Palmitoylethanolamide for the treatment of pain: pharmacokinetics, safety and efficacy

Ultramicronized palmitoylethanolamide in spinal cord injury neuropathic pain

(2016) Sven R. Andresen et al.   PAIN

The anti-inflammatory mediator palmitoylethanolamide enhances the levels of 2-arachidonoyl-glycerol and potentiates its actions at TRPV1 cation channels

(2015) Stefania Petrosino et al.   BRITISH JOURNAL OF PHARMACOLOGY

A multicenter, randomized, double-blind, placebo-controlled trial to assess the efficacy and safety of single-entity, once-daily hydrocodone tablets in patients with uncontrolled moderate to severe chronic low back pain

(2015) Warren Wen et al.   EXPERT OPINION ON PHARMACOTHERAPY

Anti-inflammatory effects of N-acylethanolamines in rheumatoid arthritis synovial cells are mediated by TRPV1 and TRPA1 in a COX-2 dependent manner

(2015) Torsten Lowin et al.   ARTHRITIS RESEARCH & THERAPY

Amino Acid Derivatives as Palmitoylethanolamide Prodrugs: Synthesis, In Vitro Metabolism and In Vivo Plasma Profile in Rats

(2015) Federica Vacondio et al.   PLoS One

Harnessing the anti-inflammatory potential of palmitoylethanolamide

(2014) Mireille Alhouayek et al.   DRUG DISCOVERY TODAY

Micronized/ultramicronized palmitoylethanolamide displays superior oral efficacy compared to nonmicronized palmitoylethanolamide in a rat model of inflammatory pain

(2014) Daniela Impellizzeri et al.   Journal of Neuroinflammation

Combining ibuprofen and acetaminophen for acute pain management after third-molar extractions

(2014) Paul A. Moore et al.   JOURNAL OF THE AMERICAN DENTAL ASSOCIATION

Palmitoylethanolamide in CNS health and disease

(2014) Giuseppina Mattace Raso et al.   PHARMACOLOGICAL RESEARCH

Marketing messages in pharmacological papers and scientific chapters: The case of palmitoylethanolamide and its formulations

(2014) R. Kriek   PHARMACOLOGICAL RESEARCH

Effect of Diet on Tissue Levels of Palmitoylethanolamide

(2013) Harald S. Hansen   CNS & Neurological Disorders-Drug Targets

The adjuvant use of N-palmitoylethanolamine and transpolydatin in the treatment of endometriotic pain

(2013) Emilio Giugliano et al.   European Journal of Obstetrics & Gynecology and Reproductive Biology

Vestibulodynia

(2013) Filippo Murina et al.   Journal of Lower Genital Tract Disease

Administration of palmitoylethanolamide (PEA) protects the neurovascular unit and reduces secondary injury after traumatic brain injury in mice

(2012) Akbar Ahmad et al.   BRAIN BEHAVIOR AND IMMUNITY

Palmitoylethanolamide Restores Myelinated-Fibre Function in Patients with Chemotherapy-Induced Painful Neuropathy

(2012) A. Truini et al.   CNS & Neurological Disorders-Drug Targets

N-Palmitoyl-ethanolamine (PEA) Induces Peripheral Antinociceptive Effect by ATP-Sensitive K+-Channel Activation

(2012) Thiago Roberto Lima Romero et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

Palmitoylethanolamide in the Treatment of Chronic Pain Caused by Different Etiopathogenesis

(2012) Antonio Gatti et al.   PAIN MEDICINE

PALMITOYLETHANOLAMIDE REDUCES EARLY RENAL DYSFUNCTION AND INJURY CAUSED BY EXPERIMENTAL ISCHEMIA AND REPERFUSION IN MICE

(2012) Rosanna Di Paola et al.   SHOCK

Multimodal stepped care approach with acupuncture and PPAR-α agonist palmitoylethanolamide in the treatment of a patient with multiple sclerosis and central neuropathic pain

(2012) David J Kopsky et al.   Acupuncture in Medicine

Effectiveness of the association micronized N-Palmitoylethanolamine (PEA)–transpolydatin in the treatment of chronic pelvic pain related to endometriosis after laparoscopic assessment: a pilot study

(2011) Luigi Cobellis et al.   European Journal of Obstetrics & Gynecology and Reproductive Biology

Palmitoylethanolamide Reduces Granuloma-Induced Hyperalgesia by Modulation of Mast Cell Activation in Rats

(2011) Daniele De Filippis et al.   Molecular Pain

Effect of palmitoylethanolamide–polydatin combination on chronic pelvic pain associated with endometriosis: Preliminary observations

(2010) Ugo Indraccolo et al.   European Journal of Obstetrics & Gynecology and Reproductive Biology

Biological, clinical, and ethical advances of placebo effects

(2010) Damien G Finniss et al.   LANCET

Misdiagnosed Chronic Pelvic Pain: Pudendal Neuralgia Responding to a Novel Use of Palmitoylethanolamide: Table 1

(2010) Rocco Salvatore Calabrò et al.   PAIN MEDICINE

Central administration of palmitoylethanolamide reduces hyperalgesia in mice via inhibition of NF-κB nuclear signalling in dorsal root ganglia

(2009) Giuseppe D'Agostino et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

GPR119 is required for physiological regulation of glucagon-like peptide-1 secretion but not for metabolic homeostasis

(2009) Hong Lan et al.   JOURNAL OF ENDOCRINOLOGY

A Saturated N-Acylethanolamine Other than N-Palmitoyl Ethanolamine with Anti-inflammatory Properties: a Neglected Story…

(2008) M. Dalle Carbonare et al.   JOURNAL OF NEUROENDOCRINOLOGY

The endogenous fatty acid amide, palmitoylethanolamide, has anti-allodynic and anti-hyperalgesic effects in a murine model of neuropathic pain: involvement of CB1, TRPV1 and PPARγ receptors and neurotrophic factors

(2008) Barbara Costa et al.   PAIN