Journal
FEBS LETTERS
Volume 594, Issue 12, Pages 1879-1890Publisher
WILEY
DOI: 10.1002/1873-3468.13710
Keywords
HAdV infection; lncRNA; miRNA; mivaRNA; proteomics; regulation of host-cell gene expression; RNA-Seq; SILAC-MS; transcriptomics; virus-host interaction
Funding
- Kjell and Marta Beijer Foundation
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Human adenoviruses (HAdVs) are common pathogens associated with a wide variety of respiratory, ocular, and gastrointestinal diseases. To achieve its effective lytic mode of replication, HAdVs have to reprogram host-cell gene expression and fine-tune viral gene expression in a temporal manner. In two decades, omics revolution has advanced our knowledge about the HAdV and host-cell interplay at the RNA and protein levels. This review summarizes the current knowledge from large-scale datasets on how HAdV infections adjust coding and noncoding RNA expression, as well as how they reprogram host-cell proteome during the lytic course of infection.
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