☆ 4.5 Article

Voluntary movements cause beta oscillations increase and broadband slope decrease in the subthalamic nucleus of parkinsonian patients

EUROPEAN JOURNAL OF NEUROSCIENCE (2021)

Journal

EUROPEAN JOURNAL OF NEUROSCIENCE

Volume 53, Issue 7, Pages 2205-2213

Publisher

WILEY

DOI: 10.1111/ejn.14715

Keywords

local field potentials; movement; Parkinson's disease; subthalamic nucleus

Funding

Russian Foundation for Basic Research [18-015-00140, 20-315-70016]
ICP RAS [0082-2014-0001, AAAA-A17-117040610310]

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Abstract

The study compared LFP signals in the STN of Parkinson's patients at rest and during hand, sometimes followed by leg movements. It found a significant increase in synchronization in the low beta range during leg movements, with an increase in gamma range synchronization for both movements. The slope of the aperiodic component may reflect the excitatory/inhibitory projections ratio in the recording site, correlating significantly with motor signs of PD.

Periodic features of local field potentials (LFP) are extensively studied to establish the pathophysiological features contributing to Parkinson's disease (PD). Pathological LFP synchronization in the subthalamic nucleus (STN) was assumed to link with motor signs of PD. Commonly, the association between oscillations and clinical signs is studied while the patients are at rest. However, changes in LFPs during movement may reflect particular traits of motor processing in the basal ganglia under PD. Recently, the aperiodic 1/f broadband component of LFP spectra has attracted the attention of researchers because it may provide meaningful information about the neural activity in the brain. Here, we compared LFP signals in the STN of parkinsonian patients at rest and during hand movements occasionally followed by leg movements using two approaches, one of which accounts for the aperiodic features of LFP spectra. Using both methods, a significant increase was observed in synchronization in the low beta range during sequent leg but not hand movements. For either movement, there was a significant increase in gamma range synchronization using uncorrected power spectra and a significant decrease in the slope of the aperiodic component for the 1/f-corrected method. These findings may support the claim that the 1/f slope possibly reflects the excitatory/inhibitory projections ratio in the recording site. Only the difference in the slope correlated significantly with motor signs of PD. These data show that the slope of aperiodic component may be a useful measure that is sensitive to the specific state and its changes in the brain.

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Single-neuron bursts encode pathological oscillations in subcortical nuclei of patients with Parkinson's disease and essential tremor

Maximilian Scherer, Leon A. Steiner, Suneil K. Kalia, Mojgan Hodaie, Andrea A. Kuhn, Andres M. Lozano, William D. Hutchison, Luka Milosevic

Summary: Deep brain stimulation procedures provide an opportunity to study disease through intracranial recordings. This study investigates the relationship between single-neuron and aggregate-level activities in patients with Parkinson's disease and essential tremor. The findings suggest that periodic single-neuron bursts encode pathophysiological LFP oscillations, and the phase-coupling relationship between LFP and high-frequency oscillation signals is similar to that between LFP and single-neuron bursting. These results shed light on the origin of pathophysiological oscillations in movement disorders.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2022)