Article
Medicine, General & Internal
Panagiotis Cherouveim, Despoina Mavrogianni, Eirini Drakaki, Anastasios Potiris, Athanasios Zikopoulos, Myrto Papamentzelopoulou, Konstantina Kouvoutsaki, Nikolaos Machairiotis, Theodoros Karampitsakos, Chara Skentou, Ekaterini Domali, Nikolaos Vrachnis, Peter Drakakis, Sofoklis Stavros
Summary: This study demonstrates for the first time an association between RPL and ANRIL rs4977574 gene polymorphism (lower prevalence of allele A), while further research is needed to confirm a difference according to the number of pregnancy losses.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Immunology
Douwe Jan Dijkstra, A. Inkeri Lokki, Lobke Marijn Gierman, Nicole Veronique Borggreven, Carin van der Keur, Michael Eikmans, Kyra Andrea Gelderman, Hannele Laivuori, Ann-Charlotte FINNPEC Core Investigator Grp, Ann-Charlotte Iversen, Marie-Louise P. van der Hoorn, Leendert Adrianus Trouw
Summary: Preeclampsia (PE) may be associated with decreased levels of C1q and FH, which are related to placental dysfunction and immune response.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Multidisciplinary Sciences
Steven Droho, Harris Perlman, Jeremy A. Lavine
Summary: Research investigated the role of dendritic cells (DCs) in age-related macular degeneration (AMD) and found three types of ocular DCs. Despite the heterogeneity, DCs did not play a significant role in the laser-induced choroidal neovascularization model of AMD.
SCIENTIFIC REPORTS
(2021)
Article
Obstetrics & Gynecology
Junxian Li, Ying Shen, Hairong Tian, Shuting Xie, Ye Ji, Ziyun Li, Junxi Lu, Huijuan Lu, Bo Liu, Fang Liu
Summary: The study found that CFH levels were higher in GDM patients compared to non-GDM controls, and were moderately associated with various clinical parameters. However, CFH was not identified as an independent risk factor for GDM and adverse pregnancy outcomes.
BMC PREGNANCY AND CHILDBIRTH
(2021)
Article
Biochemistry & Molecular Biology
Min-Jung Kwon, Ji-Hyang Kim, Jeong-Yong Lee, Eun-Ju Ko, Hyeon-Woo Park, Ji-Eun Shin, Eun-Hee Ahn, Nam-Keun Kim
Summary: The study found that the FN3KRP rs1046875 G>A gene polymorphism plays a significant role in the prevalence of recurrent pregnancy loss in Korean women. The results suggest a significant association between FN3KRP rs1046875 G>A polymorphism and RPL risk in Korean women, indicating the need for further research.
Editorial Material
Obstetrics & Gynecology
Dominique de Ziegler, Rene F. Frydman
Summary: Recurrent pregnancy loss (RPL) is defined as two to three spontaneous pregnancy terminations before 12 weeks of gestation, potentially caused by factors like gamete quality, uterine issues, endometrial receptivity alterations, immunologic factors, and thrombophilia.
FERTILITY AND STERILITY
(2021)
Article
Obstetrics & Gynecology
Kushaan Khambata, Sanketa Raut, Sharvari Deshpande, Sweta Mohan, Shobha Sonawane, Reshma Gaonkar, Zakiya Ansari, Mamata Datar, Vandana Bansal, Anushree Patil, Himangi Warke, Nafisa H. Balasinor
Summary: Aberrant sperm DNA methylation status and certain polymorphisms in imprinted genes are associated with recurrent pregnancy loss (RPL), suggesting a potential role of paternal genetic and epigenetic factors in the etiology of RPL.
HUMAN REPRODUCTION
(2021)
Article
Biochemistry & Molecular Biology
Hui-Jeong An, Sung-Hwan Cho, Han-Sung Park, Ji-Hyang Kim, Young-Ran Kim, Woo-Sik Lee, Jung-Ryeol Lee, Seong-Soo Joo, Eun-Hee Ahn, Nam-Keun Kim
Summary: This study investigated the genetic association between recurrent pregnancy loss (RPL) and microRNA (miRNA) polymorphisms in miR-10aA>T, miR-30cA>G, miR-181aT>C, and miR-499bA>G in Korean women. The study identified specific genotypes of miR-10a and miR-499 that are associated with increased RPL risk.
Article
Biochemistry & Molecular Biology
Natalia Ruiz -Molina, Juliana Parsons, Eva L. Decker, Ralf Reski
Summary: Human complement is crucial for defense against pathogens and tissue homeostasis. Factor H (FH) and Factor H-related protein 1 (FHR1) are important complement regulators. The structure of synthetic regulators based on FH and FHR1 were modeled using AlphaFold2, and the interactions between C3 fragments, MAC components (C5, C7, and C9), and various regulators were studied using AlphaFold-Multimer (AFM). The findings provide insights into the molecular mechanisms of complement regulation and can guide the development of complement-based therapies.
COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL
(2023)
Review
Immunology
Sara R. Moore, Smrithi S. Menon, Claudio Cortes, Viviana P. Ferreira
Summary: The complement system plays a crucial role in both innate and adaptive immunity, with three pathways that can be triggered spontaneously or in response to danger. Pathogens often evade this system by hijacking host complement regulators, such as Factor H, to protect themselves from immune attack. Understanding how pathogens interact with complement regulators like Factor H can provide insights into developing treatment strategies to target pathogen evasion mechanisms.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Obstetrics & Gynecology
Anita Barisic, Nina Pereza, Alenka Hodzic, Milena Gasparovic Krpina, Sasa Ostojic, Borut Peterlin
Summary: Variations in the maternal VDR FokI gene may be associated with RPL in Slovenian and Croatian women, as indicated by the higher frequency of certain genotypes and alleles in RPL women compared to controls.
JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
(2021)
Article
Urology & Nephrology
Brandon Renner, Jennifer Laskowski, Felix Poppelaars, Viviana P. Ferreira, Judith Blaine, Alexandra H. Antonioli, Jonathan P. Hannan, James M. Kovacs, Cees Van Kooten, Zhiying You, Matthew C. Pickering, V. Michael Holers, Joshua M. Thurman
Summary: This study demonstrates that the Factor H-related proteins have unique effects on different cell types within the kidney, with FHR E causing glomerular complement dysregulation in vivo. This has important implications for understanding the pathogenesis of glomerular diseases.
KIDNEY INTERNATIONAL
(2022)
Review
Obstetrics & Gynecology
Poonam Mehta, Rahul Vishvkarma, Kiran Singh, Singh Rajender
Summary: Meta-analyses showed a significant association between MTHFR 1298A>C substitution and recurrent pregnancy loss, with a stronger correlation observed in Caucasian populations compared to East Asian populations. The substitution is identified as a strong risk factor for RPL specifically in Caucasians.
REPRODUCTIVE SCIENCES
(2022)
Article
Obstetrics & Gynecology
Wael Bahia, Ismael Soltani, Anis Haddad, Assala Radhouani, Abdelkarim Mahdhi, Salima Ferchichi, Wassim Y. Almawi
Summary: This study identified a link between certain polymorphisms of the ADIPOQ gene and recurrent pregnancy loss (RPL), suggesting a potential role of adiponectin in this disease. The findings indicate different associations of ADIPOQ genotypes with RPL depending on the genetic models used, and also highlight specific haplotypes as potentially protective or susceptible to RPL. These results support the significance of ADIPOQ as a candidate locus for RPL.
REPRODUCTIVE SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Sung-Hwan Cho, Ji-Hyang Kim, Hui-Jeong An, Young-Ran Kim, Eun-Hee Ahn, Jung-Ryeol Lee, Jung-Oh Kim, Jung-Jae Ko, Nam-Keun Kim
Summary: The study identified an association between polymorphisms in miR-604A>G and miR-938G>A and the risk of idiopathic recurrent pregnancy loss (RPL), suggesting potential effects on RPL in Korean women. The results indicate that these miRNA polymorphisms may play a role in RPL susceptibility.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Obstetrics & Gynecology
Young Ran Kim, Goeun Park, Eun Hui Joo, Ji Hyon Jang, Eun Hee Ahn, Sang Hee Jung, Inkyung Jung, Hee Young Cho
Summary: This study found that in singleton pregnancies, MSAFP multiples of the median (MoM) showed the strongest association with SGA, while PAPP-A MoM showed a weaker association in multiple regression analysis. The prediction model using maternal age, maternal smoking, PAPP-A, and EPV achieved an area under the curve of 0.668 in singleton pregnancies, indicating their potential use in predicting the risk of SGA.
JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
(2022)
Article
Health Care Sciences & Services
Jung Oh Kim, Han Sung Park, Eun Ju Ko, Jung Hoon Sung, Jinkwon Kim, Seung Hun Oh, Ok Joon Kim, Nam Keun Kim
Summary: TS 1100T>C and 1170A>G polymorphisms are strongly associated with the risk of ischemic stroke and SBI in Koreans, with 1100T>C polymorphism also showing synergistic effects with low folic acid levels. These findings suggest that TS 1100T>C and 1170A>G polymorphisms may serve as potential biomarkers for ischemic stroke and SBI.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Article
Gastroenterology & Hepatology
Kwang Yoon Kim, Jung Oh Kim, Young-Sang Kim, Ja-Eun Choi, Jae-Min Park, Kunhee Han, Da-Hyun Park, Yon Chul Park, Bom Taeck Kim, Kyung-Won Hong
Summary: The study identified three genetic loci (GGT1, ZNF827, and HNF1A) significantly associated with ALD risk, with HNF1A rs1183910 showing the strongest protective effect in light drinkers. It was also found that the amount of alcohol consumed may alter the expression of genes contributing to ALD development.
Article
Obstetrics & Gynecology
Young Ran Kim, Nari Kim, Eun Hee Ahn, Sang Hee Jung, Goeun Park, Inkyung Jung, Hee Young Cho
Summary: This study retrospectively reviewed the medical records of 524 women with twin pregnancies and found that maternal serum biomarkers, including PAPP-A, uE(3), and inhibin A, were associated with birth weight in twin pregnancies, with inhibin A being significantly higher in small-for-gestational-age (SGA) foetuses. These findings provide valuable information for predicting SGA in twin pregnancies.
JOURNAL OF OBSTETRICS AND GYNAECOLOGY
(2022)
Article
Genetics & Heredity
Ji-Hyang Kim, Han-Sung Park, Jeong-Yong Lee, Eun-Ju Ko, Young-Ran Kim, Hee-Young Cho, Woo-Sik Lee, Eun-Hee Ahn, Nam-Keun Kim
Summary: The study found an association between MUC4 gene polymorphisms and RPL, particularly the rs882605 C>A and rs1104760 A>G polymorphisms. These findings suggest that MUC4 polymorphisms may serve as potential biomarkers for RPL.
Article
Health Care Sciences & Services
Eun-Ju Ko, In-Jai Kim, Jeong-Yong Lee, Hyeon-Woo Park, Han-Sung Park, Sang-Hoon Kim, Jae-Youn Moon, Jung-Hoon Sung, Nam-Keun Kim
Summary: This study investigated the relationship between VEGF polymorphisms and susceptibility to coronary artery disease (CAD) in Koreans. The results showed significant associations between certain VEGF allele combinations and CAD prevalence. The VEGF +1725AA genotype combined with several clinical factors was found to increase the risk of CAD.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Min-Jung Kwon, Ji-Hyang Kim, Jeong-Yong Lee, Eun-Ju Ko, Hyeon-Woo Park, Ji-Eun Shin, Eun-Hee Ahn, Nam-Keun Kim
Summary: The study found that the FN3KRP rs1046875 G>A gene polymorphism plays a significant role in the prevalence of recurrent pregnancy loss in Korean women. The results suggest a significant association between FN3KRP rs1046875 G>A polymorphism and RPL risk in Korean women, indicating the need for further research.
Article
Biochemistry & Molecular Biology
Hui-Jeong An, Sung-Hwan Cho, Han-Sung Park, Ji-Hyang Kim, Young-Ran Kim, Woo-Sik Lee, Jung-Ryeol Lee, Seong-Soo Joo, Eun-Hee Ahn, Nam-Keun Kim
Summary: This study investigated the genetic association between recurrent pregnancy loss (RPL) and microRNA (miRNA) polymorphisms in miR-10aA>T, miR-30cA>G, miR-181aT>C, and miR-499bA>G in Korean women. The study identified specific genotypes of miR-10a and miR-499 that are associated with increased RPL risk.
Article
Genetics & Heredity
Hyeon Woo Park, Young Ran Kim, Jeong Yong Lee, Eun Ju Ko, Min Jung Kwon, Ji Hyang Kim, Nam Keun Kim
Summary: This study analyzed the impact of HOTAIR polymorphisms on RPL in Korean women and found that rs4759314A>G and rs920778T>C were significantly associated with increased risk of RPL.
Article
Health Care Sciences & Services
Kirim Hong, Hee Yeon Jang, Sung Han Shim, Hee Young Cho, Dong Hyun Cha
Summary: This study compared the efficacy of HLA-G antibodies-G233 and 4H84 in isolating EVT cells and provided an optimized protocol for TRIC. The results showed that the use of 4H84 HLA-G antibody was more effective in capturing EVT cells, making it suitable for successful clinical application of TRIC.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Gun Ho Choi, Sung Hwan Cho, Hui Jeong An, Han Sung Park, Jeong Yong Lee, Eun Ju Ko, Seung Hun Oh, Ok Joon Kim, Nam Keun Kim
Summary: Stroke is the second leading cause of death globally, with most cases being ischemic. Increased levels of plasminogen activator inhibitor-1 (PAI-1) have been linked to higher risk of stroke. A case-control study in South Korea identified specific variations in the PAI-1 gene that are significantly associated with higher prevalence of ischemic stroke. These genetic variations could potentially serve as clinical biomarkers for stroke and improve patient prognosis and management.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Eun-Ju Ko, Ji-Eun Shin, Jung-Yong Lee, Chang-Soo Ryu, Ji-Young Hwang, Young-Ran Kim, Eun-Hee Ahn, Ji-Hyang Kim, Nam-Keun Kim
Summary: Recurrent implantation failure (RIF) refers to multiple unsuccessful in vitro fertilization embryo transfers in the same individual. Genetic factors, including SNPs in FSHR, INHA, ESR1, and BMP15, have been found to be associated with RIF development in Korean women.
Article
Health Care Sciences & Services
Da Kyung Hong, Hee Young Cho, Ji Youn Kim, Hee Jin Park, Dong Hyun Cha, Sung Shin Shim, Bo Seong Yun
Summary: The aim of this research is to study the impact of risk factors during pregnancy on abnormal lipid profiles in women during the early postpartum period. A retrospective study was conducted on 869 women who gave birth between December 2017 and May 2019. The research collected total cholesterol levels at 24-28 gestational weeks and 1 month before delivery, and retrieved lipid profiles at 6 weeks postpartum. The results showed that the risk factors for abnormal HDL level were pre-pregnancy BMI, weight gain during pregnancy, and hypertension. Pre-pregnancy BMI, weight gain during pregnancy, weight reduction after delivery were associated with abnormal triglyceride levels. Hypertension was linked to abnormal TG levels, while gestational diabetes was correlated with abnormal TG levels in the early postpartum period.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Medicine, General & Internal
Jeong Ha Wie, You Jung Han, Soo Hyun Kim, Moon Young Kim, Hee Young Cho, Mi-Young Lee, Jin Hoon Chung, Seung Mi Lee, Soo -young Oh, Joon Ho Lee, Hye Yeon Boo, Geum Joon Cho, Han -Sung Kwon, Byoung Jae Kim, Mi Hye Park, Hyun Mee Ryu, Hyun Sun Ko
Summary: This study aimed to assess the prenatal detection rates of congenital heart disease (CHD) and the associations between maternal serum biomarkers and non-chromosomal CHD in singleton pregnancies. The results showed that ultrasound screening during the second trimester could detect over 85% of critical CHDs. Low levels of maternal serum PAPP-A and high levels of inhibin-A were associated with non-chromosomal CHDs. These findings may contribute to improving the prenatal diagnosis of CHDs.
YONSEI MEDICAL JOURNAL
(2022)
Article
Microbiology
Hee Young Cho, Sung Shin Shim, Hee Jin Park, Dong Hyun Cha
Summary: This article reviews the global health issue of preterm birth and its association with various factors. Infection or inflammation and disruption of the vaginal microbiome are identified as major causes of preterm birth. Researchers have been exploring the complex interactions between the maternal microbiome and the occurrence of preterm birth and discussing recent advancements in prevention strategies.
MICROBIOLOGY RESEARCH
(2022)