Polymorphisms in ABCB1 and CYP19A1 genes affect anastrozole plasma concentrations and clinical outcomes in postmenopausal breast cancer patients

Fulvestrant decreases anastrozole drug concentrations when taken concurrently by patients with metastatic breast cancer treated on SWOG study S0226

(2016) Daniel L. Hertz et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Aromatase inhibitor associated arthralgia: the importance of oncology provider-patient communication about side effects and potential management through physical activity

(2016) Kirsten A. Nyrop et al.   SUPPORTIVE CARE IN CANCER

Influence of CYP19A1 polymorphisms on the treatment of breast cancer with aromatase inhibitors: a systematic review and meta-analysis

(2015) Osvaldo Artigalás et al.   BMC Medicine

The Concise Guide to PHARMACOLOGY 2015/16: Transporters

(2015) Stephen PH Alexander et al.   BRITISH JOURNAL OF PHARMACOLOGY

The Concise Guide to PHARMACOLOGY 2015/16: Enzymes

(2015) Stephen PH Alexander et al.   BRITISH JOURNAL OF PHARMACOLOGY

Impact of Genetic Polymorphisms of ABCB1 (MDR1, P-Glycoprotein) on Drug Disposition and Potential Clinical Implications: Update of the Literature

(2015) Stefan Wolking et al.   CLINICAL PHARMACOKINETICS

The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands

(2015) Christopher Southan et al.   NUCLEIC ACIDS RESEARCH

Estrogens and their precursors in postmenopausal women with early breast cancer receiving anastrozole

(2015) James N. Ingle et al.   STEROIDS

Genetic Variations of Drug Transporters Can Influence on Drug Response in Patients Treated with Docetaxel Chemotherapy

(2015) Jung Ran Choi et al.   Cancer Research and Treatment

Does Obesity Interfere With Anastrozole Treatment? Positive Association Between Body Mass Index and Anastrozole Plasma Levels

(2014) Michael Hubalek et al.   Clinical Breast Cancer

P-glycoprotein ABCB1: a major player in drug handling by mammals

(2013) Piet Borst et al.   JOURNAL OF CLINICAL INVESTIGATION

Investigation of the effect of active efflux at the blood–brain barrier on the distribution of nonsteroidal aromatase inhibitors in the central nervous system

(2013) Mari Miyajima et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Managing arthralgia in a postmenopausal woman taking an aromatase inhibitor for hormone-sensitive early breast cancer: a case study

(2012) Jane Bryce et al.   Cancer Management and Research

Single nucleotide polymorphisms of CYP19A1 predict clinical outcomes and adverse events associated with letrozole in patients with metastatic breast cancer

(2011) In Hae Park et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

An ultraperformance liquid chromatography-tandem mass spectrometry method for determination of anastrozole in human plasma and its application to a pharmacokinetic study

(2010) Jia Yu et al.   BIOMEDICAL CHROMATOGRAPHY

In vitro and in vivo oxidative metabolism and glucuronidation of anastrozole

(2010) Landry K. Kamdem et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Variation in Anastrozole Metabolism and Pharmacodynamics in Women with Early Breast Cancer

(2010) J. N. Ingle et al.   CANCER RESEARCH

Influence of Cremophor EL and Genetic Polymorphisms on the Pharmacokinetics of Paclitaxel and Its Metabolites Using a Mechanism-Based Model

(2010) M. N. Fransson et al.   DRUG METABOLISM AND DISPOSITION

New Pharmacogenomic Paradigm in Breast Cancer Treatment

(2010) Kenneth Offit et al.   JOURNAL OF CLINICAL ONCOLOGY

Genome-Wide Associations and Functional Genomic Studies of Musculoskeletal Adverse Events in Women Receiving Aromatase Inhibitors

(2010) James N. Ingle et al.   JOURNAL OF CLINICAL ONCOLOGY

Side effects after docetaxel treatment in Taiwanese breast cancer patients with CYP3A4, CYP3A5, and ABCB1 gene polymorphisms

(2009) Shih-Meng Tsai et al.   CLINICA CHIMICA ACTA

Meta-Analysis of Breast Cancer Outcomes in Adjuvant Trials of Aromatase Inhibitors Versus Tamoxifen

(2009) Mitch Dowsett et al.   JOURNAL OF CLINICAL ONCOLOGY

Association of the ABCB1 gene polymorphisms 2677G>T/A and 3435C>T with clinical outcomes of paclitaxel monotherapy in metastatic breast cancer patients

(2008) H. Chang et al.   ANNALS OF ONCOLOGY

A Single-Nucleotide Polymorphism in the Aromatase Gene Is Associated with the Efficacy of the Aromatase Inhibitor Letrozole in Advanced Breast Carcinoma

(2008) R. Colomer et al.   CLINICAL CANCER RESEARCH

Review of the ATAC study: tamoxifen versus anastrozole in early-stage breast cancer

(2008) Sarah J Needleman et al.   Expert Review of Anticancer Therapy