Article
Oncology
Vitoria Ramos Jayme, Gilton Marques Fonseca, Isaac Massaud Amim Amaral, Fabricio Ferreira Coelho, Jaime Arthur Pirola Kruger, Vagner Birk Jeismann, Rafael Soares Nunes Pinheiro, Evandro Sobroza de Mello, Paulo Herman
Summary: Infiltrative-type border in CRLM patients is associated with worse prognosis and higher intrahepatic recurrence. Larger margin size (> 1 cm) does not impact the prognosis in patients with infiltrative border, highlighting the importance of tumor biology in determining survival outcomes.
ANNALS OF SURGICAL ONCOLOGY
(2021)
Article
Medicine, Research & Experimental
Chen Li, Xu Li
Summary: The research demonstrates that circPTEN can upregulate PTEN expression by binding with miR-4470 in CRC cells, and inhibit the phosphorylation of AKT by competitively binding with TRAF6, thus suppressing the proliferation, migration, and invasion of CRC cells while promoting apoptosis.
MOLECULAR THERAPY-NUCLEIC ACIDS
(2021)
Article
Biochemistry & Molecular Biology
YuJian Xia, Jian Chen, Guangyao Liu, WeiBin Huang, XiaoJing Wei, ZheWei Wei, YuLong He
Summary: The study revealed that STIP1 is highly expressed in CRC tissues and is associated with poor overall survival. STIP1 promotes CRC cell proliferation and invasion through the STAT3 pathway, while its knockdown inhibits these functions. This suggests that STIP1 could be a potential target for CRC therapy.
CHEMICO-BIOLOGICAL INTERACTIONS
(2021)
Article
Oncology
Zhewen Zheng, Xue Zhang, Jian Bai, Long Long, Di Liu, Yunfeng Zhou
Summary: This study reveals that PGM1 plays a suppressive role in colorectal cancer, inhibiting CRC progression through the PI3K/AKT pathway. These findings suggest the potential of targeting PGM1 for the treatment of CRC.
CANCER CELL INTERNATIONAL
(2022)
Article
Multidisciplinary Sciences
Mahsa Saliani, Razieh Jalal, Ali Javadmanesh
Summary: This study analyzed the transcriptional profiles of KRAS mutant and wild-type cell lines using RNA-seq data and bioinformatics methods. The results showed that KRAS signaling is an oncogenic signature in KRAS mutant cells. Furthermore, differentially-expressed genes were found to be involved in cancer-associated signal transduction pathways. Additionally, several differentially-expressed lncRNAs potentially regulate genes in the Rap1 and RAS signaling pathways.
SCIENTIFIC REPORTS
(2022)
Article
Oncology
He Zhou, Yong Xiong, Zuoliang Liu, Songlin Hou, Tong Zhou, Yongfu Xiong
Summary: Most CBX proteins are highly expressed in CRC, but only elevated expression of CBX2 is associated with poor prognosis. In vitro experiments confirmed that knockdown of CBX2 suppresses CRC cell proliferation and invasion. These findings suggest that CBX2 may function as an oncogene and potential prognostic biomarker in CRC.
CANCER CELL INTERNATIONAL
(2021)
Article
Oncology
Farhadul Islam, Vinod Gopalan, Cu Tai Lu, Suja Pillai, Alfred K. Lam
Summary: The study revealed significant genetic alterations and functional roles of EPAS1 in colorectal carcinoma (CRC), as well as its correlation with clinicopathological parameters. The aberrations of EPAS1 in CRC cells led to reduced cell functions, indicating its potential as a therapeutic target for colorectal cancer.
Article
Cell Biology
Aling Shen, Liya Liu, Yue Huang, Zhiqing Shen, Meizhu Wu, Xiaoping Chen, Xiangyan Wu, Xiaoying Lin, Youqin Chen, Li Li, Ying Cheng, Jianfeng Chu, Thomas J. Sferra, Lihui Wei, Qunchuan Zhuang, Jun Peng
Summary: This study reveals that higher expression of HAUS6 is associated with shorter overall survival in colorectal cancer (CRC) patients. HAUS6 knockdown suppresses cell growth by inhibiting cell viability and arresting cell cycle progression through activation of the p53/p21 signaling pathway. Furthermore, combining HAUS6 knockdown with 5-FU treatment further enhances the suppression of cell proliferation in CRC cells. Targeting HAUS6 may serve as a promising novel prognostic marker and chemotherapeutic target for treating CRC patients.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Tianyi Ma, Tianyu Qiao, Ziming Yuan, Guiyu Wang, Rui Huang, Meng Wang, Hanqing Hu, Yihao Zhu, Xiaoming Zou, Xishan Wang
Summary: JAKMIP2-AS1 is significantly upregulated in colorectal cancer tissues, promoting cell proliferation and associated with poor prognosis. Inhibition of JAKMIP2-AS1 by RNAi decreases cell proliferation and hinders cell growth.
ONCOTARGETS AND THERAPY
(2021)
Article
Pathology
Lan Luan, Nanyang Li, Keyuan Zhang, Xiaojie Wang, Hai Pan
Summary: This study found that Diversin is highly expressed in colorectal cancer tissues and is significantly associated with tumor differentiation, clinical stage, and lymph node metastasis. In vitro experiments further revealed that Diversin promotes the proliferation of colorectal cancer cells through the regulation of cell cycle proteins and the JNK signaling pathway.
EXPERIMENTAL AND MOLECULAR PATHOLOGY
(2023)
Article
Oncology
Anzhong Huang, Chunzhi Qin, Mengting Wu, Dawei Zhang, Guangbin Wu, Peilong Sun
Summary: In this study, the role of ELAPOR1 in colorectal cancer (CRC) was investigated. The results showed that high levels of ELAPOR1 were associated with favorable disease-free survival and overall survival in CRC patients. Furthermore, ELAPOR1 overexpression significantly inhibited cell proliferation and invasion in vitro, indicating its inhibitory role in CRC.
Article
Multidisciplinary Sciences
Saharut Wongkaewkhiaw, Amaraporn Wongrakpanich, Sucheewin Krobthong, Witchuda Saengsawang, Arthit Chairoungdua, Nittaya Boonmuen
Summary: This study demonstrated the selective anticancer activity of fingerroot-derived nanovesicles (FDNVs) in colorectal cancer cell lines, with no toxicity to normal cells, suggesting a potential novel intervention for colorectal cancer patients by inducing apoptosis and disrupting intracellular redox homeostasis.
Article
Multidisciplinary Sciences
Elijah N. McCool, Tian Xu, Wenrong Chen, Nicole C. Beller, Scott M. Nolan, Amanda B. Hummon, Xiaowen Liu, Liangliang Sun
Summary: Understanding cancer metastasis at the proteoform level is crucial for discovering new protein biomarkers for cancer diagnosis and drug development. This study compared proteoform and single amino acid variant profiles of two colorectal cancer cell lines, revealing substantial differences and identifying differentially expressed proteoforms closely related to cancer.
Article
Oncology
Emilly Schlee Villodre, Xiaoding Hu, Bedrich L. Eckhardt, Richard Larson, Lei Huo, Ester C. Yoon, Yun Gong, Juhee Song, Shuying Liu, Naoto T. Ueno, Savitri Krishnamurthy, Stefan Pusch, Debu Tripathy, Wendy A. Woodward, Bisrat G. Debeb
Summary: This study found that NDRG1 drives tumor progression and brain metastasis in aggressive breast cancers and NDRG1-high expression correlates with worse clinical outcomes.
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE
(2022)
Article
Oncology
Hanna Elomaa, Maarit Ahtiainen, Sara A. Vaeyrynen, Shuji Ogino, Jonathan A. Nowak, Mai Chan Lau, Olli Helminen, Erkki-Ville Wirta, Toni T. Seppaelae, Jan Boehm, Jukka-Pekka Mecklin, Teijo Kuopio, Juha P. Vaeyrynen
Summary: The expression patterns and prognostic significance of PD-L1 and PD-1 in the colorectal cancer microenvironment are inadequately characterised. This study found that PD-L1(+) macrophages and PD-1(+) T cells were associated with better clinical outcomes in colorectal cancer patients. These findings enhance the understanding of immune checkpoints in the tumor microenvironment and could contribute to the development of improved immunotherapies.
BRITISH JOURNAL OF CANCER
(2023)
Article
Immunology
Niko Kemi, Olli Ylitalo, Juha P. Vayrynen, Olli Helminen, Anna Junttila, Johanna Mrena, Jan Bohm, Joonas H. Kauppila
Summary: TLS density and maximal diameter are associated with prognosis in gastric cancer, with moderate reproducibility in their assessments.
Article
Oncology
Hannah L. Williams, Andressa Dias Costa, Jinming Zhang, Srivatsan Raghavan, Peter S. Winter, Kevin S. Kapner, Scott P. Ginebaugh, Sara A. Vayrynen, Juha P. Vayrynen, Chen Yuan, Andrew W. Navia, Junning Wang, Annan Yang, Timothy L. Bosse, Radha L. Kalekar, Kristen E. Lowder, Mai Chan Lau, Dalia Elganainy, Vicente Morales-Oyarvide, Douglas A. Rubinson, Harshabad Singh, Kimberly Perez, James M. Cleary, Thomas E. Clancy, Jiping Wang, Joseph D. Mancias, Lauren K. Brais, Emma R. Hill, Margaret M. Kozak, David C. Linehan, Richard F. Dunne, Daniel T. Chang, Albert C. Koong, Aram F. Hezel, William C. Hahn, Alex K. Shalek, Andrew J. Aguirre, Jonathan A. Nowak, Brian M. Wolpin
Summary: A multiplex immunofluorescence (mIF) pipeline was developed to investigate the protein expression and intratumoral heterogeneity of pancreatic ductal adenocarcinoma (PDAC). The results showed that PDAC tumors exhibit extensive intratumoral heterogeneity, which is associated with patient outcomes and can be reduced in patient-derived organoid cultures. Co-expressor cells expressing both classical and basal markers were found in the majority of tumors, suggesting an intermediate state between subtype poles. This clinically applicable pipeline has implications for prognosis and treatment selection in PDAC patients.
Article
Endocrinology & Metabolism
Ville A. Palomaki, Petri Lehenkari, Sanna Merilainen, Tuomo J. Karttunen, Vesa Koivukangas
Summary: This case-control study analyzed the macrophage infiltration in subcutaneous adipose tissue after bariatric surgery or conservative treatment of obesity, and investigated whether these features could predict weight loss outcome. The study found a significant decline in crown-like structures (CLS) density after surgery, regardless of weight loss. However, surgery had no effect on the infiltration of single-cell macrophages, and the abundance of these macrophage populations before surgery did not predict weight loss or response to surgery.
Article
Oncology
Mehrdad Rakaee, Elio Adib, Biagio Ricciuti, Lynette M. Sholl, Weiwei Shi, Joao Alessi, Alessio Cortellini, Claudia A. M. Fulgenzi, Patrizia Viola, David J. Pinato, Sayed Hashemi, Idris Bahce, Ilias Houda, Ezgi B. Ulas, Teodora Radonic, Juha P. Vayrynen, Elin Richardsen, Simin Jamaly, Sigve Andersen, Tom Donnem, Mark M. Awad, David J. Kwiatkowski
Summary: This study developed a machine-learning-based approach to evaluate the association between tumor-infiltrating lymphocytes (TILs) and immune checkpoint inhibitor (ICI) therapy in lung cancer patients. The results showed that high levels of TILs were associated with ICI treatment response and could be used for patient selection and precision therapy guidance.
Article
Oncology
Topias Karjula, Hanna Elomaa, Anne Niskakangas, Olli Mustonen, Iiris Puro, Teijo Kuopio, Maarit Ahtiainen, Jukka-Pekka Mecklin, Toni T. Seppala, Erkki-Ville Wirta, Eero Sihvo, Juha P. Vayrynen, Fredrik Yannopoulos, Olli Helminen
Summary: The study found that CD3(+) and CD8(+) T-cell density and PD-1/PD-L1 expression have prognostic value in pulmonary metastases of colorectal cancer. T-cell infiltration is higher in pulmonary metastases compared to primary tumors. High CD3(+) and CD8(+) cell density are associated with better survival, while high PD-L1 expression is associated with favorable prognosis.
Article
Oncology
Meeri Kastinen, Paeivi Sirnio, Hanna Elomaa, Maarit Ahtiainen, Sara A. Vayrynen, Karl-Heinz Herzig, Sanna Merilainen, Raila Aro, Reetta Haivala, Tero Rautio, Juha Saarnio, Erkki-Ville Wirta, Olli Helminen, Toni T. Seppala, Teijo Kuopio, Jan Bohm, Anne Tuomisto, Jukka-Pekka Mecklin, Markus J. Makinen, Juha P. Vayrynen
Summary: This study analyzed data from 1413 patients with colorectal cancer and found associations between tumor necrosis percentage and tumor characteristics, immune cell infiltrates, serum cytokine concentrations, as well as prognosis. The results showed that high tumor necrosis percentage is associated with shorter colorectal cancer-specific survival, independent of other factors. Tumor necrosis is therefore considered an important prognostic factor in colorectal cancer.
BRITISH JOURNAL OF CANCER
(2023)
Article
Oncology
Hanna Elomaa, Maarit Ahtiainen, Sara A. Vaeyrynen, Shuji Ogino, Jonathan A. Nowak, Mai Chan Lau, Olli Helminen, Erkki-Ville Wirta, Toni T. Seppaelae, Jan Boehm, Jukka-Pekka Mecklin, Teijo Kuopio, Juha P. Vaeyrynen
Summary: The expression patterns and prognostic significance of PD-L1 and PD-1 in the colorectal cancer microenvironment are inadequately characterised. This study found that PD-L1(+) macrophages and PD-1(+) T cells were associated with better clinical outcomes in colorectal cancer patients. These findings enhance the understanding of immune checkpoints in the tumor microenvironment and could contribute to the development of improved immunotherapies.
BRITISH JOURNAL OF CANCER
(2023)
Letter
Hematology
Tero Vuolio, Outi Kuittinen, Juha P. Vayrynen, Hanna-Riikka Teppo, Roosa E. I. Prusil, Maria Ramet, Hanne Kuitunen, Timo Paloneva, Milla E. L. Kuusisto
BRITISH JOURNAL OF HAEMATOLOGY
(2023)
Article
Multidisciplinary Sciences
Liisa Petainen, Juha P. Vayrynen, Pekka Ruusuvuori, Ilkka Polonen, Sami Ayramo, Teijo Kuopio
Summary: This study proposes an automated method for estimating tumor-stroma ratio (TSR) from histopathological images of colorectal cancer using convolutional neural networks. The models achieved high accuracy in classifying stroma, tumor, and other tissues, with the best model reaching 99.3% accuracy for tumor classification. The predicted TSR values showed moderate correlation with pathologist estimations (0.57).
Article
Pathology
Topias Karjula, Anne Niskakangas, Olli Mustonen, Iiris Puro, Hanna Elomaa, Maarit Ahtiainen, Teijo Kuopio, Jukka-Pekka Mecklin, Toni T. Seppala, Erkki-Ville Wirta, Eero Sihvo, Fredrik Yannopoulos, Olli Helminen, Juha P. Vayrynen
Summary: In this study, the prognostic effect of tertiary lymphoid structures (TLSs) on colorectal cancer (CRC) pulmonary metastases and primary tumors was analyzed. The density and diameter of TLSs showed no prognostic value in pulmonary metastases, but higher density and diameter were associated with lower mortality in primary tumors.
Article
Oncology
Melissa Zhao, Mai Chan Lau, Koichiro Haruki, Juha P. Vayrynen, Carino Gurjao, Sara A. Vayrynen, Andressa Dias Costa, Jennifer Borowsky, Kenji Fujiyoshi, Kota Arima, Tsuyoshi Hamada, Jochen K. Lennerz, Charles S. Fuchs, Reiko Nishihara, Andrew T. Chan, Kimmie Ng, Xuehong Zhang, Jeffrey A. Meyerhardt, Mingyang Song, Molin Wang, Marios Giannakis, Jonathan A. Nowak, Kun-Hsing Yu, Tomotaka Ugai, Shuji Ogino
Summary: By using Bayesian additive regression trees (BART), a statistical learning technique, the study aimed to improve the prediction of prognosis for colorectal cancer by comprehensively analyzing patient-specific tumor characteristics. The BART risk model identified seven stable survival predictors and the risk stratifications based on model-predicted survival were statistically significant. BART demonstrated flexibility, interpretability, and comparable or superior performance to other machine-learning models, making it a valuable tool for prognostic stratifications in colorectal cancer patients.
NPJ PRECISION ONCOLOGY
(2023)
Article
Oncology
Topias Karjula, Niko Kemi, Anne Niskakangas, Olli Mustonen, Iiris Puro, Vesa-Matti Pohjanen, Teijo Kuopio, Hanna Elomaa, Maarit Ahtiainen, Jukka-Pekka Mecklin, Toni T. Seppala, Erkki-Ville Wirta, Eero Sihvo, Juha P. Vayrynen, Fredrik Yannopoulos, Olli Helminen
Summary: The prognostic value of tumor budding and tumor-stroma ratio (TSR) in resected pulmonary metastases of colorectal carcinoma (CRC) was evaluated in this study. The results showed that tumor budding and TSR after metastasectomy were not statistically correlated with overall survival rates, indicating no prognostic value. Further studies are needed for confirmation.
Article
Immunology
Tomotaka Ugai, Takashi Shimizu, Hidetaka Kawamura, Satoko Ugai, Yasutoshi Takashima, Genki Usui, Juha P. Vayrynen, Kazuo Okadome, Koichiro Haruki, Naohiko Akimoto, Yohei Masugi, Annacarolina da Silva, Kosuke Mima, Xuehong Zhang, Andrew T. Chan, Molin Wang, Wendy S. Garrett, Gordon J. Freeman, Jeffrey A. Meyerhardt, Jonathan A. Nowak, Mingyang Song, Marios Giannakis, Shuji Ogino
Summary: This study aimed to investigate the relationship between F. nucleatum (bacteria) and CD274 (tumor immune checkpoint) in colorectal cancer. The results showed that the expression level of tumor CD274 was inversely associated with the amount of F. nucleatum. This suggests that different immunosuppressive mechanisms are utilized by different tumor subgroups.
CLINICAL & TRANSLATIONAL IMMUNOLOGY
(2023)
Article
Gastroenterology & Hepatology
Henna Karjalainen, Paivi Sirnio, Anne Tuomisto, Markus J. J. Makinen, Juha P. P. Vayrynen
Summary: The study aimed to compare the prognostic value of a B cell/plasma cell-based scoring system and T cell score in colorectal cancer. Immunohistochemistry was used to analyze the expression of CD20, CD138, CD3, and CD8 in 221 colorectal cancer patients. The results showed that a high T cell score was associated with longer cancer-specific survival and clinicopathological factors typical to less aggressive tumors, while the additional prognostic value of B cell/plasma cell quantification was not supported.
INTERNATIONAL JOURNAL OF COLORECTAL DISEASE
(2023)
