Article
Clinical Neurology
Keke Liang, Xiaohuan Li, Jianjun Ma, Hongqi Yang, Xiaoxue Shi, Yongyan Fan, Dawei Yang, Dashuai Guo, Chuanze Liu, Linrui Dong, Qingqing Chang, Qi Gu, Siyuan Chen, Dongsheng Li
Summary: In this study, the incidence of and risk factors for dopamine dysregulation syndrome (DDS) in patients with early Parkinson's disease (PD) were explored. It was found that early PD patients with hypersexuality, compulsive eating, compulsive shopping, anxiety, and lower Hoehn-Yahr stage were at increased risk for DDS. Early identification of risk factors for DDS is crucial for improving the quality of life of PD patients.
NEUROLOGICAL SCIENCES
(2023)
Review
Geriatrics & Gerontology
Rwei-Ling Yu, Ruey-Meei Wu
Summary: Mild cognitive impairment (MCI) is a common non-motor symptom in patients with Parkinson's disease (PD), but lacks consistent diagnostic criteria. Different types of cognitive impairments have different progression rates. This review provides an overview of the diagnostic criteria for PD-MCI and the heterogeneity of patients' cognitive function.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Review
Clinical Neurology
Antonio Martin-Bastida, Manuel Delgado-Alvarado, Irene Navalpotro-Gomez, Maria Cruz Rodriguez-Oroz
Summary: Dementia, mild cognitive impairment, and neuropsychiatric symptoms are common non-motor symptoms of Parkinson's disease. Neuroimaging studies play a critical role in early diagnosis, monitoring, and understanding the pathophysiology of cognitive and neuropsychiatric symptoms associated with PD. This literature review provides an update on the latest neuroimaging findings for assessing cognitive dysfunction and impulse control disorders in PD.
FRONTIERS IN NEUROLOGY
(2021)
Article
Clinical Neurology
Teresa de Deus Fonticoba, Carlos Cores Bartolome, Maria J. Feal Painceiras, Iago Garcia Diaz, Maria Cristina iniguez Alvarado, Jose Manuel Paz, Silvia Jesus, Marina Cosgaya, Juan Garcia Caldentey, Nuria Caballol, Ines Legarda, Jorge Hernandez Vara, Iria Cabo, Lydia Lopez Manzanares, Isabel Gonzalez Aramburu, Maria A. avila Rivera, Victor Gomez Mayordomo, Victor Nogueira, Julio Dotor Garcia-Soto, Carmen Borrue, Berta Solano Vila, Maria alvarez Sauco, Lydia Vela, Sonia Escalante, Esther Cubo, Zebenzui Mendoza, Juan C. Martinez Castrillo, Pilar Sanchez Alonso, Maria G. Alonso Losada, Nuria Lopez Ariztegui, Itziar Gaston, Jaime Kulisevsky, Manuel Seijo, Caridad Valero, Ruben Alonso Redondo, Maria Teresa Buongiorno, Carlos Ordas, Manuel Menendez-Gonzalez, Darrian McAfee, Pablo Martinez-Martin, Pablo Mir, A. D. Adarmes, A. D. Adarmes, M. Almeria, M. G. Alonso Losada, A. Alonso Canovas, F. Alonso Frech, R. Alonso Redondo, I. alvarez, M. alvarez Sauco, A. Aneiros Diaz, S. Arnaiz, S. Arribas, A. Ascunce Vidondo, M. Aguilar, M. A. avila, N. Nernardo Lambrich, H. Bejr-Kasem, M. Blazquez Estrada, M. Boti, C. Borrue, M. T. Buongiorno, C. Cabello Gonzalez, I. Cabo Lopez, N. Caballol, A. Camara Lorenzo, H. Canfield Medina, E. Carabajal Pendon, F. Carrillo, F. J. Carrillo Padilla, E. Casas, M. J. Catalan, P. Clavero, A. Cortina Fernandez, M. Cosgaya, A. Cots Foraster, A. Crespo Cuevas, E. Cubo, T. de Deus Fonticoba, O. de Fabregues-Boixar, M. Diez-Fairen, J. Dotor Garcia-Soto, E. Erro, S. Escalante, EEstelrich Peyret, N. Fernandez Guillan, P. Gamez, M. Gallego, J. Garcia Caldentey, C. Garcia Campos, C. Garcia Diez, J. M. Garcia Moreno, I. Gaston, M. P. Gomez Garre, V. Gomez Mayordomo, J. Gonzalez Aloy, I. Gonzalez-Aramburu, J. Gonzalez Ardura, B. Gonzalez Garcia, M. J. Gonzalez Palmas, G. R. Gonzalez Toledo, A. Golpe Diaz, M. Grau Sola, G. Guardia, J. Hernandez Vara, A. Horta-Barba, DIdoate Calderon, J. Infante, S. Jesus, J. Kulisevsky, M. Kurtis, C. Labandeira, M. A. Labrador, F. Lacruz, M. Lage Castro, S. Lastres Gomez, I. Legarda, NLopez Ariztegui, L. M. Lopez Diaz, D. Lopez Dominguez, L. Lopez Manzanares, B. Lopez Seoane, S. Lucas del Pozo, Y. Macias, M. Mata, G. Marti Andres, M. J. Marti, J. C. Martinez Castrillo, P. Martinez-Martin, D. McAfee, M. T. Meitin, Z. Mendoza Plasencia, M. Menendez Gonzalez, C. Mendez del Barrio, P. Mir, J. Miranda Santiago, M. I. Morales Casado, A. Moreno Dieguez, I. Muro Garcia, V. Nogueira, A. Novo Amado, S. Novo Ponte, C. Ordas, J. Pagonabarraga, I. Parees, B. Pascual-Sedano, P. Pastor, A. Perez Fuertes, R. Perez Noguera, A. Planas-Ballve, L. Planellas, M. A. Prats, C. Prieto Jurczynska, V. Puente, M. Pueyo Morlans, A. Puig Davi, N. Redondo Rafales, L. Rodriguez Mendez, ABRodriguez Perez, F. Roldan, M. Ruiz De Arcos, J. Ruiz Martinez, P. Sanchez Alonso, M. Sanchez-Carpintero, G. Sanchez Diez, A. Sanchez Rodriguez, P. Santacruz, D. Santos Garcia, J. C. Segundo Rodriguez, M. Seijo, M. Sierra Pena, B. Solano Vila, E. Suarez Castro, J. P. Tartari, C. Valero, L. Vargas, L. Vela, C. Villanueva
Summary: This study aimed to analyze the change in cognitive function in patients with young-onset Parkinson's disease (YOPD) compared to those with a later onset and controls. The results showed that YOPD patients had better cognitive function compared to non-YOPD patients and controls, while non-YOPD patients experienced a significant decline in cognitive function during the study. At the end of the study, the incidence of dementia and mild cognitive impairment was significantly higher in non-YOPD patients than in YOPD patients.
JOURNAL OF NEUROLOGY
(2023)
Article
Neurosciences
Conor Owens-Walton, Chris Adamson, Mark Walterfang, Sara Hall, Danielle Westen, Oskar Hansson, Marnie Shaw, Jeffrey C. L. Looi
Summary: People diagnosed with Parkinson's disease can experience cognitive impairment and dementia, which may be related to structural changes in the corpus callosum. This study used magnetic resonance imaging to investigate the thickness of the corpus callosum and cortex in Parkinson's disease patients with varying levels of cognitive impairment. The results showed thinning of the callosum in patients with dementia, and a positive correlation between the thickness of the anterior callosum and the thickness of the cortex in patients with mild cognitive impairment.
EUROPEAN JOURNAL OF NEUROSCIENCE
(2022)
Article
Clinical Neurology
Alexander K. Song, Kaitlyn R. Hay, Paula Trujillo, Megan Aumann, Adam J. Stark, Yan Yan, Hakmook Kang, Manus J. Donahue, David H. Zald, Daniel O. Claassen
Summary: This study demonstrates that reward-based behaviors in Parkinson's disease are regulated by ventral striatal dopamine release, and suggests that loss of inhibitory feedback from midbrain autoreceptors may underlie the manifestation of impulsive-compulsive behaviors.
Article
Biochemistry & Molecular Biology
Mechelle M. Lewis, Lauren J. Van Scoy, Sol De Jesus, Jonathan G. Hakun, Paul J. Eslinger, Julio Fernandez-Mendoza, Lan Kong, Yang Yang, Bethany L. Snyder, Natalia Loktionova, Sridhar Duvvuri, David L. Gray, Xuemei Huang, Richard B. Mailman
Summary: Current pharmacotherapy has limited efficacy and intolerable side effects in late-stage Parkinson's disease patients. A study was conducted to explore the efficacy of a D-1/5 dopamine agonist in these patients. Caregiver assessment was used as the primary efficacy measure, and the results showed that the D-1/5 agonist had better efficacy compared to levodopa in most patients.
Article
Psychology, Multidisciplinary
Hugo Juan Camilo Clavijo-Moran, Daniela Alvarez-Garcia, Gabriel D. Pinilla-Monsalve, Beatriz Munoz-Ospina, Jorge Orozco
Summary: This study investigated the cognitive assessment scale for patients with Parkinson's disease in the Colombian population and found that the Parkinson's Disease Cognitive Rating Scale (PD-CRS) has acceptable psychometric properties and significant correlation and agreement with another validated scale (MoCA).
FRONTIERS IN PSYCHOLOGY
(2022)
Review
Psychology, Multidisciplinary
Chichun Sun, Melissa J. Armstrong
Summary: Management of cognitive impairment in Parkinson's disease is challenging, with limited effective pharmacologic treatments and insufficient evidence for non-pharmacologic interventions. Research is needed to develop both disease-modifying and symptomatic treatments for Parkinson's disease-related cognitive impairment.
BEHAVIORAL SCIENCES
(2021)
Article
Clinical Neurology
Tim D. van Balkom, Henk W. Berendse, Ysbrand D. van der Werf, Jos W. R. Twisk, Carel F. W. Peeters, Adriaan W. Hoogendoorn, Rob H. Hagen, Tanja Berk, Odile A. van den Heuvel, Chris Vriend
Summary: This study found no beneficial effect of eight-week computerized cognitive training on the primary outcome (planning accuracy) and only minor improvements on secondary outcomes (processing speed) with limited clinical impact.
PARKINSONISM & RELATED DISORDERS
(2022)
Review
Food Science & Technology
Wei Quan, Yong Lin, Huiyu Zou, Maiquan Li, Jie Luo, Zhiyong He, Jie Chen, Zhonghua Liu
Summary: Based on a unified systematic review and meta-analysis, the study found that tea consumption can improve cognitive function, especially green and black tea in Eastern countries, particularly among women. The research also revealed a beneficial effect of tea on cognitive function, but the overall quality of evidence was generally low to moderate.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2022)
Article
Psychiatry
Arnaud Pouchon, Clement Donde, Mircea Polosan
Summary: Punding behavior, characterized by stereotypic and non-goal-oriented activity, is often under-diagnosed but could serve as a red flag for dementia in patients with depression.
FRONTIERS IN PSYCHIATRY
(2021)
Article
Multidisciplinary Sciences
Joo Youn Shin, Eun Young Choi, Min Kim, Hyung Keun Lee, Suk Ho Byeon
Summary: Biomarker tests for Alzheimer's disease are typically invasive and costly. However, recent advancements in OCT and OCT angiography have allowed for noninvasive and cost-effective characterization of retinal microvascular changes in patients with mild cognitive impairment (MCI) associated with AD. The study found reduced retinal microvasculature in MCI patients but no change in retinal thickness, with potential influence from the APOE genotype. OCTA of retinal microvasculature may be a useful tool for detecting vascular changes in AD.
SCIENTIFIC REPORTS
(2021)
Review
Neurosciences
Yufei Liu, Long Niu, Xinyao Liu, Cheng Cheng, Weidong Le
Summary: Parkinson's disease (PD) is the second most common neurodegenerative disease, characterized by both motor and non-motor symptoms, with circadian rhythm dysregulation emerging as a key feature that may play a pivotal role in the pathogenesis of PD. Recent research progress has focused on understanding altered circadian rhythm in PD, from clinical manifestations to underlying causes of circadian disorders in PD.
NEUROSCIENCE BULLETIN
(2021)
Article
Clinical Neurology
Calogero Edoardo Cicero, Antonina Luca, Giovanni Mostile, Giulia Donzuso, Loretta Giuliano, Mario Zappia, Alessandra Nicoletti
Summary: In Parkinson's disease, REM sleep behavior disorder (RBD) can either precede motor symptoms or develop during the course of the disease. Patients with RBD have a higher burden of cognitive impairment and hallucinations. This study analyzed the clinical characteristics of Parkinson's disease patients based on the timeline of RBD onset.
JOURNAL OF NEUROLOGY
(2023)
Article
Clinical Neurology
Jens Bohlken, Steffi Riedel-Heller, Antje Kramer, Karel Kostev, Anette Schrag
Summary: There was no increase in the number of patients with Parkinson's disease in Germany from 2010 to 2019, but there was an increase in the proportion of elderly patients and a decrease in the proportion of female patients.
FORTSCHRITTE DER NEUROLOGIE PSYCHIATRIE
(2023)
Article
Geriatrics & Gerontology
Mouhammed Ramadhan, Anette Schrag
Summary: This study aimed to examine the validity of health-related quality of life (Hr-QoL) measures in patients with late-stage Parkinson's disease (PD). The results showed that the PDQ-8 and EQ-5D-3 L have adequate validity in late-stage PD without dementia, but in those with PD and dementia, the EQ-5D-3 L may be preferable to the DEMQOL-Proxy.
JOURNAL OF GERIATRIC PSYCHIATRY AND NEUROLOGY
(2023)
Article
Clinical Neurology
Valtteri Kaasinen, Sheng Luo, Pablo Martinez-Martin, Christopher G. G. Goetz, Glenn T. T. Stebbins
Summary: This study compared patient and clinician evaluations of levodopa-induced dyskinesia (LID) severity across multiple cultures in patients with Parkinson's disease (PD). The results showed that language and cultural differences influence the subjective perception of LID, which is important to consider in multinational clinical trials on dyskinesia assessment.
MOVEMENT DISORDERS
(2023)
Article
Clinical Neurology
Thomas F. Tropea, Teresa Waligorska, Sharon X. Xie, Ilya M. Nasrallah, Katheryn A. Q. Cousins, John Q. Trojanowski, Murray Grossman, David J. Irwin, Daniel Weintraub, Edward B. Lee, David A. Wolk, Alice S. Chen-Plotkin, Leslie M. Shaw
Summary: The objective of this study was to determine if plasma tau phosphorylated at threonine 181 (p-tau181) can distinguish Alzheimer's disease (AD) from normal cognition (NC) in adults, predict cognitive and functional decline, and validate findings in an external cohort. The results showed that plasma p-tau181 can accurately differentiate AD pathology from NC, and higher levels of p-tau181 are associated with faster cognitive and functional decline.
ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY
(2023)
Article
Clinical Neurology
Jenny M. M. Norlin, Klas Kellerborg, Ulf Persson, Daniel Oudin Astrom, Peter Hagell, Pablo Martinez-Martin, Per Odin
Summary: This study found an association between the Clinical Impression of Severity Index for Parkinson's Disease (CISI-PD) and health-related quality of life assessments. The findings suggest that CISI-PD could be used as a basis for defining health states in future health economic models and as outcomes in managed entry agreements.
MOVEMENT DISORDERS CLINICAL PRACTICE
(2023)
Article
Clinical Neurology
Veronica Bruno, Beatrice Achen, Francesca Morgante, Roberto Erro, Susan H. Fox, Mark J. Edwards, Anette Schrag, Maria Stamelou, Silke Appel-Cresswell, Giovanni Defazio, K. Ray Chaudhuri, Sarah Pirio Richardson, Hyder A. Jinnah, Davide Martino
Summary: This study developed and validated a new rating instrument, Pain in Dystonia Scale (PIDS), to assess pain in adult-onset idiopathic dystonia (AOID). The PIDS evaluates pain severity, functional impact, and external modulating factors. It demonstrated high-level psychometric properties in patients with cervical dystonia (CD).
MOVEMENT DISORDERS
(2023)
Letter
Clinical Neurology
Haotian Zou, Christopher G. Goetz, Glenn T. Stebbins, Anette Schrag, Tiago A. Mestre, Sheng Luo
MOVEMENT DISORDERS
(2023)
Editorial Material
Medicine, General & Internal
Anette Schrag
NEW ENGLAND JOURNAL OF MEDICINE
(2023)
Article
Clinical Neurology
Katheryn A. Q. Cousins, David J. Irwin, Alice Chen-Plotkin, Leslie M. Shaw, Sanaz Arezoumandan, Edward B. Lee, David A. Wolk, Daniel Weintraub, Meredith Spindler, Andres Deik, Murray Grossman, Thomas F. Tropea
Summary: This study found that plasma GFAP may be sensitive to concomitant AD pathology in LBSD, especially accumulation of beta-amyloid plaques.
ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY
(2023)
Article
Neurosciences
Kalpana M. Merchant, Tanya Simuni, Janel Fedler, Chelsea Caspell-Garcia, Michael Brumm, Kelly N. H. Nudelman, Elizabeth Tengstrandt, Frank Hsieh, Roy N. Alcalay, Christopher Coffey, Lana Chahine, Tatiana Foroud, Andrew Singleton, Daniel Weintraub, Samantha Hutten, Todd Sherer, Brit Mollenhauer, Andrew Siderowf, Caroline Tanner, Ken Marek
Summary: We quantified concentrations of three isoforms of BMP in different cohorts of Parkinson's disease patients and found that LRRK2 and GBA1 gene mutations were associated with elevated BMP levels. However, BMP is not a prognostic or disease progression biomarker.
NPJ PARKINSONS DISEASE
(2023)
Article
Clinical Neurology
Thanh Phuong Pham Nguyen, Shelly L. Gray, Craig W. Newcomb, Qing Liu, Ali G. Hamedani, Daniel Weintraub, Sean Hennessy, Allison W. Willis
Summary: This study found that there were no significant differences in medication prescriptions between Parkinson disease (PD) patients hospitalized for serious injury and those hospitalized for other reasons, indicating a missed opportunity to deprescribe high-risk medications during care transitions.
PARKINSONISM & RELATED DISORDERS
(2023)
Article
Neurosciences
Cristina Gonzalez-Robles, Rimona S. Weil, Daniel van Wamelen, Michele Bartlett, Matthew Burnell, Caroline S. Clarke, Michele T. Hu, Brook Huxford, Ashwani Jha, Christian Lambert, Michael Lawton, Georgia Mills, Alastair Noyce, Paola Piccini, Kuhan Pushparatnam, Lynn Rochester, Carroll Siu, Caroline H. Williams-Gray, Marie-Louise Zeissler, Henrik Zetterberg, Camille B. Carroll, Thomas Foltynie, Anette Schrag
Summary: This study aims to provide an inventory of outcome measures (OM) for disease-modifying trials in Parkinson's disease and a framework for future selection of OM. An extensive inventory of OM was created based on evidence evaluation. Patient and public involvement emphasized the need for OM reflecting their disease experience and applicable to diverse populations and disease stages.
JOURNAL OF PARKINSONS DISEASE
(2023)
Article
Clinical Neurology
Jason Aldred, Eric Freire-Alvarez, Alexander V. Amelin, Angelo Antonini, Bruno Bergmans, Filip Bergquist, Manon Bouchard, Kumar Budur, Camille Carroll, K. Ray Chaudhuri, Susan R. Criswell, Erik H. Danielsen, Florin Gandor, Jia Jia, Thomas E. Kimber, Hideki Mochizuki, Weining Z. Robieson, Amy M. Spiegel, David G. Standaert, Saritha Talapala, Maurizio F. Facheris, Victor S. C. Fung
Summary: This article reports the results of a 52-week open-label registrational trial that evaluated the safety, tolerability, and efficacy of 24-hour foslevodopa/foscarbidopa continuous subcutaneous infusion in patients with advanced Parkinson's disease. The findings suggest that this treatment has the potential to improve motor control, sleep quality, and quality of life in patients with Parkinson's disease.
NEUROLOGY AND THERAPY
(2023)
Editorial Material
Clinical Neurology
K. Ray Chaudhuri, Lucia Batzu
MOVEMENT DISORDERS CLINICAL PRACTICE
(2023)
Review
Clinical Neurology
Nicole Campese, Bianca Calio, Fabian Leys, Lalit Kaltenbach, Georg Goebel, Julia Wanschitz, Andreas Schlager, Laura Zamarian, Kirsty Bannister, Ray K. Chaudhuri, Anette Schrag, Roberta Granata, Stefan Kiechl, Werner Poewe, Klaus Seppi, Gregor Wenning, Alessandra Fanciulli
Summary: This study aimed to assess the prevalence, characteristics, and risk factors for pain in individuals with multiple system atrophy (MSA). The results showed that pain is a frequent but under-recognized and undertreated feature of MSA. Further research is needed to improve pain detection and treatment in MSA.
MOVEMENT DISORDERS CLINICAL PRACTICE
(2023)
