Article
Medicine, General & Internal
Xiuhui Shi, Min Wang, Yuqing Zhang, Xingjun Guo, Mingyang Liu, Zhijun Zhou, Yan Zhao, Ruizhi He, Yang Gao, Yuhui Liu, Shutao Pan, Min Zhou, Chunle Zhao, Taoyuan Yin, Xu Li, Hebin Wang, Jingxuan Yang, Feng Zhu, Min Li, Renyi Qin
Summary: High expression levels of alpha-SMA and hypoxia markers are associated with poor prognosis in pancreatic cancer patients. Mechanistically, hypoxia induces HGF expression and secretion in PSC via HIF-1 alpha, which then activates Met and suppresses pancreatic cancer cell sensitivity to EGFR inhibitors. The combination of EGFR inhibitor and Met inhibitor shows promise for pancreatic cancer treatment based on the demonstrated signaling axis between PSC and cancer cells.
Article
Immunology
Wei Wang, Bo Wang
Summary: The study demonstrated that 10(-8) mol/L OGP can induce proliferation and osteogenic differentiation of BMSCs, along with increased expression of angiogenesis-related proteins. Additionally, 1.0 ng/mL TNF-alpha has a short-term promoting effect on osteogenic differentiation of BMSCs.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Biology
Ines Lahmann, Joscha Griger, Jie-Shin Chen, Yao Zhang, Markus Schuelke, Carmen Birchmeier
Summary: MET and CXCR4 cooperate to protect muscle stem cells against the harsh inflammatory environment encountered in acute muscle injury. Lack of these factors leads to severe apoptosis in early stages of regeneration.
Article
Cell Biology
Yanlong Song, Weiting Chen, Bo Zhu, Wei Ge
Summary: Folliculogenesis is regulated by the communication between oocytes and follicle cells, with EGF signaling playing a critical role in the early stages of follicle development. Knockout mutants of Egf and Egfr in zebrafish revealed that Egfr is essential for follicle activation, while Egf mutation primarily affects fertilization rate.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Manabu Okumura, Tomomi Iwakiri, Naoki Yoshikawa, Takao Nagatomo, Takanori Ayabe, Isao Tsuneyoshi, Ryuji Ikeda
Summary: Inhibition of the HGF/c-Met axis diminishes the effects of fluoropyrimidine, caution must be exercised when using fluoropyrimidine concomitantly with inhibitors of the HGF/c-Met axis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Oncology
Ryota Tanaka, Mizue Terai, Eric Londin, Takami Sato
Summary: The HGF/MET signaling pathway is crucial in metastatic formation and treatment resistance in uveal melanoma, promoting tumorigenesis, tumor progression, and affecting cell survival, proliferation, motility, and migration. MET expression in metastatic uveal melanoma is associated with poor prognosis, with the pathway being a major mechanism of treatment resistance.
Article
Oncology
Marie Fernandes, Brynna Hoggard, Philippe Jamme, Sonia Paget, Marie-Jose Truong, Valerie Gregoire, Audrey Vinchent, Clotilde Descarpentries, Angela Morabito, Justas Stanislovas, Enoir Farage, Jean-Pascal Meneboo, Sheherazade Sebda, Katia Bouchekioua-Bouzaghou, Marie Nollet, Sarah Humez, Timothy Perera, Paul Fromme, Luca Grumolato, Martin Figeac, Marie-Christine Copin, David Tulasne, Alexis B. Cortot, Stephanie Kermorgant, Zoulika Kherrouche
Summary: Exon skipping mutations of the MET receptor tyrosine kinase (METex14) occur in a small percentage of non-small-cell lung cancer (NSCLC) and have been found to drive tumor growth and sensitivity to MET-tyrosine kinase inhibitors (TKIs). By using CRISPR/Cas9, researchers developed a METex14/WT isogenic model and demonstrated that the METex14 single alteration was sufficient to enhance cell survival and motility, as well as tumor formation, in vivo. They also found that human hepatocyte growth factor (hHGF) is required for the oncogenicity of METex14.
MOLECULAR ONCOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Hyunjun Ko, Mi-Jin Kim, Hyun Joo Park, Jung-Hoon Sohn, Jung-Hoon Bae
Summary: Human epidermal growth factor (hEGF) has potential applications due to its wide range of physiological functions, but its low stability limits its effectiveness. This study developed stable hEGF delivery system using levan-based nanoparticles. The CML-hEGF nanoparticles showed high entrapment yield, size of 199.9+/- 3.87 nm, zeta potential of -19.1 mV, and dual biological functions of skin regeneration and moisturizing. These nanoparticles maintained cell proliferation activity for 6 weeks, highlighting their potential in pharmaceutical and cosmeceutical applications.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Pathology
Shuo Zhang, Peng Wang, Binwu Hu, Xiao Lv, Weijian Liu, Songfeng Chen, Zengwu Shao
Summary: Inhibiting HSP90 can attenuate fibrosis and pathologic angiogenesis induced by macrophages in intervertebral disc degeneration. Fibrotic cells in human disc tissues were associated with angiogenesis-related processes. HSP90 inhibition reduced the fibrotic phenotype induced by macrophages and mitigated the pro-angiogenic effects. The murine model supported the amelioration of fibrosis and endothelial cell invasion by inhibiting HSP90.
AMERICAN JOURNAL OF PATHOLOGY
(2023)
Article
Chemistry, Medicinal
Yongli Shi, Xiaofei Pan, Suyue Xu, Huiqing Zhu, Bingqian Zhao, Zeyu Sun, Ruoyi Dong, Na Li, Xueyan Hou, Xue Yang
Summary: This study synthesized DHPD polymers and fabricated pH-responsive DHPD nanoparticles for investigation of their biosecurity and in vivo anti-tumor activity. The results showed that the DHPD NPs could release doxorubicin in tumor cells, reduce its toxicity, and enhance its anti-tumor effects. Furthermore, the DHPD NPs improved the anti-4T1 tumor effect of doxorubicin, suggesting their potential application in the treatment of breast cancer.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Article
Cell Biology
Jeong Seop Park, Doyoung Kim, Hyun Sook Hong
Summary: Classical aging-associated diseases include osteoporosis, diabetes, hypertension, and arthritis. This study investigates the effect of FGF2/HGF priming on the osteogenic potential of elderly adipose-derived stem cells (ADSC-E) and finds that FGF2/HGF priming can enhance the bone-forming capacity in ADSC-E.
Article
Biotechnology & Applied Microbiology
Benjamin Atwell, Cheng-Yu Chen, Matthew Christofferson, William R. Montfort, Joyce Schroeder
Summary: Targeting the retrotranslocation of EGFR may be a potent therapeutic approach for RTK-active cancer.
CANCER GENE THERAPY
(2023)
Article
Cell Biology
Eunhye Kim, Fang Wu, Danbi Lim, Christopher Zeuthen, Yiming Zhang, James Allen, Laura Muraine, Capucine Trollet, Katherine E. Vest, Hyojung J. Choo
Summary: This study reveals that pharyngeal muscles have high levels of active HGF, which drives the basal proliferation of SCs. FAPs are the major cell type providing HGF in pharyngeal muscles. Additionally, activated SCs with large cell size and increased mitochondrial content were found in pharyngeal muscles, providing new insights into the distinctive activity of pharyngeal SCs.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Biology
Griselda Awanis, Salonee Banerjee, Robert Johnson, Sathuwarman Raveenthiraraj, Aya Elmeligy, Derek Warren, Jelena Gavrilovic, Anastasia Sobolewski
Summary: Tunneling nanotubes (TNTs) play a crucial role in intercellular communication and tumor progression. This study investigates the molecular mechanisms underlying TNT formation and identifies potential targets for inhibiting TNT formation as a novel approach for cancer treatment.
LIFE SCIENCE ALLIANCE
(2023)
Article
Medicine, Research & Experimental
Asawari Korde, Maria Haslip, Prachi Pednekar, Alamzeb Khan, Maurizio Chioccioli, Sameet Mehta, Francesc Lopez-Giraldez, Santos Bermejo, Mauricio Rojas, Charles Dela Cruz, Michael A. S. Pober, Michael A. Matthay, Jordan S. Pober, Richard W. Pierce, Shervin S. Takyar
Summary: This study found that the levels of microRNA-1 (miR1), a microRNA regulated by vascular endothelial growth factor (VEGF), were reduced in lung endothelium after acute injury. Overexpression of miR-1 in pulmonary endothelial cells protected the lung against cell death and barrier dysfunction, and increased the survival of mice with pneumonia-induced acute lung injury. miR-1 had a protective effect by inhibiting apoptosis and necroptosis pathways and reducing capillary leak. The study also identified miR-1 targets and validated the regulation of angiopoietin-2 (ANGPT2) by miR-1. These findings suggest a previously unknown role of miR-1 as a cytoprotective orchestrator of endothelial responses to acute injury, with potential prognostic and therapeutic implications.
Article
Biochemistry & Molecular Biology
Haiyan Wang, Genea Edwards, Catalina Garzon, Carmen Piqueras, Sanjoy K. Bhattacharya
Article
Gastroenterology & Hepatology
Lina Sun, Kevin Beggs, Prachi Borude, Genea Edwards, Bharat Bhushan, Chad Walesky, Nairita Roy, Michael W. Manley, Sumedha Gunewardena, Maura O'Neil, Hua Li, Udayan Apte
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
(2016)
Article
Ophthalmology
Teresia A. Carreon, Genea Edwards, Haiyan Wang, Sanjoy K. Bhattacharya
EXPERIMENTAL EYE RESEARCH
(2017)
Article
Ophthalmology
Yenifer Guerra, Ayman J. Aljohani, Genea Edwards, Sanjoy K. Bhattacharya
JOURNAL OF OCULAR PHARMACOLOGY AND THERAPEUTICS
(2014)
Article
Biochemistry & Molecular Biology
Eriko Sugano, Genea Edwards, Saikat Saha, Lynda A. Wilmott, Richard C. Grambergs, Koushik Mondal, Hui Qi, Megan Stiles, Hiroshi Tomita, Nawajes Mandal
JOURNAL OF LIPID RESEARCH
(2019)
Article
Cell Biology
Won-Kyu Ju, Myoung Sup Shim, Keun-Young Kim, Tae Lim Park, Sangphil Ahn, Genea Edwards, Robert N. Weinreb
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2019)
Article
Cell Biology
Genea Edwards, Jennifer Arcuri, Haiyan Wang, Noel Ziebarth, Gulab Zode, Richard K. Lee, Sanjoy K. Bhattacharya
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2020)
Article
Cell Biology
Genea Edwards, Guy A. Perkins, Keun-Young Kim, YeEun Kong, Yonghoon Lee, Soo-Ho Choi, Liu Yujia, Dorota Skowronska-Krawczyk, Robert N. Weinreb, Linda Zangwill, Stefan Strack, Won-Kyu Ju
CELL DEATH & DISEASE
(2020)
Correction
Cell Biology
Won-Kyu Ju, Myoung Sup Shim, Keun-Young Kim, Tae Lim Park, Sangphil Ahn, Genea Edwards, Robert N. Weinreb
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2020)
Article
Biochemistry & Molecular Biology
Soo-Ho Choi, Keun-Young Kim, Guy A. Perkins, Sebastien Phan, Genea Edwards, Yining Xia, Jungsu Kim, Dorota Skowronska-Krawczyk, Robert N. Weinreb, Mark H. Ellisman, Yury Miller, Won-Kyu Ju
Article
Biochemistry & Molecular Biology
Genea Edwards, Yonghoon Lee, Martha Kim, Soham Bhanvadia, Keun-Young Kim, Won-Kyu Ju
Review
Neurosciences
Genea Edwards, Caroline G. Olson, Carlyn P. Euritt, Peter Koulen
Summary: The eye is sensitive to oxidative stress, and vitamin E plays a crucial role in protecting against degenerative diseases. Vitamin E has diverse antioxidant activity and can promote neuroprotective effects through several signaling pathways. Further research is needed to fully understand its clinical implications.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Multidisciplinary Sciences
Thomas P. Johnston, Genea Edwards, Peter Koulen
Summary: This study aimed to quantify retina function in a spontaneous mutation mouse model of diabetes, and investigate the effects of hyperglycemia and dyslipidemia on retinal and visual dysfunctions in diabetes. The results showed that the combined presence of hyperglycemia and dyslipidemia had a more severe impact on retinal function.
SCIENTIFIC REPORTS
(2023)
Article
Ophthalmology
Ayman J. Aljohani, Genea Edwards, Yenifer Guerra, Sander Dubovy, Darlene Miller, Richard K. Lee, Sanjoy K. Bhattacharya
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2014)