Article
Biotechnology & Applied Microbiology
Xiaogai Li
Summary: The study presents a personalization framework for generating subject-specific models across the lifespan and for pathological brains with significant anatomical changes. The framework includes hierarchical multiple feature and multimodality imaging registrations, mesh morphing, and mesh grouping, shown to be efficient with a heterogeneous dataset. The generated models demonstrate competitive personalization accuracy, allowing for age-dependent and groupwise brain injury mechanisms to be studied.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Article
Engineering, Biomedical
N. S. Hennicke, M. Saemann, D. Kluess, R. Bader, M. Sander
Summary: Researchers used an advanced subject specific finite element modeling technique to study the formation and risk factors of periprosthetic femoral fractures around total hip replacements. By simulating stumbling and a sideways fall on the hip, they analyzed the effects and quantified the results using experimental data.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2022)
Article
Mathematics, Applied
Jeonghun J. Lee
Summary: This paper discusses the finite element discretization and a priori error analysis of low-frequency dynamic poroelasticity models. Unlike the widely used quasi-static poroelasticity models, the dynamic models are hyperbolic partial differential equations with acceleration terms of solid and fluid phases. The problem is reformulated as a symmetric hyperbolic system and discretized using two mixed finite element methods. The error analysis of semidiscrete solutions is discussed in detail, and numerical results of the backward Euler fully discrete scheme are presented.
JOURNAL OF COMPUTATIONAL AND APPLIED MATHEMATICS
(2023)
Article
Computer Science, Interdisciplinary Applications
Colin R. Firminger, Ifaz T. Haider, Olivia L. Bruce, John W. Wannop, Darren J. Stefanyshyn, W. Brent Edwards
Summary: Research findings suggest that using generic material properties in NS and FE models for assessing patellar tendon fatigue-life estimates has poor correlation with subject-specific estimates. NS models consistently overestimated fatigue life compared to subject-specific FE models. FE models with generic tendon geometry were also inaccurate in representing the heterogeneous strain distributions found in subject-specific models.
COMPUTER METHODS IN BIOMECHANICS AND BIOMEDICAL ENGINEERING
(2022)
Article
Construction & Building Technology
Wei Liu, Yongqiang Li, Luping Tang, Feng Xing
Summary: The study establishes a mathematical model to describe the redistribution of internal chloride ions in sea-sand concrete structures exposed to atmospheric carbonation, with simulation results showing a decrease in chloride ion concentration with depth after redistribution, but a 'pseudo enrichment' of chloride content in the concrete wt% unit chloride profile.
CONSTRUCTION AND BUILDING MATERIALS
(2021)
Article
Biotechnology & Applied Microbiology
Iliana Loi, Dimitar Stanev, Konstantinos Moustakas
Summary: This study introduces a semi-automatic framework for creating subject-specific total knee replacement finite element models, which can analyze locomotion patterns and evaluate knee dynamics. By automating the finite element model development process, the framework's reliability has been validated and potential uncertainties in the models have been identified.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Review
Chemistry, Multidisciplinary
Alexander Paz, Gustavo A. Orozco, Rami K. Korhonen, Jose J. Garcia, Mika E. Mononen
Summary: Osteoarthritis is a degenerative disease lacking a cure, prompting researchers to utilize computational methods like finite element analysis to simulate risks and evaluate prevention measures. Current trends in clinical studies for knee OA emphasize speeding up analysis for personalized risk predictions.
APPLIED SCIENCES-BASEL
(2021)
Article
Biology
Dingzhong Zhang, Ahmed Aoude, Mark Driscoll
Summary: This study proposed a workflow of an automatic subject-specific vertebra reconstruction method and quantified the errors in geometry and finite element analysis. This has important applications for the development and improvement of treatments using subject-specific modeling.
COMPUTERS IN BIOLOGY AND MEDICINE
(2022)
Article
Engineering, Civil
Mithum Peiris, Mahen Mahendran
Summary: The current studies on light-gauge steel framed (LSF) wall and floor systems are limited to individual members with idealized boundary conditions. Previous idealized single stud models are unable to capture the complex behavior associated with stud-to-sheathing and stud-to-track connections. Advanced numerical models that explicitly model all LSF wall components have been developed, but they are limited to LSF walls under axial compression. This study investigates the behavior of LSF walls made of lipped channel studs under eccentric axial compression and proposes recommendations for finite element modeling of LSF walls under combined loading actions based on the findings.
ENGINEERING STRUCTURES
(2022)
Article
Biophysics
G. Rossini, A. Caimi, A. Redaelli, E. Votta
Summary: A Finite Element workflow was developed for multiscale analysis of aortic valve biomechanics, capturing the impact of anatomical features on the biomechanical environment from organ to cell scale. The study found that the dependency of leaflet biomechanics on leaflet-specific anatomy observed at the organ length-scale is reflected in the results obtained at lower length-scales.
BIOMECHANICS AND MODELING IN MECHANOBIOLOGY
(2021)
Article
Multidisciplinary Sciences
Romana Perinajova, Pim van Ooij, Sasa Kenjeres
Summary: A combination of MRI and CFD can be used to study blood flow and oxygen transport in the cerebral vasculature. Neglecting haemoglobin transport underestimates arterial wall oxygen transfer. Hypoxic regions along the arterial walls can be identified using critical thresholds obtained from comparing Damkohler number and Sherwood number. Further validations of the MRI/CFD approach in larger groups of brain vasculature systems are recommended.
ROYAL SOCIETY OPEN SCIENCE
(2023)
Article
Engineering, Biomedical
Ming Zhang, Haofei Liu, Zongxi Cai, Cuiru Sun, Wei Sun
Summary: This study presents a framework combining experiments, constitutive modeling, and computer simulation to quantify the subject-specific three-dimensional residual stress field of the aortic wall. The proposed framework was effective in quantifying the three-dimensional subject-specific residual stress field and yielded accurate results in terms of residual stress estimation for the aortic sample.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2022)
Article
Engineering, Biomedical
Bruno Klahr, Jonas Zin Lanzendorf, Jose Luis Medeiros Thiesen, Otavio Teixeira Pinto, Liz Girardi Muller, Thiago Andre Carniel, Eduardo Alberto Fancello
Summary: The present study aims to investigate the time-dependent behavior of tendons and determine the contributions of interstitial fluid and solid skeleton. The poroviscoelastic model was found to be the most accurate in characterizing the experimental responses, and both fluid flow and solid skeleton behavior were found to significantly contribute to the force response.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2023)
Article
Engineering, Biomedical
Keegan M. Yates, Amanda M. Agnew, Devon L. Albert, Andrew R. Kemper, Costin D. Untaroiu
Summary: Rib fractures are common thoracic injuries in motor vehicle crashes. Several human finite element models have been created to assess thoracic injury risks, but accurate prediction of rib biomechanical response is challenging. This study aimed to understand the role of modeling approaches on human rib biomechanical response and develop an accurate morphing approach for subject specific rib meshes. The results showed sensitivity to material modeling approach and highlighted the need for better techniques to model rib fracture in order to improve the biofidelity of human rib finite element models.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2021)
Article
Biology
Xi Chen, Tamas Jozsa, Stephen J. Payne
Summary: In the treatment of ischaemic stroke, osmotherapy is commonly used to decrease cerebral oedema. This study proposes a new Finite Element model to predict the treatment outcome of osmotherapy and demonstrates its accuracy through simulation results. Based on the simulation, personalized therapeutic strategies can be proposed for patients with different pathological parameters.
COMPUTERS IN BIOLOGY AND MEDICINE
(2022)
Article
Engineering, Biomedical
Xi Zhuo Jiang, Liwei Guo, Kai H. Luo, Yiannis Ventikos
ANNALS OF BIOMEDICAL ENGINEERING
(2020)
Article
Computer Science, Interdisciplinary Applications
Nikolaos Bempedelis, Yiannis Ventikos
Summary: A novel method for implementing surface tension effects in sharp-interface compressible flow models is proposed in this study, with the aim of addressing problems where liquid compressibility and capillarity are both important. The method is based on the principles of the grid-aligned formulation for ghost fluid techniques, and formulates Riemann problems along the grid instead of in a normal-to-the-interface direction, making the method simpler. The performance of the method is thoroughly examined after being implemented in a well-established front tracking framework.
JOURNAL OF COMPUTATIONAL PHYSICS
(2021)
Article
Computer Science, Artificial Intelligence
Duanduan Chen, Xuyang Zhang, Yuqian Mei, Fangzhou Liao, Huanming Xu, Zhenfeng Li, Qianjiang Xiao, Wei Guo, Hongkun Zhang, Tianyi Yan, Jiang Xiong, Yiannis Ventikos
Summary: This study introduced a new segmentation framework for reconstructing aortic dissection from CT-angiography, extracting true lumen, false lumen, and all branches using two cascaded neural networks and a straightening method. The method achieved high accuracy in segmenting the aorta and identified key features compared to previous deep learning methods.
MEDICAL IMAGE ANALYSIS
(2021)
Article
Mechanics
T. A. Smith, Y. Ventikos
Summary: This study investigates the flow over a flat-tipped wing at different Reynolds numbers and shows significant changes in the number of trailing vortices and tip geometry across the Reynolds number range. The vortex dynamics change with Reynolds number, impacting the minimum vortex core pressure and its location. The influence of tip flow on the boundary layer and its effect on the character of trailing edge noise are also considered.
Article
Physics, Fluids & Plasmas
N. Bempedelis, J. Zhou, M. Andersson, Y. Ventikos
Summary: The aim of the study is to investigate the interaction between an oscillating bubble and a free surface, focusing on the mechanisms of bubble-induced atomization. The patterns and dynamics of liquid jets formed at the free surface are characterized, and observations on the evolution of the free surface are presented by measuring the jet's surface area and volume. A metric is introduced based on these quantities to predict late-time atomization of the interface.
PHYSICAL REVIEW FLUIDS
(2021)
Article
Engineering, Biomedical
Chien-Chang Weng, Pei-Yu Chen, Dean Chou, Cho-Chiang Shih, Chih-Chung Huang
Summary: The study proposed an array high-frequency ultrasound elastography method based on ultrafast ultrasound imaging for estimating the viscoelastic properties of the cornea. Experimental results showed that the estimated elasticity using the Lamb wave model was close to standard values, indicating good performance. However, there was a large error when estimating elasticity values using group shear wave velocity compared to the standard values.
IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING
(2021)
Article
Thermodynamics
Chin-Wei Liu, Shyong Lee, Dean Chou, Shu-Han Hsu, Chun Lin Chu
Summary: This study focuses on improving the efficiency and dimensional accuracy of QPF in the manufacture of metal casings by designing a demolding mechanism. The results show that the proposed mechanism significantly reduces process time and improves efficiency, as well as determining the dimensional tolerance grade of the QPF process to be between IT10 and IT14, indicating commercial value in metal casing production.
ADVANCES IN MECHANICAL ENGINEERING
(2021)
Article
Cell Biology
Connor Cross, Roman H. Khonsari, Leila Galiay, Giovanna Patermoster, David Johnson, Yiannis Ventikos, Mehran Moazen
Summary: This study conducted sensitivity tests to understand the impact of various input parameters on predicting post-operative skull morphology in sagittal synostosis patients. Results showed that the choice of elastic modulus for craniotomies had the greatest influence on skull morphology, while bone formation modeling method across sutures/craniotomies had a considerable impact on brain pressure. The study lays the foundation for future comparative studies using FE method to compare outcomes of different reconstruction techniques for craniosynostosis management.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Cell Biology
Xi Zhuo Jiang, Kai H. Luo, Yiannis Ventikos
Summary: Endothelial glycocalyx (EG) is a crucial structure on blood vessel walls, impacting health and diseases. Numerical modelling and computer simulation are valuable tools for understanding EG as a mechanotransducer, offering new perspectives for research.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Chemistry, Analytical
Wei-Chun Tai, Yu-Chi Chang, Dean Chou, Lung-Ming Fu
Summary: This review highlights the recent advances in microfluidic lab-on-paper diagnostics for human health monitoring and disease diagnosis. It covers the choice of paper, fabrication methods, detection techniques, and sample pretreatment procedures for lab-on-paper devices, with a focus on disease measurement using urine samples. The review also discusses potential challenges in the future development of commercial microfluidic lab-on-paper platforms for human disease detection.
Article
Multidisciplinary Sciences
Chun-Lin Chu, Jen-Yi Chang, Po-Yen Chen, Po-Yu Wang, Shu-Han Hsu, Dean Chou
Summary: In this study, horizontally stacked pure-Ge nanosheet gate-all-around field-effect transistors (GAA FETs) were developed by intentionally growing large lattice mismatch Ge/Si multilayers. The shape of Ge nanosheets was almost retained after etching due to excellent selectivity. Through forming gas annealing of the suspended Ge nanosheets, dislocations were easily removed, resulting in structures with excellent gate control and electrical properties.
SCIENTIFIC REPORTS
(2022)
Article
Acoustics
Tom A. Smith, Yiannis Ventikos
Summary: In this study, a versatile and general three-dimensional hybrid aeroacoustic model is proposed for low Mach number turbulent flows. The model adopts a dual-domain approach and solves the fluid and acoustic fields simultaneously. Incompressible large eddy simulations are used to compute the flow field and acoustic source terms, which are then interpolated onto the acoustic domain using radial basis functions. The acoustic perturbation equations are solved using a finite-volume Riemann-based solver. The model is validated with various cases and shows excellent agreement with experimental sources, demonstrating its robustness and accuracy. The trailing edge studies also provide insights into the origin of secondary tones in the acoustic spectra.
JOURNAL OF SOUND AND VIBRATION
(2022)
Article
Green & Sustainable Science & Technology
Chih-Min Hsieh, Dean Chou, Tai-Wen Hsu
Summary: The study aims to estimate the trends of sea-level rise in Taiwan using different methods of analysis. The results suggest that the modified harmonic analysis (MHA) method is more applicable for estimating sea-level rise.
Article
Engineering, Electrical & Electronic
Chun-Lin Chu, Guang-Li Luo, Dean Chou, Shu-Han Hsu
Summary: Monolayer doping technology enables the fabrication of devices with complex geometries, which could be utilized in next-generation semiconductor technology with improved short channel control.
ACS APPLIED ELECTRONIC MATERIALS
(2022)
Article
Engineering, Multidisciplinary
Tohya Kanahama, Motohiro Sato
Summary: This study theoretically explains the effect of initial deflection and initial slope on self-buckling characteristics of heavy columns and proposes a formula characterizing the self-buckling problem. The results show that the greatest height is proportional to the 2/3 power of radius, and the formula can potentially predict the height of tree-like natural structures.
INTERNATIONAL JOURNAL OF ENGINEERING SCIENCE
(2024)
Article
Engineering, Multidisciplinary
Aps Selvadurai, Alexander P. Suvorov
Summary: This paper examines the torsion of a solid cylinder made of a fluid-saturated porous medium with a hyperelastic porous skeleton. It analyzes the mechanics of the twisted cylinder in both short-term and long-term behaviors, using numerical solutions and the ABAQUSTM finite element code.
INTERNATIONAL JOURNAL OF ENGINEERING SCIENCE
(2024)
Article
Engineering, Multidisciplinary
S. Kanaun
Summary: This study focuses on spherical radially transverse isotropic heterogeneous inclusions in homogeneous isotropic conductive host media. The volume integral equation for the field in the medium with an isolated inclusion subjected to a constant external field is solved using Mellin-transform technique. The method allows revealing tensor structure of the solution with precision to one scalar function of radial coordinate. The study also investigates the influence of neutral inclusions and conductivity coefficients on the effective conductivity of the composite material.
INTERNATIONAL JOURNAL OF ENGINEERING SCIENCE
(2024)
Article
Engineering, Multidisciplinary
Marinos Kattis, Vassilis Tsitsos, Vassilis Karatzaferis
Summary: The proposed model utilizes continuum mechanics to describe the mechanical behavior of a weakened interface between materials with microstructure, simulating the weakened interface using a surface elastic medium adhering on either side with bulk elastic continua. The model is able to investigate the effect of a weakened interface on stress concentration around inhomogeneities embedded in an unbounded matrix of Cosserat materials.
INTERNATIONAL JOURNAL OF ENGINEERING SCIENCE
(2024)
Article
Engineering, Multidisciplinary
Shixiang Zhao, Yu. V. Petrov, Yuyi Zhang, G. A. Volkov, Zejian Xu, Fenglei Huang
Summary: This paper theoretically studies the thermal softening related to stress relaxation using the incubation time approach and examines the temperature-time correspondence. The developed relaxation model of plasticity (RP model) is analyzed and compared with other constitutive models and artificial neural networks. The advantages and disadvantages of different models are discussed, and the differences between the ANN model and other constitutive models are examined.
INTERNATIONAL JOURNAL OF ENGINEERING SCIENCE
(2024)
Article
Engineering, Multidisciplinary
Ivan I. Argatov, Federico J. Sabina
Summary: This study models a seismic metabarrier as a cluster of single-degree-of-freedom resonator units and considers the scattering effects on pulsed Rayleigh waves caused by the vertical displacements of the resonators and the normal contact forces. The variation of the amplitude reduction factor due to the model parameters variation is studied in detail.
INTERNATIONAL JOURNAL OF ENGINEERING SCIENCE
(2024)
