Cancer cell-derived 12(S)-HETE signals via 12-HETE receptor, RHO, ROCK and MLC2 to induce lymph endothelial barrier breaching

Neutrophils rapidly transit inflamed lymphatic vessel endothelium via integrin-dependent proteolysis and lipoxin-induced junctional retraction

(2015) David A. Rigby et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Neutrophils support lung colonization of metastasis-initiating breast cancer cells

(2015) Stefanie K. Wculek et al.   NATURE

Deguelin inhibits vasculogenic function of endothelial progenitor cells in tumor progression and metastasis via suppression of focal adhesion

(2015) Minh Phuong Nguyen et al.   Oncotarget

Increase in cell motility by carbon ion irradiation via the Rho signaling pathway and its inhibition by the ROCK inhibitor Y-27632 in lung adenocarcinoma A549 cells

(2014) Kazutoshi Murata et al.   JOURNAL OF RADIATION RESEARCH

cAMP signaling regulates platelet myosin light chain (MLC) phosphorylation and shape change through targeting the RhoA-Rho kinase-MLC phosphatase signaling pathway

(2013) A. Aburima et al.   BLOOD

Bay11-7082 inhibits the disintegration of the lymphendothelial barrier triggered by MCF-7 breast cancer spheroids; the role of ICAM-1 and adhesion

(2012) K Viola et al.   BRITISH JOURNAL OF CANCER

Rational Design of Small Molecule Inhibitors Targeting RhoA Subfamily Rho GTPases

(2012) Xun Shang et al.   CHEMISTRY & BIOLOGY

Myosin Light Chain Kinase Signaling in Endothelial Barrier Dysfunction

(2012) Robert R. Rigor et al.   MEDICINAL RESEARCH REVIEWS

NF-κB mediates the 12(S)-HETE-induced endothelial to mesenchymal transition of lymphendothelial cells during the intravasation of breast carcinoma cells

(2011) C Vonach et al.   BRITISH JOURNAL OF CANCER

ROCK and JAK1 Signaling Cooperate to Control Actomyosin Contractility in Tumor Cells and Stroma

(2011) Victoria Sanz-Moreno et al.   CANCER CELL

Up-regulation of 12(S)-lipoxygenase induces a migratory phenotype in colorectal cancer cells

(2011) T. Klampfl et al.   EXPERIMENTAL CELL RESEARCH

Identification of the Orphan G Protein-coupled Receptor GPR31 as a Receptor for 12-(S)-Hydroxyeicosatetraenoic Acid

(2011) Yande Guo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Lipoxygenase mediates invasion of intrametastatic lymphatic vessels and propagates lymph node metastasis of human mammary carcinoma xenografts in mouse

(2011) Dontscho Kerjaschki et al.   JOURNAL OF CLINICAL INVESTIGATION

Role of GTPases in control of microvascular permeability

(2010) V. Spindler et al.   CARDIOVASCULAR RESEARCH

Myosin light chain kinase mediates transcellular intravasation of breast cancer cells through the underlying endothelial cells: a three-dimensional FRET study

(2010) S. Khuon et al.   JOURNAL OF CELL SCIENCE

Role of 12/15-lipoxygenase in the expression of MCP-1 in mouse macrophages

(2008) Yeshao Wen et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Involvement of the BLT2receptor in the itch-associated scratching induced by 12-(S)-lipoxygenase products in ICR mice

(2008) H J Kim et al.   BRITISH JOURNAL OF PHARMACOLOGY