Humanized Mice as an Effective Evaluation System for Peptide Vaccines and Immune Checkpoint Inhibitors

Next generation sequencing of PD-L1 for predicting response to immune checkpoint inhibitors

(2019) Jeffrey M. Conroy et al.   Journal for ImmunoTherapy of Cancer

Glucocorticoids promote breast cancer metastasis

(2019) Milan M. S. Obradović et al.   NATURE

Immune regulation by glucocorticoids can be linked to cell type–dependent transcriptional responses

(2019) Luis M. Franco et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Lipid-Based Vectors for Therapeutic mRNA-Based Anti-Cancer Vaccines

(2019) Maria L Guevara et al.   CURRENT PHARMACEUTICAL DESIGN

Cancer Immunotherapies and Humanized Mouse Drug Testing Platforms

(2019) Qingfeng Chen et al.   Translational Oncology

Next-generation human genetics for organism-level systems biology

(2019) Hideki Ukai et al.   CURRENT OPINION IN BIOTECHNOLOGY

The Fidelity of Cancer Cells in PDX Models: Characteristics, Mechanism and Clinical Significance

(2019) Jiahao Shi et al.   INTERNATIONAL JOURNAL OF CANCER

Application of Highly Immunocompromised Mice for the Establishment of Patient-Derived Xenograft (PDX) Models

(2019) Okada et al.   Cells

Immunological responses against hepatitis B virus in human peripheral blood mononuclear cell-engrafted mice

(2018) Satoshi Aono et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Immunotherapy in head and neck cancers: A new challenge for immunologists, pathologists and clinicians

(2018) Sophie Outh-Gauer et al.   CANCER TREATMENT REVIEWS

LAG-3 Inhibitory Receptor Expression Identifies Immunosuppressive Natural Regulatory Plasma Cells

(2018) Andreia C. Lino et al.   IMMUNITY

“NETtling” the host: Breaking of tolerance in chronic inflammation and chronic infection

(2018) Sladjana Skopelja-Gardner et al.   JOURNAL OF AUTOIMMUNITY

Self-adjuvanting nanoemulsion targeting dendritic cell receptor Clec9A enables antigen-specific immunotherapy

(2018) Bijun Zeng et al.   JOURNAL OF CLINICAL INVESTIGATION

Safety and efficacy of anti-PD-L1 therapy in the woodchuck model of HBV infection

(2018) Scott Balsitis et al.   PLoS One

PD-L1 receptor expression in vulvar carcinomas is HPV-independent

(2018) M. Choschzick et al.   VIRCHOWS ARCHIV

Zika viral infection and neutralizing human antibody response in a BLT humanized mouse model

(2018) Kimberly Schmitt et al.   VIROLOGY

Expression of glucocorticoid receptor shows negative correlation with human B-cell engraftment in PBMC-transplanted NOGhIL-4-Tg mice

(2018) Toshiro Seki et al.   BioScience Trends

Oncofetal gene SALL4 reactivation by hepatitis B virus counteracts miR-200c in PD-L1-induced T cell exhaustion

(2018) Cheng Sun et al.   Nature Communications

Outcomes by line of therapy and programmed death ligand 1 expression in patients with advanced melanoma treated with pembrolizumab or ipilimumab in KEYNOTE-006: A randomised clinical trial

(2018) Matteo S. Carlino et al.   EUROPEAN JOURNAL OF CANCER

Not All Immune Checkpoints Are Created Equal

(2018) Annika De Sousa Linhares et al.   Frontiers in Immunology

Trial watch: peptide-based vaccines in anticancer therapy

(2018) Lucillia Bezu et al.   OncoImmunology

Identification of the novel HLA allele, HLA-B*40:06:07 , by sequence-based typing

(2018) Jian-Ping Li et al.   HLA

Immuno-Oncology: Emerging Targets and Combination Therapies

(2018) Henry T. Marshall et al.   Frontiers in Oncology

Manipulation of the immune system for cancer defeat: a focus on the T cell inhibitory checkpoint molecules

(2018) Paolo D`Arrigo et al.   CURRENT MEDICINAL CHEMISTRY

Human Anti–HIV-1 gp120 Monoclonal Antibodies with Neutralizing Activity Cloned from Humanized Mice Infected with HIV-1

(2018) Melissa A. Gawron et al.   JOURNAL OF IMMUNOLOGY

Nivolumab plus ipilimumab or nivolumab alone versus ipilimumab alone in advanced melanoma (CheckMate 067): 4-year outcomes of a multicentre, randomised, phase 3 trial

(2018) Frank Stephen Hodi et al.   LANCET ONCOLOGY

A peptide-CpG-DNA-liposome complex vaccine targeting TM4SF5 suppresses growth of pancreatic cancer in a mouse allograft model

(2018) Sangkyu Park et al.   OncoTargets and Therapy

PD-L1

(2017) Anthousa Kythreotou et al.   JOURNAL OF CLINICAL PATHOLOGY

The immunoinhibitory PD-1/PD-L1 pathway in inflammatory blood vessel disease

(2017) Cornelia M. Weyand et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Modulation of Hepatitis C Virus-Specific CD8 Effector T-Cell Function with Antiviral Effect in Infectious Hepatitis C Virus Coculture Model

(2017) Keisuke Ojiro et al.   JOURNAL OF VIROLOGY

Efficacy and safety of high-dose influenza vaccine in elderly adults: A systematic review and meta-analysis

(2017) Krista Wilkinson et al.   VACCINE

Kaposi’s Sarcoma-Associated Herpesvirus Increases PD-L1 and Proinflammatory Cytokine Expression in Human Monocytes

(2017) Kurtis M. Host et al.   mBio

Clinical responses to adoptive T-cell transfer can be modeled in an autologous immune-humanized mouse model

(2017) Henrik Jespersen et al.   Nature Communications

PD-L1 (CD274) and PD-L2 (PDCD1LG2) promoter methylation is associated with HPV infection and transcriptional repression in head and neck squamous cell carcinomas

(2017) Alina Franzen et al.   Oncotarget

Interferon Receptor Signaling Pathways Regulating PD-L1 and PD-L2 Expression

(2017) Angel Garcia-Diaz et al.   Cell Reports

A combination of anti-PD-L1 mAb plus Lm-LLO-E6 vaccine efficiently suppresses tumor growth and metastasis in HPV-infected cancers

(2017) Po-Lin Lin et al.   Cancer Medicine

Host immune response index in gastric cancer identified by comprehensive analyses of tumor immunity

(2017) Charny Park et al.   OncoImmunology

NOG-hIL-4-Tg, a new humanized mouse model for producing tumor antigen-specific IgG antibody by peptide vaccination

(2017) Yoshie Kametani et al.   PLoS One

A Novel Xenogeneic Graft-Versus-Host Disease Model for Investigating the Pathological Role of Human CD4+ or CD8+ T Cells Using Immunodeficient NOG Mice

(2016) R. Ito et al.   AMERICAN JOURNAL OF TRANSPLANTATION

From HBV to HPV: Designing vaccines for extensive and intensive vaccination campaigns worldwide

(2016) Darja Kanduc et al.   AUTOIMMUNITY REVIEWS

A Novel Link between Inflammation and Cancer

(2016) Yenkel Grinberg-Bleyer et al.   CANCER CELL

Deubiquitination and Stabilization of PD-L1 by CSN5

(2016) Seung-Oe Lim et al.   CANCER CELL

Antitumor Effect of Programmed Death-1 (PD-1) Blockade in Humanized the NOG-MHC Double Knockout Mouse

(2016) Tadashi Ashizawa et al.   CLINICAL CANCER RESEARCH

Monitoring immune responses in the tumor microenvironment

(2016) Jennifer A Wargo et al.   CURRENT OPINION IN IMMUNOLOGY

Cancer Treatment with Anti-PD-1/PD-L1 Agents: Is PD-L1 Expression a Biomarker for Patient Selection?

(2016) Lucia Festino et al.   DRUGS

Programmed Death-Ligand 1 Expression and Response to the Anti–Programmed Death 1 Antibody Pembrolizumab in Melanoma

(2016) Adil I. Daud et al.   JOURNAL OF CLINICAL ONCOLOGY

Pan-Specific Prediction of Peptide–MHC Class I Complex Stability, a Correlate of T Cell Immunogenicity

(2016) Michael Rasmussen et al.   JOURNAL OF IMMUNOLOGY

A Potential Inhibitory Profile of Liver CD68+ Cells during HCV Infection as Observed by an Increased CD80 and PD-L1 but Not CD86 Expression

(2016) Elias A. Said et al.   PLoS One

Elevation of Alanine Aminotransferase Activity Occurs after Activation of the Cell-Death Signaling Initiated by Pattern-Recognition Receptors ‎but before Activation of Cytolytic Effectors in NK or CD8+ T Cells in the Liver During Acute HCV Infection

(2016) Youkyung H. Choi et al.   PLoS One

Recent developments in antivirals against hepatitis B virus

(2016) Ya-Juan Wang. et al.   VIRUS RESEARCH

PD-L1 expression in tonsillar cancer is associated with human papillomavirus positivity and improved survival: implications for anti-PD1 clinical trials

(2016) Angela M Hong et al.   Oncotarget

Immunogenicity of trivalent influenza vaccine in patients with lung cancer undergoing anticancer chemotherapy

(2016) Kei Nakashima et al.   Human Vaccines & Immunotherapeutics

HLA-B*46:40:02, a novelHLA-B*46allele identified in a Chinese individual by sequence-based typing

(2016) J. Wang et al.   HLA

Identification of a novel HLA allele,HLA-B*08:163, in a platelet donor

(2016) B. Proust et al.   HLA

Immunogenicity of Influenza Vaccination in Patients With Cancer

(2015) Saiama N. Waqar et al.   AMERICAN JOURNAL OF CLINICAL ONCOLOGY-CANCER CLINICAL TRIALS

Gapped sequence alignment using artificial neural networks: application to the MHC class I system

(2015) Massimo Andreatta et al.   BIOINFORMATICS

Induction of WT1-specific human CD8+ T cells from human HSCs in HLA class I Tg NOD/SCID/IL2rgKO mice

(2015) Y. Najima et al.   BLOOD

Xenograft models for normal and malignant stem cells

(2015) S. Goyama et al.   BLOOD

IFN-γ from lymphocytes induces PD-L1 expression and promotes progression of ovarian cancer

(2015) K Abiko et al.   BRITISH JOURNAL OF CANCER

Accurate pan-specific prediction of peptide-MHC class II binding affinity with improved binding core identification

(2015) Massimo Andreatta et al.   IMMUNOGENETICS

Human immune system mice immunized with Plasmodium falciparum circumsporozoite protein induce protective human humoral immunity against malaria

(2015) Jing Huang et al.   JOURNAL OF IMMUNOLOGICAL METHODS

HLA-A02:01–Restricted Epitopes Identified from the Herpes Simplex Virus Tegument Protein VP11/12 Preferentially Recall Polyfunctional Effector Memory CD8+T Cells from Seropositive Asymptomatic Individuals and Protect Humanized HLA-A*02:01 Transgenic Mice against Ocular Herpes

(2015) Ruchi Srivastava et al.   JOURNAL OF IMMUNOLOGY

Nivolumab in Previously Untreated Melanoma without BRAF Mutation

(2015) Caroline Robert et al.   NEW ENGLAND JOURNAL OF MEDICINE

EBV-driven LMP1 and IFN-γ up-regulate PD-L1 in nasopharyngeal carcinoma: Implications for oncotargeted therapy

(2015) Wenfeng Fang et al.   Oncotarget

Patient-derived tumour xenografts as models for breast cancer drug development

(2014) Elisabetta Marangoni et al.   CURRENT OPINION IN ONCOLOGY

Dengue virus infection induces broadly cross-reactive human IgM antibodies that recognize intact virions in humanized BLT-NSG mice

(2014) Smita Jaiswal et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Self-adjuvanting lipoimmunogens for therapeutic HPV vaccine development: potential clinical impact

(2014) Kuan-Yin Shen et al.   Expert Review of Vaccines

RGMb is a novel binding partner for PD-L2 and its engagement with PD-L2 promotes respiratory tolerance

(2014) Yanping Xiao et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Critical assessment of human antibody generation in humanized mouse models

(2014) Julien Villaudy et al.   JOURNAL OF IMMUNOLOGICAL METHODS

Generation of improved humanized mouse models for human infectious diseases

(2014) Michael A. Brehm et al.   JOURNAL OF IMMUNOLOGICAL METHODS

Synergistic effects of IL-4 and TNFα on the induction of B7-H1 in renal cell carcinoma cells inhibiting allogeneic T cell proliferation

(2014) Dagmar Quandt et al.   Journal of Translational Medicine

HIV-1 Tat Protein Induces PD-L1 (B7-H1) Expression on Dendritic Cells through Tumor Necrosis Factor Alpha- and Toll-Like Receptor 4-Mediated Mechanisms

(2014) R. Planes et al.   JOURNAL OF VIROLOGY

Evidence for a Role of the PD-1:PD-L1 Pathway in Immune Resistance of HPV-Associated Head and Neck Squamous Cell Carcinoma

(2013) S. Lyford-Pike et al.   CANCER RESEARCH

ENDOCRINE SIDE-EFFECTS OF ANTI-CANCER DRUGS: mAbs and pituitary dysfunction: clinical evidence and pathogenic hypotheses

(2013) Francesco Torino et al.   EUROPEAN JOURNAL OF ENDOCRINOLOGY

Increased expression of programmed death (PD)-1 and its ligand PD-L1 correlates with impaired cell-mediated immunity in high-risk human papillomavirus-related cervical intraepithelial neoplasia

(2013) Wen Yang et al.   IMMUNOLOGY

Establishment of a Human Allergy Model Using Human IL-3/GM-CSF-Transgenic NOG Mice

(2013) R. Ito et al.   JOURNAL OF IMMUNOLOGY

Nivolumab plus Ipilimumab in Advanced Melanoma

(2013) Jedd D. Wolchok et al.   NEW ENGLAND JOURNAL OF MEDICINE

IFN-γ-Stimulated Neutrophils Suppress Lymphocyte Proliferation through Expression of PD-L1

(2013) Stan de Kleijn et al.   PLoS One

Dendritic cell co-stimulatory and co-inhibitory markers in chronic HCV: An Egyptian study

(2013) Hanan Fouad   WORLD JOURNAL OF GASTROENTEROLOGY

PD-L1 Expression in the Merkel Cell Carcinoma Microenvironment: Association with Inflammation, Merkel Cell Polyomavirus, and Overall Survival

(2013) E. J. Lipson et al.   Cancer Immunology Research

Constitutive AP-1 Activity and EBV Infection Induce PD-L1 in Hodgkin Lymphomas and Posttransplant Lymphoproliferative Disorders: Implications for Targeted Therapy

(2012) M. R. Green et al.   CLINICAL CANCER RESEARCH

EBV stimulates TLR- and autophagy-dependent pathways and impairs maturation in plasmacytoid dendritic cells: Implications for viral immune escape

(2012) Martina Severa et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Induction of human humoral immune responses in a novel HLA-DR-expressing transgenic NOD/Shi-scid/ cnull mouse

(2012) M. Suzuki et al.   INTERNATIONAL IMMUNOLOGY

An Improved Protocol for Efficient Engraftment in NOD/LTSZ-SCIDIL-2RγNULL Mice Allows HIV Replication and Development of Anti-HIV Immune Responses

(2012) Maneesh Singh et al.   PLoS One

Colocalization of Inflammatory Response with B7-H1 Expression in Human Melanocytic Lesions Supports an Adaptive Resistance Mechanism of Immune Escape

(2012) J. M. Taube et al.   Science Translational Medicine

Systemic Human T Cell Developmental Processes in Humanized Mice Cotransplanted With Human Fetal Thymus/Liver Tissue and Hematopoietic Stem Cells

(2012) Sung-Yeon Joo et al.   TRANSPLANTATION

PROVENGE (Sipuleucel-T) in Prostate Cancer: The First FDA-Approved Therapeutic Cancer Vaccine

(2011) M. A. Cheever et al.   CLINICAL CANCER RESEARCH

Humoral immune responses in humanized BLT mice immunized with West Nile virus and HIV-1 envelope proteins are largely mediated via human CD5+ B cells

(2011) Subhabrata Biswas et al.   IMMUNOLOGY

HIV-Mediated Phosphatidylinositol 3-Kinase/Serine-Threonine Kinase Activation in APCs Leads to Programmed Death-1 Ligand Upregulation and Suppression of HIV-Specific CD8 T Cells

(2011) K. Muthumani et al.   JOURNAL OF IMMUNOLOGY

gp100 Peptide Vaccine and Interleukin-2 in Patients with Advanced Melanoma

(2011) Douglas J. Schwartzentruber et al.   NEW ENGLAND JOURNAL OF MEDICINE

Human IL-3/GM-CSF knock-in mice support human alveolar macrophage development and human immune responses in the lung

(2011) T. Willinger et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Interferon-  and tumor necrosis factor-  induce an immunoinhibitory molecule, B7-H1, via nuclear factor- B activation in blasts in myelodysplastic syndromes

(2010) A. Kondo et al.   BLOOD

The Protein Moiety of Brucella abortus Outer Membrane Protein 16 Is a New Bacterial Pathogen-Associated Molecular Pattern That Activates Dendritic Cells In Vivo, Induces a Th1 Immune Response, and Is a Promising Self-Adjuvanting Vaccine against Systemic and Oral Acquired Brucellosis

(2010) K. A. Pasquevich et al.   JOURNAL OF IMMUNOLOGY

PD-1 regulates germinal center B cell survival and the formation and affinity of long-lived plasma cells

(2010) Kim L Good-Jacobson et al.   NATURE IMMUNOLOGY

Upregulation of PD-L1 on monocytes and dendritic cells by HIV-1 derived TLR ligands

(2009) Angela Meier et al.   AIDS

Comparison of human fetal liver, umbilical cord blood, and adult blood hematopoietic stem cell engraftment in NOD-scid/γc−/−, Balb/c-Rag1−/−γc−/−, and C.B-17-scid/bg immunodeficient mice

(2009) Christin M. Lepus et al.   HUMAN IMMUNOLOGY

The analysis of the functions of human B and T cells in humanized NOD/shi-scid/γcnull (NOG) mice (hu-HSC NOG mice)

(2009) Yohei Watanabe et al.   INTERNATIONAL IMMUNOLOGY

Self-Adjuvanting Lipopeptide Vaccines

(2008) Peter Moyle et al.   CURRENT MEDICINAL CHEMISTRY

A New Humanized Mouse Model of Epstein‐Barr Virus Infection That Reproduces Persistent Infection, Lymphoproliferative Disorder, and Cell‐Mediated and Humoral Immune Responses

(2008) Misako Yajima et al.   JOURNAL OF INFECTIOUS DISEASES

Interaction of human PD-L1 and B7-1

(2008) Manish J. Butte et al.   MOLECULAR IMMUNOLOGY