Leptin Restores Endothelial Function via Endothelial PPARγ-Nox1–Mediated Mechanisms in a Mouse Model of Congenital Generalized Lipodystrophy

Metreleptin-mediated improvements in insulin sensitivity are independent of food intake in humans with lipodystrophy

(2018) Rebecca J. Brown et al.   JOURNAL OF CLINICAL INVESTIGATION

Effects of Metreleptin in Pediatric Patients With Lipodystrophy

(2017) Rebecca J. Brown et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Leptin Induces Hypertension and Endothelial Dysfunction via Aldosterone-Dependent Mechanisms in Obese Female MiceNovelty and Significance

(2016) Anne-Cécile Huby et al.   HYPERTENSION

Adipocyte-Derived Hormone Leptin Is a Direct Regulator of Aldosterone Secretion, Which Promotes Endothelial Dysfunction and Cardiac FibrosisCLINICAL PERSPECTIVE

(2015) Anne-Cécile Huby et al.   CIRCULATION

Obesity-Induced Hypertension: Interaction of Neurohumoral and Renal Mechanisms

(2015) J. E. Hall et al.   CIRCULATION RESEARCH

Leptin and the brain: then and now

(2013) Michael W. Schwartz et al.   JOURNAL OF CLINICAL INVESTIGATION

Leptin Potentiates Endothelium-Dependent Relaxation by Inducing Endothelial Expression of Neuronal NO Synthase

(2012) Sebastian Benkhoff et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Berardinelli-Seip Congenital Lipodystrophy 2/Seipin Is a Cell-Autonomous Regulator of Lipolysis Essential for Adipocyte Differentiation

(2012) W. Chen et al.   MOLECULAR AND CELLULAR BIOLOGY

Restoring leptin signaling reduces hyperlipidemia and improves vascular stiffness induced by chronic intermittent hypoxia

(2011) Ronghua Yang et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Adiponectin Is Required for PPARγ-Mediated Improvement of Endothelial Function in Diabetic Mice

(2011) Wing Tak Wong et al.   Cell Metabolism

Clinical Effects of Long-Term Metreleptin Treatment in Patients with Lipodystrophy

(2011) Jean Chan et al.   Endocrine Practice

Impact of Leptin-Mediated Sympatho-Activation on Cardiovascular Function in Obese Mice

(2011) Eric J. Belin de Chantemèle et al.   HYPERTENSION

Obesity-induced Hypertension: Role of Sympathetic Nervous System, Leptin, and Melanocortins

(2010) John E. Hall et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Leptin Inhibits the Proliferation of Vascular Smooth Muscle Cells Induced by Angiotensin II through Nitric Oxide-Dependent Mechanisms

(2010) Amaia Rodríguez et al.   MEDIATORS OF INFLAMMATION

Lipodystrophy: pathophysiology and advances in treatment

(2010) Christina G. Fiorenza et al.   Nature Reviews Endocrinology

Protein Tyrosine Phosphatase 1B, a Major Regulator of Leptin-Mediated Control of Cardiovascular Function

(2009) Eric J. Belin de Chantemèle et al.   CIRCULATION

The Human Lipodystrophy Gene Product Berardinelli-Seip Congenital Lipodystrophy 2/Seipin Plays a Key Role in Adipocyte Differentiation

(2009) Weiqin Chen et al.   ENDOCRINOLOGY

The Effects of Recombinant Human Leptin on Visceral Fat, Dyslipidemia, and Insulin Resistance in Patients with Human Immunodeficiency Virus-Associated Lipoatrophy and Hypoleptinemia

(2009) Kathleen Mulligan et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Paradoxical Activation of Endothelial Nitric Oxide Synthase by NADPH Oxidase

(2008) Qian Zhang et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Leptin and Cardiovascular Disease

(2008) Kwang Kon Koh et al.   CIRCULATION

Severe cardiac phenotype of Berardinelli-Seip congenital lipodystrophy in an infant with homozygous E189X BSCL2 mutation

(2008) B. Friguls et al.   European Journal of Medical Genetics