Article
Oncology
Felipe Dubourcq de Barros, Leuridan Cavalcante Torres, Carolline Araujo, Felipe da Silva Marinho, Beatriz Cavalcanti Dubourcq, Luis Cavalcanti Dubourcq, Gustavo Cardoso Guimaraes
Summary: The expression of SOX2, STAT3, and CD44(high)/CD24(low) in penile squamous cell carcinoma is significantly associated with aggressive tumor behavior, making them potential prognostic indicators and allowing for more aggressive treatment when necessary.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2023)
Article
Medicine, Research & Experimental
Geoffrey Casas, Federico Perche, Patrick Midoux, Chantal Pichon, Jean-Marc Malinge
Summary: Decoy technology using 95-bp minicircles with STAT3 binding sequences shows promising therapeutic potential in triple-negative breast cancer by specifically interacting with and inhibiting STAT3 activity, leading to suppression of tumor growth and metastasis. Increasing the number of binding sites enhances the anticancer activity, suggesting a multitargeting strategy may be effective in TF decoy therapy.
MOLECULAR THERAPY-NUCLEIC ACIDS
(2022)
Article
Oncology
Seo Yun Moon, Heejin Lee, Seoree Kim, Ji Hyung Hong, Sang Hoon Chun, Hee Yeon Lee, Keunsoo Kang, Ho Shik Kim, Hye Sung Won, Yoon Ho Ko
Summary: The EGFR and Src-mediated STAT3 signaling pathway is activated in tamoxifen-resistant breast cancer cells, and inhibition of STAT3 may be a potential target for overcoming tamoxifen resistance. Increase in nuclear p21(Cip1) may play a key role in STAT3 inhibitor-induced cell death in tamoxifen-resistant cells.
Article
Biochemistry & Molecular Biology
Griffin Wright, Manoj Sonavane, Natalie R. Gassman
Summary: STAT3 is identified as a novel regulator of XRCC1, with its activation through the IL-6 signaling pathway increasing the expression level of XRCC1 and impacting its role in triple negative breast cancer. The upregulation of XRCC1 is associated with the aggressiveness and chemotherapeutic resistance in cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Huang Chen, Aiwu Bian, Lian-fang Yang, Xuan Yin, Jie Wang, Chaowen Ti, Ying Miao, Shihong Peng, Shifen Xu, Mingyao Liu, Wen-Wei Qiu, Zhengfang Yi
Summary: A new small-molecule inhibitor N4 shows potent anti-tumor bioactivity in pancreatic cancer by targeting STAT3, effectively suppressing tumor growth and metastasis, and potentially offering clinical benefits for treatment.
Article
Oncology
Zhen-ning Tang, Xiao-fang Bi, Wei-liang Chen, Chao-lin Zhang
Summary: This study reveals that RANKL/RANK induces autophagy and mediates chemoresistance in breast cancer cells through the activation of the STAT3 signaling pathway. Targeting RANKL/RANK and STAT3 may be a potential therapeutic strategy against chemoresistance in breast cancer.
CLINICAL BREAST CANCER
(2023)
Article
Cell Biology
Chen-Yan Wu, Lei Li, Shi-Lu Chen, Xia Yang, Chris Zhiyi Zhang, Yun Cao
Summary: Clear cell renal cell carcinoma (ccRCC) is a common malignancy with rapid growth and high metastasis and lacks effective therapeutic targets. This study demonstrates that the Zic2/Runx2/NOLC1 signaling axis plays a crucial role in promoting ccRCC progression, providing potential therapeutic targets and prognostic indicators. Patients with high Zic2/Runx2 and low NOLC1 expression have the worst outcomes according to Kaplan-Meier survival analyses.
CELL DEATH & DISEASE
(2021)
Article
Oncology
Zhen Zhang
Summary: This study identified high expression of POLD2 in TNBC and poor clinical outcomes in patients with high POLD2 expression. Functional and mechanistic studies revealed the involvement of the E2F1-POLD2 axis in TNBC proliferation, suggesting POLD2 as a potential therapeutic target for TNBC treatment.
FRONTIERS IN ONCOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Woong Sub Byun, Eun Seo Bae, Jinsheng Cui, Hyen Joo Park, Dong-Chan Oh, Sang Kook Lee
Summary: Pulvomycin effectively inhibits cell proliferation, induces cell cycle arrest and apoptosis by suppressing STAT3 activation, significantly inhibits invasion and migration of TNBC cells, and in combination with docetaxel effectively inhibits tumor growth in xenograft mouse model through STAT3 regulation.
Article
Chemistry, Medicinal
Peng He, Ying Miao, Yue Sun, Aiwu Bian, Wangrui Jin, Jiangnan Ye, Huang Chen, Jia He, Yangrui Peng, Haijun Gu, Mingyao Liu, Zhengfang Yi, Yihua Chen
Summary: This study describes the design, synthesis, and structure-activity relationship studies of triaromatic heterocyclic derivatives as potent dual phosphorylation STAT3 inhibitors. The best compound 3h (HP590) was discovered with high inhibitory activity against p-Tyr(705) and p-Ser(727), resulting in the growth inhibition of gastric cancer both in vitro and in vivo.
JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Review
Oncology
Megan G. G. Matherne, Emily S. S. Phillips, Samuel J. J. Embrey, Caitlin M. M. Burke, Heather L. L. Machado
Summary: Breast tumorigenesis is influenced by the interactions between tumor cells and their microenvironment, regulated by transcriptional networks. C/EBP beta, a transcription factor, plays important roles in cell proliferation, differentiation, and various biological processes. It is overexpressed in breast cancer and has tumor-promoting functions. This review discusses the specific roles of C/EBP beta in breast tumorigenesis, isoform-specific gene regulation, and regulation of the tumor immune response, emphasizing the importance of C/EBP beta isoform-specific gene regulation in developing new therapeutic strategies.
FRONTIERS IN ONCOLOGY
(2023)
Article
Oncology
Chenlin Liu, Jun Han, Xiaoju Li, Tonglie Huang, Yuan Gao, Baolong Wang, Kuo Zhang, Shuning Wang, Wangqian Zhang, Weina Li, Qiang Hao, Meng Li, Yingqi Zhang, Cun Zhang
Summary: This study systematically explored a new mechanism by which FOXP3 inhibits breast cancer metastasis through the FOXP3-MTA1 pathway. It was found that FOXP3 downregulated MTA1 expression in breast cancer cells by directly inhibiting MTA1 promoter activity, affecting the invasion and metastasis abilities of breast cancer cells. Clinical data showed a significant negative correlation between the expression levels of FOXP3 and MTA1 in breast cancer.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Huang Chen, Wenbo Zhou, Aiwu Bian, Qiansen Zhang, Ying Miao, Xuan Yin, Jiangnan Ye, Shifen Xu, Chaowen Ti, Zhenliang Sun, Jianghua Zheng, Yihua Chen, Mingyao Liu, Zhengfang Yi
Summary: This study identifies a novel drug called WB436B as a selective STAT3 inhibitor for the treatment of pancreatic cancer. WB436B effectively inhibits tumor growth and metastasis, providing hope for the treatment of pancreatic cancer.
CLINICAL CANCER RESEARCH
(2023)
Article
Oncology
Claudia Maresca, Giulia Di Maggio, Carmine Stolfi, Federica Laudisi, Marco Colella, Teresa Pacifico, Antonio Di Grazia, Davide Di Fusco, Daniele Congiu, Andrea Martina Guida, Giuseppe Sica, Ivan Monteleone, Giovanni Monteleone
Summary: The study reveals a novel positive feedback loop involving Smad7 and Stat3 in CRC cells, suggesting therapeutic targeting of Smad7 in patients with colorectal cancer.
Article
Multidisciplinary Sciences
Chao Zhang, Yu Wang, Wei Shao, Dongrui Zhou, Dong Yu, Shiqiang Hou, Ning Lin
Summary: The NFAT1-mediated IL6/JAK-STAT signaling pathway is a useful tool for predicting the overall survival rate of glioma patients. By analyzing the expression of NFAT1 and its relationship with clinicopathological factors and Transcriptional subtypes, a predictive model based on the IL6/JAK/STAT signaling pathway was developed. The model showed strong predictive performance and can be used to predict the survival rate of glioma patients at different time points.
SCIENTIFIC REPORTS
(2023)
Article
Biochemistry & Molecular Biology
Han Xue, Qingfeng Zhang, Panqin Wang, Bijin Cao, Chongchong Jia, Ben Cheng, Yuhua Shi, Wei-Feng Guo, Zhenlong Wang, Ze-Xian Liu, Han Cheng
Summary: The paper introduces an integrative database of quantitative PTMs in plants named qPTMplants, which includes experimentally identified PTM events for 123,551 proteins at 429,821 nonredundant sites under 583 conditions for 43 plant species from 293 published studies. This database is expected to be a valuable resource for further research on PTMs in plants.
NUCLEIC ACIDS RESEARCH
(2022)
Article
Biochemical Research Methods
Jing Liang, Zong-Wei Li, Cai-Tong Yue, Zhuo Hu, Han Cheng, Ze-Xian Liu, Wei-Feng Guo
Summary: This study developed a novel model (MMPDNB) that can provide multiple personalized biomarker modules and uncover their multi-modal properties. By validating genomic data of breast or lung cancer patients, the experimental results demonstrated that MMPDNB can more effectively predict key states with the highest early warning signals during cancer development.
BRIEFINGS IN BIOINFORMATICS
(2022)
Article
Oncology
Jia Liu, Ze-Xian Liu, Jia-Jun Li, Zhao-Lei Zeng, Jin-Hong Wang, Xiao-Jing Luo, Chau-Wei Wong, Jia-Bo Zheng, Heng-Ying Pu, Hui Sheng, Qi-Nian Wu, Hao Li, Gang Wan, Bo Li, De-shen Wang, Rui-Hua Xu, Huai-Qiang Ju
Summary: Tumor-associated macrophages (TAM) are important for tumor development and progression. This study found that the long noncoding RNA MALR promoted aerobic glycolysis and angiogenesis in tumor cells by activating the HIF1a signaling pathway. It also identified the MALR-ILF3-HIF1a axis as a potential target for cancer therapy.
Editorial Material
Biochemical Research Methods
Jia Meng, Zhixiang Zuo, Tzong-Yi Lee, Zexian Liu, Yufei Huang
Article
Biochemistry & Molecular Biology
Kai Yu, Ye Wang, Yongqiang Zheng, Zekun Liu, Qingfeng Zhang, Siyu Wang, Qi Zhao, Xiaolong Zhang, Xiaoxing Li, Rui-Hua Xu, Ze-Xian Liu
Summary: Post-translational modifications (PTMs) play critical roles in regulating protein functions and understanding biological processes and diseases. The qPTM database serves as a comprehensive one-stop data resource, providing massive quantitative PTM proteome datasets and a scoring system to assess PTM site reliability.
NUCLEIC ACIDS RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Ying-Nan Wang, Dan-Yun Ruan, Zi-Xian Wang, Kai Yu, Dai-Lin Rong, Ze-Xian Liu, Feng Wang, Jia-Jia Hu, Ying Jin, Qi-Nian Wu, Heng-Ying Pu, Min Wang, Rui-Hua Xu, Zhao-Lei Zeng
Summary: Dysregulated cholesterol metabolism is a characteristic of colorectal cancer, but the use of cholesterol-lowering agents seems to have no benefit in CRC patients. This study reveals the importance of the cholesterol-nuclear receptors axis in CRC, with ROR alpha/gamma being a key nuclear receptor. Treatment with ROR alpha/gamma agonists significantly inhibits the proliferation and migration of CRC cells. Mechanistically, ROR alpha/gamma agonists promote the degradation of c-myc protein by activating the transcription of the ubiquitinase NEDD4. Furthermore, the combination of ROR alpha/gamma agonists and atorvastatin has a synergistic effect on inhibiting CRC cells.
Article
Chemistry, Multidisciplinary
Chunhua Zhao, Zekun Liu, Chia-Che Chang, Yi-Chia Chen, Qize Zhang, Xiao-Dong Zhang, Chrysalis Andreou, Jiadong Pang, Ze-Xian Liu, Di-Yan Wang, Moritz F. Kircher, Jiang Yang
Summary: Through bioinformatic analysis, researchers found that TNBC has a higher ferroptosis potential index (FPI) than non-TNBC. They developed a phototheranostic nanocrystal that can trigger both apoptosis and ferroptosis in TNBC cells, effectively limiting the growth and metastasis of TNBC.
Article
Biochemical Research Methods
Kai Yu, Zekun Liu, Haoyang Cheng, Shihua Li, Qingfeng Zhang, Jia Liu, Huai-Qiang Ju, Zhixiang Zuo, Qi Zhao, Shiyang Kang, Ze-Xian Liu
Summary: This study presents a novel software, dSCOPE, for predicting protein sequence segments critical for liquid-liquid phase separation (LLPS). The large-scale analysis of the human proteome based on dSCOPE reveals potential roles and associations with post-translational modifications, cancer mutations, and cellular signaling pathways.
BRIEFINGS IN BIOINFORMATICS
(2023)
Article
Oncology
Xiaoming Liu, Yongqiang Zheng, Mengqing Xiao, Xingyu Chen, Yuxing Zhu, Canxia Xu, Fen Wang, Zexian Liu, Ke Cao
Summary: The study found that SRSF10 is enriched in HCC tissues and promotes HCC proliferation, cell cycle, and invasion. SRSF10 promotes exon 6 exclusion of CDC25A pre-mRNA. CDC25A(oE6) is identified as a crucial cell cycle mediator that is stabilized and retained in the nucleus due to the deletion of two ubiquitination sites in exon 6.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2022)
Article
Genetics & Heredity
Ze-Xian Liu, Panqin Wang, Qingfeng Zhang, Shihua Li, Yuxin Zhang, Yutong Guo, Chongchong Jia, Tian Shao, Lin Li, Han Cheng, Zhenlong Wang
Summary: In this study, we developed an integrated resource (iHypoxia) for the expression dynamics of proteins in response to hypoxia. The database contains expression data of proteins from multiple mammals, candidate genes associated with hypoxia, and information about posttranslational modifications. iHypoxia provides a convenient way for users to access hypoxia-related information.
GENOMICS PROTEOMICS & BIOINFORMATICS
(2023)
Article
Genetics & Heredity
Ye Hong, Yan Yuan, Zekun Liu, Zexian Liu, Yizhuo Zhang
Summary: The dysregulation of cell death is closely associated with the development, progression, tumor microenvironment (TME), and prognosis of cancer. This study comprehensively explores the prognostic and immunological role of cell death in human pan-cancer using RNA-sequencing and clinical data. A reliable gene signature was constructed to distinguish prognosis-favorable and prognosis-unfavorable patients, showing significant associations with genomic mutation frequency, hypoxia score, immune gene expression, malignant signaling pathways, and cancer immunity cycle.
Article
Oncology
Jia Liu, Wei-Yi Zhou, Xiao-Jing Luo, Yan-Xing Chen, Chau-Wei Wong, Ze-Xian Liu, Jia- Bo Zheng, Hai- Yu Mo, Jun-Quan Chen, Jia-Jun Li, Ming Zhong, Yu-Hong Xu, Qi-Hua Zhang, Heng-Ying Pu, Qi-Nian Wu, Ying Jin, Zi-Xian Wang, Rui-Hua Xu, Hui-Yan Luo
Summary: This study reveals the critical role of the RIME-MLL1-H3K4me3 axis in tumor immunosuppression. RIME may serve as a potential prognostic biomarker for immunotherapy, and developing drugs targeting RIME may be a new therapeutic strategy to overcome immunotherapy resistance.
CLINICAL AND TRANSLATIONAL MEDICINE
(2023)
Article
Cell Biology
Rongjie Cheng, Fanying Li, Maolei Zhang, Xin Xia, Jianzhuang Wu, Xinya Gao, Huangkai Zhou, Zhi Zhang, Nunu Huang, Xuesong Yang, Yaliang Zhang, Shunli Shen, Tiebang Kang, Zexian Liu, Feizhe Xiao, Hongwei Yao, Jianbo Xu, Chao Yan, Nu Zhang
Summary: This study identifies RASON as a positive regulator of oncogenic RAS signaling and reveals its aberrant overexpression in pancreatic ductal adenocarcinoma. RASON promotes tumor cell proliferation and tumor growth by sustaining the hyperactive state of KRAS through inhibiting GTP hydrolysis. Deprivation of RASON sensitizes KRAS mutant pancreatic cancer cells to EGFR inhibitors.
Article
Biochemistry & Molecular Biology
Xiao-Jing Luo, Ming-Ming He, Jia Liu, Jia-Bo Zheng, Qi-Nian Wu, Yan-Xing Chen, Qi Meng, Kong-Jia Luo, Dong-Liang Chen, Rui-Hua Xu, Zhao-Lei Zeng, Ze-Xian Liu, Hui-Yan Luo
Summary: TMPO-AS1, an important regulatory RNA, is overexpressed in esophageal cancer and correlates with shorter survival times in patients by promoting cancer cell proliferation and metastasis. This study reveals the molecular mechanisms by which TMPO-AS1 activates the gene coding for thymopoietin, a hormone associated with tumor progression.
EXPERIMENTAL AND MOLECULAR MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Jin-Fei Lin, Pei-Shan Hu, Yi-Yu Wang, Yue-Tao Tan, Kai Yu, Kun Liao, Qi-Nian Wu, Ting Li, Qi Meng, Jun-Zhong Lin, Ze-Xian Liu, Heng-Ying Pu, Huai-Qiang Ju, Rui-Hua Xu, Miao-Zhen Qiu
Summary: This study reveals the role and regulation mechanism of cysteine desulfurase (NFS1) in the sensitivity of colorectal cancer cells to oxaliplatin. Loss of NFS1 enhances the sensitivity of colorectal cancer cells to oxaliplatin and triggers PANoptosis by increasing intracellular levels of reactive oxygen species (ROS). In addition, high expression of NFS1 is associated with poor survival and chemoresistance in patients with colorectal cancer.
SIGNAL TRANSDUCTION AND TARGETED THERAPY
(2022)