Article
Chemistry, Multidisciplinary
Jonathan O. Martinez, Michael Evangelopoulos, Ava A. Brozovich, Guillermo Bauza, Roberto Molinaro, Claudia Corbo, Xuewu Liu, Francesca Taraballi, Ennio Tasciotti
Summary: The study introduces a versatile multicomponent delivery platform that combines MSC tropism with MSV-mediated payload delivery, demonstrating increased drug release and reduced inflammation, resulting in improved outcomes in experimental models.
ADVANCED FUNCTIONAL MATERIALS
(2021)
Review
Polymer Science
Cecilie Hoeeg, Alireza Dolatshahi-Pirouz, Bjarke Follin
Summary: Cell therapy has the potential to regenerate cardiac tissue and treat various cardiac diseases. Injectable hydrogels have been investigated for their potential to improve cell graft retention and enhance the effects of cardiac cell therapy.
Article
Biotechnology & Applied Microbiology
Kyong-Su Park, Markus Bergqvist, Cecilia Lasser, Jan Lotvall
Summary: This study presents a simple method for generating synthetic eukaryotic vesicles (SyEV) from cells, which can efficiently load anti-inflammatory drugs and suppress systemic inflammation. The loaded SyEV with peptides targeting Myd88 show enhanced therapeutic potential in bacteria outer membrane vesicles (OMV)-induced macrophages. In vivo experiments demonstrate that MSC-SyEV encapsulating peptides synergistically suppress cytokine production. These findings suggest the promising use of SyEV-based therapeutics for treating systemic inflammation without severe side effects.
JOURNAL OF NANOBIOTECHNOLOGY
(2022)
Article
Multidisciplinary Sciences
Martha G. Castillo, Tomas M. Peralta, Paola Locatelli, Candela Velazquez, Yamila Herrero, Alberto J. Crottogini, Fernanda D. Olea, Luis A. Cuniberti
Summary: BM-Muse cells have shown potential in reducing myocardial infarct size and improving cardiac function, but their ability to promote new blood-vessel formation needs further investigation. The present study examined the neovascularization capacity of AT-Muse cells in vitro and in vivo using an ovine model of acute myocardial infarction. The results demonstrated that intramyocardially administered AT-Muse cells displayed significant neovascularization activity and survival capacity in the animal model.
Review
Biochemistry & Molecular Biology
Hsuan Peng, Kazuhiro Shindo, Renee R. Donahue, Ahmed Abdel-Latif
Summary: Stem cell-based cardiac therapies present challenges in cell delivery, engraftment, and differentiation, but still lead to sustained cardiac benefits. Current research focuses on exploring the mechanisms of stem cell-mediated cardiac immunomodulation, with efforts to improve current strategies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Pharmacology & Pharmacy
Jocelyn Nikita Campa-Carranza, Jesus Paez-Mayorga, Corrine Ying Xuan Chua, Joan E. Nichols, Alessandro Grattoni
Summary: This article reviews recent advances in immunoengineering strategies for localized immunomodulation, aiming to support allograft function and provide immune tolerance in a safe and effective manner.
EXPERT OPINION ON DRUG DELIVERY
(2022)
Review
Medicine, Research & Experimental
Jianghong Huang, Qisong Liu, Jiang Xia, Xi Chen, Jianyi Xiong, Lei Yang, Yujie Liang
Summary: This article comprehensively reviews the homing effect of stem cells in joints and highlights progress towards the targeted modification of MSCs.
JOURNAL OF TRANSLATIONAL MEDICINE
(2022)
Article
Veterinary Sciences
Eva Punzon, Maria Garcia-Castillo, Miguel A. Rico, Laura Padilla, Almudena Pradera
Summary: This study aimed to evaluate the safety of intra-articular administration of equine umbilical cord mesenchymal stem cells (EUC-MSC) in young healthy dogs under field conditions. The safety profile of allogenic canine adipose derived mesenchymal stem cells (CAD-MSC) and placebo was also compared. The results show that the intra-articular administration of equine umbilical cord mesenchymal stem cells in dogs is safe.
FRONTIERS IN VETERINARY SCIENCE
(2023)
Article
Cell Biology
Denise Zujur, Ziadoon Al-Akashi, Anna Nakamura, Chengzhu Zhao, Kazuma Takahashi, Shizuka Aritomi, William Theoputra, Daisuke Kamiya, Koichi Nakayama, Makoto Ikeya
Summary: We developed a stepwise differentiation method to generate matrix-rich cartilage spheroids from induced pluripotent stem cell-derived mesenchymal stem/stromal cells (iMSCs) via the induction of neural crest cells under xeno-free conditions. By using a thienoindazole derivative, TD-198946, we achieved enhanced chondrogenesis in iMSCs. Our findings provide a novel cell source for stem cell-based cartilage repair and offer the potential for biofabrication of larger cartilage tissues using chondrogenic spheroids and technologies such as Kenzan Bioprinting.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Review
Oncology
Zhijie Weng, Bowen Zhang, Chenzhou Wu, Fanyuan Yu, Bo Han, Bo Li, Longjiang Li
Summary: Extracellular vesicles (EVs) are essential regulators of intercellular communication enclosing various biomolecules, and MSC-derived EVs have shown potential applications in cancer treatment. However, challenges remain in translating MSC-derived EVs from bench to bedside.
JOURNAL OF HEMATOLOGY & ONCOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Blazej Nowak, Piotr Rogujski, Miroslaw Janowski, Barbara Lukomska, Anna Andrzejewska
Summary: Mesenchymal stem cells (MSCs) show potential in the treatment of glioblastoma (GBM), with possibilities of anti-tumor properties as well as risks of increasing tumor aggressiveness.
BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER
(2021)
Article
Cell & Tissue Engineering
Eun-Young Shin, Da-Seul Kim, Min Ji Lee, Ah Reum Lee, Sung Han Shim, Seung Woon Baek, Dong Keun Han, Dong Ryul Lee
Summary: This study successfully delivered human ESC-MPCs locally to the ovaries in mice using two bioinspired scaffolds, effectively restoring ovarian functions, increasing ovarian reserve numbers and sex hormone levels, reducing apoptotic levels, and improving oocyte and embryo quality as well as estrous cycle regularity.
STEM CELL RESEARCH & THERAPY
(2021)
Article
Biochemistry & Molecular Biology
Paula Laranjeira, Francisco dos Santos, Maria Joao Salvador, Irina N. Simoes, Carla M. P. Cardoso, Barbara M. Silva, Helena Henriques-Antunes, Luisa Corte-Real, Sofia Couceiro, Filipa Monteiro, Carolina Santos, Tania Santiago, Jose A. P. da Silva, Artur Paiva
Summary: Systemic sclerosis (SSc) is an immune-mediated disease with poor prognosis and limited therapeutic options. Mesenchymal-stem/stromal-cell (MSC)-based therapies have potential benefits for SSc patients due to their immunomodulatory, anti-fibrotic, and pro-angiogenic properties. This study found that MSCs downregulated the activation of T cell subsets and affected their polarization in SSc patients, including subsets implicated in SSc's pathogenesis. This provides further support for the potential of MSC-based therapies to regulate T cells in SSc.
Review
Pharmacology & Pharmacy
Muhammad Tahir, Nadeem Ahmad, Dong Lei, Sakhawat Ali
Summary: Recombinant virus-based transgene therapy shows promising results in solid tumors. Utilizing mesenchymal stem cells as Trojan horses for systemic administration of recombinant viruses provides a safer and more effective drug delivery method with potential applications in glioblastoma and other studies.
DRUG DISCOVERY TODAY
(2022)
Article
Medicine, Research & Experimental
Youngrong Park, Abraham S. Moses, Ananiya A. Demessie, Prem Singh, Hyelim Lee, Tetiana Korzun, Olena R. Taratula, Adam W. G. Alani, Oleh Taratula
Summary: This study reports on mRNA-loaded polymeric nanoparticles that induce protein expression in the lungs and muscles. The density of polyethylene glycol on the nanoparticle surface should be optimized based on the purpose of the mRNA treatment and the delivery route.
MOLECULAR PHARMACEUTICS
(2022)
Review
Medicine, Research & Experimental
Chang-Xing Li, Sobia Noreen, Li-Xue Zhang, Muhammad Saeed, Pei-Feng Wu, Muhammad Ijaz, Dong-Fang Dai, Irsah Maqbool, Asadullah Madni, Faizan Akram, Muhammad Naveed, Jian-Hua Li
Summary: This article summarizes the global outbreak of coronavirus disease, different strains of SARS-CoV-2, etiology, complexities in treatment, and the current status of vaccines for COVID-19.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Environmental Sciences
Manthar Ali Mallah, Changxing Li, Mukhtiar Ali Mallah, Sobia Noreen, Yang Liu, Muhammad Saeed, He Xi, Bilal Ahmed, Feifei Feng, Ali Asghar Mirjat, Wei Wang, Abdul Jabar, Muhammad Naveed, Jian-Hua Li, Qiao Zhang
Summary: Polycyclic aromatic hydrocarbons (PAHs) are chemical contaminants of environmental significance. PAH pollution mainly comes from anthropogenic sources and can pose a significant threat to human health. Long-term exposure to PAHs can lead to tumor development in multiple organs and increase the risk of lung cancer and cardiovascular diseases. Studies have shown a relationship between PAH exposure, oxidative stress, and atherosclerosis.
Review
Pharmacology & Pharmacy
Qin-Yuan Li, Mahzaib Munawar, Muhammad Saeed, Ji-Qiang Shen, Muhammad Sajjad Khan, Sobia Noreen, Mahmoud Alagawany, Muhammad Naveed, Asadullah Madni, Chang-Xing Li
Summary: Increasing health consciousness and knowledge about synthetic drug side effects have led to a growing interest in traditional medicines, especially herb-based medicines like Citrullus colocynthis. This herbaceous plant is rich in nutrients and bioactive compounds, offering various medicinal properties such as antioxidative, anti-inflammatory, and even pesticidal effects. Comprehensive research and analysis have shown the potential of C. colocynthis in treating disorders in both humans and animals, highlighting its positive impacts and potential risks on human health, particularly in veterinary and poultry fields.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Muhammad Naveed, Lian-Di Li, Gang Sheng, Zi-Wei Du, Ya-Ping Zhou, Sun Nan, Ming-Yi Zhu, Jing Zhang, Qi-Gang Zhou
Summary: Agomelatine, a unique melatonin analog, has antidepressant properties and a large therapeutic index that improves clinical safety. It acts as an agonist on melatonin receptors (MT1 and MT2) and an antagonist on 5HT2C receptors, enabling the resynchronization of circadian rhythms and improving sleep architecture.
CURRENT MOLECULAR PHARMACOLOGY
(2022)
Review
Urology & Nephrology
Muhammad Naveed, Changxing Li, Awais Ullah Ihsan, Muhammad Shumzaid, Asghar Ali Kamboh, Ali Asghar Mirjat, Muhammad Saeed, Mirza Muhammad Faran Ashraf Baig, Hafiz Muhammad Zubair, Sobia Noreen, Asadullah Madni, Xiaohui Zhou
Summary: The assessment and management of urologic chronic pelvic pain syndrome (UCPPS) is controversial due to the lack of reliable tools for evaluating symptoms and quality of life impact. The etiology is multifactorial, and treatment options are uncertain. The immune system plays an important role in the disease. The UPOINT system can guide treatment and improve symptoms.
Article
Environmental Sciences
Manthar Ali Mallah, Li Changxing, Mukhtiar Ali Mallah, Muhammad Naveed, Yang Liu, Sobia Noreen, He Xi, Wei Wang, Feifei Feng, Qiao Zhang
Summary: This study aimed to investigate the association between urinary PAHs and cardiovascular diseases. The results showed a positive correlation between urinary PAHs and the prevalence of coronary heart disease, angina, heart attack, and stroke.
ENVIRONMENTAL RESEARCH
(2022)
Article
Materials Science, Multidisciplinary
Sobia Noreen, Arslan Maqbool, Irsah Maqbool, Afifa Shafique, Muhammad Muzamil Khan, Yasmeen Junejo, Bilal Ahmed, Maryam Anwar, Asma Majeed, Muhammad Abbas, Muhammad Naveed, Asadullah Madni
Summary: Nanotechnology is the emerging field that focuses on controlling material configuration at a reduced scale, and multifunctional mesoporous silica nanoparticles (MSNPs) have been shown to have great potential in tumor treatment and imaging. Functionalized mesoporous silica materials have rapidly advanced in imaging and therapeutic applications.
MATERIALS CHEMISTRY AND PHYSICS
(2022)
Article
Chemistry, Multidisciplinary
Asiya Bashir, Muhammad Asif, Malik Saadullah, Mohammad Saleem, Syed Haroon Khalid, Liaqat Hussain, Ikram Ullah Khan, Hafiza Sidra Yaseen, Hafiz Muhammad Zubair, Muhammad Usman Shamas, Raghdaa Al Zarzour, Tahir Ali Chohan
Summary: The study found that Melilotus indicus has anti-inflammatory and anticancer properties. The ethanolic extract of Melilotus indicus showed potential in attenuating skin carcinogenesis in an animal model. Quercetin and coumarin, the primary phytochemicals in Melilotus indicus, also exhibited anticancer effects against skin cancer. Furthermore, the extract demonstrated antiangiogenic properties and decreased levels of carcinoembryonic antigen and tumor necrosis factor-alpha in the serum. Docking studies indicated the binding potential of quercetin and coumarin with certain proteins related to cancer. Further research is needed to explore the potential of Melilotus indicus and its bioactive molecules as adjuvant therapy with low dose anticancer drugs.
Article
Integrative & Complementary Medicine
Muhammad Furqan Akhtar, Komal Maria Ashraf, Ammara Saleem, Ali Sharif, Hafiz Muhammad Zubair, Fareeha Anwar
Summary: The aim of this study was to evaluate the antioxidant and antidiabetic potential of Indian olive seed extracts. The results showed that these extracts exhibited significant antioxidant and antidiabetic activities, and improved the liver and kidney function of diabetic rats.
EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
(2022)
Review
Rehabilitation
Manthar Ali Mallah, Tahmina Soomro, Sobia Noreen, Mukhtiar Ali, Akriti Kafle, Nafeesa Khatoon, Muhammad Naveed
Summary: Obesity is a severe health concern that is associated with heart failure and cardiovascular disease. It is caused by a metabolic imbalance where more calories are consumed than burnt. Obesity has adverse impacts on the cardiovascular system, including inflammation, atherosclerosis, and high blood pressure. It is also a known risk factor for various diseases.
INTERNATIONAL JOURNAL OF REHABILITATION RESEARCH
(2023)
Article
Immunology
Amna Tahir, Muhammad Furqan Akhtar, Ammara Saleem, Muhammad Naveed, Basiru Olaitan Ajiboye, Fareeha Anwar, Aslam Khan
Summary: PCCR is a traditional herbal medicine used for treating muscular swelling, inflammation, pain, and fever. This study confirmed the anti-inflammatory, analgesic, and neuroprotective effects of PCCR in arthritic rats. PCCR exhibited antioxidant and anti-inflammatory activities, improved oxidative stress, and reduced inflammatory markers in rats with arthritis.
INFLAMMOPHARMACOLOGY
(2023)
Article
Oncology
Hafiz Muhammad Zubair, Muhammad Arslan Khan, Faisal Gulzar, Musaed Alkholief, Abdul Malik, Suhail Akhtar, Ali Sharif, Muhammad Furqan Akhtar, Muhammad Abbas
Summary: This study aims to explore the experiences of NSCLC patients receiving palliative chemotherapy and their adaptation to post-chemotherapy life, beliefs, and quality of life. Through face-to-face interviews, the patients' experiences were categorized into five themes, revealing the importance of shared decision-making between clinicians and patients.
CANCER MANAGEMENT AND RESEARCH
(2023)
Article
Medicine, General & Internal
Muhammad Safdar, Mehmet Ozaslan, Rebaz M. Mustafa, Shukur W. Smail, Samiha S. Khan, Muhammad Sajjad Khan, Muhammad Asad Akhtar, Hafiz Khawar Ali, Umair Younas, Muhammad Saeed, Faisal Siddique, Muhammad Naveed, SaifUr Rehman
Summary: This study explores the association between increased susceptibility and severity in hypertensive COVID-19 patients. The findings suggest that certain SNPs in the ACE2 gene may contribute to the severity of COVID-19 in individuals with hypertension.
JOURNAL OF TAIBAH UNIVERSITY MEDICAL SCIENCES
(2023)
Article
Pharmacology & Pharmacy
Shahbaz Irshad, Irfan Anjum, Muhammad Naveed Mushtaq, Kalim Ullah, Kashif Barkat, Muhammad Nasir Hayat Malik, Muhammad Ahmer Raza, Muhammad Zubair
Summary: This study confirmed the anti-inflammatory, analgesic, and antipyretic properties of Fagonia bruguieri, which may be attributed to the presence of various phyto-constituents.
PAKISTAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2022)