Facile green synthesis of bioresorbable polyester from soybean oil and recycled plastic waste for osteochondral tissue regeneration

Despite the recent progress in the field of tissue engineering still there are great challenges to regenerate osteochondral tissue interface due to its complex material composition and mechanical properties. A series of biomaterials have been developed in the last few decades, still suitable biomaterial remained undiscover to regenerate osteochondral tissue interface. Here we have reported a new family of low cost biopolymer derived from edible soybean oil (SO) and recycled polyethylene terephthalate (PET) waste along with other renewable resources such as citric acid, sebacic acid and mannitol by facile catalyst and solvent free melt polycondensation process. The physicochemical properties of the synthesized polyester can be tailored by simply varying the monomer feed ratio. The polyesters were found to be elastomeric and biodegradable in nature. 3D porous scaffold shows in vitro mineralization which attributes that the polymer may be applicable for bone formation. 2D polyester film exhibited excellent cytocompatibility to the stem cell and interestingly the polyester guided the stem cell towards both osteogenic and chondrogenic differentiation without using any external differentiating chemicals. Thus this novel class of polyester derived from SO, recycled PET waste and other low cost renewable resources may be a potential candidate in field of interfacial tissue engineering for the treatment of arthritic patients in future.