Article
Zoology
Michele M. Mulholland, Chet C. Sherwood, Steven J. Schapiro, Mary Ann Raghanti, William D. Hopkins
Summary: Research has shown that chimpanzees, like humans, experience age-related declines in cognitive function and motor skills. Older chimpanzees with higher cognitive scores than expected have greater gray matter volume in many brain regions compared to those with lower scores. This suggests that cognitive health in aging chimpanzees is associated with differences in brain structure.
AMERICAN JOURNAL OF PRIMATOLOGY
(2021)
Article
Neurosciences
Jiayan Liu, Yahui Lei, Yuyao Diao, Yamei Lu, Xingbo Teng, Qingting Chen, Lian Liu, Jingxiang Zhong
Summary: This study investigates the morphological alterations in gray matter volume (GMV) in form-deprivation myopia (FDM) rats using voxel-based morphometry (VBM) method. The results show that compared to the normal controls, the FDM group exhibits significantly decreased GMVs in the left primary visual cortex, left secondary visual cortex, right subiculum, right cornu ammonis, right entorhinal cortex, and bilateral molecular layer of the cerebellum, while significantly increased GMVs were found in the right dentate gyrus, parasubiculum, and olfactory bulb.
FRONTIERS IN NEUROSCIENCE
(2023)
Article
Neurosciences
Chaofan Sui, Hongwei Wen, Jingchao Han, Tao Chen, Yian Gao, Yuanyuan Wang, Linfeng Yang, Lingfei Guo
Summary: This study investigated the effects of chronic hypertension with superimposed preeclampsia on the structure and function of the human brain. It found that CHTN-PE patients showed significantly decreased gray matter volume (GMV) in the right middle temporal gyrus compared to the non-pregnant and pregnant healthy controls. This GMV decrease may be related to the decline in cognitive function in CHTN-PE patients.
FRONTIERS IN NEUROSCIENCE
(2023)
Article
Neurosciences
Sebastien Celle, Claire Boutet, Cedric Annweiler, Romain Ceresetti, Vincent Pichot, Jean-Claude Barthelemy, Frederic Roche
Summary: This study found that leukoaraiosis is associated with gray matter defects and reduced cognitive performance in healthy older adults. Specifically, leukoaraiosis in the middle temporal gyrus, right medial frontal gyrus, and left parahippocampal gyrus is associated with decreased gray matter. In addition, leukoaraiosis is also associated with decreased performances in memory recall, executive functioning, and depression.
FRONTIERS IN NEUROSCIENCE
(2022)
Review
Clinical Neurology
Xiang Huang, Junyu Lin, Huifang Shang, Jing Yang
Summary: In this study, a meta-analysis was conducted to investigate gray matter changes in patients with idiopathic dystonia. The results showed consistent widespread gray matter abnormalities in various brain regions. These abnormalities were shared among different subtypes of idiopathic dystonia and were not limited to the corticostriatal circuits.
JOURNAL OF NEUROLOGY
(2022)
Article
Clinical Neurology
Yahui Liu, Jiajia Zhang, Meng Zhang, Xianrui Li, Kun Li, Bi Wang, Yongfeng Yang, Ruize Song, Yajing Si, Tianjun Ni, Xueke Wang, Yibo Geng, Qiaohua Chang, Haisan Zhang, Zhijun Zhang, Hongxing Zhang
Summary: This study found that patients with major depressive disorders have abnormalities in the frontal-limbic structures of the brain, specifically decreased gray matter volume in the right middle frontal and precentral gyri. Childhood trauma may be a contributing factor to these structural abnormalities and increased susceptibility to depression.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Review
Psychiatry
Lei Li, Hua Yu, Ming Zhong, Siyi Liu, Wei Wei, Yajing Meng, Ming-li Li, Tao Li, Qiang Wang
Summary: This study used a meta-analysis approach to investigate brain structural changes in overweight and obese individuals. The results indicated lower gray matter volume in certain brain regions compared to lean controls. Furthermore, the study found a negative correlation between gray matter volume and BMI.
FRONTIERS IN PSYCHIATRY
(2022)
Article
Neuroimaging
Alessandro Miola, Nicolo Trevisan, Arcangelo Merola, Francesco Folena Comini, Daniele Olivo, Matteo Minerva, Silvia Valeggia, Tommaso Toffanin, Angela Favaro, Renzo Manara, Fabio Sambataro
Summary: This study reported widespread gray matter volume alterations in bipolar disorder patients. BD-I showed different GMV features compared to controls, which were associated with illness severity and cognitive function performance. The impaired prefrontal-temporal-occipital network structure was related to deficits in visuospatial processing and emotional processing in BD-I patients.
BRAIN IMAGING AND BEHAVIOR
(2022)
Article
Engineering, Biomedical
Cansel Ficici, Ziya Telatar, Osman Erogul
Summary: A method analyzing gray matter reduction in brain magnetic resonance images was proposed to identify epileptogenic focus of temporal lobe epilepsy (TLE) patients. Experimental results showed that the proposed algorithm can reveal subtle Gray matter reduction in the temporal lobe and limbic lobe areas, thus providing an automated medical support system for the expert in identifying the epileptic focus of TLE patients.
BIOMEDICAL SIGNAL PROCESSING AND CONTROL
(2023)
Article
Substance Abuse
Deokjong Lee, Woojin Kim, Jung Eun Lee, Jung Han Lee, Yun Tae Kim, Seung Koo Lee, Sung Soo Oh, Ki Soo Park, Sang Baek Koh, Changsoo Kim, Young-Chul Jung
Summary: The study found that heavy alcohol use among firefighters is associated with lower gray matter volume in core brain regions such as the thalamus and insula. As alcohol consumption increases, the volume of gray matter in the right thalamus decreases. These findings suggest a need for concern regarding heavy alcohol use and its impact on cognitive and behavioral control among firefighters.
DRUG AND ALCOHOL DEPENDENCE
(2021)
Article
Anatomy & Morphology
Firat Soylu, Kaitlyn May, Rajesh Kana
Summary: This study investigated white matter volume and gray matter volume differences between autistic and nonautistic samples, and their relationships with age and theory of mind (ToM) skills. The results showed widespread differences in both gray and white matter volumes between the two groups in regions crucial for social processes. The autistic group exhibited different correlations between age and structural changes compared to the nonautistic group, suggesting abnormalities in developmental structural changes. Additionally, differences were found in how gray and white matter volumes relate to ToM skills, particularly in the left frontal regions and cingulate/corpus callosum, respectively. The left insula was identified as a crucial region distinguishing ToM performance between the two groups.
BRAIN STRUCTURE & FUNCTION
(2023)
Article
Clinical Neurology
Reuben Heyman-Kantor, Mina Rizk, M. Elizabeth Sublette, Harry Rubin-Falcone, Yashar Yousefzadeh Fard, Ainsley K. Burke, Maria A. Oquendo, Gregory M. Sullivan, Matthew S. Milak, Francesca Zanderigo, J. John Mann, Jeffrey M. Miller
Summary: The study found that BI scores were inversely correlated with GMV in unmedicated subjects with MDD and BD, but these correlations appeared to be driven by categorical diagnosis.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Review
Neurosciences
Teng Ma, Yuan-Yuan Ji, Lin-Feng Yan, Jia-Ji Lin, Ze-Yang Li, Wen Wang, Jin-Lian Li, Guang-Bin Cui
Summary: Gray matter volume (GMV) alteration in specific brain regions is associated with chronic pain comorbid depression. This study aims to explore the characteristic brain regions using voxel-based morphometry (VBM) studies on GMV alteration between chronic pain patients with depressive symptoms (CP-D) and healthy controls (HCs). The results show robust and reproducible GMV abnormalities in specific brain areas, suggesting their significant involvement in this comorbidity disease.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Neuroimaging
Mandy Pirlich, Cathleen Hoefer, Christopher M. Weise, Anika Stockert, Angelika Thoene-Otto, Alexander Garthe, Stefan Schob, Joseph Classen, Karl-Titus Hoffmann, Dorothee Saur
Summary: After TGA, patients may show increased hippocampal GMV, but only subtle neurocognitive deficits are detected, without signs of hippocampal microstructural damage.
NEUROIMAGE-CLINICAL
(2021)
Article
Neurosciences
Xia Zhe, Xiaoling Zhang, Li Chen, Li Zhang, Min Tang, Dongsheng Zhang, Longchao Li, Xiaoyan Lei, Chenwang Jin
Summary: This study found that patients with vestibular migraine show structural alterations in areas associated with pain and vestibular processing, as well as changes in resting-state functional connectivity in these regions. Reduced gray matter volume in the left parietoinsular vestibular cortex was negatively correlated with Dizziness Handicap Inventory score in patients, and increased functional connectivity was observed between the left primary somatosensory cortex/inferior parietal lobule and the left PIVC in patients with vestibular migraine.
FRONTIERS IN NEUROSCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Chen Xue, Haiting Sun, Yingying Yue, Siyu Wang, Wenzhang Qi, Guanjie Hu, Honglin Ge, Qianqian Yuan, Jiang Rao, Lei Tian, Chaoyong Xiao, Jiu Chen
Summary: The salience network (SN) is disrupted in patients with subjective cognitive decline (SCD) and amnestic mild cognitive impairment (aMCI), with changes in gray matter volume, spontaneous brain activity, and functional connectivity. These alterations are closely linked to cognitive decline, with combined multiple indicators serving as powerful biomarkers for diagnosis.
ACS CHEMICAL NEUROSCIENCE
(2021)
Article
Neuroimaging
Chenxi Pan, Jingru Ren, Lanting Li, Yuqian Li, Jianxia Xu, Chen Xue, Guanjie Hu, Miao Yu, Yong Chen, Li Zhang, Wenbing Zhang, Xiao Hu, Yu Sun, Weiguo Liu, Jiu Chen
Summary: The study found distinct differences in insular subdivision functional connectivity among Parkinson's disease patients with different cognitive levels, which are associated with various cognitive domains. Particularly, alterations in functional connectivity were observed in PD-MCI group compared to PD-NC group and healthy controls, with implications for attention, working memory, visuospatial function, language, executive function, and memory levels.
BRAIN IMAGING AND BEHAVIOR
(2022)
Article
Genetics & Heredity
Fuquan Zhang, Ancha Baranova, Chao Zhou, Hongbao Cao, Jiu Chen, Xiangrong Zhang, Mingqing Xu
Summary: The study found that neuroticism is genetically correlated with most health-related traits, and has causal effects on 12 mental traits and two physical diseases. Conversely, major depressive disorder, subjective well-being, and insomnia also have causal effects on neuroticism.
Article
Biochemical Research Methods
Shuquan Rao, Ancha Baranova, Hongbao Cao, Jiu Chen, Xiangrong Zhang, Fuquan Zhang
Summary: This study found that smoking has a significant impact on the risk of severe COVID-19 and COVID-19-induced hospitalization, while alcohol consumption has no significant association with COVID-19 outcomes. Analysis of risk genes and genomic loci identified several genes related to COVID-19 outcomes.
BRIEFINGS IN BIOINFORMATICS
(2021)
Article
Biochemistry & Molecular Biology
Shanshan Chen, Yu Song, Huimin Wu, Honglin Ge, Wenzhang Qi, Yue Xi, Jiayi Wu, Yuxiang Ji, Kexin Chen, Xingjian Lin, Jiu Chen
Summary: In patients with amnestic mild cognitive impairment (aMCI), anosognosia is associated with increased tau accumulation in specific brain regions, disrupted functional connectivity, and accelerates progression to Alzheimer's disease dementia.
ACS CHEMICAL NEUROSCIENCE
(2022)
Article
Neurosciences
Wen-ying Ma, Min-jie Tian, Qun Yao, Qian Li, Fan-yu Tang, Chao-yong Xiao, Jing-Ping Shi, Jiu Chen
Summary: The study aimed to identify brain regions with abnormalities in patients with DLB and differences between DLB and AD. Neural networks involved in these abnormal brain regions were described. DLB patients showed dysfunction in certain brain regions compared to control groups and distinction from AD, suggesting potential markers for diagnosis and specific interventions for both DLB and AD.
CNS NEUROSCIENCE & THERAPEUTICS
(2022)
Article
Neurosciences
Chenxi Pan, Yuqian Li, Jingru Ren, Lanting Li, Peiyu Huang, Pingyi Xu, Li Zhang, Wenbing Zhang, Min-Ming Zhang, Jiu Chen, Weiguo Liu
Summary: The study evaluated the frequency and clinical features of mild cognitive impairment in prodromal Parkinson's disease in elderly Chinese individuals. It found that memory, attention/working memory, and executive function were the most commonly impaired domains in pPD, and that cognitive performance was correlated with motor symptoms in this population.
CNS NEUROSCIENCE & THERAPEUTICS
(2022)
Article
Neurosciences
Jiu Chen, Rong Chen, Chen Xue, Wenzhang Qi, Guanjie Hu, Wenwen Xu, Shanshan Chen, Jiang Rao, Fuquan Zhang, Xiangrong Zhang
Summary: This study provides experimental evidence that repetitive transcranial magnetic stimulation (rTMS) can restore altered hippocampal subregions (HIPsub) and their network connectivity, leading to improvement in episodic memory in amnestic mild cognitive impairment (aMCI) patients. The connectivity between HIPsub and the left middle temporal gyrus (MTG.L) plays a significant role in enhancing episodic memory.
JOURNAL OF ALZHEIMERS DISEASE
(2022)
Article
Neurosciences
Yingying Yue, Rui Liu, Jiu Chen, Yin Cao, Yanfeng Wu, Shining Zhang, Huajie Li, Jijun Zhu, Aiqin Wu, Yonggui Yuan
Summary: The self-rating post stroke depression scale (PSDS) demonstrated good reliability and validity in assessing depressive symptoms among stroke patients. The study retested the psychometric properties of PSDS in different types of post-stroke depression (PSD) and found it to be a useful screening tool with acceptable properties for estimating different subtypes of PSD patients.
JOURNAL OF STROKE & CEREBROVASCULAR DISEASES
(2022)
Review
Geriatrics & Gerontology
Qianqian Yuan, Wenzhang Qi, Chen Xue, Honglin Ge, Guanjie Hu, Shanshan Chen, Wenwen Xu, Yu Song, XuLian Zhang, Chaoyong Xiao, Jiu Chen
Summary: This study identified specific changes in the default mode network (DMN) in patients with mild cognitive impairment (MCI), providing insights into the pathology of MCI and potential mechanisms of conversion to Alzheimer's disease (AD). The findings offer a new target and direction for delaying the progression from MCI to AD.
FRONTIERS IN AGING NEUROSCIENCE
(2021)
Article
Neurosciences
Chenxi Pan, Jingru Ren, Ping Hua, Lei Yan, Miao Yu, Yajie Wang, Gaiyan Zhou, Ronggui Zhang, Jiu Chen, Weiguo Liu
Summary: SCCs are common in early PD patients, with distinct prevalence and risk factors between PD-MCI and PD-NC patients.
FRONTIERS IN NEUROSCIENCE
(2021)
Article
Neuroimaging
Wen-Ying Ma, Qun Yao, Guan-Jie Hu, Hong-Lin Ge, Chen Xue, Ying-Ying Wang, Yi-Xin Yan, Chao-Yong Xiao, Jing-Ping Shi, Jiu Chen
Summary: The study revealed different patterns of functional reorganization in DLB and AD patients, with the conversion and redistribution of rich club nodes possibly playing a causal role in disease-specific outcomes. This could serve as a potential biomarker for more accurate prevention and treatment strategies.
NEUROIMAGE-CLINICAL
(2022)
Article
Neurosciences
Ju Gao, Rongtao Jiang, Xiaowei Tang, Jiu Chen, Miao Yu, Chao Zhou, Xiang Wang, Hongying Zhang, Chengbing Huang, Yong Yang, Xiaobin Zhang, Zaixu Cui, Xiangrong Zhang
Summary: This study demonstrated that local properties of brain regions extracted from multimodal imaging data could be used to distinguish deficit schizophrenia (DS) from non-deficit schizophrenia (NDS) with a machine learning approach, and confirmed the relationship between these features and the negative symptoms subdomain. These findings may improve the identification of potential neuroimaging signatures and enhance the clinical assessment of deficit syndrome.
CNS NEUROSCIENCE & THERAPEUTICS
(2023)
Article
Behavioral Sciences
Qianqian Yuan, Chen Xue, Xuhong Liang, Wenzhang Qi, Shanshan Chen, Yu Song, Huimin Wu, Xulian Zhang, Chaoyong Xiao, Jiu Chen
Summary: This study investigates the functional changes in patients with early-stage Alzheimer's disease (aMCI) and compares the changes before and after repetitive transcranial magnetic stimulation (rTMS) targeting the precuneus. The results show that rTMS targeting the precuneus can improve cognitive function in aMCI patients and is closely related to brain connectivity modulation.
BRAIN AND BEHAVIOR
(2023)
Article
Medicine, Research & Experimental
Fuquan Zhang, Shuquan Rao, Hongbao Cao, Xiangrong Zhang, Qiang Wang, Yong Xu, Jing Sun, Chun Wang, Jiu Chen, Xijia Xu, Ning Zhang, Lin Tian, Jianmin Yuan, Guoqiang Wang, Lei Cai, Mingqing Xu, Ancha Baranova
Summary: This study investigates the relationship between PTSD and three types of depressive phenotypes, namely MDD, DAF, and DEP. The results suggest that PTSD shares genetic factors with MDD and supports the idea that PTSD can be considered as a subtype of MDD, which can help reduce heterogeneity in psychiatric diagnosis.
JOURNAL OF CLINICAL INVESTIGATION
(2022)
