Interrogating the Gut-Brain Axis in the Context of Inflammatory Bowel Disease: A Translational Approach

Clock Gene Disruption is an Initial Manifestation of Inflammatory Bowel Disease

(2019) Yael Weintraub et al.   Clinical Gastroenterology and Hepatology

Circadian Rhythm Disruption Aggravates DSS-Induced Colitis in Mice with Fecal Calprotectin as a Marker of Colitis Severity

(2019) Joseph Amara et al.   DIGESTIVE DISEASES AND SCIENCES

Effect of Cognitive Behavioral Therapy on Clinical Disease Course in Adolescents and Young Adults With Inflammatory Bowel Disease and Subclinical Anxiety and/or Depression: Results of a Randomized Trial

(2019) Gertrude van den Brink et al.   INFLAMMATORY BOWEL DISEASES

Melatonin reduces inflammatory response in human intestinal epithelial cells stimulated by interleukin‐1β

(2019) Giuseppe Mannino et al.   JOURNAL OF PINEAL RESEARCH

Review article: the role of the autonomic nervous system in the pathogenesis and therapy of IBD

(2019) Tamara Mogilevski et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

Bi-directionality of Brain–Gut Interactions in Patients With Inflammatory Bowel Disease

(2018) David J. Gracie et al.   GASTROENTEROLOGY

Risk for depression in patients with inflammatory bowel diseases

(2018) Thomas Geiss et al.   Journal of Digestive Diseases

Anti-TNFα therapy in IBD alters brain activity reflecting visceral sensory function and cognitive-affective biases

(2018) Marcus A. Gray et al.   PLoS One

Amitriptyline Treatment Mitigates Sepsis-Induced Tumor Necrosis Factor Expression and Coagulopathy

(2018) Brent T. Xia et al.   SHOCK

Altered Brain Excitability and Increased Anxiety in Mice With Experimental Colitis: Consideration of Hyperalgesia and Sex Differences

(2018) Kewir D. Nyuyki et al.   Frontiers in Behavioral Neuroscience

Circadian Clocks and Sleep: Impact of Rhythmic Metabolism and Waste Clearance on the Brain

(2018) Urs Albrecht et al.   TRENDS IN NEUROSCIENCES

Depression increases the risk of inflammatory bowel disease, which may be mitigated by the use of antidepressants in the treatment of depression

(2018) Alexandra D Frolkis et al.   GUT

The Influence of Antidepressants on the Disease Course Among Patients With Crohn’s Disease and Ulcerative Colitis—A Danish Nationwide Register–Based Cohort Study

(2018) Marie Skov Kristensen et al.   INFLAMMATORY BOWEL DISEASES

Circadian rhythm disruption impairs tissue homeostasis and exacerbates chronic inflammation in the intestine

(2017) René Pagel et al.   FASEB JOURNAL

Complementary and Alternative Medicines Used by Patients With Inflammatory Bowel Diseases

(2017) Adam S. Cheifetz et al.   GASTROENTEROLOGY

Psychological Considerations and Interventions in Inflammatory Bowel Disease Patient Care

(2017) Tiffany H. Taft et al.   GASTROENTEROLOGY CLINICS OF NORTH AMERICA

Bidirectional Regulation of Circadian Disturbance and Inflammation in Inflammatory Bowel Disease

(2017) Xiaojing Liu et al.   INFLAMMATORY BOWEL DISEASES

Antidepressants in Inflammatory Bowel Disease

(2017) Benjamin J. D. Macer et al.   INFLAMMATORY BOWEL DISEASES

Inflammatory Bowel Disease and Eating Disorders: A systematized review of comorbidity

(2017) L. Ilzarbe et al.   JOURNAL OF PSYCHOSOMATIC RESEARCH

Stress and brain functional changes in patients with Crohn's disease: A functional magnetic resonance imaging study

(2017) A. Agostini et al.   NEUROGASTROENTEROLOGY AND MOTILITY

Anxiety- and Depressive-Like Behaviors are Associated with Altered Hippocampal Energy and Inflammatory Status in a Mouse Model of Crohn’s Disease

(2017) Arya Haj-Mirzaian et al.   NEUROSCIENCE

Vagal Nerve Stimulation for Treatment-Resistant Depression

(2017) Flavia R. Carreno et al.   Neurotherapeutics

Rising incidence of psychiatric disorders before diagnosis of immune-mediated inflammatory disease

(2017) R. A. Marrie et al.   Epidemiology and Psychiatric Sciences

Gut–brain actions underlying comorbid anxiety and depression associated with inflammatory bowel disease

(2017) Áine Abautret-Daly et al.   ACTA NEUROPSYCHIATRICA

Prevalence of Anxiety and Depression in Patients with Inflammatory Bowel Disease

(2017) Glynis Byrne et al.   Canadian Journal of Gastroenterology and Hepatology

Intrinsic neural network dysfunction in quiescent Crohn’s Disease

(2017) Anne K. Thomann et al.   Scientific Reports

Association Between Affective-Cognitive Symptoms of Depression and Exacerbation of Crohn’s Disease

(2016) Lawrence S Gaines et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

Poor Correlation Between Clinical Disease Activity and Mucosal Inflammation and the Role of Psychological Comorbidity, in Inflammatory Bowel Disease

(2016) David J Gracie et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

Symptoms of Depression and Anxiety Are Independently Associated With Clinical Recurrence of Inflammatory Bowel Disease

(2016) Antonina Mikocka-Walus et al.   Clinical Gastroenterology and Hepatology

Impact of High-Dose Vitamin D3 Supplementation in Patients with Crohn’s Disease in Remission: A Pilot Randomized Double-Blind Controlled Study

(2016) Neeraj Narula et al.   DIGESTIVE DISEASES AND SCIENCES

Vedolizumab Therapy Is Associated with an Improvement in Sleep Quality and Mood in Inflammatory Bowel Diseases

(2016) Betsy W. Stevens et al.   DIGESTIVE DISEASES AND SCIENCES

Empirically Supported Use of Psychiatric Medications in Adolescents and Adults with IBD

(2016) Gregory Thorkelson et al.   INFLAMMATORY BOWEL DISEASES

Controversies Revisited

(2016) Antonina Mikocka-Walus et al.   INFLAMMATORY BOWEL DISEASES

Pilot Study of Functional Magnetic Resonance Imaging Responses to Somatic Pain Stimuli in Youth With Functional and Inflammatory Gastrointestinal Disease

(2016) Jeannie S. Huang et al.   JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION

Food Intake Adequacy in Children and Adolescents With Inflammatory Bowel Disease

(2016) Corina Hartman et al.   JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION

Depression and anxiety in patients with Inflammatory Bowel Disease: A systematic review

(2016) Rachel Neuendorf et al.   JOURNAL OF PSYCHOSOMATIC RESEARCH

Chronic vagus nerve stimulation in Crohn's disease: a 6-month follow-up pilot study

(2016) B. Bonaz et al.   NEUROGASTROENTEROLOGY AND MOTILITY

Melatonin modulates adiponectin expression on murine colitis with sleep deprivation

(2016) Tae Kyun Kim et al.   WORLD JOURNAL OF GASTROENTEROLOGY

The Relationship Among Perceived Stress, Symptoms and Inflammation in Persons With Inflammatory Bowel Disease

(2015) Laura E Targownik et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

Comorbidity between depression and inflammatory bowel disease explained by immune-inflammatory, oxidative, and nitrosative stress; tryptophan catabolite; and gut–brain pathways

(2015) Marta Martin-Subero et al.   CNS SPECTRUMS

Evaluation of anti-colitic effect of fluvoxamine against acetic acid-induced colitis in normal and reserpinized depressed rats

(2015) Mohsen Minaiyan et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Alterations in Brain Grey Matter Structures in Patients With Crohn’s Disease and Their Correlation With Psychological Distress☆

(2015) Chun Hui Bao et al.   Journal of Crohns & Colitis

Neuroimmune mechanisms of depression

(2015) Georgia E Hodes et al.   NATURE NEUROSCIENCE

Autonomic dysfunction and heart rate variability in depression

(2015) Andrea Sgoifo et al.   STRESS-THE INTERNATIONAL JOURNAL ON THE BIOLOGY OF STRESS

Sleep Duration Affects Risk for Ulcerative Colitis: A Prospective Cohort Study

(2014) Ashwin N. Ananthakrishnan et al.   Clinical Gastroenterology and Hepatology

Treatment with Immunosuppressive Therapy May Improve Depressive Symptoms in Patients with Inflammatory Bowel Disease

(2014) Sara Horst et al.   DIGESTIVE DISEASES AND SCIENCES

Melatonin Attenuates Dextran Sodium Sulfate Induced Colitis with Sleep Deprivation: Possible Mechanism by Microarray Analysis

(2014) Sook Hee Chung et al.   DIGESTIVE DISEASES AND SCIENCES

Physiological links between circadian rhythms, metabolism and nutrition

(2014) Jonathan D. Johnston   EXPERIMENTAL PHYSIOLOGY

Antidepressant use among paediatric patients with recent-onset inflammatory bowel disease: A nationwide case control study in Finland

(2014) Lauri J Virta et al.   JOURNAL OF PAEDIATRICS AND CHILD HEALTH

Early maternal separation: a rodent model of depression and a prevailing human condition

(2014) Jerzy Vetulani   Pharmacological Reports

A tale of two diseases: The history of inflammatory bowel disease

(2013) Daniel J. Mulder et al.   Journal of Crohns & Colitis

Antidepressant effects of TNF-α blockade in an animal model of depression

(2013) Ute Krügel et al.   JOURNAL OF PSYCHIATRIC RESEARCH

Involvement of MAPK/NF-κB Signaling in the Activation of the Cholinergic Anti-Inflammatory Pathway in Experimental Colitis by Chronic Vagus Nerve Stimulation

(2013) Peng Sun et al.   PLoS One

Effects of complete vagotomy and blockage of cell adhesion molecules on interferon-α induced behavioral changes in mice

(2012) Astrid Friebe et al.   BEHAVIOURAL BRAIN RESEARCH

Association Study of a Polymorphism in Clock GenePERIOD3and Risk of Inflammatory Bowel Disease

(2012) Gianluigi Mazzoccoli et al.   CHRONOBIOLOGY INTERNATIONAL

Brain-Gut Interactions in Inflammatory Bowel Disease

(2012) Bruno L. Bonaz et al.   GASTROENTEROLOGY

The interplay between the intestinal microbiota and the brain

(2012) Stephen M. Collins et al.   NATURE REVIEWS MICROBIOLOGY

Medication use among inflammatory bowel disease patients: excessive consumption of antidepressants and analgesics

(2012) Johanna Haapamäki et al.   SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY

Common Symptoms and Stressors Among Individuals With Inflammatory Bowel Diseases

(2011) Sunny Singh et al.   Clinical Gastroenterology and Hepatology

The Intestinal Microbiota Affect Central Levels of Brain-Derived Neurotropic Factor and Behavior in Mice

(2011) Premysl Bercik et al.   GASTROENTEROLOGY

Adoptive transfer of macrophage from mice with depression-like behavior enhances susceptibility to colitis

(2011) Jean-Eric Ghia et al.   INFLAMMATORY BOWEL DISEASES

Do Antidepressants Influence the Disease Course in Inflammatory Bowel Disease? A Retrospective Case-Matched Observational Study

(2011) J. R. Goodhand et al.   INFLAMMATORY BOWEL DISEASES

A Prospective Population-Based Study of Triggers of Symptomatic Flares in IBD

(2010) Charles N Bernstein et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

The Mammalian Circadian Timing System: Organization and Coordination of Central and Peripheral Clocks

(2010) Charna Dibner et al.   Annual Review of Physiology

Anti-inflammatory effect of vagus nerve stimulation in a rat model of inflammatory bowel disease

(2010) J. Meregnani et al.   AUTONOMIC NEUROSCIENCE-BASIC & CLINICAL

Chronic Gastrointestinal Inflammation Induces Anxiety-Like Behavior and Alters Central Nervous System Biochemistry in Mice

(2010) Premysl Bercik et al.   GASTROENTEROLOGY

A population-based study of fatigue and sleep difficulties in inflammatory bowel disease

(2010) Lesley A. Graff et al.   INFLAMMATORY BOWEL DISEASES

Reactivation of Inflammatory Bowel Disease in a Mouse Model of Depression

(2009) Jean–Eric Ghia et al.   GASTROENTEROLOGY

Sleep deprivation worsens inflammation and delays recovery in a mouse model of colitis

(2009) Yueming Tang et al.   SLEEP MEDICINE

The Effect of Hypnosis on Systemic and Rectal Mucosal Measures of Inflammation in Ulcerative Colitis

(2008) Joel E. Mawdsley et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

The Manitoba IBD Cohort Study: A Population-Based Study of the Prevalence of Lifetime and 12-Month Anxiety and Mood Disorders

(2008) John R. Walker et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

The alpha7 nicotinic acetylcholine receptor as a pharmacological target for inflammation

(2007) W J Jonge et al.   BRITISH JOURNAL OF PHARMACOLOGY