Article
Cell Biology
Jiazhou Liu, Xiaoyu Wang, Jiazheng Sun, Yuru Chen, Jie Li, Jing Huang, Huimin Du, Lu Gan, Zhu Qiu, Hongzhong Li, Guosheng Ren, Yuxian Wei
Summary: In this study, the researchers identified NPY5R as a hub gene in breast cancer and found that it was frequently downregulated in breast cancer tissues. Higher expression of NPY5R was associated with better prognosis for breast cancer patients. Mechanistically, NPY5R suppressed breast tumor cell growth, induced apoptosis and cell cycle arrest, and enhanced sensitivity to doxorubicin through inhibiting the STAT3 signaling pathway. These findings suggest that NPY5R functions as a tumor suppressor in breast cancer.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Oncology
Yi Zhao, Zhansheng Hu, Jincheng Li, Tingyan Hu
Summary: EZH2 exacerbates breast cancer by methylating STAT3 directly, providing a promising therapeutic target for breast cancer.
Article
Biochemistry & Molecular Biology
Heejoo Kim, Hwee Won Ji, Hyeon Woo Kim, Sung Hwan Yun, Jae Eun Park, Sun Jung Kim
Summary: The research revealed that Rg3 regulates the expression of lncRNA ATXN8OS and miR-424-5p in MCF-7 cancer cells, impacting cell proliferation and apoptosis, and subsequently affecting the expression of oncogenic target genes.
Article
Oncology
Bo Bin Lee, Dongho Kim, Yujin Kim, Joungho Han, Young Mog Shim, Duk-Hwan Kim
Summary: This study found that metformin inhibits the expression of DNMTs in non-small cell lung cancer cells by upregulating miR-148/-152 family members.
CLINICAL EPIGENETICS
(2023)
Review
Pharmacology & Pharmacy
Dawid Dorna, Adriana Grabowska, Jaroslaw Paluszczak
Summary: Many natural products can exert anticancer or chemopreventive activity by interfering with the cellular epigenetic machinery, which can modulate cancer-related gene expression and functional changes, including reduced cell proliferation and migration, and enhanced apoptosis.
BRITISH JOURNAL OF PHARMACOLOGY
(2023)
Article
Oncology
Hyeon Woo Kim, Jae Eun Park, Minjae Baek, Heejoo Kim, Hwee Won Ji, Sung Hwan Yun, Dawoon Jeong, Juyeon Ham, Sungbin Park, Xinpei Lu, Han-Sung Kang, Sun Jung Kim
Summary: In this study, it was found that MMP1 locus was hypomethylated and overexpressed in tamoxifen-resistant breast cancer cells and tissues. Downregulating MMP1 expression could inhibit the growth of resistant cells and increase sensitivity to tamoxifen. MMP1 has the potential to be a target gene for controlling tamoxifen resistance in breast cancer.
Review
Biotechnology & Applied Microbiology
Deepa Ramasamy, Arunagiri Kuha Deva Magendhra Rao, Thangarajan Rajkumar, Samson Mani
Summary: Non-CpG methylation, a distinct epigenetic modification in DNA, plays a crucial role in gene regulation. Advances in technology have allowed for a better understanding of its genome-wide distribution, but its specific role in cancer development remains unclear. This review focuses on the mechanism of non-CpG methylation in embryos and tissues, particularly its relevance to cancer progression.
BRIEFINGS IN FUNCTIONAL GENOMICS
(2021)
Article
Oncology
Juyeong Hong, Ji Hoon Lee, Zhao Zhang, Yanming Wu, Mei Yang, Yiji Liao, Richard de la Rosa, Jessica Scheirer, Douglas Pechacek, Nu Zhang, Zhenming Xu, Tyler Curiel, Xi Tan, Tim H. -M. Huang, Kexin Xu
Summary: Inhibition of cancer-intrinsic EZH2 promotes antitumor immunity in breast cancer, requiring specific activation of type I IFN signaling. High levels of EZH2 and low levels of STAT2 in breast cancer patients are associated with the worst antitumor immune responses.
Article
Chemistry, Medicinal
Cheng Wang, Lailiang Qu, Shang Li, Fucheng Yin, Limei Ji, Wan Peng, Heng Luo, Dehua Lu, Xingchen Liu, Xinye Chen, Lingyi Kong, Xiaobing Wang
Summary: The dual action of PARP inhibitors and EZH2 inhibitors can enhance the treatment of TNBC, with the compound 5a showing potential in reducing sensitivity to inhibitors in BRCA cells.
JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Article
Biochemical Research Methods
Jianxiong Tang, Jianxiao Zou, Mei Fan, Qi Tian, Jiyang Zhang, Shicai Fan
Summary: CaMelia, a CatBoost gradient boosting method, predicts missing methylation states based on locally paired intercellular methylation similarity. It significantly improves imputation performance on real single-cell methylation datasets, helping to discover intercellular differentially methylated loci masked by sparsity in raw data. The results demonstrate that CaMelia preserves cell-cell relationships, enhances cell type identification, and improves subpopulation detection.
Article
Biochemistry & Molecular Biology
Suman Abhishek, Naveen Kumar Nakarakanti, Waghela Deeksha, Eerappa Rajakumara
Summary: UHRF1 SRA can recognize non-mCpG DNA, with contrasting mechanisms for hemi-mCpG and fully-mCpHpG DNA recognition. While the binding affinity for fully-mCpG is weaker, UHRF1 SRA exhibits higher affinity for fully-mCpHpG.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Genetics & Heredity
Sebastian Kaluscha, Silvia Domcke, Christiane Wirbelauer, Michael B. Stadler, Sevi Durdu, Lukas Burger, Dirk Schuebeler
Summary: Cytosine methylation efficiently silences CpG-rich regulatory regions of genes and repeats in mammalian genomes by directly inhibiting the binding of transcription factors rather than indirectly inhibiting via recruitment of methyl-CpG-binding domain proteins.
Review
Oncology
Kazem Nejati-Koshki, Chris-Tiann Roberts, Ghader Babaei, Mojgan Rastegar
Summary: Epigenetic mechanisms control gene expression and cellular identity, with DNA methylation being an important epigenetic modification. Methyl-CpG-Binding Protein 2 (MeCP2) is a reader of DNA methylation and plays key roles in cellular identity and function. Recent studies have uncovered MeCP2's involvement in tumorigenesis of various human cancers, highlighting its potential oncogenic properties. This article provides an overview of the emerging role of MeCP2 as an oncogene in different types of human cancer.
Article
Medicine, Research & Experimental
Chunli Wang, Fei Wang, Fang Liu, Shuyan Chen
Summary: Cardiovascular disease (CVD) is a significant public health issue, especially for the elderly, with atherosclerosis as its pathological basis. Epigenetics has been shown to play a critical role in the development of atherosclerotic disease through mechanisms like DNA methylation and histone modification. Research on various epigenetic mechanisms is necessary to uncover new targets for treatment of atherosclerosis.
DISCOVERY MEDICINE
(2021)
Article
Oncology
Zhenghua Zhang, Zhan Shi, Su Zhang, Qiong Lu, Haimin Wei, Xueyong Wu, Li Han
Summary: CircRNAs like hsa_circ_0000129 are considered as potential biomarkers for cancer. The study showed that high expression of hsa_circ_0000129 in breast cancer tissues is associated with lymph node metastasis and advanced cancer stages. Overexpression of hsa_circ_0000129 in breast cancer cell lines leads to increased cell proliferation, migration, and colony formation, with a positive correlation to EZH2 expression.