Journal
EUROPEAN POLYMER JOURNAL
Volume 123, Issue -, Pages -Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.eurpolymj.2019.109462
Keywords
Poly(amide-imide); Polymer prodrug; Self-assembly; Responsive drug delivery
Categories
Funding
- National Natural Science Foundation of China [31671035, 31971316]
- Six Talent Peaks Project in Jiangsu Province [WSN-082]
- Natural Science Foundation of Jiangsu Province [BK20170204]
- Jiangsu Provincial Medical Innovation Team [CXTDA2017024]
- National Significant New Drugs Creation Program [2017ZX09304021]
- Overseas Students Science and Technology Activities Project Merit Funding of Wuxi
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Poly(amide-imide)s (PAIs) present limited use in bioapplications due to their poor aqueous solubility and difficulty in functional accessibility. Herein, we prepared PM-based prodrugs by leveraging aliphatic PAls as the polymer scaffolds and conjugating camptothecin (CPT) via thiol-disulfide exchange reaction. The degree of CPT attachment can be smoothly controlled by initial feed ratios of PEG and a pyridinedisulfide-modified CPT precursor. Due to the abundant secondary amine groups in PAI backbones, amphiphilic PAI-CPT prodrugs self-assembled into cationic nanoparticles and showed an efficient cellular internalization (< 2 h). The presence of disulfide linkers between PAI scaffolds and CPT endowed PAI-CPT prodrugs a reductive-responsive drug release profile. Moreover, when PAI-CPT prodrug nanoparticles were further used as nanocarriers, doxorubicin (DOX) was additionally encapsulated and variable nanomorphologies (nanospheres, branched nanoparticles) were obtained, and an enhanced chemotherapy efficacy was achieved as well.
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