Article
Infectious Diseases
Maria E. Riccio, Tess Verschuuren, Nadine Conzelmann, Daniel Martak, Alexandre Meunier, Elena Salamanca, Mercedes Delgado, Julia Guther, Silke Peter, Julian Paganini, Romain Martischang, Julien Sauser, Marlieke E. A. de Kraker, Abdessalam Cherkaoui, Ad C. Fluit, Ben S. Cooper, Didier Hocquet, Jan A. J. W. Kluytmans, Evelina Tacconelli, Jesus Rodriguez-Bano, Stephan Harbarth
Summary: The study found that ESBL-PE positive index patients discharged from hospitals are significant sources of ESBL-PE transmission within households, particularly during the first two months after discharge. The household transmission rate of ESBL-Kp was higher than ESBL-Ec, although there were more acquisitions of ESBL-Ec. Assisting the index patient with urinary and fecal excretions increased the risk of ESBL-PE transmission.
CLINICAL MICROBIOLOGY AND INFECTION
(2021)
Article
Immunology
Judith A. Anesi, Ebbing Lautenbach, Pranita D. Tamma, Kerri A. Thom, Emily A. Blumberg, Kevin Alby, Warren B. Bilker, Alissa Werzen, Pam Tolomeo, Jacqueline Omorogbe, Lisa Pineles, Jennifer H. Han
Summary: The study identified several risk factors for ESBL-EB BSIs among solid organ transplant recipients, including prior ESBL-EB colonization, corticosteroid-containing immunosuppression regimen, corticosteroid treatment for acute rejection, and exposure to certain antibiotics. Further studies and interventions are needed to explore and address these modifiable risk factors in this population.
CLINICAL INFECTIOUS DISEASES
(2021)
Article
Infectious Diseases
Kalisvar Marimuthu, Yin Mo, Moi Lin Ling, Anastasia Hernandez-Koutoucheva, Shannon N. Fenlon, Denis Bertrand, David Chien Lye, Brenda Sze Peng Ang, Eli Perencevich, Oon Tek Ng, Ben S. Cooper, Niranjan Nagarajan, Swaine L. Chen, Timothy Barkham
Summary: This study estimated the transmission rate of carbapenemase-producing Enterobacteriaceae in households with recently hospitalized carriers. The results showed limited transmission, with further research and preventive strategies needed.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2021)
Review
Immunology
Hiroki Namikawa, Waki Imoto, Koichi Yamada, Yoshihiro Tochino, Yukihiro Kaneko, Hiroshi Kakeya, Taichi Shuto
Summary: This systematic review and meta-analysis identified predictors of mortality from extended-spectrum beta-lactamase-producing Enterobacteriaceae (ESBL-PE) bacteremia. Previous antimicrobial therapy, neutropenia, nosocomial infection, rapidly fatal underlying disease, respiratory tract infection, Pitt bacteremia score, severe sepsis, and urinary tract infection were found to be predictors of mortality. Appropriate empirical therapy was identified as a protective factor against mortality.
EMERGING MICROBES & INFECTIONS
(2023)
Article
Microbiology
Dagninet Alelign, Aschalew Kidanewold
Summary: The study identified a significant number of multidrug-resistant ES beta L and carbapenemase-producing Enterobacteriaceae in street foods, suggesting they may be a potential source of multidrug-resistant foodborne infections. Regular examinations of street food items and tracking medication resistance trends are essential.
Article
Oncology
Wubalech Temsegen, Kasahun Gorems, Mekidim Mekonnen, Diriba Fufa, Tesfaye Kassa
Summary: This study revealed alarmingly high carriage rates of ESBL and CPE among all study participants. The isolates also showed increased resistance rates to alternative drugs and had multiple antibiotic-resistant patterns. Hence, it is important to emphasize strict adherence to antimicrobial stewardship program as well as infection prevention and control practices.
CANCER MANAGEMENT AND RESEARCH
(2023)
Article
Infectious Diseases
Demissew Shenkute, Melese Hailu Legese, Berhanu Yitayew, Asaye Mitiku, Getabalew Engidaye, Saba Gebremichael, Daniel Asrat, Yimtubezinash Woldeamanuel
Summary: This study revealed a high prevalence of gastrointestinal colonization of ESBL-PE among hospitalized patients at Debre Berhan Comprehensive Hospital, with E. coli and K. pneumoniae being the predominant strains. The resistance rates to antibiotics like ampicillin were also high. History of antibiotic use, admission in neonatal intensive care unit, and presence of chronic disease were identified as independent risk factors for ESBL-PE fecal carriage.
INFECTION AND DRUG RESISTANCE
(2022)
Article
Infectious Diseases
Se Ra Shin, Seong Mi Noh, Woo Kyung Jung, Sook Shin, Young Kyung Park, Dong Chan Moon, Suk-Kyung Lim, Yong Ho Park, Kun Taek Park
Summary: The study conducted in South Korea between 2017 and 2019 identified various ESC-resistant bacterial isolates in companion animals, with predominant species being E. coli, Klebsiella, and others. These isolates displayed diversity in sequence types and resistance genes.
Article
Veterinary Sciences
Mizuki Kusumoto, Tomoki Motegi, Haruna Uno, Mizuki Yokono, Kazuki Harada
Summary: This study investigated the pharmacokinetic indices of cefmetazole (CMZ) in dogs and performed pharmacokinetic-pharmacodynamic (PK-PD) analyses using Monte Carlo Simulation (MCS). The results showed that a regimen of 40 mg/kg every 6 hours of CMZ could be a viable treatment option for dogs infected with ESBL-producing Escherichia coli and Klebsiella pneumoniae.
FRONTIERS IN VETERINARY SCIENCE
(2023)
Article
Infectious Diseases
Tushar Kumar Dey, Johanna Frida Lindahl, Ake Lundkvist, Delia Grace, Ram Pratim Deka, Rajeswari Shome, Samiran Bandyopadhyay, Naresh Kumar Goyal, Garima Sharma, Bibek Ranjan Shome
Summary: This study investigated the prevalence of beta-lactamase-producing Enterobacteriaceae in milk samples from two Indian states, revealing the presence of various prevalent beta-lactamase genes. The findings underscore the potential risk of antimicrobial-resistant bacteria in dairy products and the need for comprehensive approaches to accurately assess antibiotic resistance.
Review
Biotechnology & Applied Microbiology
Sohyun Cho, Charlene R. Jackson, Jonathan G. Frye
Summary: Surface water is a favorable environment for the accumulation and spread of antibiotic resistant bacteria, including ESBL-producing Enterobacteriaceae. The prevalence of ESBL-producing Enterobacteriaceae, particularly E. coli and K. pneumoniae, in aquatic environments worldwide poses a growing threat to public health. This review aims to explore the contamination of ESBL-producing Enterobacteriaceae in freshwater environments and understand their sources and transmission routes, as well as the factors driving their presence.
JOURNAL OF APPLIED MICROBIOLOGY
(2023)
Review
Infectious Diseases
Huan Zhang, Beibei Liang, Jin Wang, Yun Cai
Summary: This study compared the efficacy of non-carbapenem beta-lactam/beta-lactamase inhibitors (BLBLIs) with carbapenems for the treatment of UTIs caused by ESBL-PE. The results showed no significant difference in clinical success and mortality between the two treatment groups, but a slightly higher rate of microbiological success was observed in the BLBLIs group.
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
(2021)
Article
Public, Environmental & Occupational Health
Oranuch Promsuwan, Kumthorn Malathum, Atiporn Ingsathit
Summary: This study described the epidemiology of ESBL-GNB infection in kidney transplant recipients and found that ESBL carriage may be a risk factor for the development of bacteremia and other serious infections. Additionally, it highlighted the need for more stringent infection prevention and control efforts.
ANTIMICROBIAL RESISTANCE AND INFECTION CONTROL
(2023)
Article
Obstetrics & Gynecology
Inshirah Sgayer, Daniel Glikman, Raneen Abu Shqara, Maya Maimon, Hagai Rechnitzer, Lior Lowenstein, Maya Frank Wolf
Summary: This study aimed to examine the prevalence and risk factors of extended-spectrum beta-lactamase-producing Enterobacteriaceae (ESBL-E) colonization among women who delivered preterm and at term. The results showed that the colonization rate of ESBL-E was similar in both preterm and term groups, but the maternal-neonatal transmission rate was higher in the preterm group. Prematurity was identified as a risk factor for neonatal ESBL-E colonization. These findings highlight the need for further research on the cost-effectiveness of screening for maternal ESBL-E colonization in preterm labor.
INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS
(2023)
Article
Immunology
Laure Surgers, Thibault Chiarabini, Guilhem Royer, Hayette Rougier, Melanie Mercier-Darty, Dominique Decre, Nadia Valin, Paul-Louis Woerther, Jean-Winoc Decousser, Pierre-Marie Girard, Karine Lacombe, Anders Boyd
Summary: This study found that MSM receiving preexposure prophylaxis or living with HIV, as well as individuals with a higher number of sexual partners, have a higher prevalence of ESBL-E carriage. These populations may serve as important reservoirs for ESBL-E transmission. Further research is needed to understand the consequences of ESBL-E carriage in these populations and how transmission can be reduced.
CLINICAL INFECTIOUS DISEASES
(2022)
Article
Public, Environmental & Occupational Health
Romain Martischang, Anne Iten, Isabelle Arm, Mohamed Abbas, Benjamin Meyer, Sabine Yerly, Isabella Eckerle, Jacques Pralong, Julien Sauser, Jean-Claude Suard, Laurent Kaiser, Didier Pittet, Stephan Harbarth
Summary: The seroconversion proportion of hospital employees increased during the study period, especially in employees working in COVID-19 geriatrics and non-COVID-19 geriatrics wards. Nursing assistants had a significantly higher risk of seroconversion compared to office workers. Significant risk factors for seroconversion included the use of public transportation, community exposure, nosocomial COVID outbreak, and working in geriatrics wards.
INFECTION CONTROL AND HOSPITAL EPIDEMIOLOGY
(2022)
Article
Infectious Diseases
Georg Marcus Froehlich, Marlieke E. A. De Kraker, Mohamed Abbas, Olivia Keiser, Amaury Thiabaud, Maroussia Roelens, Alexia Cusini, Domenica Flury, Peter W. Schreiber, Michael Buettcher, Natascia Corti, Danielle Vuichard-Gysin, Nicolas Troillet, Julien Sauser, Roman Gaudenz, Lauro Damonti, Carlo Balmelli, Anne Iten, Andreas Widmer, Stephan Harbarth, Rami Sommerstein
Summary: This study compared in-hospital outcomes for patients with community-acquired COVID-19 and influenza in Switzerland. The results showed that COVID-19 was associated with worse outcomes, with higher in-hospital mortality and ICU admission rates compared to influenza, with the risks being about two to three times higher.
Article
Gastroenterology & Hepatology
Mohamed Abbas, Nadia Gaia, Nicolas C. Buchs, Vaihere Delaune, Myriam Girard, Diego O. Andrey, Jeremy Meyer, Jacques Schrenzel, Frederic Ris, Stephan Harbarth, Vladimir Lazarevic
Summary: This study found that there were rapid changes in the rectal microbiota following colon cancer surgery, mainly characterized by significant increases in the genus Enterococcus. There were also significant differences in the postoperative microbiome between patients who received different antimicrobial prophylaxis regimens.
Letter
Medicine, General & Internal
Niccolo Buetti, Mohamed Abbas, Walter Zingg
JAMA INTERNAL MEDICINE
(2022)
Article
Public, Environmental & Occupational Health
Stephanie J. Curtis, Asanka Rathnayaka, Fan Wu, Abdulla Al Mamun, Craig Spiers, Gordon Bingham, Colleen L. Lau, Anton Y. Peleg, Mehmet Rasit Yuce, Andrew J. Stewardson
Summary: This study developed a Bluetooth Low Energy system to monitor interactions between healthcare workers and patients in hospital settings. The pilot study supported the functionality of this system in quantifying healthcare worker proximity networks and patient close contact.
INFECTION DISEASE & HEALTH
(2022)
Review
Public, Environmental & Occupational Health
Breanne Kunstler, Skye Newton, Hayley Hill, John Ferguson, Phillipa Hore, Tari Turner
Summary: This study analyzed the efficacy of healthcare workers wearing P2/N95 respirators and surgical masks in preventing SARS-CoV-2 infection and experiencing adverse events. The results showed no significant difference in infection prevention between respirators and masks, but wearing respirators increased the likelihood of healthcare workers experiencing headaches, respiratory distress, facial irritation, and pressure-related injuries.
INFECTION DISEASE & HEALTH
(2022)
Review
Infectious Diseases
Iain J. Abbott, Trisha N. Peel, Kelly A. Cairns, Andrew J. Stewardson
Summary: This article highlights the key clinical decisions involved in the diagnosis and treatment of urinary tract infections (UTIs) in adult women, emphasizing the importance of clinical effectiveness and antimicrobial stewardship in the post-antimicrobial era. The article discusses the diagnosis and treatment of UTIs, as well as emerging areas of research in this field.
CLINICAL MICROBIOLOGY AND INFECTION
(2023)
Article
Public, Environmental & Occupational Health
Alisha Baswa, Philip L. Russo, Joseph S. Doyle, Darshini Ayton, Andrew J. Stewardson
Summary: This study describes the experiences of IPC staff in Australian hospitals during the COVID-19 pandemic. It identifies avoidable barriers to the implementation of COVID-19 infection prevention guidance, such as unstable guidelines, untimely updates, and contradictory information sources. The survey also reveals increased workload leading to difficulties in completing work and feeling burnt out.
ANTIMICROBIAL RESISTANCE AND INFECTION CONTROL
(2022)
Article
Public, Environmental & Occupational Health
M. J. Lydeamore, B. G. Mitchell, T. Bucknall, A. C. Cheng, P. L. Russo, A. J. Stewardson
Summary: This study estimates the burden of healthcare associated infections (HAIs) in Australian public hospitals using a standard international framework. The results show that there are approximately 170,574 HAIs occurring in adults admitted to public hospitals in Australia annually, resulting in 7583 deaths. Hospital acquired pneumonia is the most frequent HAI, followed by surgical site infections and urinary tract infections. The study highlights the high burden of HAIs in Australia and the need for continued investment in prevention efforts.
ANTIMICROBIAL RESISTANCE AND INFECTION CONTROL
(2022)
Article
Substance Abuse
Stephanie J. Curtis, Freya J. Langham, Mei Jie Tang, Olga Vujovic, Joseph S. Doyle, Colleen L. Lau, Andrew J. Stewardson
Summary: Validated ICD-based algorithms can effectively identify hospital admissions with IRI, and the study found an increasing trend of IRIs over the years, with skin and soft tissues infections being the most common. Developing effective ICD algorithms is crucial for passive surveillance systems, and strategies to reduce hospitalisation with IRIs should focus on early intervention and prevention.
DRUG AND ALCOHOL REVIEW
(2022)
Article
Immunology
Steven Y. C. Tong, Jocelyn Mora, Asha C. Bowen, Matthew P. Cheng, Nick Daneman, Anna L. Goodman, George S. Heriot, Todd C. Lee, Roger J. Lewis, David C. Lye, Robert K. Mahar, Julie Marsh, Anna McGlothlin, Zoe McQuilten, Susan C. Morpeth, David L. Paterson, David J. Price, Jason A. Roberts, J. Owen Robinson, Sebastiaan J. van Hal, Genevieve Walls, Steve A. Webb, Lyn Whiteway, Dafna Yahav, Joshua S. Davis
Summary: The Staphylococcus aureus Network Adaptive Platform (SNAP) trial is a multicenter international adaptive platform trial that aims to address multiple key questions in the management of S. aureus bloodstream infections. It involves over 7000 adult and child participants and commenced enrolling patients in multiple countries in 2022.
CLINICAL INFECTIOUS DISEASES
(2022)
Article
Computer Science, Information Systems
Asanka Rathnayaka, Maggie Ezzat Gaber Gendy, Fan Wu, Md Abdulla Al Mamun, Stephanie J. Curtis, Gordon Bingham, Anton Y. Peleg, Andrew J. Stewardson, Mehmet R. Yuce
Summary: Since 2020, the COVID-19 pandemic has greatly impacted the healthcare sector worldwide, especially in terms of the risk healthcare workers face due to occupational exposure. This article proposes an Internet of Things-based contact tracing system using Bluetooth low-energy devices to track interactions between healthcare workers and their time spent in patient rooms. The collected data is transmitted wirelessly and analyzed to inform infection prevention activities.
IEEE INTERNET OF THINGS JOURNAL
(2023)
Article
Medical Informatics
Ashleigh Myall, James R. Price, Robert L. Peach, Mohamed Abbas, Sid Mookerjee, Nina Zhu, Isa Ahmad, Damien Ming, Farzan Ramzan, Daniel Teixeira, Christophe Graf, Andrea Y. Weisse, Stephan Harbarth, Alison Holmes, Mauricio Barahona
Summary: This study developed a real-time machine-learning framework that incorporated dynamic patient-contact networks to predict individual hospital-onset COVID-19 infections (HOCIs). The results showed that contact networks are robust predictors of individual patient risk of HOCIs, and their integration in clinical care could enhance individualized infection prevention and early diagnosis.
LANCET DIGITAL HEALTH
(2022)
Letter
Medicine, General & Internal
Niccolo Buetti, Mohamed Abbas, Walter Zingg
JAMA INTERNAL MEDICINE
(2022)
