Review
Biochemistry & Molecular Biology
Ujjayani Saha, Rashmi Gondi, Amrita Patil, Sunil D. Saroj
Summary: ESKAPE pathogens have developed resistance to multiple antimicrobials, posing a serious threat to public health. The CRISPR-Cas system provides a novel method for managing antibiotic-resistant strains by programming specific Cas nucleases against bacterial genomic sequences. However, some pathogens acquire antibiotic resistance due to the presence of the CRISPR-Cas system.
MOLECULAR BIOTECHNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Camilla Pecoraro, Daniela Carbone, Barbara Parrino, Stella Cascioferro, Patrizia Diana
Summary: Infectious diseases caused by antimicrobial-resistant strains have become a serious threat to global health, with a high social and economic impact. Strategies to fight antibiotic resistance, such as inhibiting bacterial adhesion to host surfaces, can effectively hamper bacterial virulence without affecting cell viability. Targeting structures and biomolecules involved in the adhesion of Gram-positive and Gram-negative pathogens can lead to the development of promising tools against pathogens.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Infectious Diseases
Giancarlo Perez-Lazo, Susan Abarca-Salazar, Renata Lovon, Rocio Rojas, Jose Ballena-Lopez, Adriana Morales-Moreno, Wilfredo Flores-Paredes, Berenice Arenas-Ramirez, Luis Ricardo Illescas
Summary: A descriptive study conducted in a Peruvian hospital found a significant correlation between the use of ceftazidime and carbapenem-resistant Pseudomonas aeruginosa isolates, as well as a correlation between resistance to piperacillin/tazobactam and ciprofloxacin usage in Enterobacter spp. in the medical wards. Notably, there was a significant reduction in Pseudomonas aeruginosa resistance to piperacillin/tazobactam and amikacin in the ICU from 2015 to 2018. These findings highlight the importance of continuous support and assessment of antimicrobial stewardship strategies in hospitals.
Review
Infectious Diseases
Tehrim Motiwala, Qiniso Mthethwa, Ikechukwu Achilonu, Thandeka Khoza
Summary: Bacterial antibiotic resistance is a growing global concern, with an increase in multidrug resistant and extensively drug-resistant bacteria posing a severe health threat. This resistance is partly due to natural evolution, but largely attributed to antibiotic misuse and overuse. It is crucial to develop new drugs to combat the emergence of resistant pathogens. Various strategies, such as anti-virulence approach, antimicrobial peptides, and phage therapy, are employed to address bacterial antibiotic resistance. This review focuses on ESKAPE pathogens, which cause nosocomial infections and are able to escape antibiotic actions, and suggests caseinolytic proteins as potential therapeutic targets to combat these pathogens.
Article
Pharmacology & Pharmacy
Cristian Rangel-Nunez, Inmaculada Molina-Pinilla, Cristina Ramirez-Trujillo, Adrian Suarez-Cruz, Samuel Bernal Martinez, Manuel Bueno-Martinez
Summary: Multidrug-resistant pathogenic bacteria pose a significant threat to public health. The synthesis of new linear cationic antibacterial polytriazoles has shown potential as a source of effective antibacterial compounds. By varying the size and nature of the side chains, the antimicrobial activity of these materials can be modulated. These polymers demonstrate high bactericidal activity against pathogens of the ESKAPE group and do not induce resistance in certain bacteria. Additionally, they disrupt the membrane of Escherichia coli, leading to depolarization and disruption.
Review
Medicine, General & Internal
Sriram Kalpana, Wan-Ying Lin, Yu-Chiang Wang, Yiwen Fu, Amrutha Lakshmi, Hsin-Yao Wang
Summary: Antibiotic resistance is a pressing global pandemic. Rapid diagnostic assays can differentiate bacterial infections from other diseases, aiding antimicrobial stewardship, therapy optimization, and surveillance. Traditional methods often have longer turnaround times for definitive results. On the other hand, proteomic studies have advanced in qualitative and quantitative analysis, with reduced error rates due to the availability of diverse datasets. This review provides insights into state-of-the-art proteomic techniques for diagnosing antibiotic resistance in ESKAPE pathogens, with a future outlook for tackling the imminent pandemic.
Review
Chemistry, Medicinal
Stella Cascioferro, Daniela Carbone, Barbara Parrino, Camilla Pecoraro, Elisa Giovannetti, Girolamo Cirrincione, Patrizia Diana
Summary: Methicillin-resistant Staphylococcus aureus (MRSA) is a major cause of persistent human infections, with the ability to colonize asymptomatically and cause moderate to severe infections. It is considered a superbug due to its high morbidity and mortality rates, as well as its resistance to most antibiotics on the market. Its formation of biofilms on various surfaces is believed to be the primary means of its antibiotic resistance and widespread presence. Development of new anti-virulence strategies is crucial in combating MRSA infections associated with biofilms.
Review
Infectious Diseases
Dhiviya Prabaa Muthuirulandi Sethuvel, Yamuna Devi Bakthavatchalam, Maruthan Karthik, Madhumathi Irulappan, Rahul Shrivastava, Hariharan Periasamy, Balaji Veeraraghavan
Summary: Bacteria develop beta-lactam resistance through various mechanisms, with beta-lactamase production being the most common, especially in Gram-negative bacteria. Structural changes in penicillin-binding proteins (PBPs) are prevalent in Gram-positive bacteria and increasingly observed in Gram-negative bacteria. PBP-mediated resistance is primarily achieved through accumulation of mutations that result in reduced binding affinity to beta-lactams. In this review, we discuss PBP-mediated resistance among ESKAPE pathogens, which cause a wide range of hospital- and community-acquired infections globally.
INFECTIOUS DISEASES AND THERAPY
(2023)
Article
Nutrition & Dietetics
Juliana Garcia, Francisca Rodrigues, Flavia Castro, Alfredo Aires, Guilhermina Marques, Maria Jose Saavedra
Summary: The aqueous and methanolic extracts of Boletus edulis and Neoboletus luridiformis have antimicrobial and antibiofilm properties against multidrug-resistant bacteria, possibly due to the presence of phenolic compounds.
FRONTIERS IN NUTRITION
(2022)
Review
Environmental Sciences
Sanchita Das, Sakina Bombaywala, Shweta Srivastava, Atya Kapley, Rita Dhodapkar, Nishant A. Dafale
Summary: Persistent selective pressure in the environment is the major reason behind the spread of antibiotic resistance genes (ARGs). Genome plasticity plays a crucial role in dissemination of antibiotic resistance among bacterial pathogens. Mobile genetic elements aid horizontal gene transfer (HGT) and provide resistance against bacterial immune system.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Infectious Diseases
Nian Zhang, Wenying Shan, Liangliang Gao, Si Hoi Kou, Chang Lu, Huilin Yang, Bo Peng, Kin Yip Tam, Leo Tsz On Lee, Jun Zheng
Summary: The emergence and spread of drug-resistant bacterial pathogens, such as ESKAPE, present a serious global health threat. However, the development of new antibiotics is hindered by challenges in identifying new drug targets and the rapid development of resistance. Drug repurposing, such as the use of BMS-833923, offers an effective strategy to combat antibiotic resistance by enhancing the efficacy of existing antibiotics. BMS-833923 kills Gram-positive bacteria and potentiates colistin to destroy various Gram-negative bacteria by targeting membrane phospholipids, ultimately causing cell death.
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
(2023)
Article
Multidisciplinary Sciences
Fariza Abrao, Thayna Souza Silva, Claudia L. Moura, Sergio Ricardo Ambrosio, Rodrigo Cassio Sola Veneziani, Raphael E. F. de Paiva, Jairo Kenupp Bastos, Carlos Henrique Gomes Martins
Summary: The study evaluated the antibacterial and antivirulence activity of oleoresins from different copaifera species and isolated compounds against periodontitis-causing bacteria. These compounds showed promising activity in inhibiting biofilm formation and eradication, as well as in cysteine protease and leucotoxin inhibition, suggesting their potential as novel sources for combating periodontal pathogens.
SCIENTIFIC REPORTS
(2021)
Article
Public, Environmental & Occupational Health
Julia Denissen, Brandon Reyneke, Monique Waso-Reyneke, Benjamin Havenga, Tobias Barnard, Sehaam Khan, Wesaal Khan
Summary: The ESKAPE pathogens exhibit increased resistance to multiple classes of antibiotics and may be linked to community-acquired infections.
INTERNATIONAL JOURNAL OF HYGIENE AND ENVIRONMENTAL HEALTH
(2022)
Review
Medicine, Research & Experimental
Madalina Maria Muntean, Andrei-Alexandru Muntean, Madalina Preda, Loredana Sabina Cornelia Manolescu, Cerasella Dragomirescu, Mircea-Ioan Popa, Gabriela Loredana Popa
Summary: Antimicrobial resistance (AMR) is a growing global public health problem, and ESKAPE pathogens are a group of highly resistant and epidemiologically important microorganisms. This review provides an overview of various methods used to detect the AMR mechanisms of ESKAPE pathogens, and analyzes this issue from a One Health perspective.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2022)
Article
Microbiology
Sidrah Asghar, Ayaz Ahmed, Saeed Khan, Amanullah Lail, Muhammad Shakeel
Summary: This study aimed to isolate, characterize and develop a phage cocktail as a therapy against carbapenem resistance and extended spectrum beta-lactamases (ESBL) producing strains of Klebsiella pneumoniae. The results showed that the isolated phages displayed good stability and biofilm eradication ability, and significantly inhibited K. pneumoniae infections.
MICROBIOLOGICAL RESEARCH
(2022)
