Article
Chemistry, Multidisciplinary
Jiahao Liu, Weikang Li, Yinwu Li, Yan Liu, Zhuofeng Ke
Summary: The study introduces a molybdenum complex with a readily available bis-N-heterocyclic carbene ligand for catalyzing beta-alkylation of secondary alcohols via borrowing-hydrogen strategy. It shows remarkable activity, excellent selectivity, and broad substrate compatibility, with the use of low catalyst amounts, NaOH as the base, and H2O as the by-product. Mechanistic studies suggest an outer-sphere mechanism where alcohol dehydrogenation is the rate-determining step.
CHEMISTRY-AN ASIAN JOURNAL
(2021)
Article
Chemistry, Applied
Leo Bettoni, Nicolas Joly, Jean-Francois Lohier, Sylvain Gaillard, Albert Poater, Jean-Luc Renaud
Summary: The borrowing hydrogen strategy was used in a tandem three-component reaction catalyzed by a phosphine free diaminocyclopentadienone ruthenium tricarbonyl complex to synthesize nonsymmetric N,N-dialkylated acyl hydrazides. Different aromatic acyl hydrazides underwent dialkylation with various alcohols in mild reaction conditions, with primary or secondary alcohols serving as the hydrogen source. DFT calculations showed that the tandem mixed product formation could be influenced by the physical state of the aldehyde or ketone intermediate.
ADVANCED SYNTHESIS & CATALYSIS
(2021)
Article
Chemistry, Multidisciplinary
Ved Vyas, Priyanka Maurya, Arindam Indra
Summary: N-alkylation of anilines using alcohols is an efficient strategy to synthesize various secondary amines. Metal-organic framework-derived CoNx@NC catalysts were reported for selective N-alkylation reactions, showing high yield and recyclability due to the importance of Co-N coordination.
Article
Chemistry, Physical
Peifeng Su, Zhe Chen, Jinyu Ni, Zhenjie Yang, Yinwu Li, Zhuofeng Ke
Summary: This study demonstrates the importance of overcoming the alkoxide trap problem and the impact of the chromium center's oxidation state on catalytic activity. By surmounting the alkoxide trap, a Cr(0) catalyst is developed for efficient C-alkylation between alcohols via borrowing hydrogen/hydrogen autotransfer. The Cr(0) catalyst shows excellent catalytic performance and can avoid the d-p p interaction, overcoming the thermodynamic sink caused by the alkoxide trap. This strategy could be helpful in developing efficient and nonprecious transition metal catalysts.
Article
Chemistry, Inorganic & Nuclear
Viktoriia Zubar, Aleksandra Brzozowska, Jan Sklyaruk, Magnus Rueping
Summary: A new manganese-catalyzed heterocyclization of aminoalcohols has been developed, leading to a wide range of heterocycles including tetrahydroquinolines, dihydroquinolinones, and tetrahydro-1H-benzo[b]azepines. The reaction is conducted under mild conditions using air and moisture stable manganese catalysts, resulting in good to excellent yields of the desired heterocycles.
Article
Chemistry, Organic
Ming Huang, Yinwu Li, Xiao-Bing Lan, Jiahao Liu, Cunyuan Zhao, Yan Liu, Zhuofeng Ke
Summary: A new type of ruthenium(s) complexes was reported, realizing smart pathway selection in the N-alkylated reaction by reactivity tuning of IRu-H) species. These complexes exhibit high catalytic efficiency under low temperature and neat conditions, with high conversion rates for various amines and alcohols.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2021)
Article
Chemistry, Organic
S. N. R. Donthireddy, Misba Siddique, Arnab Rit
Summary: In this paper, an efficient protocol was presented for the N,N'-dialkylation of aromatic diamines using a Ni-NHC complex as catalyst. Various N,N'-dialkylated phenylenediamines were obtained in good to excellent yields. The method was also successfully applied to the derivatization of a clinically important drug molecule, Dapsone. The control experiments confirmed that the protocol proceeded via a borrowing hydrogen sequence.
JOURNAL OF ORGANIC CHEMISTRY
(2023)
Article
Chemistry, Organic
S. N. R. Donthireddy, Misba Siddique, Arnab Rit
Summary: The N-alkylation of phenylenediamines using alcohols as coupling partners is challenging due to selectivity issues. This study presents an efficient protocol for N,N'-di-alkylation using a nickel-NHC complex, which allows for the synthesis of a wide range of substituted aromatic diamines in good yields. The protocol also demonstrates successful derivatization of a clinically important drug molecule.
JOURNAL OF ORGANIC CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Reshma Babu, Subarna Sukanya Padhy, Rohit Kumar, Ekambaram Balaraman
Summary: Sustainable chemical production requires the development of coherent and robust catalytic systems based on earth-abundant transition metals. This study explores a novel tandem reaction that converts cyclic and acyclic diazo compounds into valuable amines using a single-site molecular manganese complex as the catalyst. The reaction involves dehydrogenation, transfer hydrogenation, and borrowing hydrogenation strategies, and utilizes renewable feedstocks such as alcohols. The synthetic application of this approach in pharmaceutical synthesis and the production of N-CH3/CD3 derivatives is also demonstrated.
CHEMISTRY-A EUROPEAN JOURNAL
(2023)
Article
Multidisciplinary Sciences
You-Feng Han, Ying Huang, Hao Liu, Zhong-Hua Gao, Chun-Lin Zhang, Song Ye
Summary: We developed a new method for the carboacylation of simple alkenes using a photoredox cooperative catalyst and unactivated alkyl halides, which provides ketones in high yields. This method has a wide scope of alkenes, broad functional group compatibility and does not require exogenous photosensitizer or external reductant.
NATURE COMMUNICATIONS
(2022)
Article
Chemistry, Inorganic & Nuclear
Xinshu Feng, Ming Huang
Summary: The study found that an iridium (III) complex with special ligands exhibited the highest activity in the N-alkylation reaction of amines with alcohols, efficiently converting a large variety of amines and primary alcohols into mono-N-alkylated amines. Selective N-monomethylation of MeOH could be achieved using KOH as a base under an air atmosphere. This catalytic system was also successfully applied to the gram-scale synthesis of some valuable compounds.
Article
Chemistry, Organic
Zakaria Moutaoukil, Emmanuel Serrano-Diez, Isidro G. Collado, Manuel Jimenez-Tenorio, Jose Manuel Botubol-Ares
Summary: An efficient ruthenium-catalyzed N-alkylation method has been developed for amines, amides, and sulfonamides using novel pentamethylcyclopentadienylruthenium(II) complexes. The method shows high functional group tolerance and can achieve up to 99% yield even on gram-scale reactions. This is the first example of N-alkylation of sulfonamides using transition-metal complexes with NHC ligands.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Chenchen Yang, Shushu Hao, Lu Shen, Peng Liu, Jiazhi Yang, Feng Li
Summary: A new covalent triazine framework was synthesized using the ionothermal technique, and a high-efficiency selective catalyst was prepared for the N-alkylation reaction of aminobenzenesulfonamides with alcohols.
MATERIALS CHEMISTRY FRONTIERS
(2022)
Article
Chemistry, Inorganic & Nuclear
Victoria Mechrouk, Aline Maisse-Francois, Stephane Bellemin-Laponnaz, Thierry Achard
Summary: A catalytic system for the direct beta-alkylation of secondary alcohol with primary alcohol has been studied, using cationic Ru(II)(eta(6)-p-cymene) complexes with thioether-functionalized N-heterocyclic carbene ligands as catalysts. The results show that modifications in the ligand moiety have a strong effect on both selectivity and reactivity. Imidazole-based complex 1c exhibited the best catalytic activity and highest selectivity for the beta-alcohol, with 98:2 selectivity. Moderate yields of beta-alkylated secondary alcohols have been obtained with complete conversion and high selectivity.
EUROPEAN JOURNAL OF INORGANIC CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
En Li, Kai Tang, Zhuhui Ren, Xiaoyun Liao, Qianchen Liu, Yong Huang, Jiean Chen
Summary: The successful enantioselective beta-alkylation of homoenolates using C-sp3 electrophiles through an S(N)2 strategy is reported. The method shows a broad scope and delivers good yields and excellent enantioselectivities (up to 99% ee). It enables the installation of drug-like structural motifs and presents a concise synthetic route to chiral pyrroloindoline-type skeletons. Preliminary mechanistic studies support a direct S(N)2 mechanism.
Article
Chemistry, Multidisciplinary
Murat Kaloglu, Nazan Kaloglu, Ismail Ozdemir
Article
Chemistry, Inorganic & Nuclear
Umran Kizrak, Osman Ciftci, Ilknur Ozdemir, Nevin Gurbuz, Serpil Demir Dusunceli, Murat Kaloglu, Lamjed Mansour, Fethi Zaghrouba, Naceur Hamdi, Ismail Ozdemir
JOURNAL OF ORGANOMETALLIC CHEMISTRY
(2019)
Article
Chemistry, Applied
Murat Kaloglu, Nevin Gurbuz, Ilkay Yildirim, Namik Ozdemir, Ismail Ozdemir
APPLIED ORGANOMETALLIC CHEMISTRY
(2020)
Article
Chemistry, Inorganic & Nuclear
Murat Kaloglu, Ismail Ozdemir
INORGANICA CHIMICA ACTA
(2020)
Article
Chemistry, Physical
Murat Kaloglu, Nazan Kaloglu, Ilkay Ylidirim, Namik Ozdemir, Ismail Ozdemir
JOURNAL OF MOLECULAR STRUCTURE
(2020)
Article
Chemistry, Inorganic & Nuclear
Murat Kaloglu, Serpil Demir Dusunceli, Ismail Ozdemir
JOURNAL OF ORGANOMETALLIC CHEMISTRY
(2020)
Article
Chemistry, Multidisciplinary
Murat Kaloglu, Nazan Kaloglu, Namik ozdemir, Ismail ozdemir
Summary: In this study, four new NHC ligand precursors and palladium complexes were successfully synthesized for the direct C-H bond arylation of heteroarenes. Structural characterization of one of the palladium complexes was determined in detail by single-crystal X-ray diffraction study. Under low catalyst loading conditions, aryl halides were used as arylating reagents to achieve C5-arylated furans and thiophenes in high yields.
RESEARCH ON CHEMICAL INTERMEDIATES
(2021)
Article
Chemistry, Physical
Murat Kaloglu, Mehmet Hanifi Sahan, Serpil Demir Dusunceli, Ismail Ozdemir
Summary: In this study, quinoxaline-linked bis(benzimidazolium) salts were synthesized as bis-N-heterocyclic carbene (NHC) precursors, which were used as multidentate ligands for the construction of bi(hetero)aryls by palladium-catalyzed direct C-H activation process. The in situ prepared palladium complexes by mixtures of the Pd(OAc)(2) and the bis(NHC) precursors were used as the catalyst for direct C-H activation of heteroarenes, exhibiting a modest catalytic activity in the direct C-H activation of five-membered heteroarenes with a wide range of (hetero)aryl bromides.
Article
Chemistry, Applied
Murat Kaloglu, Namik Ozdemir, Ismail Ozdemir
Summary: In this study, four novel PEPPSI-type palladium-complexes with 4,5-dihydro-imidazol-2-ylidene ligands were prepared and tested as catalysts for direct arylation reactions. The results demonstrated that these new palladium complexes are effective catalysts.
APPLIED ORGANOMETALLIC CHEMISTRY
(2022)
Article
Chemistry, Inorganic & Nuclear
Murat Kaloglu, Nazan Kaloglu, Selami Gunal, Ismail Ozdemir
Summary: N-Heterocyclic carbene-based silver complexes (Ag-NHCs) are widely used in medicinal and pharmaceutical chemistry research due to their low toxicity. In this study, ten Ag-NHC complexes containing benzimidazol-2-ylidene ligand were synthesized and showed effective antimicrobial activity against microorganisms, making them potential metallopharmaceutical agents.
JOURNAL OF COORDINATION CHEMISTRY
(2022)
Article
Chemistry, Inorganic & Nuclear
Murat Kaloglu, Ichraf Slimani, Namik Ozdemir, Nevin Gurbuz, Naceur Hamdi, Ismail Ozdemir
Summary: In this study, a series of air- and moisture-stable imidazolidin-2-ylidene-based new palladium complexes were synthesized and characterized. The catalytic activities of these complexes in direct arylation reactions were tested, yielding desired products in moderate to good yields.
JOURNAL OF ORGANOMETALLIC CHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
Serpil Demir Dusunceli, Mehmet Hanifi Sahan, Murat Kaloglu, Elvan Ustun, Ismail Ozdemir
Summary: In this study, a series of quinoxaline-bridged bis(benzimidazolium) salts were synthesized and their photophysical properties were investigated. The salts exhibited moderate-to-high activity in the palladium-catalyzed cross-coupling reactions.
JOURNAL OF THE CHINESE CHEMICAL SOCIETY
(2022)
Article
Chemistry, Physical
Murat Kaloglu, Ismail Ozdemir
Summary: Six novel palladium N-heterocyclic carbene complexes with different ancillary ligands were successfully prepared and used as pre-catalysts in the Buchwald-Hartwig amination reaction. These complexes showed good catalytic activity in the amination of cyclic secondary amines with aryl chlorides, leading to moderate to high yields of N-arylamines under mild reaction conditions.
Correction
Chemistry, Multidisciplinary
Murat Kaloglu, Nazan Kaloglu, Ismail Ozdemir
CHINESE JOURNAL OF CHEMISTRY
(2019)
Article
Chemistry, Inorganic & Nuclear
Angela Lis, Viorica Gladchi, Gheorghe Duca, Sergey Travin
Summary: This work presents studies on the photochemical transformations of TU and Cys with the addition of Cu(II) or Fe(III) ions. The results show that the oxidation rate of the thiols increases significantly when Cu(II) or Fe(III) ions are added to the system. It has also been found that TU and Cys can form stable complex compounds with the studied metal ions. The oxidation rates of the thiols are found to depend on the radiation intensity and emission spectrum of the irradiation sources.
INORGANICA CHIMICA ACTA
(2024)
Article
Chemistry, Inorganic & Nuclear
Cristiane F. A. Teixeira, Estefane I. Teixeira, J. P. C. Nascimento, M. Amilcar Junior, L. M. C. Pinto, Anderson R. L. Caires, G. B. Alcantara, Ana C. Micheletti, Victor M. Deflon, Davi F. Back, Heveline Silva, Lucas Pizzuti, Gleison Antonio Casagrande
Summary: Novel binuclear heteroleptic copper(I) complexes based on mixed DPPE/thiocarbamoyl-pyrazoline ligands were synthesized and structurally characterized. These complexes exhibited similar structural behavior around the Copper(I) atoms and showed promising antimicrobial and anticancer activities.
INORGANICA CHIMICA ACTA
(2024)
Article
Chemistry, Inorganic & Nuclear
Chen Chen, Li Liu, Xin-Xin Zhong, Fa-Bao Li, Hai-Mei Qin
Summary: Thermally activated delayed fluorescent (TADF) Cu(I) halide complexes with short lifetimes and intense emissions were synthesized and characterized. These complexes exhibit intense green to yellow-green delayed fluorescence and are suitable for OLED devices.
INORGANICA CHIMICA ACTA
(2024)
Article
Chemistry, Inorganic & Nuclear
Tian-Yu Zhang, Xue-Qian Wu, Heng-Yu Ruan, Yi Yuan, Le Wang, Ya-Pan Wu, Qing-Wen Han, Ruan Chi, Dong-Sheng Li
Summary: In this study, a novel Ni(II)-based metal-organic framework with good electrocatalytic oxidation performance was successfully synthesized, showing potential for direct alcohol fuel cells.
INORGANICA CHIMICA ACTA
(2024)
Article
Chemistry, Inorganic & Nuclear
Susanta Das Baishnab, R. N. Dutta Purkayastha, Waldemar Maniukiewicz, Rosa M. Gomila, Antonio Frontera
Summary: The synthesis, structure, and DNA binding ability of three decavanadate complexes containing cationic organic moieties were reported. The complexes were characterized by various techniques and their solid-state structures were analyzed. The complexes showed interesting assembly patterns and exhibited moderately strong intercalative binding with CTDNA. Additionally, their micellization behavior in the presence of the surfactant CTAB was studied.
INORGANICA CHIMICA ACTA
(2024)
Review
Chemistry, Inorganic & Nuclear
Jubaraj B. Baruah
Summary: Isomorphous series are generated by replacing atoms or molecules to form materials with similar compositions. They allow modulation of structure and properties, and generate equivalent compositions with novel material properties. The study of stereo-electronic aspects of different equivalent compositions can improve the utility of the original composition.
INORGANICA CHIMICA ACTA
(2024)
Article
Chemistry, Inorganic & Nuclear
Kamelah S. Al-Rashdi, Bandar A. Babgi, Ehab M. M. Ali, Bambar Davaasuren, Abdul-Hamid M. Emwas, Mariusz Jaremko, Mark G. Humphrey, Mostafa A. Hussien
Summary: Tridentate ligands were used to synthesize a set of palladium complexes, which were characterized and found to have DNA and BSA binding abilities. The complexes also showed differences in anticancer activities.
INORGANICA CHIMICA ACTA
(2024)
Article
Chemistry, Inorganic & Nuclear
Diane Isaacs, Chandler Cox, Mark A. Bezpalko, W. Scott Kassel, William G. Dougherty
Summary: The structure and electrochemical properties of zinc(II) complexes with a face-capping ligand have been investigated, revealing the effect of the ligand on bound semiquinonate (SQ) radicals. The substitution pattern of the SQ ring plays a crucial role in determining the fate of the bound SQ radicals. Additionally, the protective pocket formed by the ligand's phenyl substituents is unable to prevent decomposition of SQ radicals with minimal steric bulk, suggesting that substitution of the SQ ring is the main contributor to their stabilization.
INORGANICA CHIMICA ACTA
(2024)
Article
Chemistry, Inorganic & Nuclear
Xingliang Chen, Zhiqiang Jiang
Summary: Here, a series of zinc tetrahedral tetrazolate frameworks (Zn-TTFs) are presented, and it is demonstrated that rotation of carboxyl group can generate structural diversity. Compound 3 exhibits a unique zeolite-like structure, while compound 4 shows both super acid and alkali resistance.
INORGANICA CHIMICA ACTA
(2024)
Article
Chemistry, Inorganic & Nuclear
Ankita Puri, Allison Mcaninch, Sheng Shu, Khashayar Rajabimoghadam, Maxime A. Siegler, Marcel Swart, Isaac Garcia-Bosch
Summary: In this article, the synthesis and characterization of copper, nickel, and palladium complexes bound by bidentate ligands derived from ortho-phenylenediamine are described. The complexes contain tunable H-bond donors and their crystal structures reveal intramolecular H-bonding interactions between the ligand scaffolds. Variations in the coordination sphere led to the isolation of the complexes in square-planar or twisted pseudo-tetrahedral geometries. Structural analysis showed that intramolecular H-bonding interactions can be altered by disrupting the bonds between countercations, solvent of crystallization, and ligand scaffold, resulting in changes in the geometry of the complexes. DFT calculations confirmed that Cu complexes prefer twisted geometries while Ni and Pd complexes favor square-planar geometries.
INORGANICA CHIMICA ACTA
(2024)
Article
Chemistry, Inorganic & Nuclear
Laiane dos Santos Oliveira, Pedro Henrique de Souza Guarda, Leticia Bazilio Rosa, Gustavo Clauss Rodrigues, Daniele Daiane Affonso, Joao Ernesto de Carvalho, Igor Andrade Santos, Mark Harris, Douglas Hideki Nakahata, Jose Ricardo Sabino, Danilo Ciccone Miguel, Ana Lucia Tasca Gois Ruiz, Ana Carolina Gomes Jardim, Camilla Abbehausen
Summary: Chalcones are chemical precursors of flavonoids that have various biological properties. In this study, novel copper(II)-2'-hydroxy-4-benzyloxychalcone complexes were synthesized and evaluated for their antileishmanial, antiproliferative, and antiviral activities. The results demonstrated that these complexes showed potential effects against tumor cells, leishmania parasites, and SARS-CoV-2 virus. The study also highlighted the influence of ligand structure on biological activity.
INORGANICA CHIMICA ACTA
(2024)
Review
Chemistry, Inorganic & Nuclear
Archana Thakur, Harpreet Kaur, Vishal Tyagi
Summary: This review article discusses the findings of research on the 13C NMR spectra of di- and tri-butyltin carboxylates, highlighting the importance of 13C NMR chemical shifts in determining the chemical surroundings of carbon nuclei and their role in structure elucidation.
INORGANICA CHIMICA ACTA
(2024)
Article
Chemistry, Inorganic & Nuclear
Qiang Zhao, Qi-Yang Li, Zhi Shen, Guo Zang, Wen-Jun Lv
Summary: In this study, five metal complexes were synthesized using a solvothermal reaction and their structures were analyzed by single crystal X-ray diffraction. Fluorescence and magnetic properties of some complexes were also investigated.
INORGANICA CHIMICA ACTA
(2024)
Article
Chemistry, Inorganic & Nuclear
Jeremy Erb, Darcy Setter, Jake Swavey, Frederick Willits, Shawn Swavey
Summary: Three BODIPY-Ru(II) complexes were synthesized by coordinating [Ru(bpy)2Cl]+ complexes to BODIPY ligands. The spectroscopic and electrochemical properties of the complexes were characterized. The complexes exhibited intense absorption peaks due to the pi pi* transitions localized on the BODIPY core, and additional charge transfer transitions associated with the metal center. The complexes showed significant singlet oxygen generation and were able to induce photo-nicking of DNA.
INORGANICA CHIMICA ACTA
(2024)
Article
Chemistry, Inorganic & Nuclear
Sahin Reja, Dilip Sarkar, Kaushik Sarkar, Deboshmita Mukherjee, T. K. S. Fayaz, Palash Sanphui, Rajesh Kumar Das
Summary: A promising bioinspired metallocatalyst has been produced and characterized, showing high catalytic activity in oxygen dependant enzymatic radical pathway. The catalyst also exhibits inter and intra molecular H-bonding and C-H-pi interactions.
INORGANICA CHIMICA ACTA
(2024)