Article
Gastroenterology & Hepatology
Oscar Victor Hernandez Mondragon, Luis Fernando Garcia Contreras, Gerardo Blanco Velasco, Omar Michel Solorzano Pineda, Daniel Mitchell Castillo Carrillo, Enrique Murcio Perez
Summary: Gastric peroral endoscopic myotomy (G-POEM) is an effective 4-year treatment for refractory gastroparesis (RG), especially in diabetic gastroparesis (DG) patients, establishing a potential first-line therapy. Early diagnosis, nausea/vomiting, GCSI score at 6 months (1.5-2), and RP4H <10% at 6 months are predictive factors for long-term success.
GASTROINTESTINAL ENDOSCOPY
(2022)
Article
Gastroenterology & Hepatology
Mohamed M. Abdelfatah, Alan Noll, Neil Kapil, Rushikesh Shah, Lianyong Li, Rosemary Nustas, Baiwen Li, Hui Luo, Huimin Chen, Liang Xia, Parit Mekaroonkamol, Nikrad Shahnavaz, Steven Keilin, Field Willingham, Jennifer Christie, Qiang Cai
Summary: A retrospective analysis of 90 patients who underwent GPOEM for refractory gastroparesis showed that 81.1% had a clinical response at initial follow-up. One year after GPOEM, 69.1% of all patients had a clinical response and 85.2% of initial responders maintained a clinical response. Patients maintained a clinical response and improved quality of life for as long as 3 years after the procedure, with high BMI and long duration gastroparesis associated with failure of GPOEM.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2021)
Article
Gastroenterology & Hepatology
Amelie Labonde, Guillaume Lades, Antoine Debourdeau, Olivier Ragi, Lauriane Lehmann, Veronique Vitton, Marc Barthet, Romain Legros, Jeremie Albouys, Sophie Geyl, Veronique Loustaud-Ratti, Jacques Monteil, Sandra Gonzalez, Jean-Michel Gonzalez, Jeremie Jacques
Summary: This study evaluated the 3-year efficiency of G-POEM as a treatment for refractory gastroparesis, and found that the clinical success rate was 65.2% at 36 months. There was significant improvement in symptom severity. The study also introduced a predictive score for G-POEM success, which can help predict the clinical success rate of the procedure.
GASTROINTESTINAL ENDOSCOPY
(2022)
Article
Gastroenterology & Hepatology
Hanhua Zhang, Zuqiang Liu, Liyun Ma, Quanlin Li, Ying Huang, Kuiran Dong, Hong Ye, Jiangbin Liu, Haifeng Liu, Xiaoxia Ren, Hongbin Yang, Chongzhi Hou, Kuku Ge, Hua Wang, Pinghong Zhou, Ying Fang
Summary: This study aimed to evaluate the efficacy and safety of gastric peroral endoscopic pyloromyotomy (G-POEM) in treating infants with congenital hypertrophic pyloric stenosis (CHPS). The results showed that G-POEM was successfully performed in all patients, with a median operative duration of 49 minutes and no recurrent symptoms within 3 months of the procedure. The study suggests that further multicenter studies should be conducted to compare the long-term outcomes of this minimally invasive technique with traditional surgery.
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2023)
Article
Gastroenterology & Hepatology
Lauren Pioppo, Debashis Reja, Monica Gaidhane, Romy Bareket, Augustine Tawadros, Ana L. Madrigal Mendez, Jose Nieto, Felipe Zamarripa, Ma Guadalupe Martinez, Mine C. Carames, Juan C. Carames, Jennifer Liu-Burdowski, Marina Kim, Ameya A. Deshmukh, Supriya Suresh, Resheed Alkhiari, Iman Andalib, Haroon M. Shahid, Avik Sarkar, Amy Tyberg, Michel Kahaleh
Summary: This study compared the efficacy and safety of GPOEM versus laparoscopic pyloromyotomy for refractory gastroparesis. The results showed that GPOEM had better clinical outcomes, shorter procedure time, reduced retention rates, shorter hospital stay, and fewer adverse events compared to surgery.
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2021)
Review
Medicine, General & Internal
Sz-Iuan Shiu, Shih-Hsiung Shen, Hua-Nong Luo
Summary: This meta-analysis compared the efficacy and complication rates of different modalities of pyloromyotomy and gastric electrical stimulation for the treatment of gastroparesis. The results suggest that double per-oral pyloromyotomy has better clinical success compared to the other interventions, while gastric electrical stimulation may lead to higher recurrence rates.
Article
Gastroenterology & Hepatology
Vaibhav Wadhwa, Adalberto Gonzalez, Francisco Azar, Harjinder Singh, Kapil Gupta, Hong Liang, Alison Schneider, Jeffery Ponsky, Tolga Erim, John Rodriguez, Fernando J. Castro
Summary: This retrospective cohort study found that symptomatic improvement after botulinum toxin injection is a predictor of response to peroral pyloromyotomy in patients with gastroparesis. This information can be useful in improving patient selection for pyloromyotomy.
Article
Gastroenterology & Hepatology
Lennon Gregor, John Wo, John DeWitt, Brandon Yim, Robert Siwiec, Thomas Nowak, Martha Mendez, Anita Gupta, Destenee Dickason, Sarah Stainko, Mohammad Al-Haddad
Summary: G-POEM is a safe and feasible treatment option for refractory gastroparesis, with significant short-term and mid-term improvements in overall symptoms, quality of life scores, and healthcare utilization for patients.
GASTROINTESTINAL ENDOSCOPY
(2021)
Article
Surgery
R. Hustak, Z. Vackova, J. Krajciova, J. Spicak, E. Kieslichova, J. Mares, Jan Martinek
Summary: This study compared the efficacy of two closure methods (clips and endoscopic suturing) after G-POEM. Both methods were found to be effective for mucosal closure, with clips being quicker and cheaper than endoscopic suturing.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2022)
Review
Gastroenterology & Hepatology
Faisal Kamal, Muhammad Ali Khan, Wade Lee-Smith, Sachit Sharma, Ashu Acharya, Dawit Jowhar, Umer Farooq, Muhammad Aziz, Abdul Kouanda, Sun-Chuan Dai, Colin W. Howden, Craig A. Munroe
Summary: A meta-analysis evaluating the mid-term efficacy of gastric peroral endoscopic myotomy (G-POEM) found that it is associated with modest clinical success at 1 year, with a 61% clinical success rate and 8% adverse event rate. Additional studies with longer follow-up are needed to further assess its longer-term efficacy.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2022)
Article
Gastroenterology & Hepatology
Mouen A. Khashab, Andrew Y. Wang, Qiang Cai
Summary: This article is an update from the American Gastroenterological Association (AGA) that reviews the evidence and provides expert advice on the cognitive, procedural, and post-procedural aspects of performing gastric peroral endoscopic myotomy for refractory gastroparesis.
Article
Cardiac & Cardiovascular Systems
Jesse M. P. Rappaport, Siva Raja, Scott Gabbard, Lucy Thuita, Madhusudhan R. Sanaka, Eugene H. Blackstone, Usman Ahmad
Summary: This study evaluated the safety and clinical effectiveness of per-oral endoscopic pyloromyotomy in relieving gastroparesis after lung transplant. The results showed that this procedure can effectively alleviate the symptoms of gastroparesis and also improve gastroesophageal reflux and allograft function.
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
(2022)
Article
Gastroenterology & Hepatology
Muhammad Haseeb, Zubair Khan, Muhammad Umar Kamal, Pichamol Jirapinyo, Christopher C. Thompson
Summary: This study compared the short-term outcomes and safety profiles of three treatment modalities for achalasia: peroral endoscopic myotomy (POEM), laparoscopic Heller myotomy (LHM), and pneumatic dilation (PD). The results showed that patients undergoing PD had higher readmission rates and resource utilization, while the outcomes of POEM and LHM were comparable, but there was a significant difference in the utilization of these myotomy procedures.
GASTROINTESTINAL ENDOSCOPY
(2023)
Article
Surgery
Harry J. Wong, Bailey Su, Mikhail Attaar, Kristine Kuchta, John G. Linn, Woody Denham, Stephen P. Haggerty, Michael B. Ujiki
Summary: The simulation-based curriculum for peroral endoscopic pyloromyotomy proved effective in improving practitioner knowledge, confidence, and technical skills. Participants showed significant improvements in all aspects of the procedure, leading to a high adoption rate among the practitioners.
Article
Gastroenterology & Hepatology
Roberta Maselli, Alessandra Oliva, Matteo Badalamenti, Piera Alessia Galtieri, Paul James Belletrutti, Marco Spadaccini, Rosangela Nicoletti, Elena Finati, Stefania Vetrano, Federica Fosso, Carmen Correale, Gaia Pellegatta, Cesare Hassan, Alessandro Repici
Summary: The study indicates that postprophylactic short-term antimicrobial therapy after POEM is not necessary due to a very low residual infective risk.
GASTROINTESTINAL ENDOSCOPY
(2021)
Article
Otorhinolaryngology
Lei Wang, Gang Wang, Lianyong Li, Xin Fan, Hongdan Liu, Zhezhe Sun, Haolun Han, Baowei Li, Ruiying Ding, Wei Wu
AMERICAN JOURNAL OF OTOLARYNGOLOGY
(2020)
Article
Gastroenterology & Hepatology
Lian Yong Li, Bai Wen Li, Parit Mekaroonkamol, Hui Min Chen, Shan Shan Shen, Hui Luo, Sunil Dacha, Yue Xue, Sarah Cristofaro, Steven Keilin, Field Willingham, Qiang Cai
JOURNAL OF DIGESTIVE DISEASES
(2020)
Article
Gastroenterology & Hepatology
Mohamed M. Abdelfatah, Alan Noll, Neil Kapil, Rushikesh Shah, Lianyong Li, Rosemary Nustas, Baiwen Li, Hui Luo, Huimin Chen, Liang Xia, Parit Mekaroonkamol, Nikrad Shahnavaz, Steven Keilin, Field Willingham, Jennifer Christie, Qiang Cai
Summary: A retrospective analysis of 90 patients who underwent GPOEM for refractory gastroparesis showed that 81.1% had a clinical response at initial follow-up. One year after GPOEM, 69.1% of all patients had a clinical response and 85.2% of initial responders maintained a clinical response. Patients maintained a clinical response and improved quality of life for as long as 3 years after the procedure, with high BMI and long duration gastroparesis associated with failure of GPOEM.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2021)
Review
Gastroenterology & Hepatology
Lian Yong Li, Wei Wu, Sheng Chen, Jian Wen Gu, Xin Lou Li, Hai Jing Song, Feng Du, Gang Wang, Chang Qing Zhong, Xiao Ying Wang, Yan Chen, Rushikesh Shah, He Ming Yang, Qiang Cai
JOURNAL OF DIGESTIVE DISEASES
(2020)
Article
Cell Biology
Feng Du, Zhijun Li, Guohua Zhang, Si Shaoyan, Dejun Geng, Zhougen Tao, Kunhua Qiu, Silei Liu, Yu Zhou, Yichao Zhang, Jianwen Gu, Gang Wang, Lianyong Li, Wei Wu
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2020)
Article
Gastroenterology & Hepatology
Huimin Chen, Lucie F. Calderon, Rushikesh Shah, Wei Zheng, Liang Xia, Wei Wang, Lianyong Li, Baiwen Li, Yue Xue, Steve Keilin, Qiang Cai
Summary: This study evaluated the prevalence of eosinophilic infiltration in the esophageal mucosa and muscle layer of achalasia patients through muscle layer biopsy during POEM. Only 3 out of 20 patients showed eosinophilic infiltration in the distal esophageal mucosa. Contrary to previous studies, no association between esophageal eosinophilic infiltration and achalasia was observed in this small sample study.
DIGESTIVE DISEASES AND SCIENCES
(2022)
Article
Physics, Multidisciplinary
Wang Xiao-Ying, Xing Yu-Ting, Chen Run-Zhi, Jia Xue-Qi, Wu Ji-Hua, Jiang Jin, Li Lian-Yong, Chang Guo-Qing
Summary: Nonlinear optical microscopy has unique advantages in tissue imaging, but its wide applications are limited by the lack of broadly tunable femtosecond sources for driving multimodalities simultaneously. To solve this challenge, we propose a new wavelength conversion approach called SESS, which uses self-phase modulation to broaden the input spectrum and select well-isolated spectral lobes. We demonstrate a fiber-optic SESS source for multimodal nonlinear optical microscopy, which can generate femtosecond pulses at different wavelengths for various imaging modalities.
ACTA PHYSICA SINICA
(2022)
Article
Gastroenterology & Hepatology
Rushikesh Shah, Lucie F. Calderon, Brenna E. Sanders, Grace Mccurdy, Aqsa Nasir, Wei Zheng, Julia Massaad, Mengdan Xie, Hui Luo, Lianyong Li, Baiwen Li, Huimin Chen, Steve Keilin, Alyssa Kransinskas, Qiang Cai
Summary: This study presents a new technique for obtaining gastric muscle samples and quantifying the number of Interstitial Cells of Cajal (ICC) in patients with gastroparesis. The results suggest that the number of ICC may be related to the response to treatment. However, further studies with a larger number of patients are needed to confirm these findings.
DIGESTIVE DISEASES AND SCIENCES
(2022)
Article
Oncology
Yongtao Yang, Lianyong Li, Huan He, Mengyang Shi, Lanying He, Shuwen Liang, Jun Qi, Weiqing Chen
Summary: Numb regulates cell proliferation, differentiation, migration, and apoptosis through the RhoA/ROCK signaling pathway in colorectal cancer. Its expression is correlated with prognosis and provides a new theoretical molecular basis for understanding the pathogenesis of colorectal cancer.
EXPERIMENTAL CELL RESEARCH
(2022)
Review
Gastroenterology & Hepatology
Sheng Chen, Feng Du, Changqing Zhong, Caifang Liu, Xiaoying Wang, Yan Chen, Gang Wang, Xiaopei Gao, Lu Zhang, Lianyong Li, Wei Wu
Summary: Innovations in endoscopy have significantly improved the diagnosis and treatment of GERD. Endoscopy and biopsies can directly observe and determine esophageal abnormalities. Future research should focus on personalized treatment and the primary pathophysiology of GERD.
GASTROENTEROLOGY REPORT
(2021)
Article
Oncology
Xinke Sui, Xiaopei Gao, Lu Zhang, Bin Zhang, Changqing Zhong, Yan Chen, Xiaoying Wang, Dou Li, Wei Wu, Lianyong Li
Summary: This study compared the clinical efficacies of antireflux mucosectomy (ARMS) and Stretta radiofrequency (SRF) in patients with gastroesophageal reflux disease (GERD). The results showed that both ARMS and SRF treatment were effective in improving symptoms and quality of life. For patients with gastroesophageal flap valve (GEFV) grade II and III, both treatments were equally effective, while ARMS treatment was more effective for patients with GEFV grade IV.
ANNALS OF TRANSLATIONAL MEDICINE
(2022)
Article
Gastroenterology & Hepatology
Shuai Zhang, Ying-Di Liu, Ning-Li Chai, Yi Yao, Fei Gao, Bo Liu, Zhan-Di He, Lu Bai, Xin Huang, Chao Gao, En-Qiang Linghu, Lian-Yong Li
Summary: This study aimed to evaluate the efficacy and safety of endoscopic submucosal dissection (ESD) in the treatment of early cancers or precancerous lesions of the upper GI tract in patients with cirrhosis and esophagogastric varices (EGVs), and explore optimal treatment strategies. The results showed that ESD has good efficacy and safety in the treatment of early cancers or precancerous lesions of the upper GI tract in patients with cirrhosis and EGV.
GASTROINTESTINAL ENDOSCOPY
(2023)
Review
Gastroenterology & Hepatology
Sheng Chen, Min Wang, Lei Liu, Guodong Wang, Lei Wang, Changqing Zhong, Chao Gao, Wei Wu, Lianyong Li
Summary: Pancreatic ductal adenocarcinoma (PDAC) is a malignant cancer with a poor prognosis and has become an urgent clinical problem. Organoid technology has emerged as a powerful tool to culture pancreatic tissues and can retain important attributes of the primary tumor. Organoids have significant value in predicting therapeutic response and offer new avenues for drug discovery and translational medicine in the future.
GASTROENTEROLOGY REPORT
(2023)
Review
Oncology
Xiaoying Wang, Di Zhang, Xiaochun Zhang, Yuting Xing, Jihua Wu, Xinke Sui, Xin Huang, Guoqing Chang, Lianyong Li
Summary: Multiphoton microscopy (MPM) imaging is a powerful medical imaging technique that can identify the structural characteristics of tissues at the cellular and subcellular levels, featuring larger penetration depth and less phototoxicity.
TECHNOLOGY IN CANCER RESEARCH & TREATMENT
(2022)