhibit bacteria translocation, and exhibit antibacterial and anti-inflammatory activities. BTP also significantly inhibited the adhesion and invasion of S. typhimurium to cells.
Letter
Oncology
Zhao Deng, Zhipeng Yang, Chenbin Cui, Hongkui Wei, Lijia Wang, Dean Tian, Fang Xiao, Jian Peng
CLINICAL AND TRANSLATIONAL MEDICINE
(2021)
Article
Nutrition & Dietetics
Miaomiao Wang, Zhaoyu Wang, Yueyue Miao, Hongkui Wei, Jian Peng, Yuanfei Zhou
Summary: This study found that hydrogen sulfide (H2S) can serve as an important signaling molecule to regulate placental angiogenesis and improve reproductive performance in maternal obesity. Treatment with the H2S donor diallyl trisulfide (DATS) promoted placental angiogenesis by regulating lipid metabolism and alleviating inflammatory responses in obese pregnant mice.
Article
Agriculture, Dairy & Animal Science
Yanan Wang, Zhipeng Yang, Yuanfei Zhou, Jiajian Tan, Haiqing Sun, Defa Sun, Yuyun Mu, Jian Peng, Hongkui Wei
Summary: The study reveals that high AA level and dietary supplementation with CB can improve the growth performance of weaned pigs in an antibiotic-free diet by improving AA metabolism and intestinal antioxidant capacity, thereby alleviating diarrhea symptoms and improving feed conversion ratio.
JOURNAL OF ANIMAL SCIENCE AND BIOTECHNOLOGY
(2022)
Article
Nutrition & Dietetics
Fangrui Zuo, Hongkui Wei, Jian Peng, Shengqing Li, Yuanfei Zhou
Summary: The study found that L-Met and DL-HMTBA have significant effects on methionine metabolism, especially on transmethylation, suggesting that DL-HMTBA has the potential to influence the intestinal barrier function of animals through epigenetic processes.
FRONTIERS IN NUTRITION
(2022)
Article
Biochemistry & Molecular Biology
Jianwei Gao, Chuanhui Xu, Mengdi Zhang, Jianhua Liu, Xiaoyu Wu, Chenbin Cui, Hongkui Wei, Jian Peng, Rong Zheng
Summary: The combination of functional fiber (FF) and every-other-day fasting (EODF) can improve insulin sensitivity and curb weight gain by regulating the composition of gut microbiota. In the study, 6% FF-EODF significantly improved insulin sensitivity in obese mice and increased satiety, energy consumption, weight, and adipose loss during a normal chow diet phase. Additionally, FF supplementation increased the abundance of beneficial bacteria such as Lactobacillus and Bifidobacterium in the intestine, which was correlated with decreased adiposity and insulin resistance.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2022)
Article
Nutrition & Dietetics
Mengdi Zhang, Jianhua Liu, Chen Li, Jianwei Gao, Chuanhui Xu, Xiaoyu Wu, Tiesheng Xu, Chenbin Cui, Hongkui Wei, Jian Peng, Rong Zheng
Summary: This study found that a synthetic functional fiber can alleviate obesity and metabolic syndrome by modulating intestinal microbiota and metabolites, leading to improvements in gut health.
Review
Immunology
Zhipeng Yang, Xiangchen Liu, Yanting Wu, Jian Peng, Hongkui Wei
Summary: This review explores the significance of early-life microbial colonization and the development of intestinal innate immunity, as well as discusses two main methods of early-life intervention.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Ningning Huang, Xiangchen Liu, Xiaoqi Pei, Jian Peng, Hongkui Wei
Summary: This study analyzed the concentrations of oxylipins in feces of suckling piglets and identified the importance of ARA-derived oxylipins in the physiological changes of the piglets. The results provide new information on the physiological changes during the suckling period.
Article
Spectroscopy
Yang Cao, Yinghui Wu, Zihui Liu, Qinshu Kang, Hongkui Wei, Jian Peng, Shengqing Li
Summary: Trace elements play a crucial role in the spermatogenesis, maturation, and fertilization of sperm. In this study, a simple method using time resolved inductively coupled plasma mass spectrometry (ICP-MS) was developed to accurately determine trace elements in single boar's sperm cells. The method provides valuable information for evaluating the quality of boar semen and has potential applications in studying sperm signal transduction and relevant physiological topics.
SPECTROCHIMICA ACTA PART B-ATOMIC SPECTROSCOPY
(2022)
Article
Nutrition & Dietetics
Zhipeng Yang, Yanting Wu, Xiangchen Liu, Mei Zhang, Jian Peng, Hongkui Wei
Summary: This study found that early intervention with Saccharomyces boulardii improved growth performance and gut microbiome in early-weaned rats. It also enhanced gut mucosal barrier function and suppressed inflammatory response while promoting anti-inflammatory response.