Article
Engineering, Environmental
Yangchun Zhang, Ziqi Liu, Ziwei Wang, Huan Gao, Yuqing Wang, Mengxing Cui, Honghao Peng, Yongmei Xiao, Yuan Jin, Dianke Yu, Wen Chen, Qing Wang
Summary: Cadmium exposure can pose health risks to the kidney, and this study aimed to explore the risk and compare human equivalent doses obtained from in vitro tests with current guidance values. The findings suggest a potential concern for renal toxicity in populations living in cadmium-contaminated regions. The study also introduces a new approach methodology for environmental chemical risk assessment.
JOURNAL OF HAZARDOUS MATERIALS
(2023)
Article
Chemistry, Applied
Christina Vlachou, Antonia Griesbacher, Klemens Fuchs, Josef Wolf, Daniela Mihats, Johann Steinwider, Daniela Hofstaedter
Summary: Probabilistic exposure and risk assessment of cadmium in the diet for Austrian adults were conducted using Monte Carlo Risk Assessment (MCRA) software and R programming, revealing underestimated levels of exposure and risk. Grains, potatoes, and leafy vegetables were identified as the main contributors to intake.
FOOD ADDITIVES AND CONTAMINANTS PART A-CHEMISTRY ANALYSIS CONTROL EXPOSURE & RISK ASSESSMENT
(2021)
Article
Environmental Sciences
Muhammad Aamir, Shanshan Yin, Yingxue Liu, Habib Ullah, Sardar Khan, Weiping Liu
Summary: Analysis of sixteen priority polycyclic aromatic hydrocarbons (PAHs) in twenty-one food items consumed by the Pakistani population revealed varying levels of exposure, with fish having the highest and rice the lowest concentrations. The dietary exposure to PAHs showed potential cancer risks for both adults and children, and males generally had higher exposure levels compared to females. Wheat and milk contributed the most to the total dietary exposure of PAHs, while rice and egg contributed the least. Sensitivity analysis identified daily dietary intake, exposure duration, and cancer slope factor as the most influential variables affecting the risk assessment.
SCIENCE OF THE TOTAL ENVIRONMENT
(2021)
Article
Engineering, Environmental
Annika Mangold-Doring, Chelsea Grimard, Derek Green, Stephanie Petersen, John W. Nichols, Natacha Hogan, Lynn Weber, Henner Hollert, Markus Hecker, Markus Brinkmann
Summary: Standardized laboratory tests with a limited number of model species play a crucial role in chemical risk assessments. A multispecies toxicokinetic model based on data from 69 freshwater fish species in Canada was developed to predict bioconcentration, showing promising results with some tendency of overestimating measured values. This bottom-up approach potentially provides more accurate predictions for chemical risk assessments.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2021)
Review
Environmental Sciences
Mengting Chen, Ruihu Du, Tao Zhang, Chutao Li, Wenqiang Bao, Fan Xin, Shaozhang Hou, Qiaomei Yang, Li Chen, Qi Wang, An Zhu
Summary: Toxicokinetics plays a crucial role in health risk assessments, and physiologically based toxicokinetic (PBTK) models are powerful tools that quantitatively describe the absorption, distribution, metabolism, and excretion of chemicals in organisms and establish correlations with toxic effects.
Article
Multidisciplinary Sciences
Aude Ratier, Sandrine Charles
Summary: This article discusses the regulatory requirement for bioaccumulation evaluation of chemicals within organisms and the use of toxicokinetic (TK) data to predict internal concentrations. To increase the availability of TK data, researchers have developed an innovative database to support TK modelling.
Article
Environmental Sciences
Cheng-Jih Cheng, Yuh-Ting Kuo, Jein-Wen Chen, Guor-Jien Wei, Yi-Jun Lin
Summary: This study conducted a probabilistic risk-benefit assessment of dietary nitrates and nitrites and found that exposure to nitrates and nitrites exceeding acceptable daily intakes in a variety of foods showed cardiovascular benefits without posing appreciable health and safety risks. The results suggest that dietary nitrates and nitrites have clear cardiovascular benefits that may outweigh potential risks.
ENVIRONMENT INTERNATIONAL
(2021)
Article
Engineering, Environmental
Ying Qing, Jiaqi Yang, Qiang Zhang, Yuanshen Zhu, Patricia Ruiz, Min Wu, Genming Zhao, Qi Zhao, Hong Liu, Hua Cai, Luxin Qin, Weiwei Zheng, Gengsheng He
Summary: Adapting existing Cd TK models based on exposure data from Chinese residents, this study developed a one-compartment TK model and a multi-compartment PBTK model that consider gender differences and individual variability in Cd kinetics. The validated models can serve as new quantitative assessment tools for the risk assessment of Cd in the Chinese population, with an improvement in RMSE and acceptable prediction on other Chinese datasets.
JOURNAL OF HAZARDOUS MATERIALS
(2021)
Article
Environmental Sciences
Chi-Yun Chen, Tien-Hsuan Lu, Chung-Min Liao
Summary: Marine microplastics pose a serious threat to shallow-water corals, necessitating interdisciplinary research. The ecotoxicological effects of MPs on corals are complex and need to be evaluated in a species-specific manner. Toxicokinetic and toxicodynamic modeling can help quantify the impacts of MPs on coral health and growth.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Article
Water Resources
Ying Qing, Yongzhen Li, Xinyi Cai, Wenting He, Shishi Liu, Yunhe Ji, Meng Jiang, Linjing Yang, Jutao Wang, Siyuan Ping, Yu Chen, Yingyi Luo, Yanfei Li
Summary: This study established a comprehensive database of cadmium concentrations in Chinese foods and described the spatial and temporal trends. The average dietary cadmium exposure of Chinese residents was 34.3 μg/day, with cereals, vegetables, and aquatic food contributing the most. Approximately 15.4% of the Chinese population exceeded the health-based guidance value.
EXPOSURE AND HEALTH
(2023)
Article
Toxicology
Christoph Hethey, Niklas Hartung, Gaby Wangorsch, Karin Weisser, Wilhelm Huisinga
Summary: A sufficient quantitative understanding of aluminium toxicokinetics in humans is lacking, but progress has been made through the development of a physiologically-based model using Al-26 tracer and a curated dataset. These advancements allow for valid predictions of aluminium levels in different tissues, paving the way for more quantitative risk assessment in humans.
ARCHIVES OF TOXICOLOGY
(2021)
Article
Environmental Sciences
Keng-Wen Lien, Min-Hsiung Pan, Min-Pei Ling
Summary: Cadmium is a toxic pollutant with health risks associated with exposure through rice consumption. A study in Taiwan assessed cadmium levels in rice consumption among different age-gender subgroups, revealing potential health hazards for certain populations.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Article
Environmental Sciences
Man Hu, Yining Zhang, Ming Zhan, Gengsheng He, Weidong Qu, Ying Zhou
Summary: This study developed a dermal physiologically based toxicokinetics (PBTK) model for diethyl phthalate (DEP) exposure via personal care products (PCPs) and indoor air in humans. The results showed that dermal exposure to DEP poses a greater risk to human health compared with oral exposure.
Article
Environmental Sciences
Chi-Yun Chen, Tien-Hsuan Lu, Ying-Fei Yang, Chung-Min Liao
Summary: This study developed a toxicokinetic/toxicodynamic-based risk assessment framework to examine the health effects of zebrafish and red tilapia in response to environmental concentrations of microplastics. The findings suggest that microplastic pollution is likely to enhance fish health risks and should be considered in evaluations of freshwater fish susceptibility to microplastics.
SCIENCE OF THE TOTAL ENVIRONMENT
(2021)
Article
Environmental Sciences
Johanna Suomi, Pirkko Tuominen
Summary: This pilot study used published toxicological endpoints to evaluate the importance of cadmium, lead, arsenic, mercury, nickel, and aluminum in the mixture of Finnish adults' daily diet. The study found that the cumulative dietary exposure to these chemicals was alarmingly high, posing the risk of neurological damage and kidney effects, especially for fertile age women. The main sources of exposure for Finns below the age of 65 were bread and cereals, non-alcoholic drinks, and vegetables. Women aged 25 to 45 had significantly higher exposure compared to men of the same age and women aged 46 to 64.
ENVIRONMENTAL MONITORING AND ASSESSMENT
(2023)
Article
Chemistry, Applied
Virginie Desvignes, Aurelie Mahe, Xavier Laffray, Carole Vigreux-Besret, Cyril Feidt, Pierre-Marie Badot, Jean-Luc Volatier, Gilles Riviere
FOOD ADDITIVES AND CONTAMINANTS PART A-CHEMISTRY ANALYSIS CONTROL EXPOSURE & RISK ASSESSMENT
(2017)
Article
Food Science & Technology
Gilles Riviere, Julien Jean, Sebastien Gorecki, Marion Hulin, Martine Kolf-Clauw, Cyril Feidt, Nicole Picard-Hagen, Paule Vasseur, Bruno Le Bizec, Veronique Sirot
FOOD AND CHEMICAL TOXICOLOGY
(2019)
Article
Chemistry, Applied
Manon Pruvost-Couvreur, Bruno Le Bizec, Camille Bechaux, Gilles Riviere
FOOD ADDITIVES AND CONTAMINANTS PART A-CHEMISTRY ANALYSIS CONTROL EXPOSURE & RISK ASSESSMENT
(2020)
Article
Public, Environmental & Occupational Health
Manon Pruvost-Couvreur, Nicole Picard-Hagen, Bruno Le Bizec, Gilles Riviere
Summary: Bisphenol A is a well-known chemical substance that affects reproductive and endocrine systems, with higher sensitivity of fetuses to BPA during pregnancy. While health risks from dietary exposure to BPA can be excluded for the general population, pregnant women and their unborn children are still at risk due to the levels of fetal exposure to BPA.
INTERNATIONAL JOURNAL OF HYGIENE AND ENVIRONMENTAL HEALTH
(2021)
Article
Chemistry, Applied
Geraldine Carne, David Makowski, Sandrine Carrillo, Thierry Guerin, Petru Jitaru, Jean-Cedric Reninger, Gilles Riviere, Nawel Bemrah
Summary: European and French populations are overexposed to cadmium through their foods. This study aimed to derive a low and protective cadmium concentration in edible seaweeds to limit overexposure. The research used a probabilistic approach considering other sources of cadmium exposure and identified a cadmium concentration that ensures the seaweed-consuming population does not exceed the tolerable daily intake of cadmium. This generic approach could be applied to other food/substance pairs in setting maximum limits, providing better protection for consumer health.
FOOD ADDITIVES AND CONTAMINANTS PART A-CHEMISTRY ANALYSIS CONTROL EXPOSURE & RISK ASSESSMENT
(2022)
Article
Chemistry, Applied
Philippe Palmont, Jeanne-Marie Membre, Gilles Riviere, Nawel Bemrah
Summary: The aim of this study was to rank the chemical hazards present in infant formula using two different methods of aggregation. The study identified the potentially present substances in infant foods and built three criteria for ranking the hazards. The results showed that six prioritized substances remained the same, demonstrating the robustness of the approaches.
FOOD ADDITIVES AND CONTAMINANTS PART A-CHEMISTRY ANALYSIS CONTROL EXPOSURE & RISK ASSESSMENT
(2023)
