Double-Blind Randomized Phase 3 Study Comparing Esaxerenone (CS-3150) and Eplerenone in Patients With Essential Hypertension (ESAX-HTN Study)

Efficacy and safety of esaxerenone (CS-3150) for the treatment of essential hypertension: a phase 2 randomized, placebo-controlled, double-blind study

(2019) Sadayoshi Ito et al.   JOURNAL OF HUMAN HYPERTENSION

Efficacy and Safety of Esaxerenone (CS-3150) for the Treatment of Type 2 Diabetes with Microalbuminuria

(2019) Sadayoshi Ito et al.   Clinical Journal of the American Society of Nephrology

Efficacy and safety of dosage-escalation of low-dosage esaxerenone added to a RAS inhibitor in hypertensive patients with type 2 diabetes and albuminuria: a single-arm, open-label study

(2019) Hiroshi Itoh et al.   HYPERTENSION RESEARCH

Long-term phase 3 study of esaxerenone as mono or combination therapy with other antihypertensive drugs in patients with essential hypertension

(2019) Hiromi Rakugi et al.   HYPERTENSION RESEARCH

Single- and multiple-dose escalation study to assess pharmacokinetics, pharmacodynamics and safety of oral esaxerenone in healthy Japanese subjects

(2018) Manabu Kato et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Salt, Blood Pressure, and Aldosterone in Women and Men

(2018) Friedrich C. Luft   HYPERTENSION

Biological Sex Modulates the Adrenal and Blood Pressure Responses to Angiotensin IINovelty and Significance

(2018) Mohammad Zaki Shukri et al.   HYPERTENSION

Pathophysiological mechanisms of mineralocorticoid receptor-dependent cardiovascular and chronic kidney disease

(2018) Akira Nishiyama   HYPERTENSION RESEARCH

Resistant Hypertension and the Pivotal Role for Mineralocorticoid Receptor Antagonists: A Clinical Update 2016

(2016) Murray Epstein et al.   AMERICAN JOURNAL OF MEDICINE

The Effects of Aldosterone Antagonists in Patients With Resistant Hypertension: A Meta-Analysis of Randomized and Nonrandomized Studies

(2015) Khagendra Dahal et al.   AMERICAN JOURNAL OF HYPERTENSION

Nonsteroidal antagonists of the mineralocorticoid receptor

(2015) Peter Kolkhof et al.   CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION

CS-3150, a novel non-steroidal mineralocorticoid receptor antagonist, prevents hypertension and cardiorenal injury in Dahl salt-sensitive hypertensive rats

(2015) Kiyoshi Arai et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Spironolactone versus placebo, bisoprolol, and doxazosin to determine the optimal treatment for drug-resistant hypertension (PATHWAY-2): a randomised, double-blind, crossover trial

(2015) Bryan Williams et al.   LANCET

The Japanese Society of Hypertension Guidelines for the Management of Hypertension (JSH 2014)

(2014)   HYPERTENSION RESEARCH

Efficacy and safety of eplerenone in the management of mild to moderate arterial hypertension: Systematic review and meta-analysis

(2014) Francesco Pelliccia et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

2013 ESH/ESC Guidelines for the management of arterial hypertension

(2013)   EUROPEAN HEART JOURNAL

Mineralocorticoid Receptor-Associated Hypertension and Its Organ Damage: Clinical Relevance for Resistant Hypertension

(2012) H. Shibata et al.   AMERICAN JOURNAL OF HYPERTENSION

Incidence and Prognosis of Resistant Hypertension in Hypertensive Patients

(2012) Stacie L. Daugherty et al.   CIRCULATION

Gender Differences in the Effects of Angiotensin Receptor Blockers on Cardiovascular Disease

(2012) Hiroshi Yoshida et al.   CURRENT PHARMACEUTICAL DESIGN

Spironolactone, eplerenone and the new aldosterone blockers in endocrine and primary hypertension

(2012) GianLuca Colussi et al.   JOURNAL OF HYPERTENSION

Efficacy, safety and tolerability of aliskiren, a direct renin inhibitor, in women with hypertension: a pooled analysis of eight studies

(2010) A H Gradman et al.   JOURNAL OF HUMAN HYPERTENSION

Treatment of resistant hypertension

(2010) Eduardo Pimenta et al.   JOURNAL OF HYPERTENSION

A randomized, double-blind, four-arm parallel-group study of the efficacy and safety of azelnidipine and olmesartan medoxomil combination therapy compared with each monotherapy in Japanese patients with essential hypertension: the REZALT study

(2009) Toshio Ogihara et al.   HYPERTENSION RESEARCH

Resistant Hypertension: Diagnosis, Evaluation, and Treatment

(2008) David A. Calhoun et al.   HYPERTENSION

Blood Pressure Control in Patients With Comorbidities

(2008) Roland E. Schmieder et al.   Journal of Clinical Hypertension

Effectiveness of the selective aldosterone blocker, eplerenone, in patients with resistant hypertension

(2008) David A. Calhoun et al.   Journal of the American Society of Hypertension