Article
Chemistry, Medicinal
Sridhar Goud Nerella, Ahana Bhattacharya, Pavitra S. Thacker, Sanam Tulja
Summary: Fluorine-18 is a promising radionuclide for developing novel PET radiotracers due to its characteristic features such as convenient half-life, metabolic stability, good imaging properties, and easy access to various clinical PET centers. This review covers the patents and research papers of F-18-radiotracers with clinical applications in various diseases using PET modality since 2015 until the present. Despite other PET radionuclides C-11, N-13, and O-15, F-18 is widely used for radiotracer development because it has a maximum half-life of 109.8 min. Various synthetic methodologies have been developed for radiofluorination using nucleophilic, electrophilic, transition metal mediated, and prosthetic groups mediated reactions. Automated radiosynthesis methods have also been adapted for easy and convenient synthesis of F-18-radiotracers. PET provides functional information about disease conditions and is an essential tool in drug discovery for studying therapeutic drug development and pharmacokinetic profiles.
EXPERT OPINION ON THERAPEUTIC PATENTS
(2022)
Review
Chemistry, Multidisciplinary
Mitchell A. Klenner, Giancarlo Pascali, Massimiliano Massi, Benjamin H. Fraser
Summary: PET-fluorescence imaging is an emerging field that combines positron emission tomography and fluorescence imaging techniques, utilizing probes containing fluorophores and radioisotopes to provide complementary information. Different fluorine-18 labelled PET-fluorescence probes have been classified into four groups based on the implemented fluorophore, with a systematic comparison of their properties to aid future endeavors in PET-fluorescence chemistry.
CHEMISTRY-A EUROPEAN JOURNAL
(2021)
Article
Medicine, General & Internal
Tian Xiaoxue, Wang Yinzhong, Qi Meng, Xingru Lu, Junqiang Lei
Summary: This study aimed to evaluate the diagnostic accuracy of six different imaging modalities for differentiating glioma recurrence from postradiotherapy changes through a network meta-analysis. The results suggest that F-18-FET and F-18-FDOPA may have higher diagnostic value for glioma recurrence.
Article
Chemistry, Medicinal
Malvika Sardana, Louise Breuil, Sebastien Goutal, Maud Goislard, Mikhail Kondrashov, Etienne Marchal, Florent L. Besson, Christophe Dugave, Gail Wrigley, Anna C. Jonson, Bertrand Kuhnast, Magnus Schou, Nicolas Tournier, Charles S. Elmore, Fabien Caille
Summary: A spirocyclic hypervalent iodine precursor was synthesized for the isotopic labeling of Crizotinib, and PET imaging demonstrated the feasibility of [F-18](R)-Crizotinib for in vivo imaging. The study suggests that this method can be used for further research on enhancing the brain penetration of Crizotinib.
Article
Medicine, Research & Experimental
Zhengyuan Zhou, Michael R. Zalutsky, Satish K. Chitneni
Summary: The study investigated the feasibility of using F-18-labeled RG7388 as a PET tracer for imaging MDM2 expression in tumors. Fluorinated analogues of RG7388 were synthesized and their inhibitory potency against MDM2 was determined. F-18-labeled RG7388 showed good uptake and specificity in cell lines and in vivo mouse models, suggesting its potential for PET imaging of MDM2.
MOLECULAR PHARMACEUTICS
(2021)
Review
Biochemistry & Molecular Biology
Jatinder Kaur, Atul Bhardwaj, Frank Wuest
Summary: Molecular imaging probes enable early and accurate detection of disease-specific biomarkers and facilitate personalized treatment. Positron emission tomography (PET) plays a significant role in cancer detection and response monitoring. COX-2 isozyme has been identified as a crucial factor in cancer development, making it a promising biomarker.
Article
Oncology
Erik P. Sulman, David D. Eisenstat
Summary: Advances in the molecular genetics of pediatric and adult brain tumors have led to improvements in diagnostic accuracy and therapy targets, as well as enhancements in clinical care. However, further research is needed to improve survival rates, especially for patients with specific mutations. Access to technological advances in developing and developed countries is crucial for improving outcomes for patients with brain tumors.
FRONTIERS IN ONCOLOGY
(2021)
Review
Nutrition & Dietetics
Matthias Laudes, Corinna Geisler, Nathalie Rohmann, Jildau Bouwman, Tobias Pischon, Kristina Schlicht
Summary: Recent research has revealed the importance of high diversity in gut microbiota for maintaining health and the beneficial effects of certain bacteria on various host functions. Changes in microbiome are associated not only with nutrition-related diseases such as obesity and diabetes, but also with chronic inflammatory, oncologic, and neurological abnormalities. The challenge for microbiome-based biomedical research is to translate knowledge into clinical practice and identify potential targets for intervention studies.
Article
Medicine, General & Internal
Deborah Anne Forst, John Y. Rhee, Michelle Marie Mesa, Alyx F. Podgurski, Sumita Madhok Strander, Shibani Datta, Emilia Kaslow-Zieve, Nora K. Horick, Joseph A. Greer, Areej El-Jawahri, Timothy S. Sannes, Jennifer S. Temel, Jamie Jacobs
Summary: This study aims to develop and test a population-specific telehealth intervention (NeuroCARE) to reduce anxiety symptoms and improve psychosocial functioning in caregivers of patients with primary malignant brain tumours. The study is a non-blinded, randomised controlled trial enrolling 120 caregivers. The primary outcome is anxiety symptoms at 11 weeks among NeuroCARE participants, compared with usual care. The study is approved by the Dana-Farber/Harvard Cancer Center Institutional Review Board.
Article
Chemistry, Medicinal
Jason Beaufrez, Stephane Guillouet, Yann Seimbille, Cecile Perrio
Summary: In this study, we investigated the design, synthesis, radiosynthesis, physicochemical characterization, in vitro and in vivo stability, as well as the pharmacokinetics and biodistribution of a novel hydrophilic F-18-fluorosulfotetrazine. The F-18-fluorosulfotetrazine was prepared and labeled with fluorine-18 using a three-step procedure, starting from propargylic butanesultone. In vitro and in vivo studies demonstrated the hydrophilicity, stability, and suitable pharmacokinetics of F-18-fluorosulfotetrazine for pre-targeting applications.
Article
Oncology
Yang Chen, Jingya Han, Yan Zhao, Xinming Zhao, Mengmeng Zhao, Jingmian Zhang, Jianfang Wang
Summary: This study proposes an imaging method for assessing FGFR1 expression, utilizing [18F]F-FGFR1 as a peptide probe. In vitro and in vivo experiments demonstrate that [18F]F-FGFR1 shows high stability, affinity, specificity, and good imaging capacity in FGFR1-overexpressing tumors.
FRONTIERS IN ONCOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Thu Hang Lai, Magali Toussaint, Rodrigo Teodoro, Sladjana Dukic-Stefanovic, Mathias Kranz, Winnie Deuther-Conrad, Rares-Petru Moldovan, Peter Brust
Summary: The research focuses on developing a PET radiotracer for monitoring the expression and occupancy of the non-dopaminergic target A(2A) receptor in Parkinson's disease therapy. Novel fluorinated analogs are designed and evaluated in preclinical studies, showing specific in vitro binding to A(2A)R but no specific in vivo binding in dynamic PET/MRI studies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Medicine, General & Internal
Mantas Vaisvilas, Nicolas Lundahl Ciano-Petersen, M. D. Macarena Villagran-Garcia, Sergio Muniz-Castrillo, Alberto Vogrig, Jerome Honnorat
Summary: Paraneoplastic neurological syndromes (PNSs) are immune-mediated nervous system diseases triggered by an underlying malignancy, with distinct clinical presentations and outcomes. Updated diagnostic criteria have improved specificity and standardized research initiatives. Current treatments are rarely effective in reversing disability, but in-depth understanding of PNS pathogenesis promises new strategies.
POSTGRADUATE MEDICAL JOURNAL
(2023)
Article
Biochemistry & Molecular Biology
Katarina Varnas, Sangram Nag, Christer Halldin, Lars Farde
Summary: In this study, a novel reversible radioligand[F-18]GEH200449 for MAO-B was evaluated as a PET imaging marker in non-human primates. The PET studies demonstrated that [F-18]GEH200449 had suitable brain exposure and regional distribution consistent with the known localization of MAO-B. The binding of [F-18]GEH200449 to MAO-B was reversible and could be displaced by the administration of selective MAO-B ligands.
ACS CHEMICAL NEUROSCIENCE
(2023)
Review
Neurosciences
Matthew A. Smith-Cohn, Nicholas B. Burley, Stuart A. Grossman
Summary: This narrative review summarizes the available data on vasoactive peptides, exploring their potential in improving treatment for neurological diseases. Currently, there is no evidence of vasoactive peptides opening the blood-brain barrier in humans, but some have shown increased permeability in rodents.
CURRENT NEUROPHARMACOLOGY
(2022)
Article
Chemistry, Inorganic & Nuclear
Raman Kumar Joshi, Nerella Sridhar Goud, Chandana Nagaraj, Dinesh Kumar, R. Gopinath, Naren P. Rao, Anmol Dhawan, Ahana Bhattacharya, Sandhya Mangalore, Rose Dawn Bharath, Pardeep Kumar
Summary: The article discusses the importance of glucose as a source of energy for cancer growth and the development of tracers for specific receptors and metabolic pathways. Three radiotracers were synthesized using different modules, with evaluation of their radiochemical purity and yields. The validation of PET-MR imaging using these tracers demonstrates their potential for future clinical applications.
APPLIED RADIATION AND ISOTOPES
(2021)
Article
Chemistry, Medicinal
Nerella Sridhar Goud, Ahana Bhattacharya, Raman Kumar Joshi, Chandana Nagaraj, Rose Dawn Bharath, Pardeep Kumar
Summary: PET molecular imaging technique, with carbon-11 as a promising radiotracer, has become a valuable tool in medical diagnosis and biomedical research. Various carbon-11 PET radiotracers have been developed for imaging different diseases, targeting upregulated and emerging markers in oncology, cardiology, and neurology.
JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Article
Agronomy
Tulja Sanam, S. Triveni, Sridhar Goud Nerella, Santosh Nagappa Ningoji, Suseelendra Desai
Summary: This research focused on evaluating the performance of different bacteria on plant growth abilities, with the finding that using the Azospirillum strain ASP25 led to higher yields in tomato plants. Correlation and regression models suggested that plant growth variables have a positive impact on yield.
Article
Chemistry, Medicinal
Priti Singh, Dilep Kumar Sigalapalli, Nerella Sridhar Goud, Baijayantimala Swain, Santosh Kumar Sahoo, Andrea Angeli, Afzal B. Shaik, Venkata Madhavi Yaddanapudi, Claudiu T. Supuran, Mohammed Arifuddin
Summary: The study focused on the design and synthesis of 30 new non-sulfonamide sulfocoumarin derivatives as carbonic anhydrase (CA) inhibitors, with two compounds showing stronger inhibition against the tumor-associated isoenzyme hCA IX. The results provide new insights for the future development of non-sulfonamide derivatives as selective CA inhibitors.
Article
Chemistry, Medicinal
Sridhar Goud Nerella, Ahana Bhattacharya, Pavitra S. Thacker, Sanam Tulja
Summary: Fluorine-18 is a promising radionuclide for developing novel PET radiotracers due to its characteristic features such as convenient half-life, metabolic stability, good imaging properties, and easy access to various clinical PET centers. This review covers the patents and research papers of F-18-radiotracers with clinical applications in various diseases using PET modality since 2015 until the present. Despite other PET radionuclides C-11, N-13, and O-15, F-18 is widely used for radiotracer development because it has a maximum half-life of 109.8 min. Various synthetic methodologies have been developed for radiofluorination using nucleophilic, electrophilic, transition metal mediated, and prosthetic groups mediated reactions. Automated radiosynthesis methods have also been adapted for easy and convenient synthesis of F-18-radiotracers. PET provides functional information about disease conditions and is an essential tool in drug discovery for studying therapeutic drug development and pharmacokinetic profiles.
EXPERT OPINION ON THERAPEUTIC PATENTS
(2022)
Article
Oncology
Pavitra S. Thacker, Arifuddin Mohammed, Claudiu T. Supuran, Prerna L. Tiwari, Nerella S. Goud, Danaboina. Srikanth, Andrea Angeli
Summary: A series of coumarin carboxamides were synthesized and tested for their inhibitory activity against hCA isoforms. The results showed that these compounds selectively inhibited isoforms IX and XII, with 6a and 6b exhibiting the most potent inhibitory activity. These compounds may serve as valuable starting points for the design and development of selective and potent hCA IX and XII inhibitors.
ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY
(2022)
Review
Chemistry, Medicinal
Sridhar Goud Nerella, Priti Singh, Sanam Tulja
Summary: Carbon-11 is widely used in PET radiotracer development due to its direct insertion into bioactive compounds and less isotopic dilution. This article reviews patents and research articles on carbon-11 radiotracer synthesis and PET imaging applications in various diseases from 2012 to 2022.
EXPERT OPINION ON THERAPEUTIC PATENTS
(2022)
Review
Chemistry, Medicinal
Sridhar Goud Nerella, Priti Singh, Mohammed Arifuddin, Claudiu T. Supuran
Summary: This article discusses the therapeutic strategy targeting human carbonic anhydrase and its application in tumor management, providing new directions for cancer treatment.
EXPERT OPINION ON THERAPEUTIC PATENTS
(2022)
Article
Chemistry, Organic
Priti Singh, Santosh Kumar Sahoo, Nerella Sridhar Goud, Baijayantimala Swain, Venkata Madhavi Yaddanapudi, Mohammed Arifuddin
Summary: A protocol has been developed for the synthesis of 2-aryl/heteroaryl-4-quinolones using readily available and affordable starting materials. The reaction, conducted under microwave conditions with a copper catalyst, proceeded with moderate to high yields. The method is characterized by short reaction time, good functional group tolerance, high atom economy, non-toxic byproduct, and no need for special ligands, highlighting its applicability in organic synthesis.
ASIAN JOURNAL OF ORGANIC CHEMISTRY
(2022)
Review
Medicine, General & Internal
Sridhar Goud Nerella, Priti Singh, Tulja Sanam, Chander Singh Digwal
Summary: Positron emission tomography with selective radioligands plays a significant role in drug discovery and development by providing target-specific information, revealing disease progression, and advancing clinical investigation.
FRONTIERS IN MEDICINE
(2022)
Article
Pharmacology & Pharmacy
Nerella Sridhar Goud, Mahammad S. Ghouse, Chandana Nagaraju, Rose Dawn Bharath, Mallika Alvala, Pardeep Kumar
Summary: This study reports the feasibility of labeling coumarin-triazole hybrid with fluorine-18 as a radiotracer for oncology diagnosis. The results show that [F-18]SG-2 radiolabeling with F-18 radionuclide is feasible, and molecular docking studies suggest possible interactions with Galectin-1.
CURRENT RADIOPHARMACEUTICALS
(2022)
Article
Chemistry, Medicinal
Priti Singh, Nerella Sridhar Goud, Baijayantimala Swain, Santosh Kumar Sahoo, Abhishek Choli, Andrea Angeli, Bhoopendra Singh Kushwah, Venkata Madhavi Yaddanapudi, Claudiu T. Supuran, Mohammed Arifuddin
Summary: This manuscript reports the design, synthesis, and inhibitory profile of quinoline/pyridine linked indole-3-sulfonamide derivatives on carbonic anhydrase (CA) isoforms. The study found that pyridine indole-3-sulfonamide hybrids selectively inhibit transmembrane tumor-associated isoforms, while quinoline indole-3-sulfonamide hybrids have inhibitory effects on multiple isoforms. Compounds 6q and 6p showed promising inhibitory activity against hCA IX and could be potential lead candidates as anti-cancer agents.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2022)
Article
Chemistry, Medicinal
Pavitra S. Thacker, Vaishnavi Newaskar, Andrea Angeli, Dilep Kumar Sigalapalli, Nerella Sridhar Goud, Hepsibha Chirra, Afzal B. Shaik, Mohammed Arifuddin, Claudiu T. Supuran
Summary: A series of coumarin-linked thiazoles were synthesized and evaluated for their selective inhibition against human carbonic anhydrases IX and XII, which have been implicated in cancer. Compound 6o showed the best inhibition of hCA XII and can serve as a template for the design of other potent inhibitors.
ARCHIV DER PHARMAZIE
(2022)
Article
Multidisciplinary Sciences
Pardeep Kumar, Riptee Thakur, Pratap Chandra Acharya, Hosahalli K. Mohan, U. N. Pallavi, Divya Maheshwari, Afsal K. M. Mohammed, Aishwarya Kumar, Sridhar Goud Nerella, Raman Kumar Joshi, Manoj Kumar, Chandana Nagaraj
Summary: The study successfully synthesized a F-18 labeled tracer AVT-011 and demonstrated its specificity for Pgp and safety for patient use.
SCIENTIFIC REPORTS
(2022)
Article
Oncology
Krishna K. Chinchilli, Priti Singh, Baijayantimala Swain, Nerella S. Goud, Dilep K. Sigalapalli, Abhishek Choli, Andrea Angeli, Srinivas Nanduri, Venkata M. Yaddanapudi, Claudiu T. Supuran, Mohammed Arifuddin
Summary: A series of indole-3-sulfonamide-heteroaryl hybrids were synthesized and screened for their inhibition of human hCA isoforms I, II, IX, and XII. Compound 6l showed activity against all screened hCA isoforms, while compounds 6i, 6j, 6q, 6s, and 6t exhibited high selectivity against tumor-associated hCA IX. Compound 6u displayed moderate inhibitory activity against both hCA II and hCA IX. These compounds may serve as potential drug leads for anticancer drug discovery, particularly targeting tumor-associated hCA IX.
ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY
(2023)
Article
Chemistry, Medicinal
Shuang Mei, Su Jiang, Yuting Wang, Han Jing, Peng Yang, Miao-Miao Niu, Jindong Li, Kai Yuan, Yan Zhang
Summary: This study identifies a dual-targeting peptide, AP-1, that effectively inhibits variants of concern (VOCs) of SARS-CoV-2 without impairing host cell viability. The findings suggest that AP-1 could be a promising broad-spectrum agent for treating emerging VOCs of SARS-CoV-2.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2024)
Article
Chemistry, Medicinal
Hyeonjun Lee, Ju Yeon Lee, Hyunsoo Jang, Hye Young Cho, Minhee Kang, Sang Hyun Bae, Suin Kim, Eunji Kim, Jaebong Jang, Jin Young Kim, Young Ho Jeon
Summary: By using liquid chromatography-tandem mass spectrometry and nuclear magnetic resonance experiments, we identified new chemical moieties that bind to the target sites of the protein of interest, allowing for reversible binding and protein degradation. This method has the potential to expand the application of PROTAC technology.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2024)
Article
Chemistry, Medicinal
Yingying Li, Xiyou Du, Xinru Kong, Yuelin Fang, Zhijing He, Dongzhu Liu, Hang Wu, Jianbo Ji, Xiaoye Yang, Lei Ye, Guangxi Zhai
Summary: This study proposes a novel nanoplatform based on the autophagy cascade to overcome the obstacles in chemo-immunotherapy. The platform combines chemotherapy and starvation therapy to initiate pro-death autophagy and enhance antigen presentation, while also remodeling the immunosuppressive tumor microenvironment. Furthermore, the study discovers a new therapeutic direction for the respiration inhibitor 3-bromopyruvic acid (3BP) in cancer treatment. Overall, this study offers an opportunity to improve antitumor efficacy and boost immune responses.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2024)
Article
Chemistry, Medicinal
Bingsi Wang, Mingxu Ma, Yusen Dai, Pengfei Yu, Liang Ye, Wenyan Wang, Chunjie Sha, Huijie Yang, Yingjie Yang, Yunjing Zhu, Lin Dong, Shujuan Wei, Linlin Wang, Jingwei Tian, Hongbo Wang
Summary: Breast cancer is a common malignant tumor in women, and drug resistance remains a clinical challenge. In this study, a novel compound, G-5b, was developed with potent antagonistic and degradation activities comparable to the current drug fulvestrant. G-5b also showed improved stability and solubility. Mechanistically, G-5b engages the proteasome pathway to degrade ER, inhibiting the ER signaling pathway and inducing apoptosis and cell cycle arrest. In animal models, G-5b exhibited superior pharmacokinetics and pharmacodynamics properties. Overall, G-5b is a promising long-acting SERD worthy of further investigation and optimization.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2024)
Article
Chemistry, Medicinal
Karoline B. Waitman, Larissa C. de Almeida, Marina C. Primi, Jorge A. E. G. Carlos, Claudia Ruiz, Thales Kronenberger, Stefan Laufer, Marcia Ines Goettert, Antti Poso, Sandra V. Vassiliades, Vinicius A. M. de Souza, Monica F. Z. J. Toledo, Neuza M. A. Hassimotto, Michael D. Cameron, Thomas D. Bannister, Leticia Costa-Lotufo, Joa o A. Machado-Neto, Mauricio T. Tavares, Roberto Parise-Filho
Summary: A series of hybrid inhibitors combining pharmacophores of known kinase inhibitors and benzohydroxamate HDAC inhibitors were synthesized and evaluated for their anticancer activity and pharmacokinetic properties. Compounds 4d-f exhibited promising cytotoxicity against hematological cells and moderate activity against solid tumor models. Compound 4d showed potent inhibition of multiple kinase targets and had stable interactions with HDAC and members of the JAK family. These compounds showed selective cytotoxicity with minimal effects on non-tumorigenic cells and favorable pharmacokinetic profiles.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2024)
Article
Chemistry, Medicinal
Michal Sulik, Diana Fontinha, Dietmar Steverding, Szymon Sobczak, Michal Antoszczak, Miguel Prudencio, Adam Huczynski
Summary: This study describes the synthesis of the first-in-class ivermectin derivatives obtained through derivatization of the C13 position, along with the unexpected rearrangement of the macrolide ring. These derivatives show potential for antiparasitic activity and are important for the development of new antiparasitic agents.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2024)
Article
Chemistry, Medicinal
Jun Liu, Qiu-Xian Chen, Wen-Fu Wu, Dong Wang, Si -Yu Zhao, Jia-Hao Li, Yi-Qun Chang, Shao-Gao Zeng, Jia-Yi Hu, Yu-Jie Li, Jia-Xin Du, Shu-Meng Jiao, Hai-Chuan Xiao, Qiang Zhang, Jun Xu, Jian-Fu Zhao, Hai -Bo Zhou, Yong-Heng Wang, Jian Zou, Ping-Hua Sun
Summary: A new anti-infective drug strategy has been discovered to attenuate virulence and modulate inflammation caused by drug-resistant Pseudomonas aeruginosa infections. Compound 5f inhibits biofilm formation, macrophage migration, and inflammatory response induced by P. aeruginosa, showing potential as a novel candidate against drug-resistant infections.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2024)
Article
Chemistry, Medicinal
Liuzeng Chen, Ke Wang, Lingyun Wang, Wei Wang, Lifan Wang, Jia Li, Xiaohan Liu, Mengya Wang, Banfeng Ruan
Summary: In this study, a series of novel anti-inflammatory compounds were designed and synthesized based on the natural product pterostilbene skeleton. Among them, compound 8 showed the highest activity and exhibited its effects through inhibition of pro-inflammatory cytokines by blocking the NF-KB/MAPK signaling pathway. Compound 8 also demonstrated a good relieving effect on acute colitis in mice and showed good safety in acute toxicity experiments.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2024)
Article
Chemistry, Medicinal
Si-Min Liang, Gui-Bin Liang, Hui-Ling Wang, Hong Jiang, Xian-Li Ma, Jian-Hua Wei, Ri-Zhen Huang, Ye Zhang
Summary: A series of novel multi-target antitumor agents were designed, synthesized, and evaluated. Some compounds exhibited significant antitumor activity and one compound showed excellent efficacy, limited toxicity, and low resistance. Further mechanism studies revealed that the compound exerted antitumor effects through multiple pathways.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2024)
