The mechanistic target of rapamycin pathway downregulates bone morphogenetic protein signaling to promote oligodendrocyte differentiation

Myelination and mTOR

(2017) Gianluca Figlia et al.   GLIA

Expression of NG2 and platelet-derived growth factor receptor alpha in the developing neonatal rat brain

(2017) Jiang-hua Lai et al.   Neural Regeneration Research

Loss of mTORC2 signaling in oligodendrocyte precursor cells delays myelination

(2017) Mark D. Grier et al.   PLoS One

H3K9ac and HDAC2 Activity Are Involved in the Expression of Monocarboxylate Transporter 1 in Oligodendrocyte

(2017) Qingwei Lai et al.   Frontiers in Molecular Neuroscience

Lineage, fate, and fate potential of NG2-glia

(2016) Akiko Nishiyama et al.   BRAIN RESEARCH

Rapid production of new oligodendrocytes is required in the earliest stages of motor-skill learning

(2016) Lin Xiao et al.   NATURE NEUROSCIENCE

Keratan Sulfate Regulates the Switch from Motor Neuron to Oligodendrocyte Generation During Development of the Mouse Spinal Cord

(2016) Hirokazu Hashimoto et al.   NEUROCHEMICAL RESEARCH

Oligodendrocyte heterogeneity in the mouse juvenile and adult central nervous system

(2016) S. Marques et al.   SCIENCE

Dual regulatory switch through interactions of Tcf7l2/Tcf4 with stage-specific partners propels oligodendroglial maturation

(2016) Chuntao Zhao et al.   Nature Communications

BMP7 retards peripheral myelination by activating p38 MAPK in Schwann cells

(2016) Xiaoyu Liu et al.   Scientific Reports

Transcription factors Sox5 and Sox6 exert direct and indirect influences on oligodendroglial migration in spinal cord and forebrain

(2015) Tina Baroti et al.   GLIA

mTOR signaling promotes stem cell activation via counterbalancing BMP-mediated suppression during hair regeneration

(2015) Zhili Deng et al.   Journal of Molecular Cell Biology

Transcriptional and Epigenetic Regulation of Oligodendrocyte Development and Myelination in the Central Nervous System

(2015) Ben Emery et al.   Cold Spring Harbor Perspectives in Biology

An RNA-Sequencing Transcriptome and Splicing Database of Glia, Neurons, and Vascular Cells of the Cerebral Cortex

(2014) Y. Zhang et al.   JOURNAL OF NEUROSCIENCE

Conditional Ablation of Raptor or Rictor Has Differential Impact on Oligodendrocyte Differentiation and CNS Myelination

(2014) K. K. Bercury et al.   JOURNAL OF NEUROSCIENCE

Mammalian Target of Rapamycin Promotes Oligodendrocyte Differentiation, Initiation and Extent of CNS Myelination

(2014) S. E. Wahl et al.   JOURNAL OF NEUROSCIENCE

Balanced mTORC1 Activity in Oligodendrocytes Is Required for Accurate CNS Myelination

(2014) F. Lebrun-Julien et al.   JOURNAL OF NEUROSCIENCE

E2F1 Coregulates Cell Cycle Genes and Chromatin Components during the Transition of Oligodendrocyte Progenitors from Proliferation to Differentiation

(2014) L. Magri et al.   JOURNAL OF NEUROSCIENCE

MYRF Is a Membrane-Associated Transcription Factor That Autoproteolytically Cleaves to Directly Activate Myelin Genes

(2013) Helena Bujalka et al.   PLOS BIOLOGY

Inhibition of mTOR Suppresses UVB-Induced Keratinocyte Proliferation and Survival

(2012) T. D. Carr et al.   Cancer Prevention Research

Insulin-like growth factor I regulates G2/M progression through mammalian target of rapamycin signaling in oligodendrocyte progenitors

(2012) Jungsoo Min et al.   GLIA

Arrest of Myelination and Reduced Axon Growth When Schwann Cells Lack mTOR

(2012) D. L. Sherman et al.   JOURNAL OF NEUROSCIENCE

ID2: A negative transcription factor regulating oligodendroglia differentiation

(2012) Xing-Shu Chen et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Dual-Mode Modulation of Smad Signaling by Smad-Interacting Protein Sip1 Is Required for Myelination in the Central Nervous System

(2012) Qinjie Weng et al.   NEURON

Proteomic identification of novel targets regulated by the mammalian target of rapamycin pathway during oligodendrocyte differentiation

(2011) William A. Tyler et al.   GLIA

Erk1/2 MAPK and mTOR signaling sequentially regulates progression through distinct stages of oligodendrocyte differentiation

(2011) Hebe M. Guardiola-Diaz et al.   GLIA

Noggin

(2011) Carola Krause et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

How Histone Deacetylases Control Myelination

(2011) Claire Jacob et al.   MOLECULAR NEUROBIOLOGY

Skeletal muscle protein balance in mTOR heterozygous mice in response to inflammation and leucine

(2010) Charles H. Lang et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Oligodendrocyte PTEN is required for myelin and axonal integrity, not remyelination

(2010) Emily P. Harrington et al.   ANNALS OF NEUROLOGY

Identification of BMP-responsive elements in the mouse Id2 gene

(2010) Takeshi Nakahiro et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Implication of RICTOR in the mTOR inhibitor-mediated induction of insulin-like growth factor-I receptor (IGF-IR) and human epidermal growth factor receptor-2 (Her2) expression in gastrointestinal cancer cells

(2010) Sven A. Lang et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Elevated Phosphatidylinositol 3,4,5-Trisphosphate in Glia Triggers Cell-Autonomous Membrane Wrapping and Myelination

(2010) S. Goebbels et al.   JOURNAL OF NEUROSCIENCE

Epigenetic regulation of oligodendrocyte identity

(2010) Jia Liu et al.   TRENDS IN NEUROSCIENCES

Activation of the Mammalian Target of Rapamycin (mTOR) Is Essential for Oligodendrocyte Differentiation

(2009) W. A. Tyler et al.   JOURNAL OF NEUROSCIENCE

Akt Signals through the Mammalian Target of Rapamycin Pathway to Regulate CNS Myelination

(2009) S. P. Narayanan et al.   JOURNAL OF NEUROSCIENCE

HDAC1 and HDAC2 regulate oligodendrocyte differentiation by disrupting the β-catenin–TCF interaction

(2009) Feng Ye et al.   NATURE NEUROSCIENCE

Rapamycin Promotes the Osteoblastic Differentiation of Human Embryonic Stem Cells by Blocking the mTOR Pathway and Stimulating the BMP/Smad Pathway

(2009) Kyu-Won Lee et al.   STEM CELLS AND DEVELOPMENT

Constitutively Active Akt Induces Enhanced Myelination in the CNS

(2008) A. I. Flores et al.   JOURNAL OF NEUROSCIENCE