The contribution of Parkin, PINK1 and DJ‐1 genes to selective neuronal degeneration in Parkinson's disease

Protein damage, ageing and age-related diseases

(2019) Anita Krisko et al.   Open Biology

Alpha-synuclein mitochondrial interaction leads to irreversible translocation and complex I impairment

(2018) Jimena H. Martínez et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

A tango for two: Dopamine and α-synuclein synergy may explain nigrostriatal degeneration in Parkinson's disease

(2018) Vivian Chen et al.   MOVEMENT DISORDERS

DJ-1 deficiency impairs synaptic vesicle endocytosis and reavailability at nerve terminals

(2018) Jae Won Kyung et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Can Interactions Between α-Synuclein, Dopamine and Calcium Explain Selective Neurodegeneration in Parkinson's Disease?

(2018) Michael R. Post et al.   Frontiers in Neuroscience

Epidemiology of Parkinson’s disease

(2017) Ole-Bjørn Tysnes et al.   JOURNAL OF NEURAL TRANSMISSION

α-Synuclein promotes dilation of the exocytotic fusion pore

(2017) Todd Logan et al.   NATURE NEUROSCIENCE

The two-century journey of Parkinson disease research

(2017) Serge Przedborski   NATURE REVIEWS NEUROSCIENCE

Dopamine oxidation mediates mitochondrial and lysosomal dysfunction in Parkinson’s disease

(2017) Lena F. Burbulla et al.   SCIENCE

DJ-1 Inhibits α-Synuclein Aggregation by Regulating Chaperone-Mediated Autophagy

(2017) Chuan-Ying Xu et al.   Frontiers in Aging Neuroscience

The MPTP Story

(2017) J. William Langston   Journal of Parkinsons Disease

DJ-1 linked parkinsonism (PARK7) is associated with Lewy body pathology

(2016) Ricardo Taipa et al.   BRAIN

Alpha-synuclein structure, functions, and interactions

(2016) FatemehNouri Emamzadeh   Journal of Research in Medical Sciences

Dynamic structural flexibility of α-synuclein

(2016) Danielle E. Mor et al.   NEUROBIOLOGY OF DISEASE

Vesicular Monoamine Transporter 2 (VMAT2) Level Regulates MPTP Vulnerability and Clearance of Excess Dopamine in Mouse Striatal Terminals

(2016) Kelly M. Lohr et al.   TOXICOLOGICAL SCIENCES

The relevance of pre-motor symptoms in Parkinson’s disease

(2015) Naomi Visanji et al.   Expert Review of Neurotherapeutics

Human J-protein DnaJB6b Cures a Subset ofSaccharomyces cerevisiaePrions and Selectively Blocks Assembly of Structurally Related Amyloids

(2015) Michael Reidy et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Parkinson's disease

(2015) Lorraine V Kalia et al.   LANCET

Increased expression of the dopamine transporter leads to loss of dopamine neurons, oxidative stress and l-DOPA reversible motor deficits

(2015) S.T. Masoud et al.   NEUROBIOLOGY OF DISEASE

The Roles of PINK1, Parkin, and Mitochondrial Fidelity in Parkinson’s Disease

(2015) Alicia M. Pickrell et al.   NEURON

Aggregated α-synuclein and complex I deficiency: exploration of their relationship in differentiated neurons

(2015) A K Reeve et al.   Cell Death & Disease

The relevance of pre-motor symptoms in Parkinson’s disease

(2015) Naomi Visanji et al.   Expert Review of Neurotherapeutics

Prion-like propagation of human brain-derived alpha-synuclein in transgenic mice expressing human wild-type alpha-synuclein

(2015) Maria E. Bernis et al.   Acta Neuropathologica Communications

PINK1 Is Dispensable for Mitochondrial Recruitment of Parkin and Activation of Mitophagy in Cardiac Myocytes

(2015) Dieter A. Kubli et al.   PLoS One

Divergent effects of the H50Q and G51DSNCAmutations on the aggregation of α-synuclein

(2014) Nicola J. Rutherford et al.   JOURNAL OF NEUROCHEMISTRY

α-Synuclein assembles into higher-order multimers upon membrane binding to promote SNARE complex formation

(2014) Jacqueline Burré et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dopamine-induced α-synuclein oligomers show self- and cross-propagation properties

(2014) Matthew S. Planchard et al.   PROTEIN SCIENCE

Lysosomes and α-synuclein form a dangerous duet leading to neuronal cell death

(2014) Mathieu Bourdenx et al.   Frontiers in Neuroanatomy

MUL1 acts in parallel to the PINK1/parkin pathway in regulating mitofusin and compensates for loss of PINK1/parkin

(2014) Jina Yun et al.   eLife

Evidence of oxidative stress in young and aged DJ-1-deficient mice

(2013) Arjun V. Raman et al.   FEBS LETTERS

Characterization of PINK1 (PTEN-induced Putative Kinase 1) Mutations Associated with Parkinson Disease in Mammalian Cells andDrosophila

(2013) Saera Song et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Parkinson Disease Protein DJ-1 Binds Metals and Protects against Metal-induced Cytotoxicity

(2013) Benny Björkblom et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Function of α-Synuclein

(2013) Jacob T. Bendor et al.   NEURON

Genetics of Parkinson's Disease

(2013) C. Klein et al.   Cold Spring Harbor Perspectives in Medicine

Structure and Function of Parkin, PINK1, and DJ-1, the Three Musketeers of Neuroprotection

(2013) Jean-François Trempe et al.   Frontiers in Neurology

Dopamine-derived Quinones Affect the Structure of the Redox Sensor DJ-1 through Modifications at Cys-106 and Cys-53

(2012) Stefania Girotto et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

DJ-1 Protects Against Dopamine Toxicity: Implications for Parkinson's Disease and Aging

(2012) N. Lev et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Living on the edge with too many mouths to feed: Why dopamine neurons die

(2012) J. Paul Bolam et al.   MOVEMENT DISORDERS

Dopamine Oxidation and Autophagy

(2012) Patricia Muñoz et al.   Parkinsons Disease

DJ-1 regulation of mitochondrial function and autophagy through oxidative stress

(2011) Melissa K. McCoy et al.   Autophagy

Depletion of PINK1 affects mitochondrial metabolism, calcium homeostasis and energy maintenance

(2011) B. Heeman et al.   JOURNAL OF CELL SCIENCE

Functional Alterations to the Nigrostriatal System in Mice Lacking All Three Members of the Synuclein Family

(2011) S. Anwar et al.   JOURNAL OF NEUROSCIENCE

Molecular chaperones in protein folding and proteostasis

(2011) F. Ulrich Hartl et al.   NATURE

In vivo demonstration that  -synuclein oligomers are toxic

(2011) B. Winner et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

PINK1 stabilized by mitochondrial depolarization recruits Parkin to damaged mitochondria and activates latent Parkin for mitophagy

(2010) Noriyuki Matsuda et al.   JOURNAL OF CELL BIOLOGY

Protein degradation, aggregation, and misfolding

(2010) Ana Maria Cuervo et al.   MOVEMENT DISORDERS

Membrane Permeabilization by Oligomeric α-Synuclein: In Search of the Mechanism

(2010) Bart D. van Rooijen et al.   PLoS One

A Biochemical and Functional Protein Complex Involving Dopamine Synthesis and Transport into Synaptic Vesicles

(2009) Etienne A. Cartier et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Interplay between Cytosolic Dopamine, Calcium, and α-Synuclein Causes Selective Death of Substantia Nigra Neurons

(2009) Eugene V. Mosharov et al.   NEURON

Neuromelanin Activates Microglia and Induces Degeneration of Dopaminergic Neurons: Implications for Progression of Parkinson’s Disease

(2009) Wei Zhang et al.   NEUROTOXICITY RESEARCH

Wild Type α-Synuclein Is Degraded by Chaperone-mediated Autophagy and Macroautophagy in Neuronal Cells

(2008) Tereza Vogiatzi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Parkin is recruited selectively to impaired mitochondria and promotes their autophagy

(2008) Derek Narendra et al.   JOURNAL OF CELL BIOLOGY

Lewy bodies in grafted neurons in subjects with Parkinson's disease suggest host-to-graft disease propagation

(2008) Jia-Yi Li et al.   NATURE MEDICINE

Structural effects of Parkinson's disease linked DJ-1 mutations

(2008) Gaetano Malgieri et al.   PROTEIN SCIENCE