Journal
FERTILITY AND STERILITY
Volume 112, Issue 6, Pages 987-993Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.fertnstert.2019.10.011
Keywords
IVF add-on; treatment add-on; adjuvant; IVF adjunct
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The probability of live birth from an in vitro fertilization (IVF) cycle is modest. Many additional treatments (add-ons) are available which promise to improve the success of IVF. This review summarizes the current evidence for common IVF add-ons which are suggested to improve endometrial receptivity. Systematic reviews of randomized controlled trials and individual trials were included. Five add-ons were included: immune therapies, endometrial scratching, endometrial receptivity array, uterine artery vasodilation, and human chorionic gonadotropin instillation. The results suggest there is no robust evidence that these add-ons are effective or safe. Many IVF addons are costly, consuming precious resources which may be better spent on evidence-based treatments or further IVF. Large randomized controlled trials and appropriate safety assessment should be mandatory before the introduction of IVF add-ons into routine practice. (C) 2019 by American Society for Reproductive Medicine.
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