Metabolic changes related to the IDH1 mutation in gliomas preserve TCA‐cycle activity: An investigation at the protein level

Isocitrate dehydrogenase 1–mutated human gliomas depend on lactate and glutamate to alleviate metabolic stress

(2018) Krissie Lenting et al.   FASEB JOURNAL

Determination of Site-Specific Phosphorylation Ratios in Proteins with Targeted Mass Spectrometry

(2018) Lennard J. M. Dekker et al.   JOURNAL OF PROTEOME RESEARCH

Integrated Metabolomics and Lipidomics Analyses Reveal Metabolic Reprogramming in Human Glioma with IDH1 Mutation

(2018) Lina Zhou et al.   JOURNAL OF PROTEOME RESEARCH

In silico gene expression analysis reveals glycolysis and acetate anaplerosis in IDH1 wild-type glioma and lactate and glutamate anaplerosis in IDH1-mutated glioma

(2017) Mohammed Khurshed et al.   Oncotarget

Hexokinase 2 (HK2), the tumor promoter in glioma, is downregulated by miR-218/Bmi1 pathway

(2017) Hui Liu et al.   PLoS One

A Brain Penetrant Mutant IDH1 Inhibitor Provides In Vivo Survival Benefit

(2017) Johnny Kopinja et al.   Scientific Reports

The 2016 World Health Organization Classification of Tumors of the Central Nervous System: a summary

(2016) David N. Louis et al.   ACTA NEUROPATHOLOGICA

Metabolic response of glioblastoma cells associated with glucose withdrawal and pyruvate substitution as revealed by GC-MS

(2016) Henry Oppermann et al.   Nutrition & Metabolism

Targeting hexokinase 2 enhances response to radio-chemotherapy in glioblastoma

(2016) Alenoush Vartanian et al.   Oncotarget

Metabolomics profiling in plasma samples from glioma patients correlates with tumor phenotypes

(2016) Hua Zhao et al.   Oncotarget

Comprehensive Proteomic Analysis of Human Erythropoiesis

(2016) Emilie-Fleur Gautier et al.   Cell Reports

IDH1, lipid metabolism and cancer: Shedding new light on old ideas

(2015) Elena Bogdanovic   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Metabolic consequences of oncogenic IDH mutations

(2015) Seth J. Parker et al.   PHARMACOLOGY & THERAPEUTICS

Inhibition of mutant IDH1 decreases D-2-HG levels without affecting tumorigenic properties of chondrosarcoma cell lines

(2015) Johnny Suijker et al.   Oncotarget

Metabolic Reprogramming in Mutant IDH1 Glioma Cells

(2015) Jose L. Izquierdo-Garcia et al.   PLoS One

IDH1 Mutations Alter Citric Acid Cycle Metabolism and Increase Dependence on Oxidative Mitochondrial Metabolism

(2014) A. R. Grassian et al.   CANCER RESEARCH

Glutamate as a neurotransmitter in the healthy brain

(2014) Y. Zhou et al.   JOURNAL OF NEURAL TRANSMISSION

Metabolic alterations due to IDH1 mutation in glioma: opening for therapeutic opportunities?

(2014) Dana A N Mustafa et al.   Acta Neuropathologica Communications

IDH1 and IDH2 Mutations in Gliomas

(2013) Adam L. Cohen et al.   Current Neurology and Neuroscience Reports

Mutations in ALDH6A1 encoding methylmalonate semialdehyde dehydrogenase are associated with dysmyelination and transient methylmalonic aciduria

(2013) Julien L Marcadier et al.   Orphanet Journal of Rare Diseases

IDH1 mutation is sufficient to establish the glioma hypermethylator phenotype

(2012) Sevin Turcan et al.   NATURE

Hexokinase 2 is a key mediator of aerobic glycolysis and promotes tumor growth in human glioblastoma multiforme

(2011) Amparo Wolf et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The Contribution of Blood Lactate to Brain Energy Metabolism in Humans Measured by Dynamic 13C Nuclear Magnetic Resonance Spectroscopy

(2010) F. Boumezbeur et al.   JOURNAL OF NEUROSCIENCE

IDH1andIDH2Mutations in Gliomas

(2009) Hai Yan et al.   NEW ENGLAND JOURNAL OF MEDICINE

Magnetic resonance imaging of pH in vivo using hyperpolarized 13C-labelled bicarbonate

(2008) Ferdia A. Gallagher et al.   NATURE