Article
Agriculture, Multidisciplinary
Jian Bao, Zheng Liang, Xiaokang Gong, Yanna Zhao, Mengjuan Wu, Wei Liu, Chenyu Tu, Xiaochuan Wang, Xiji Shu
Summary: This study found that Tangeretin (TAN) exhibits antidementia activity in APPswe/PSEN1dE9 transgenic mice, reducing cognitive impairment, synaptic impairments, and beta-amyloid accumulations. TAN also showed powerful inhibitory activity against beta-secretase, suggesting it as a potential drug for preventing Alzheimer's disease pathology.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2022)
Article
Neurosciences
Suzanne D. Lanooij, W. H. I. M. Drinkenburg, U. L. M. Eisel, E. A. van der Zee, Martien J. H. Kas
Summary: Social factors are linked to the risk of developing Alzheimer's Disease. Social housing conditions have a significant effect on amyloid plaques and microglia, particularly in certain genotypes.
NEUROBIOLOGY OF DISEASE
(2023)
Article
Biochemistry & Molecular Biology
Lidia Castillo-Mariqueo, M. Jose Perez-Garcia, Lydia Gimenez-Llort
Summary: The study on the 3xTg-AD mouse model reveals significant functional impairments in gait and exploratory activity in patients with Alzheimer's disease, which worsen with disease severity and aging. This indicates the potential for using the ICF framework in rehabilitation and understanding of functional decline in AD patients.
Article
Behavioral Sciences
Chun Wang, Wen-Rui Gao, Jing Yin, Zhao-Jun Wang, Jin-Shun Qi, Hong-Yan Cai, Mei-Na Wu
Summary: The study found that chronic sleep deprivation significantly exacerbated cognitive impairments in APP/PS1 mice by accelerating the development of AD pathologies, reducing the expression of PSD95, and aggravating LTP suppression in the hippocampus. At the same time, chronic sleep deprivation also impaired cognitive functions and synaptic plasticity in wild type mice by down-regulating the level of PSD95 and activating microglia. These findings clarify the electrophysiological and molecular mechanisms of exacerbated cognitive deficits in AD caused by chronic sleep deprivation.
BEHAVIOURAL BRAIN RESEARCH
(2021)
Article
Nutrition & Dietetics
Yacoubou Abdoul Razak Mahaman, Jun Feng, Fang Huang, Maibouge Tanko Mahamane Salissou, Jianzhi Wang, Rong Liu, Bin Zhang, Honglian Li, Feiqi Zhu, Xiaochuan Wang
Summary: Alzheimer's disease is a global health problem with no effective single therapy. Nutraceutical agents like Moringa oleifera (MO), which have multiple effects, show promise in treating AD. This study found that MO treatment improved behavioral and cognitive deficits, reduced A beta burden, and improved synaptic plasticity and neurodegeneration in AD mice.
Article
Immunology
Jia-Mei Li, Ting Hu, Xiao-Na Zhou, Ting Zhang, Jia-Hui Guo, Min-Yuan Wang, Yi-Lin Wu, Wen-Jun Su, Chun-Lei Jiang
Summary: Inhibiting NLRP3 inflammasome expression can improve depressive-like behaviors in mice and this study aimed to understand its impact on cognitive decline in depression and explore the common neuro-immunological mechanisms of depression and Alzheimer's disease (AD).
JOURNAL OF NEUROINFLAMMATION
(2023)
Review
Neurosciences
Christopher Daniel Morrone, Radha Raghuraman, S. Abid Hussaini, Wai Haung Yu
Summary: Failed proteostasis, reduced protein degradation and clearance, is a well-documented feature in Alzheimer's disease. The contribution of failed proteostasis to neuronal circuit dysfunction and cognitive decline is an emerging concept in neurodegenerative research. This study highlights the bidirectional relationship between sleep disruption and proteostasis failure in Alzheimer's disease progression, where sleep loss impairs protein clearance and disrupted proteostasis further impairs sleep, ultimately leading to memory impairments.
MOLECULAR NEURODEGENERATION
(2023)
Article
Geriatrics & Gerontology
Nienke Legdeur, Maryam Badissi, Maqsood Yaqub, Nina Beker, Carole H. Sudre, Mara ten Kate, Mark Forrest Gordon, Gerald Novak, Frederik Barkhof, Bart N. M. van Berckel, Henne Holstege, Majon Muller, Philip Scheltens, Andrea B. Maier, Pieter Jelle Visser
Summary: In individuals aged 90 years and older, factors such as handgrip strength, physical performance, nutritional status, WMH, hippocampal atrophy, and amyloid binding are associated with cognitive impairment. Physical performance may affect cognition through hippocampal atrophy. This study emphasizes the importance of considering multiple factors when assessing cognition in the oldest-old.
JOURNALS OF GERONTOLOGY SERIES B-PSYCHOLOGICAL SCIENCES AND SOCIAL SCIENCES
(2021)
Article
Neurosciences
Donna J. Cross, Bertrand R. Huber, Michael A. Silverman, Marcella M. Cline, Trevor B. Gill, Chloe G. Cross, David G. Cook, Satoshi Minoshima
Summary: Intranasally administered microtubule-stabilizing drugs, specifically paclitaxel, have shown promise in altering the phenotypic progression of Alzheimer's disease in 3xTg-AD mice. These drugs can increase axonal transport rates, reduce phospho-tau containing neurons, improve performance in behavioral tests, and decrease anxiety-related behaviors.
JOURNAL OF ALZHEIMERS DISEASE
(2021)
Article
Neurosciences
Feng Zhang, Long Niu, Rujia Zhong, Song Li, Weidong Le
Summary: Sleep disturbances are common non-cognitive symptoms of Alzheimer's disease (AD), and they may contribute to the pathogenesis of this disease. This study found that chronic sleep deprivation (CSD) caused sleep disturbances and increased tau phosphorylation in AD mice. This alteration may be associated with the epigenetic modification of tau kinase gene.
JOURNAL OF ALZHEIMERS DISEASE
(2023)
Article
Biochemistry & Molecular Biology
Xuexia Li, Linfeng Le, Qingqing Shi, Hao Xu, Chao Wang, Yufang Xiong, Xun Wang, Guoli Wu, Qiong Liu, Xiubo Du
Summary: The pathogenesis of Alzheimer's disease (AD) is complex and multifactorial. Tau pathology is more related to clinical symptoms and severity of AD compared to A beta. The interaction between Zn2+ and tau plays a role in tau toxicity, but the mechanism is not fully understood.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Clinical Neurology
Eun-Hye Lee, Hyuk Sung Kwon, Seong-Ho Koh, Seong Hye Choi, Jeong-Hwa Jin, Jee Hyang Jeong, Jae-Won Jang, Kyung Won Park, Eun-Joo Kim, Hee Jin Kim, Jin Yong Hong, Soo Jin Yoon, Bora Yoon, Ju-Hee Kang, Jong-Min Lee, Hyun-Hee Park, Jungsoon Ha
Summary: This study found that higher serum NFL levels are associated with increased risk of cognitive stage transition in both mild cognitive impairment (MCI) and cognitively unimpaired (CU) participants. Serum NFL levels are negatively correlated with cortical thickness in the brain.
ALZHEIMERS RESEARCH & THERAPY
(2022)
Article
Neurosciences
Suzanne Lam, Fanny Petit, Anne-Sophie Herard, Susana Boluda, Sabiha Eddarkaoui, Martine Guillermier, Luc Buee, Charles Duyckaerts, Stephane Haik, Jean-Luc Picq, Marc Dhenain
Summary: The transmission of tau pathology by human brain extracts inoculations in primates has been experimentally demonstrated for the first time. Widespread A beta and tau pathologies can be associated with cognitive decline. The study highlights the importance of systematic monitoring for individuals at risk of iatrogenic transmission of A beta and tau.
ACTA NEUROPATHOLOGICA COMMUNICATIONS
(2021)
Article
Cell Biology
Jing Liu, Zongren Hou, Jun Wu, Kailun Liu, Da Li, Tingting Gao, Wenjing Liu, Bin An, Yun Sun, Fan Mo, Liu Wang, Yukai Wang, Jie Hao, Baoyang Hu
Summary: The study demonstrated that peripheral administration of IMRCs significantly improved cognitive deficits in early-stage AD mice through tail vein injection, while no significant changes were observed in the ICV group. IMRCs inhibited inflammatory responses and reduced microglial activation in vivo.
CELL PROLIFERATION
(2021)
Article
Biochemistry & Molecular Biology
Xia Zhao, Xiaosu Huang, Chao Yang, Yizhou Jiang, Wenshu Zhou, Wenhua Zheng
Summary: The abnormal immune response in Alzheimer's disease can be improved by regulating microglial activation and neuroinflammation using Artemisinin.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Nanoscience & Nanotechnology
Qiulan Li, Dezhi Yang, Qinhong Yin, Wanyi Li, Yaling Yang
Summary: The g-C3N4/Cu-CDs nanocomposite exhibits both peroxidase-like and oxidase-like activities, and has the potential to be used as a green catalyst for the degradation of phenolic pollutants, as well as for quantitative detection of total phenolic substances.
ACS APPLIED NANO MATERIALS
(2022)
Article
Environmental Sciences
Lei King, Yue Huang, Tao Li, Qiang Wang, Wanyi Li, Zhilei Shan, Jiawei Yin, Liangkai Chen, Pei Wang, Changchang Dun, Litao Zhuang, Xiaolin Peng, Liegang Liu
Summary: Higher levels of urinary perchlorate, thiocyanate, and their co-occurrence are associated with increased central thyroid hormones sensitivity among US general adults.
ENVIRONMENT INTERNATIONAL
(2022)
Article
Neurosciences
Wan-yi Li, Jun-yan Gao, Su-Yang Lin, Shao-tao Pan, Biao Xiao, Yu-tao Ma, Kai Xie, Wei Shen, Zhi-tao Liu, Guang-yu Li, Jie-jie Guo, Qin-wen Wang, Li-ping Li
Summary: This study investigated the effect of multifactor intervention on a mouse model of Alzheimer's disease (AD), and found that it can promote neurogenesis, improve cognitive impairment and behavioral abnormalities, and affect the expression of related proteins and serum metabolites. These findings suggest that multifactor intervention may be a non-invasive therapeutic strategy for AD.
MOLECULAR NEUROBIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Zhi-tao Liu, Yu-tao Ma, Shao-tao Pan, Kai Xie, Wei Shen, Su-Yang Lin, Jun-yan Gao, Wan-yi Li, Guang-yu Li, Qin-wen Wang, Li-ping Li
Summary: Aerobic interval exercise can ameliorate cognitive impairment and behavioral problems in a mouse model of AD, while promoting adult neurogenesis and improving levels of neurons and astrocytes. The exercise also affects serum metabolites and proteins related to lipid and amino acid metabolism, as well as neurotransmitters.
NEUROCHEMISTRY INTERNATIONAL
(2022)
Article
Computer Science, Artificial Intelligence
Yuxin Sun, Li Su, Yongkang Luo, Hao Meng, Wanyi Li, Zhi Zhang, Peng Wang, Wen Zhang
Summary: Instance segmentation technology plays an important role in the visual perception of marine scenes, especially for the development of unmanned ships. However, there is currently a lack of suitable open-source datasets. To address this issue, a dataset called MariShipInsSeg, consisting of 4k high-quality visible light marine ship images with 8,413 instances, was collected and labeled. A new method called Global Mask R-CNN (GM R-CNN) was proposed, which achieved state-of-the-art performance in ship instance segmentation.
Article
Environmental Sciences
Lei King, Qiang Wang, Lili Xia, Pei Wang, Guanhua Jiang, Wanyi Li, Yue Huang, Xiaoling Liang, Xiaolin Peng, Yonggang Li, Liangkai Chen, Liegang Liu
Summary: This study investigated the associations between environmental exposure to perchlorate, nitrate, and thiocyanate, and markers of thyroid function in the Chinese population. The results showed that perchlorate exposure was associated with changes in thyroid function markers. Nitrate and thiocyanate exposure were also associated with thyroid function. This study provides evidence on the environmental exposure and thyroid function in the Chinese population.
ENVIRONMENT INTERNATIONAL
(2023)
Article
Engineering, Environmental
Lingzhan Miao, Wanyi Li, Tanveer M. Adyel, Yu Yao, Ye Deng, Jun Wu, Yongqiang Zhou, Yue Yu, Jun Hou
Summary: Plastics in the environment create a unique microorganism habitat called the plastisphere. This study investigates the microbial communities in the plastisphere and their ability to biodegrade non-biodegradable and biodegradable plastics. The results show that biodegradable plastics have higher degradation rates and trigger faster succession of the plastisphere compared to non-biodegradable plastics. Ecological networks reveal that biodegradable plastics attract and retain key microorganisms that enhance biodegradation in freshwater ecosystems.
Article
Agronomy
Haipeng Zhang, Fuxing Liao, Wanyi Li, Yunlong Li, Shuo Yang, Hongcheng Zhang, Yanju Yang, Yuhua Shan
Summary: Nitrification in the rhizosphere plays a crucial role in controlling nitrogen-use efficiency in flooded paddy soils. The study found that the nitrification rate in the rhizosphere soil affects rice yield, biomass, and NUE, as well as denitrification losses.
FOOD AND ENERGY SECURITY
(2023)
Article
Plant Sciences
Shou-Jia Wang, Wen Ye, Wan-Yi Li, Wen Tian, Meng Zhang, Yang Sun, Ying-Da Feng, Chen-Xu Liu, Shao-Yuan Liu, Wei Cao, Jing-Ru Meng, Xiao-Qiang Li
Summary: This study explores the therapeutic effects of Xiaochaihu Tang (XCHT) on liver fibrosis and its underlying molecular mechanisms through network pharmacology and experimental research. Results show that XCHT can alleviate liver fibrosis, improve liver function, protect hepatocytes, inhibit HSC activation, and reduce hepatic collagen accumulation. Network analysis also identifies core targets and pathways of XCHT, which are validated through in vitro experiments.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Article
Engineering, Environmental
Wanyi Li, Lingzhan Miao, Tanveer M. Adyel, Jun Wu, Yue Yu, Jun Hou
Summary: Recently, biodegradable plastics (BPs) have emerged as a sustainable alternative to traditional plastics. However, studies on the biodegrading capacity of BPs and traditional plastics within the plastisphere are still limited.
JOURNAL OF HAZARDOUS MATERIALS
(2023)
Article
Computer Science, Information Systems
Yunqian He, Zhi Zhang, Zhe Wang, Yongkang Luo, Li Su, Wanyi Li, Peng Wang, Wen Zhang
Summary: Existing point cloud classification researches are usually conducted on complete and semantically clear datasets. However, in real point cloud scenes, occlusion and truncation can affect classification performance by destroying object completeness. To address this issue, we propose an incomplete point cloud classification network (IPC-Net) that utilizes data augmentation and similarity measurement. IPC-Net learns feature representation of incomplete point clouds and semantic differences compared to complete ones for improved classification. Experimental results validate the ability of IPC-Net to classify incomplete point clouds and enhance the robustness of point cloud classification under varying completeness levels.
JOURNAL OF VISUAL COMMUNICATION AND IMAGE REPRESENTATION
(2023)
Article
Endocrinology & Metabolism
Qiyao Wang, Chenglong Xia, An Zhu, Yongjie Bao, Jiani Lu, Yuan Chen, Jiayi Xu, Binbin Wang, C. Benjamin Naman, Liping Li, Qinwen Wang, Hao Liu, Hongze Liang, Wei Cui
Summary: Alzheimer's disease (AD) is a common neurodegenerative disorder caused by the overproduction of Aβ and the hyperphosphorylation of tau. This study used quantitative phosphoproteomics analysis to evaluate protein phosphorylation in AD mouse models. The results showed that Aβ and tau induce different phosphorylation profiles, affecting synapses and microtubules, respectively.
METABOLIC BRAIN DISEASE
(2023)
Article
Computer Science, Information Systems
Li Su, Yusheng Chen, Hao Song, Wanyi Li
Summary: The field of computer vision has found application in various fields and scenarios, particularly in the shipping industry which holds significant position in global trade. As ship intelligence advances, tasks such as detection, tracking, segmentation, and classification of specific targets become increasingly important. Publicly available datasets serve as the foundation for advancing research in shipping. In this paper, we provide a systematic review of maritime datasets for maritime perception, comparing them based on data type, environment, ground truth, and applicable research directions. The aim is to assist researchers in quickly identifying the most suitable dataset for their work.
MULTIMEDIA TOOLS AND APPLICATIONS
(2023)
Article
Nanoscience & Nanotechnology
Huojiao Sun, Jie Wang, Zong Xu, Ke Tang, Wanyi Li
Summary: Fiber optic sensors are commonly used as acoustic sensors to detect sound waves due to their advantages, including anti-electromagnetic interference and strong environmental adaptability. By using a simple model, the principle of the optical fiber sensor to detect acoustic wave signals was explored, and it was found that the change in birefringence of the fiber can only be effectively caused by the acoustic wave when the number of azimuthal modes is 2. The acoustic wave was successfully detected using a fiber sensor. By analyzing the detection mechanism, it was found that the spectral width is proportional to the acoustic impedance of the surrounding medium, and the acoustic interaction between the TR22 mode and the surrounding medium is much weaker than that of the TR21 mode. This provides a theoretical basis for the detection of acoustic signals by fiber optic sensors.
Article
Multidisciplinary Sciences
Wanyi Li, Wei Wei, Peng Wang
Summary: The article introduces a neuro-inspired approach for improving the grasping capability of anthropomorphic robots through continuous learning. The proposed NICAG approach combines a framework for continual learning and a neuro-inspired algorithm, achieving better continual learning with reduced loss and forgetting, as well as higher grasping success rate.
